Homo sapiens

6 known processes

CTSD

cathepsin D

(Aliases: CPSD,MGC2311,CLN10)

CTSD biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
elastin catabolic process GO:0060309 1 0.779
regulation of elastin catabolic process GO:0060310 1 0.743
regulation of blood vessel remodeling GO:0060312 2 0.703
vacuole organization GO:0007033 44 0.484
Mouse
negative regulation of elastin catabolic process GO:0060311 1 0.415
negative regulation of collagen catabolic process GO:0010711 1 0.378
regulation of lipid metabolic process GO:0019216 96 0.314
negative regulation of blood vessel remodeling GO:0060313 1 0.275
ion homeostasis GO:0050801 230 0.252
cellular amine metabolic process GO:0044106 41 0.233
regulation of mapk cascade GO:0043408 262 0.219
Human
lipid metabolic process GO:0006629 381 0.211
oxidation reduction process GO:0055114 396 0.205
epithelium development GO:0060429 227 0.200
Zebrafish
ion transmembrane transport GO:0034220 338 0.174
negative regulation of cell death GO:0060548 345 0.169
response to abiotic stimulus GO:0009628 336 0.166
locomotory behavior GO:0007626 1 0.164
response to oxygen containing compound GO:1901700 369 0.131
carbohydrate metabolic process GO:0005975 207 0.131
regulation of oxidative stress induced cell death GO:1903201 24 0.124
maintenance of location GO:0051235 112 0.123
circadian behavior GO:0048512 2 0.118
positive regulation of cellular amine metabolic process GO:0033240 7 0.117
regulation of protein processing GO:0070613 150 0.116
neuromuscular process GO:0050905 15 0.114
response to oxidative stress GO:0006979 121 0.106
cellular lipid metabolic process GO:0044255 303 0.099
positive regulation of phosphorylation GO:0042327 394 0.098
regulation of cellular ketone metabolic process GO:0010565 50 0.093
neurological system process GO:0050877 163 0.091
regulation of cellular response to stress GO:0080135 244 0.090
cellular response to hydrogen peroxide GO:0070301 37 0.086
regulation of peptidase activity GO:0052547 180 0.085
negative regulation of response to oxidative stress GO:1902883 18 0.084
peptidyl tyrosine phosphorylation GO:0018108 170 0.081
vesicle mediated transport GO:0016192 371 0.079
epithelial cell differentiation GO:0030855 141 0.079
cellular response to reactive oxygen species GO:0034614 50 0.078
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.076
chemical homeostasis GO:0048878 306 0.075
Human
central nervous system development GO:0007417 123 0.075
cellular response to oxidative stress GO:0034599 85 0.075
regulation of transferase activity GO:0051338 355 0.075
eye development GO:0001654 42 0.075
Zebrafish
negative regulation of protein metabolic process GO:0051248 391 0.075
signal transduction by phosphorylation GO:0023014 297 0.073
Human
cellular amide metabolic process GO:0043603 69 0.073
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.072
organ morphogenesis GO:0009887 147 0.072
collagen catabolic process GO:0030574 10 0.071
amine metabolic process GO:0009308 44 0.070
transmembrane transport GO:0055085 399 0.070
negative regulation of collagen metabolic process GO:0010713 3 0.069
regulation of cellular response to oxidative stress GO:1900407 26 0.066
cell morphogenesis GO:0000902 296 0.066
cellular amino acid metabolic process GO:0006520 116 0.065
negative regulation of cellular protein metabolic process GO:0032269 353 0.065
cation transport GO:0006812 331 0.063
negative regulation of peptidase activity GO:0010466 91 0.059
cation transmembrane transport GO:0098655 238 0.059
response to hormone GO:0009725 175 0.059
glycerophospholipid metabolic process GO:0006650 84 0.058
cellular ketone metabolic process GO:0042180 80 0.058
negative regulation of multicellular organismal metabolic process GO:0044252 3 0.058
mapk cascade GO:0000165 288 0.057
Human
response to hydrogen peroxide GO:0042542 40 0.057
carbohydrate catabolic process GO:0016052 36 0.056
sensory perception of bitter taste GO:0050913 28 0.056
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.055
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.055
Yeast
cell development GO:0048468 328 0.055
monovalent inorganic cation transport GO:0015672 128 0.054
inorganic ion transmembrane transport GO:0098660 231 0.054
positive regulation of cell proliferation GO:0008284 301 0.054
positive regulation of protein kinase activity GO:0045860 190 0.054
circulatory system development GO:0072359 262 0.053
lipid localization GO:0010876 106 0.053
post embryonic development GO:0009791 2 0.052
single organism carbohydrate metabolic process GO:0044723 193 0.052
anatomical structure homeostasis GO:0060249 100 0.052
Human
protein processing GO:0016485 226 0.051
Human
hematopoietic or lymphoid organ development GO:0048534 186 0.051
negative regulation of cellular response to oxidative stress GO:1900408 18 0.049
response to cytokine GO:0034097 232 0.048
apoptotic signaling pathway GO:0097190 268 0.048
cellular carbohydrate metabolic process GO:0044262 84 0.047
nervous system development GO:0007399 293 0.047
positive regulation of transport GO:0051050 336 0.047
prostate gland development GO:0030850 3 0.046
negative regulation of apoptotic process GO:0043066 316 0.046
amino acid transport GO:0006865 28 0.046
regulation of secretion GO:0051046 194 0.046
negative regulation of cellular amine metabolic process GO:0033239 3 0.046
immune response GO:0006955 307 0.045
response to reactive oxygen species GO:0000302 61 0.045
regulation of collagen catabolic process GO:0010710 3 0.045
hexose catabolic process GO:0019320 7 0.044
regulation of vesicle mediated transport GO:0060627 130 0.044
regulation of protein maturation GO:1903317 150 0.044
negative regulation of protein maturation GO:1903318 142 0.043
cellular response to oxygen containing compound GO:1901701 276 0.043
negative regulation of protein processing GO:0010955 142 0.042
response to organic cyclic compound GO:0014070 204 0.042
negative regulation of cellular component organization GO:0051129 235 0.041
protein localization to organelle GO:0033365 280 0.040
detection of chemical stimulus GO:0009593 55 0.040
response to axon injury GO:0048678 1 0.040
regulation of cellular amine metabolic process GO:0033238 11 0.039
cell death in response to oxidative stress GO:0036473 29 0.038
alcohol metabolic process GO:0006066 114 0.037
gland development GO:0048732 48 0.037
negative regulation of multicellular organismal process GO:0051241 317 0.037
lipid catabolic process GO:0016042 84 0.037
organic hydroxy compound metabolic process GO:1901615 147 0.036
positive regulation of protein phosphorylation GO:0001934 313 0.036
cellular homeostasis GO:0019725 196 0.036
negative regulation of catalytic activity GO:0043086 335 0.035
reproductive process GO:0022414 106 0.035
muscle cell cellular homeostasis GO:0046716 3 0.034
cellular macromolecule catabolic process GO:0044265 380 0.033
Yeast
exocytosis GO:0006887 71 0.033
negative regulation of proteolysis GO:0045861 132 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
system process GO:0003008 349 0.032
Human
monovalent inorganic cation homeostasis GO:0055067 37 0.032
cation homeostasis GO:0055080 189 0.032
positive regulation of mapk cascade GO:0043410 190 0.032
negative regulation of hydrolase activity GO:0051346 182 0.031
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.031
cell activation GO:0001775 213 0.031
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.031
secretion by cell GO:0032940 226 0.030
negative regulation of oxidative stress induced cell death GO:1903202 17 0.030
regulation of anatomical structure morphogenesis GO:0022603 286 0.030
lipid storage GO:0019915 28 0.030
cytoplasmic transport GO:0016482 379 0.030
negative regulation of intracellular signal transduction GO:1902532 183 0.029
response to decreased oxygen levels GO:0036293 96 0.029
myeloid cell differentiation GO:0030099 117 0.029
response to oxygen levels GO:0070482 100 0.028
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.028
determination of adult lifespan GO:0008340 2 0.028
Worm
cellular component morphogenesis GO:0032989 314 0.028
glycoprotein catabolic process GO:0006516 7 0.028
positive regulation of cellular component organization GO:0051130 376 0.027
membrane lipid metabolic process GO:0006643 53 0.027
hair cell differentiation GO:0035315 2 0.027
regulation of kinase activity GO:0043549 314 0.026
rhythmic behavior GO:0007622 2 0.026
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.026
regulation of glycoprotein metabolic process GO:1903018 19 0.026
nuclear division GO:0000280 128 0.026
sleep GO:0030431 2 0.025
skin development GO:0043588 76 0.025
peptide catabolic process GO:0043171 10 0.025
positive regulation of transferase activity GO:0051347 227 0.024
generation of precursor metabolites and energy GO:0006091 68 0.024
amino sugar catabolic process GO:0046348 3 0.024
negative regulation of glycoprotein metabolic process GO:1903019 8 0.024
chordate embryonic development GO:0043009 34 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
multicellular organismal macromolecule metabolic process GO:0044259 29 0.023
response to inorganic substance GO:0010035 127 0.023
carboxylic acid transport GO:0046942 63 0.023
single organism reproductive process GO:0044702 98 0.023
immune system development GO:0002520 195 0.023
response to thyroid hormone GO:0097066 9 0.023
proteasomal protein catabolic process GO:0010498 176 0.023
protein modification by small protein conjugation GO:0032446 342 0.023
posttranscriptional regulation of gene expression GO:0010608 213 0.023
negative regulation of protein modification process GO:0031400 200 0.022
response to alcohol GO:0097305 64 0.022
regulation of intracellular transport GO:0032386 195 0.022
regulation of cytokine production GO:0001817 232 0.022
defense response GO:0006952 315 0.022
Worm
cellular ion homeostasis GO:0006873 168 0.022
peripheral nervous system development GO:0007422 2 0.022
response to hypoxia GO:0001666 96 0.022
positive regulation of epithelial cell proliferation GO:0050679 65 0.021
positive regulation of kinase activity GO:0033674 204 0.021
cytokine production GO:0001816 247 0.021
regulation of erk1 and erk2 cascade GO:0070372 99 0.021
positive regulation of leukocyte degranulation GO:0043302 3 0.021
microtubule based process GO:0007017 210 0.021
regulation of proteolysis GO:0030162 293 0.021
regulation of cell adhesion GO:0030155 166 0.021
regulation of endopeptidase activity GO:0052548 170 0.020
regulation of response to oxidative stress GO:1902882 26 0.020
negative regulation of endopeptidase activity GO:0010951 84 0.020
response to organonitrogen compound GO:0010243 156 0.020
regulation of cellular ph GO:0030641 17 0.020
cellular protein catabolic process GO:0044257 261 0.020
Yeast
cellular cation homeostasis GO:0030003 163 0.020
reactive oxygen species biosynthetic process GO:1903409 4 0.020
sensory perception GO:0007600 103 0.020
wnt signaling pathway GO:0016055 156 0.020
response to fungus GO:0009620 4 0.020
circadian sleep wake cycle process GO:0022410 2 0.019
epidermis development GO:0008544 59 0.019
regulation of protein kinase activity GO:0045859 289 0.019
sulfur compound metabolic process GO:0006790 101 0.019
negative regulation of cellular catabolic process GO:0031330 83 0.019
cerebellum development GO:0021549 2 0.019
female gamete generation GO:0007292 2 0.019
cellular protein complex assembly GO:0043623 188 0.019
dna replication GO:0006260 116 0.019
response to lipid GO:0033993 206 0.018
reproductive system development GO:0061458 56 0.018
blood vessel remodeling GO:0001974 2 0.018
growth GO:0040007 202 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
small molecule biosynthetic process GO:0044283 157 0.018
head development GO:0060322 108 0.018
positive regulation of secretion by cell GO:1903532 108 0.018
developmental process involved in reproduction GO:0003006 66 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
reactive oxygen species metabolic process GO:0072593 75 0.017
phospholipid metabolic process GO:0006644 99 0.017
cellular chemical homeostasis GO:0055082 180 0.017
positive regulation of immune system process GO:0002684 283 0.017
single organism membrane organization GO:0044802 268 0.017
Yeast
regulation of cellular component movement GO:0051270 334 0.017
protein stabilization GO:0050821 64 0.017
multicellular organismal metabolic process GO:0044236 34 0.017
protein ubiquitination GO:0016567 314 0.016
regeneration GO:0031099 4 0.016
urogenital system development GO:0001655 65 0.016
Human
protein maturation GO:0051604 233 0.016
Human
thiamine transport GO:0015888 3 0.016
regulation of cell motility GO:2000145 299 0.016
reactive nitrogen species metabolic process GO:2001057 3 0.016
multicellular organismal aging GO:0010259 3 0.016
Worm
divalent metal ion transport GO:0070838 152 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
developmental growth involved in morphogenesis GO:0060560 23 0.016
neuromuscular process controlling balance GO:0050885 7 0.016
embryo development GO:0009790 123 0.016
neurogenesis GO:0022008 169 0.016
positive regulation of necrotic cell death GO:0010940 4 0.015
hemopoiesis GO:0030097 180 0.015
sensory perception of taste GO:0050909 36 0.015
lysosome organization GO:0007040 24 0.015
response to nitrogen compound GO:1901698 184 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
positive regulation of endocytosis GO:0045807 42 0.015
reproductive structure development GO:0048608 55 0.015
embryonic morphogenesis GO:0048598 85 0.015
metal ion homeostasis GO:0055065 169 0.015
leukocyte mediated immunity GO:0002443 59 0.015
activation of protein kinase activity GO:0032147 90 0.015
negative regulation of transferase activity GO:0051348 124 0.015
positive regulation of secretion GO:0051047 116 0.015
azole transport GO:0045117 4 0.015
hydrogen transport GO:0006818 23 0.015
hormone metabolic process GO:0042445 61 0.015
Human
brain development GO:0007420 97 0.015
leukocyte activation GO:0045321 164 0.015
respiratory system process GO:0003016 3 0.014
negative regulation of protein catabolic process GO:0042177 59 0.014
cellular component disassembly GO:0022411 92 0.014
cellular divalent inorganic cation homeostasis GO:0072503 128 0.014
regulation of exocytosis GO:0017157 46 0.014
cholesterol metabolic process GO:0008203 28 0.014
tissue regeneration GO:0042246 3 0.014
regulation of lymphocyte activation GO:0051249 103 0.014
regulation of growth GO:0040008 165 0.014
bone resorption GO:0045453 6 0.014
regulation of homeostatic process GO:0032844 121 0.014
hindbrain development GO:0030902 3 0.014
internal peptidyl lysine acetylation GO:0018393 97 0.014
neuromuscular junction development GO:0007528 3 0.014
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.014
neuromuscular process controlling posture GO:0050884 2 0.014
cell type specific apoptotic process GO:0097285 125 0.013
alcohol biosynthetic process GO:0046165 52 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
generation of neurons GO:0048699 152 0.013
steroid metabolic process GO:0008202 94 0.013
response to external biotic stimulus GO:0043207 261 0.013
Zebrafish
antigen processing and presentation GO:0019882 33 0.013
Human
lipid biosynthetic process GO:0008610 177 0.013
peptidyl lysine modification GO:0018205 144 0.013
calcium ion homeostasis GO:0055074 122 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
regulation of protein catabolic process GO:0042176 155 0.013
regulation of cell cycle process GO:0010564 266 0.013
regulation of bone remodeling GO:0046850 6 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
regulation of multicellular organismal metabolic process GO:0044246 17 0.012
protein localization to endoplasmic reticulum GO:0070972 19 0.012
tissue morphogenesis GO:0048729 96 0.012
cell growth GO:0016049 160 0.012
blastocyst development GO:0001824 3 0.012
organic hydroxy compound transport GO:0015850 63 0.012
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.012
protein autophosphorylation GO:0046777 123 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
cell projection organization GO:0030030 252 0.012
segmentation GO:0035282 4 0.012
cellular lipid catabolic process GO:0044242 65 0.012
circadian sleep wake cycle sleep GO:0050802 2 0.012
negative regulation of catabolic process GO:0009895 104 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
heart morphogenesis GO:0003007 48 0.012
regulation of cell cycle GO:0051726 393 0.012
receptor metabolic process GO:0043112 81 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
negative regulation of hydrogen peroxide induced cell death GO:1903206 9 0.012
organic acid transport GO:0015849 65 0.012
hexose metabolic process GO:0019318 55 0.012
regulation of cell activation GO:0050865 125 0.012
cholesterol transport GO:0030301 39 0.011
innate immune response GO:0045087 178 0.011
negative regulation of platelet derived growth factor receptor signaling pathway GO:0010642 4 0.011
cellular monovalent inorganic cation homeostasis GO:0030004 26 0.011
divalent inorganic cation homeostasis GO:0072507 136 0.011
regulation of cell division GO:0051302 116 0.011
detection of stimulus GO:0051606 85 0.011
extracellular matrix disassembly GO:0022617 16 0.011
regulation of endocytosis GO:0030100 72 0.011
sequestering of metal ion GO:0051238 24 0.011
cell substrate adhesion GO:0031589 132 0.011
divalent inorganic cation transport GO:0072511 158 0.011
ph reduction GO:0045851 11 0.011
cell part morphogenesis GO:0032990 137 0.011
erbb signaling pathway GO:0038127 44 0.011
regulation of secretion by cell GO:1903530 177 0.011
response to estrogen GO:0043627 47 0.011
cell adhesion GO:0007155 325 0.011
decidualization GO:0046697 4 0.011
positive regulation of cell death GO:0010942 263 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.011
actin filament based process GO:0030029 224 0.011
negative regulation of cell cycle GO:0045786 193 0.010
involuntary skeletal muscle contraction GO:0003011 1 0.010
monosaccharide metabolic process GO:0005996 74 0.010
negative regulation of synaptic transmission GO:0050805 2 0.010
mitotic cell cycle GO:0000278 326 0.010
negative regulation of organelle organization GO:0010639 126 0.010
syncytium formation by plasma membrane fusion GO:0000768 2 0.010
secretion GO:0046903 254 0.010
endocrine process GO:0050886 25 0.010
Human
cellular macromolecular complex assembly GO:0034622 324 0.010
behavior GO:0007610 112 0.010
erk1 and erk2 cascade GO:0070371 104 0.010
metencephalon development GO:0022037 2 0.010

CTSD disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.986
inherited metabolic disorder DOID:655 242 0.986
lipid storage disease DOID:9455 28 0.961
lysosomal storage disease DOID:3211 47 0.961
central nervous system disease DOID:331 186 0.595
nervous system disease DOID:863 431 0.595
cerebral degeneration DOID:1443 16 0.299
brain disease DOID:936 73 0.299
leukodystrophy DOID:10579 8 0.299
neuronal ceroid lipofuscinosis DOID:14503 11 0.209
neurodegenerative disease DOID:1289 102 0.101
sensory system disease DOID:0050155 203 0.044
eye and adnexa disease DOID:1492 150 0.044
eye disease DOID:5614 149 0.044
acquired metabolic disease DOID:0060158 58 0.042
carbohydrate metabolic disorder DOID:2978 55 0.041
glycogen metabolism disorder DOID:0050728 10 0.041
retinal disease DOID:5679 118 0.030
retinal degeneration DOID:8466 89 0.030
degeneration of macula and posterior pole DOID:2007 17 0.030
macular degeneration DOID:4448 20 0.030
disease of mental health DOID:150 70 0.029
cognitive disorder DOID:1561 29 0.029
sphingolipidosis DOID:1927 14 0.028
glycogen storage disease DOID:2747 10 0.024
immune system disease DOID:2914 155 0.021
cancer DOID:162 167 0.020
disease of cellular proliferation DOID:14566 174 0.020
musculoskeletal system disease DOID:17 223 0.012
disease by infectious agent DOID:0050117 34 0.012
age related macular degeneration DOID:10871 17 0.011
hematopoietic system disease DOID:74 100 0.010
cardiovascular system disease DOID:1287 106 0.010