Homo sapiens

18 known processes

TOP3A

topoisomerase (DNA) III alpha

(Aliases: TOP3)

TOP3A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of telomere maintenance via telomerase GO:0032210 6 0.792
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.543
positive regulation of telomere maintenance GO:0032206 4 0.430
double strand break repair via single strand annealing GO:0045002 4 0.368
telomere maintenance via telomere lengthening GO:0010833 9 0.357
anatomical structure homeostasis GO:0060249 100 0.304
telomere maintenance GO:0000723 32 0.290
telomere maintenance via telomerase GO:0007004 8 0.289
dna replication GO:0006260 116 0.240
protein localization to chromosome telomeric region GO:0070198 6 0.236
regulation of transferase activity GO:0051338 355 0.178
meiotic chromosome separation GO:0051307 3 0.172
negative regulation of t cell apoptotic process GO:0070233 4 0.171
replication fork processing GO:0031297 13 0.165
chromatin modification GO:0016568 298 0.157
negative regulation of telomere maintenance GO:0032205 9 0.148
cellular macromolecule catabolic process GO:0044265 380 0.125
protein oligomerization GO:0051259 173 0.112
organelle fission GO:0048285 149 0.110
negative regulation of thymocyte apoptotic process GO:0070244 1 0.110
regulation of telomere maintenance GO:0032204 13 0.109
chromosome separation GO:0051304 23 0.107
regulation of mitosis GO:0007088 63 0.102
cellular response to dna damage stimulus GO:0006974 379 0.102
Fly
regulation of cell cycle GO:0051726 393 0.100
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.100
replicative cell aging GO:0001302 3 0.096
hemopoiesis GO:0030097 180 0.096
regulation of mitotic cell cycle phase transition GO:1901990 118 0.096
protein catabolic process GO:0030163 325 0.096
response to dietary excess GO:0002021 2 0.088
determination of adult lifespan GO:0008340 2 0.087
multicellular organismal aging GO:0010259 3 0.082
cell cycle checkpoint GO:0000075 117 0.082
chromatin organization GO:0006325 351 0.079
modification dependent protein catabolic process GO:0019941 209 0.078
cell cycle phase transition GO:0044770 173 0.078
ubiquitin dependent protein catabolic process GO:0006511 206 0.078
telomere capping GO:0016233 5 0.077
negative regulation of cell cycle GO:0045786 193 0.077
nuclear division GO:0000280 128 0.076
regulation of cell division GO:0051302 116 0.075
telomere organization GO:0032200 33 0.073
cellular protein catabolic process GO:0044257 261 0.072
negative regulation of apoptotic process GO:0043066 316 0.072
hematopoietic or lymphoid organ development GO:0048534 186 0.072
regulation of dna replication GO:0006275 68 0.071
negative regulation of cell cycle process GO:0010948 121 0.070
chemical homeostasis GO:0048878 306 0.070
reciprocal dna recombination GO:0035825 4 0.068
mitotic cell cycle process GO:1903047 286 0.067
ribonucleoside triphosphate catabolic process GO:0009203 391 0.067
chromosome segregation GO:0007059 114 0.066
microtubule polymerization GO:0046785 18 0.065
regulation of kinase activity GO:0043549 314 0.065
negative regulation of protein maturation GO:1903318 142 0.063
positive regulation of cell death GO:0010942 263 0.062
regulation of microtubule based process GO:0032886 74 0.061
negative regulation of cell death GO:0060548 345 0.059
positive regulation of cytoskeleton organization GO:0051495 83 0.058
protein localization to organelle GO:0033365 280 0.057
cell division GO:0051301 168 0.056
mitotic cell cycle phase transition GO:0044772 162 0.056
dna dependent dna replication GO:0006261 44 0.056
purine nucleoside triphosphate metabolic process GO:0009144 412 0.055
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.053
positive regulation of t cell proliferation GO:0042102 33 0.053
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.051
meiotic chromosome segregation GO:0045132 4 0.049
regulation of proteasomal protein catabolic process GO:0061136 87 0.049
positive regulation of dna metabolic process GO:0051054 73 0.049
intracellular protein transport GO:0006886 270 0.049
negative regulation of mitotic cell cycle GO:0045930 102 0.048
dna geometric change GO:0032392 32 0.048
negative regulation of telomerase activity GO:0051974 6 0.047
negative regulation of protein metabolic process GO:0051248 391 0.046
regulation of cell cycle phase transition GO:1901987 126 0.046
positive regulation of cell proliferation GO:0008284 301 0.046
positive regulation of protein polymerization GO:0032273 45 0.046
cellular amino acid metabolic process GO:0006520 116 0.044
regulation of microtubule polymerization GO:0031113 12 0.044
regulation of proteolysis GO:0030162 293 0.044
positive regulation of organelle organization GO:0010638 195 0.043
positive regulation of chromosome organization GO:2001252 41 0.043
negative regulation of programmed cell death GO:0043069 321 0.043
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
protein maturation GO:0051604 233 0.042
purine ribonucleotide catabolic process GO:0009154 404 0.041
proteasomal protein catabolic process GO:0010498 176 0.041
mitotic cell cycle GO:0000278 326 0.041
ribonucleoside triphosphate metabolic process GO:0009199 412 0.040
cell development GO:0048468 328 0.039
cell type specific apoptotic process GO:0097285 125 0.039
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.038
regulation of microtubule cytoskeleton organization GO:0070507 61 0.038
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.038
negative regulation of chromosome organization GO:2001251 48 0.038
modification dependent macromolecule catabolic process GO:0043632 212 0.037
negative regulation of cellular catabolic process GO:0031330 83 0.037
nucleoside phosphate catabolic process GO:1901292 412 0.037
positive regulation of protein complex assembly GO:0031334 86 0.037
growth GO:0040007 202 0.037
Fly
mitotic cell cycle checkpoint GO:0007093 68 0.036
regulation of cellular ketone metabolic process GO:0010565 50 0.036
positive regulation of cellular component organization GO:0051130 376 0.036
protein homooligomerization GO:0051260 100 0.036
regulation of cytoskeleton organization GO:0051493 177 0.035
negative regulation of developmental process GO:0051093 247 0.035
regulation of protein catabolic process GO:0042176 155 0.035
positive regulation of hydrolase activity GO:0051345 331 0.035
cellular macromolecular complex assembly GO:0034622 324 0.035
regulation of protein maturation GO:1903317 150 0.035
positive regulation of cell cycle process GO:0090068 106 0.035
cellular amine metabolic process GO:0044106 41 0.035
regulation of protein serine threonine kinase activity GO:0071900 179 0.035
negative regulation of organelle organization GO:0010639 126 0.035
regeneration GO:0031099 4 0.034
Fly
protein processing GO:0016485 226 0.034
regulation of mitotic cell cycle GO:0007346 189 0.034
sister chromatid segregation GO:0000819 54 0.034
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.034
positive regulation of apoptotic process GO:0043065 246 0.034
amine metabolic process GO:0009308 44 0.034
mitotic nuclear division GO:0007067 119 0.033
cellular response to organic cyclic compound GO:0071407 127 0.033
protein targeting GO:0006605 187 0.033
positive regulation of programmed cell death GO:0043068 249 0.033
regulation of cell cycle process GO:0010564 266 0.033
nucleotide catabolic process GO:0009166 408 0.033
covalent chromatin modification GO:0016569 254 0.032
response to extracellular stimulus GO:0009991 85 0.032
regulation of protein kinase activity GO:0045859 289 0.032
purine nucleotide catabolic process GO:0006195 405 0.032
purine ribonucleoside metabolic process GO:0046128 437 0.032
negative regulation of protein processing GO:0010955 142 0.032
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
negative regulation of homeostatic process GO:0032845 59 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.031
stem cell development GO:0048864 69 0.031
positive regulation of immune system process GO:0002684 283 0.031
leukocyte apoptotic process GO:0071887 31 0.030
negative regulation of protein catabolic process GO:0042177 59 0.030
positive regulation of mitosis GO:0045840 25 0.030
regulation of cellular response to stress GO:0080135 244 0.030
negative regulation of transferase activity GO:0051348 124 0.030
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
regulation of cell differentiation GO:0045595 393 0.029
regulation of dna metabolic process GO:0051052 153 0.029
behavior GO:0007610 112 0.028
microtubule based process GO:0007017 210 0.028
metaphase anaphase transition of cell cycle GO:0044784 21 0.028
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.028
regulation of cellular protein catabolic process GO:1903362 96 0.028
cellular protein complex assembly GO:0043623 188 0.028
dephosphorylation GO:0016311 209 0.027
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.027
purine containing compound catabolic process GO:0072523 411 0.027
cellular response to organonitrogen compound GO:0071417 124 0.027
negative regulation of cell cycle phase transition GO:1901988 89 0.027
regulation of cellular component biogenesis GO:0044087 281 0.027
negative regulation of proteolysis GO:0045861 132 0.026
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.026
cellular response to nitrogen compound GO:1901699 144 0.026
negative regulation of glycoprotein metabolic process GO:1903019 8 0.026
microtubule polymerization or depolymerization GO:0031109 37 0.026
organophosphate catabolic process GO:0046434 430 0.026
histone methylation GO:0016571 60 0.025
male meiosis GO:0007140 1 0.025
oocyte development GO:0048599 1 0.025
regulation of leukocyte activation GO:0002694 115 0.025
purine nucleoside monophosphate metabolic process GO:0009126 186 0.025
cellular ketone metabolic process GO:0042180 80 0.025
segmentation GO:0035282 4 0.024
negative regulation of cell differentiation GO:0045596 171 0.024
positive regulation of cell activation GO:0050867 81 0.024
glycosyl compound catabolic process GO:1901658 413 0.024
protein localization to chromosome GO:0034502 30 0.024
cellular component disassembly GO:0022411 92 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.023
glycoprotein metabolic process GO:0009100 110 0.023
purine nucleoside monophosphate catabolic process GO:0009128 158 0.023
negative regulation of catalytic activity GO:0043086 335 0.023
cellular response to abiotic stimulus GO:0071214 117 0.023
dna biosynthetic process GO:0071897 40 0.023
reciprocal meiotic recombination GO:0007131 4 0.023
positive regulation of leukocyte proliferation GO:0070665 48 0.023
regulation of homeostatic process GO:0032844 121 0.022
regulation of protein processing GO:0070613 150 0.022
aging GO:0007568 66 0.022
cellular response to endogenous stimulus GO:0071495 336 0.022
cytoplasmic transport GO:0016482 379 0.022
vesicle mediated transport GO:0016192 371 0.022
methylation GO:0032259 106 0.022
ribonucleotide catabolic process GO:0009261 405 0.022
epidermis morphogenesis GO:0048730 3 0.022
neuromuscular junction development GO:0007528 3 0.022
single organism carbohydrate metabolic process GO:0044723 193 0.021
oocyte differentiation GO:0009994 2 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
regulation of t cell activation GO:0050863 77 0.021
rna processing GO:0006396 255 0.021
response to organic cyclic compound GO:0014070 204 0.021
negative regulation of cell division GO:0051782 31 0.021
protein ubiquitination GO:0016567 314 0.021
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.020
immune system development GO:0002520 195 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
positive regulation of leukocyte activation GO:0002696 80 0.020
protein polymerization GO:0051258 71 0.020
hindlimb morphogenesis GO:0035137 2 0.020
t cell activation GO:0042110 99 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
histone modification GO:0016570 251 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
telomere maintenance in response to dna damage GO:0043247 3 0.020
spermatid differentiation GO:0048515 4 0.020
cell activation GO:0001775 213 0.020
single organism membrane organization GO:0044802 268 0.019
regulation of nuclear division GO:0051783 65 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
regulation of mitotic sister chromatid segregation GO:0033047 27 0.019
regulation of mitotic sister chromatid separation GO:0010965 27 0.019
locomotory behavior GO:0007626 1 0.019
hindbrain development GO:0030902 3 0.019
mitochondrion organization GO:0007005 156 0.019
Fly
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.019
negative regulation of cellular protein catabolic process GO:1903363 38 0.019
response to inorganic substance GO:0010035 127 0.019
atp metabolic process GO:0046034 176 0.019
glucose homeostasis GO:0042593 31 0.018
cellular response to inorganic substance GO:0071241 45 0.018
negative regulation of transport GO:0051051 176 0.018
negative regulation of catabolic process GO:0009895 104 0.018
regulation of growth GO:0040008 165 0.018
nucleoside catabolic process GO:0009164 408 0.018
positive regulation of phosphorylation GO:0042327 394 0.018
oogenesis GO:0048477 2 0.018
post embryonic development GO:0009791 2 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
single organism cellular localization GO:1902580 332 0.018
positive regulation of cellular component biogenesis GO:0044089 158 0.018
meiosis i GO:0007127 4 0.017
response to oxygen containing compound GO:1901700 369 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
positive regulation of transferase activity GO:0051347 227 0.017
response to organonitrogen compound GO:0010243 156 0.017
cell fate determination GO:0001709 3 0.017
regulation of protein localization GO:0032880 296 0.017
regulation of chromosome organization GO:0033044 103 0.017
mitotic sister chromatid separation GO:0051306 18 0.017
regulation of binding GO:0051098 111 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.017
regulation of dna biosynthetic process GO:2000278 18 0.017
positive regulation of cell division GO:0051781 59 0.017
lymphocyte proliferation GO:0046651 70 0.017
compound eye development GO:0048749 1 0.017
negative regulation of dna replication GO:0008156 29 0.017
protein methylation GO:0006479 74 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
nitrogen compound transport GO:0071705 191 0.016
regulation of protein transport GO:0051223 213 0.016
lymphocyte activation GO:0046649 133 0.016
memory GO:0007613 3 0.016
protein dna complex subunit organization GO:0071824 80 0.016
stem cell differentiation GO:0048863 93 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
regulation of t cell proliferation GO:0042129 42 0.016
apoptotic signaling pathway GO:0097190 268 0.016
regulation of mononuclear cell proliferation GO:0032944 65 0.016
negative regulation of mitosis GO:0045839 24 0.016
cellular response to radiation GO:0071478 65 0.016
regulation of response to dna damage stimulus GO:2001020 94 0.016
mrna metabolic process GO:0016071 175 0.016
negative regulation of dna metabolic process GO:0051053 57 0.016
rna dependent dna replication GO:0006278 16 0.016
maintenance of location GO:0051235 112 0.016
embryo development GO:0009790 123 0.016
positive regulation of nuclear division GO:0051785 27 0.016
regulation of cell activation GO:0050865 125 0.016
positive regulation of mitotic cell cycle GO:0045931 60 0.016
female gamete generation GO:0007292 2 0.015
positive regulation of lymphocyte activation GO:0051251 73 0.015
cell cycle g2 m phase transition GO:0044839 43 0.015
regulation of sister chromatid segregation GO:0033045 27 0.015
dna synthesis involved in dna repair GO:0000731 6 0.015
protein modification by small protein conjugation GO:0032446 342 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
regulation of protein polymerization GO:0032271 63 0.015
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.015
anterior posterior axis specification GO:0009948 2 0.015
protein localization to nucleus GO:0034504 136 0.015
endocytosis GO:0006897 159 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
g1 s transition of mitotic cell cycle GO:0000082 78 0.015
spindle assembly checkpoint GO:0071173 17 0.015
nervous system development GO:0007399 293 0.014
actin filament based process GO:0030029 224 0.014
mitotic sister chromatid segregation GO:0000070 53 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
regulation of protein complex assembly GO:0043254 147 0.014
protein import into nucleus GO:0006606 104 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.014
positive regulation of mononuclear cell proliferation GO:0032946 47 0.014
dna conformation change GO:0071103 113 0.014
ion transmembrane transport GO:0034220 338 0.014
mononuclear cell proliferation GO:0032943 71 0.014
regulation of lymphocyte proliferation GO:0050670 64 0.014
cell adhesion GO:0007155 325 0.014
cation transport GO:0006812 331 0.014
base excision repair GO:0006284 21 0.014
macromolecule glycosylation GO:0043413 63 0.014
positive regulation of alpha beta t cell proliferation GO:0046641 5 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
spindle checkpoint GO:0031577 26 0.014
response to nutrient levels GO:0031667 81 0.014
lipid metabolic process GO:0006629 381 0.014
morphogenesis of embryonic epithelium GO:0016331 4 0.014
defense response GO:0006952 315 0.014
small molecule catabolic process GO:0044282 92 0.014
regulation of lymphocyte activation GO:0051249 103 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
alcohol metabolic process GO:0006066 114 0.014
rna splicing GO:0008380 131 0.014
cellular lipid metabolic process GO:0044255 303 0.013
peptidyl lysine modification GO:0018205 144 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
adult locomotory behavior GO:0008344 1 0.013
carbohydrate metabolic process GO:0005975 207 0.013
regulation of intracellular transport GO:0032386 195 0.013
biological adhesion GO:0022610 331 0.013
pharyngeal system development GO:0060037 2 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.013
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
cell morphogenesis GO:0000902 296 0.013
regulation of chromosome segregation GO:0051983 44 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.013
negative regulation of leukocyte apoptotic process GO:2000107 16 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
t cell differentiation GO:0030217 29 0.012
membrane organization GO:0061024 292 0.012
positive regulation of t cell activation GO:0050870 54 0.012
positive regulation of lymphocyte proliferation GO:0050671 46 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
regulation of leukocyte proliferation GO:0070663 67 0.012
protein import GO:0017038 130 0.012
blastoderm segmentation GO:0007350 2 0.012
rna interference GO:0016246 4 0.012
regulation of alpha beta t cell activation GO:0046634 13 0.012
neurogenesis GO:0022008 169 0.012
regulation of t cell apoptotic process GO:0070232 8 0.012
protein glycosylation GO:0006486 62 0.012
positive regulation of catabolic process GO:0009896 310 0.012
response to tumor necrosis factor GO:0034612 76 0.012
carbohydrate homeostasis GO:0033500 31 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
spermatid development GO:0007286 4 0.012
negative regulation of cell proliferation GO:0008285 228 0.011
negative regulation of synaptic transmission GO:0050805 2 0.011
response to external biotic stimulus GO:0043207 261 0.011
peripheral nervous system development GO:0007422 2 0.011
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.011
atp catabolic process GO:0006200 157 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
protein acetylation GO:0006473 116 0.011
cellular component morphogenesis GO:0032989 314 0.011
transmembrane transport GO:0055085 399 0.011
positive regulation of cell cycle GO:0045787 140 0.011
positive regulation of cell fate commitment GO:0010455 2 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
neurotransmitter secretion GO:0007269 4 0.011
positive regulation of developmental process GO:0051094 314 0.011
embryonic hindlimb morphogenesis GO:0035116 2 0.011
cell growth GO:0016049 160 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
mrna splicing via spliceosome GO:0000398 89 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
t cell proliferation GO:0042098 45 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
negative regulation of epithelial cell proliferation GO:0050680 48 0.011
small molecule biosynthetic process GO:0044283 157 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.010
negative regulation of protein transport GO:0051224 75 0.010
secretion GO:0046903 254 0.010
negative regulation of phosphorus metabolic process GO:0010563 267 0.010
leukocyte proliferation GO:0070661 74 0.010
regulation of synaptic plasticity GO:0048167 3 0.010
innate immune response GO:0045087 178 0.010
leukocyte differentiation GO:0002521 98 0.010
cellular response to ionizing radiation GO:0071479 32 0.010
sex determination GO:0007530 3 0.010
negative regulation of multicellular organismal process GO:0051241 317 0.010
positive regulation of protein catabolic process GO:0045732 75 0.010
nuclear transport GO:0051169 179 0.010
regulation of phosphatase activity GO:0010921 81 0.010
dna duplex unwinding GO:0032508 30 0.010

TOP3A disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.236
bone marrow disease DOID:4961 31 0.236
hematopoietic system disease DOID:74 100 0.236
congenital hypoplastic anemia DOID:1342 26 0.038
aplastic anemia DOID:12449 30 0.038
fanconi s anemia DOID:13636 16 0.038
anemia DOID:2355 55 0.038
musculoskeletal system disease DOID:17 223 0.028
disease of cellular proliferation DOID:14566 174 0.019
disease of metabolism DOID:0014667 295 0.019
central nervous system disease DOID:331 186 0.018
brain disease DOID:936 73 0.018
nervous system disease DOID:863 431 0.018
cancer DOID:162 167 0.016
organ system cancer DOID:0050686 164 0.016
inherited metabolic disorder DOID:655 242 0.014
sensory system disease DOID:0050155 203 0.013
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
connective tissue disease DOID:65 109 0.012
muscular disease DOID:0080000 114 0.010
muscle tissue disease DOID:66 113 0.010
retinal disease DOID:5679 118 0.010