IMP

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Homo sapiens

26 genes annotated in human

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spindle checkpoint

GO:0031577

A cell cycle checkpoint that originates from the mitotic or meiotic spindle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "spindle checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "spindle checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.983	Yeast
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.957
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.918	Fly
AURKB	aurora kinase B	0.903
H2AFX	H2A histone family, member X	0.799
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.695
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.605
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.486
BRCA2	breast cancer 2, early onset	0.363
ANAPC4	anaphase promoting complex subunit 4	0.357
INCENP	inner centromere protein antigens 135/155kDa	0.317
CDCA8	cell division cycle associated 8	0.272
CENPJ	centromere protein J	0.266
PLK1	polo-like kinase 1	0.233
CBX5	chromobox homolog 5	0.213
SASS6	spindle assembly 6 homolog (C. elegans)	0.169
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.142
STARD9	StAR-related lipid transfer (START) domain containing 9	0.138
CDT1	chromatin licensing and DNA replication factor 1	0.128
ANAPC7	anaphase promoting complex subunit 7	0.120
C19orf39	chromosome 19 open reading frame 39	0.088
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.087
FXR2	fragile X mental retardation, autosomal homolog 2	0.081
KIF2C	kinesin family member 2C	0.076
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.070
HDAC1	histone deacetylase 1	0.070
TP53BP1	tumor protein p53 binding protein 1	0.065
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.059
CDK1	cyclin-dependent kinase 1	0.058
CDK2	cyclin-dependent kinase 2	0.057
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.054
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.053
TROAP	trophinin associated protein (tastin)	0.052
MDC1	mediator of DNA-damage checkpoint 1	0.048
ANAPC1	anaphase promoting complex subunit 1	0.048
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.046
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.044
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.043
ANAPC5	anaphase promoting complex subunit 5	0.043
RANBP9	RAN binding protein 9	0.043
PBK	PDZ binding kinase	0.040
PTTG1	pituitary tumor-transforming 1	0.040
SGOL1	shugoshin-like 1 (S. pombe)	0.039
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.037
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.037
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.036
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.036
PARP3	poly (ADP-ribose) polymerase family, member 3	0.035
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.035
ANAPC11	anaphase promoting complex subunit 11	0.033
UBE2C	ubiquitin-conjugating enzyme E2C	0.032
LMNA	lamin A/C	0.032
CCNA2	cyclin A2	0.031
TP53	tumor protein p53	0.031
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.030	Yeast
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.030
GAS2L3	growth arrest-specific 2 like 3	0.029
CEP135	centrosomal protein 135kDa	0.029
MYST1	MYST histone acetyltransferase 1	0.029
HERC2	hect domain and RLD 2	0.028
PRNP	prion protein	0.028
TCP1	t-complex 1	0.027
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.027
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.027
PLK4	polo-like kinase 4	0.027
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.026
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.025
KIF11	kinesin family member 11	0.025
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.025
TRIP13	thyroid hormone receptor interactor 13	0.024
GTSE1	G-2 and S-phase expressed 1	0.023
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.023
CENPF	centromere protein F, 350/400kDa (mitosin)	0.023
PPME1	protein phosphatase methylesterase 1	0.022
PPP4C	protein phosphatase 4, catalytic subunit	0.022
MED1	mediator complex subunit 1	0.022
NKAP	NFKB activating protein	0.022
C13orf34	chromosome 13 open reading frame 34	0.022
ATMIN	ATM interactor	0.022
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.022
BAG3	BCL2-associated athanogene 3	0.021
CSNK2B	casein kinase 2, beta polypeptide	0.021
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.021
KAT5	K(lysine) acetyltransferase 5	0.020
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.020
HUWE1	HECT, UBA and WWE domain containing 1	0.020
HSPB1	heat shock 27kDa protein 1	0.020
GSK3B	glycogen synthase kinase 3 beta	0.020
CCNF	cyclin F	0.020
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.020
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.020
HIST1H2AL	histone cluster 1, H2al	0.019
HIST1H1E	histone cluster 1, H1e	0.019
SGOL2	shugoshin-like 2 (S. pombe)	0.019
AXIN2	axin 2	0.019
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.018
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.018
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.018
HIST1H4F	histone cluster 1, H4f	0.018
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.018
TERF2	telomeric repeat binding factor 2	0.017	Human
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.017
TTK	TTK protein kinase	0.017	Yeast
MAD2L1BP	MAD2L1 binding protein	0.017
ARIH2	ariadne homolog 2 (Drosophila)	0.016
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.016
BAG2	BCL2-associated athanogene 2	0.016
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.016
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.016
KDM4A	lysine (K)-specific demethylase 4A	0.016
CCNE1	cyclin E1	0.015
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.015
CCNB1	cyclin B1	0.015
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.015
HIST1H1B	histone cluster 1, H1b	0.015
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.015
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.015
RNF8	ring finger protein 8	0.015
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.014
ZWINT	ZW10 interactor	0.014
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.014
BCL2L1	BCL2-like 1	0.014
MASTL	microtubule associated serine/threonine kinase-like	0.014
TOP3A	topoisomerase (DNA) III alpha	0.014
TRAIP	TRAF interacting protein	0.014
HIST1H3F	histone cluster 1, H3f	0.014
FANCD2	Fanconi anemia, complementation group D2	0.014
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.014
SERTAD4	SERTA domain containing 4	0.013
RFWD2	ring finger and WD repeat domain 2	0.013
SRRM2	serine/arginine repetitive matrix 2	0.013
KIF4A	kinesin family member 4A	0.013
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.013
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.013
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.013
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.013
HIST1H2BB	histone cluster 1, H2bb	0.013
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.013
TP53BP2	tumor protein p53 binding protein, 2	0.013
CASC5	cancer susceptibility candidate 5	0.013
ZSWIM7	zinc finger, SWIM-type containing 7	0.013
HIST1H3G	histone cluster 1, H3g	0.013
RIF1	RAP1 interacting factor homolog (yeast)	0.013
HIST1H4B	histone cluster 1, H4b	0.012
NRD1	nardilysin (N-arginine dibasic convertase)	0.012
HIST1H3A	histone cluster 1, H3a	0.012	Yeast
CDCA2	cell division cycle associated 2	0.012
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.012
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.012
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.012
SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	0.012
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.012
DAXX	death-domain associated protein	0.012
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.012
HIST1H2AB	histone cluster 1, H2ab	0.012
TACC2	transforming, acidic coiled-coil containing protein 2	0.012
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.012
HIST1H4D	histone cluster 1, H4d	0.012
ANKRD52	ankyrin repeat domain 52	0.012
HJURP	Holliday junction recognition protein	0.012
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.011
DIAPH3	diaphanous homolog 3 (Drosophila)	0.011
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.011
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.011	Yeast
HIST1H1D	histone cluster 1, H1d	0.011
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.011
KIF20A	kinesin family member 20A	0.011
BIRC5	baculoviral IAP repeat containing 5	0.011
RAD52	RAD52 homolog (S. cerevisiae)	0.011
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.011
ARHGAP11A	Rho GTPase activating protein 11A	0.011
ATP1B1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.011
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.011	Yeast
PLRG1	pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)	0.011
PHF20	PHD finger protein 20	0.010
DCLRE1B	DNA cross-link repair 1B	0.010
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.010
KIF14	kinesin family member 14	0.010
HIST1H3C	histone cluster 1, H3c	0.010	Yeast
CCDC101	coiled-coil domain containing 101	0.010
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.010
KIFC1	kinesin family member C1	0.010
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.010