Homo sapiens

166 known processes

AIF1

allograft inflammatory factor 1

(Aliases: IRT1,IBA1,AIF-1,IRT-1)

AIF1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cell activation GO:0001775 213 0.283
regulation of myeloid leukocyte mediated immunity GO:0002886 4 0.283
regulation of leukocyte proliferation GO:0070663 67 0.251
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.229
regulation of lymphocyte proliferation GO:0050670 64 0.219
leukocyte proliferation GO:0070661 74 0.198
regulation of mononuclear cell proliferation GO:0032944 65 0.195
regulation of t cell proliferation GO:0042129 42 0.193
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.192
cell development GO:0048468 328 0.190
regulation of immune response GO:0050776 201 0.175
positive regulation of developmental process GO:0051094 314 0.171
t cell activation GO:0042110 99 0.163
serotonin secretion GO:0001820 1 0.156
mononuclear cell proliferation GO:0032943 71 0.156
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.145
membrane organization GO:0061024 292 0.138
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.115
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 4 0.113
positive regulation of immune response GO:0050778 159 0.106
negative regulation of immune system process GO:0002683 136 0.097
negative regulation of interferon beta secretion GO:0035548 1 0.094
endomembrane system organization GO:0010256 196 0.089
innate immune response GO:0045087 178 0.085
positive regulation of cell differentiation GO:0045597 211 0.084
cellular lipid metabolic process GO:0044255 303 0.083
lymphocyte proliferation GO:0046651 70 0.082
cytokine production GO:0001816 247 0.078
plasma membrane organization GO:0007009 115 0.078
myeloid leukocyte migration GO:0097529 62 0.075
lymphocyte activation GO:0046649 133 0.074
endocytosis GO:0006897 159 0.072
Mouse
positive regulation of transport GO:0051050 336 0.071
leukocyte activation GO:0045321 164 0.071
cellular ketone metabolic process GO:0042180 80 0.070
positive regulation of cell death GO:0010942 263 0.069
regulation of cell activation GO:0050865 125 0.066
regulation of cellular ketone metabolic process GO:0010565 50 0.066
immune effector process GO:0002252 159 0.064
regulation of vesicle mediated transport GO:0060627 130 0.061
exocytosis GO:0006887 71 0.061
actin filament based process GO:0030029 224 0.061
regulation of secretion by cell GO:1903530 177 0.060
regulation of protein transport GO:0051223 213 0.059
regulation of cell migration GO:0030334 289 0.056
response to oxygen containing compound GO:1901700 369 0.056
Rat
granulocyte migration GO:0097530 40 0.055
regulation of multi organism process GO:0043900 157 0.054
regulation of immune effector process GO:0002697 91 0.054
membrane disruption in other organism GO:0051673 1 0.054
immune response GO:0006955 307 0.054
small gtpase mediated signal transduction GO:0007264 78 0.053
Mouse
leukocyte apoptotic process GO:0071887 31 0.052
response to external biotic stimulus GO:0043207 261 0.052
cation transport GO:0006812 331 0.051
regulation of gamma delta t cell activation involved in immune response GO:2001191 1 0.050
positive regulation of response to external stimulus GO:0032103 88 0.049
regulation of dendritic cell apoptotic process GO:2000668 4 0.049
regulation of cell cycle GO:0051726 393 0.048
nucleoside phosphate catabolic process GO:1901292 412 0.047
purine ribonucleoside catabolic process GO:0046130 398 0.047
regulation of secretion GO:0051046 194 0.046
post embryonic development GO:0009791 2 0.046
protein localization to plasma membrane GO:0072659 93 0.046
purine nucleoside triphosphate catabolic process GO:0009146 392 0.044
response to bacterium GO:0009617 144 0.044
regulation of proteolysis GO:0030162 293 0.044
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:2001188 2 0.044
regulation of nucleotide catabolic process GO:0030811 205 0.043
single organism membrane organization GO:0044802 268 0.043
response to fungus GO:0009620 4 0.043
fc receptor mediated inhibitory signaling pathway GO:0002774 2 0.042
apoptotic signaling pathway GO:0097190 268 0.042
nitrogen compound transport GO:0071705 191 0.042
protein processing GO:0016485 226 0.042
positive regulation of programmed cell death GO:0043068 249 0.041
regulation of cell differentiation GO:0045595 393 0.041
cell chemotaxis GO:0060326 112 0.041
cell morphogenesis GO:0000902 296 0.041
regulation of cell development GO:0060284 161 0.040
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:0002291 4 0.039
cellular protein complex assembly GO:0043623 188 0.039
antigen processing and presentation GO:0019882 33 0.039
regulation of cell morphogenesis GO:0022604 153 0.038
cell projection organization GO:0030030 252 0.038
Mouse
positive regulation of t cell proliferation GO:0042102 33 0.038
negative regulation of cellular component organization GO:0051129 235 0.038
defense response GO:0006952 315 0.038
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 1 0.037
vesicle mediated transport GO:0016192 371 0.037
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.037
regulation of mast cell degranulation GO:0043304 3 0.037
regulation of apoptotic signaling pathway GO:2001233 175 0.037
positive regulation of t cell activation GO:0050870 54 0.037
cellular component morphogenesis GO:0032989 314 0.036
single organism cellular localization GO:1902580 332 0.036
negative regulation of protein metabolic process GO:0051248 391 0.036
regulation of gamma delta t cell activation GO:0046643 1 0.035
regulation of t cell tolerance induction GO:0002664 4 0.035
lymphocyte mediated immunity GO:0002449 48 0.035
regulation of hormone levels GO:0010817 125 0.035
neutrophil chemotaxis GO:0030593 24 0.034
cellular macromolecular complex assembly GO:0034622 324 0.034
protein maturation GO:0051604 233 0.034
serotonin transport GO:0006837 3 0.034
cell morphogenesis involved in differentiation GO:0000904 144 0.034
inflammatory response GO:0006954 79 0.034
Rat
secretion by cell GO:0032940 226 0.034
ras protein signal transduction GO:0007265 73 0.034
Mouse
regulation of response to biotic stimulus GO:0002831 55 0.034
regulation of lymphocyte mediated immunity GO:0002706 33 0.033
negative regulation of cell proliferation GO:0008285 228 0.033
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 1 0.033
immune response in mucosal associated lymphoid tissue GO:0002386 1 0.033
organic hydroxy compound transport GO:0015850 63 0.033
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.033
cation homeostasis GO:0055080 189 0.033
regulation of adaptive immune response GO:0002819 33 0.033
cellular amine metabolic process GO:0044106 41 0.033
purinergic receptor signaling pathway GO:0035587 8 0.033
amine metabolic process GO:0009308 44 0.033
regulation of osteoclast development GO:2001204 1 0.032
cytokine biosynthetic process GO:0042089 37 0.032
positive regulation of immune system process GO:0002684 283 0.032
negative regulation of dendritic cell apoptotic process GO:2000669 3 0.032
negative regulation of mononuclear cell proliferation GO:0032945 15 0.031
purine nucleotide catabolic process GO:0006195 405 0.031
regulation of leukocyte activation GO:0002694 115 0.031
fc receptor signaling pathway GO:0038093 2 0.031
negative regulation of defense response GO:0031348 47 0.031
integrin mediated signaling pathway GO:0007229 32 0.031
response to lipid GO:0033993 206 0.030
Rat
response to biotic stimulus GO:0009607 276 0.030
negative regulation of hydrolase activity GO:0051346 182 0.030
defense response to other organism GO:0098542 129 0.030
positive regulation of transferase activity GO:0051347 227 0.030
oogenesis GO:0048477 2 0.030
positive regulation of acute inflammatory response GO:0002675 2 0.030
single organismal cell cell adhesion GO:0016337 148 0.029
immune response regulating signaling pathway GO:0002764 97 0.029
multicellular organismal aging GO:0010259 3 0.029
immune system development GO:0002520 195 0.028
single organism cell adhesion GO:0098602 179 0.028
response to other organism GO:0051707 261 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
regulation of nucleoside metabolic process GO:0009118 209 0.028
positive regulation of cellular catabolic process GO:0031331 284 0.027
purinergic nucleotide receptor signaling pathway GO:0035590 4 0.027
cell substrate adhesion GO:0031589 132 0.027
organophosphate catabolic process GO:0046434 430 0.027
monocarboxylic acid metabolic process GO:0032787 185 0.027
regulation of nk t cell activation GO:0051133 4 0.027
cell matrix adhesion GO:0007160 85 0.027
cellular response to biotic stimulus GO:0071216 71 0.026
activation of immune response GO:0002253 114 0.026
negative regulation of cell death GO:0060548 345 0.026
Rat
gamma delta t cell activation GO:0046629 3 0.026
ribonucleoside catabolic process GO:0042454 406 0.026
nucleotide catabolic process GO:0009166 408 0.026
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.026
acute inflammatory response to antigenic stimulus GO:0002438 1 0.025
protein localization to membrane GO:0072657 160 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
regulation of actin cytoskeleton organization GO:0032956 116 0.025
negative regulation of transforming growth factor beta secretion GO:2001202 1 0.024
positive regulation of kinase activity GO:0033674 204 0.024
leukocyte migration GO:0050900 107 0.024
positive regulation of nucleoside metabolic process GO:0045979 186 0.024
regulation of t cell activation GO:0050863 77 0.024
positive regulation of secretion by cell GO:1903532 108 0.024
protein secretion GO:0009306 98 0.024
negative regulation of cell activation GO:0050866 33 0.024
t cell proliferation involved in immune response GO:0002309 1 0.024
regulation of defense response GO:0031347 154 0.024
cell adhesion GO:0007155 325 0.023
negative regulation of osteoclast development GO:2001205 1 0.023
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.023
regulation of intracellular transport GO:0032386 195 0.023
negative regulation of interleukin 10 production GO:0032693 7 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
regulation of cytokine production GO:0001817 232 0.022
nucleoside catabolic process GO:0009164 408 0.022
positive regulation of leukocyte activation GO:0002696 80 0.022
regulation of response to external stimulus GO:0032101 222 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.021
leukocyte mediated immunity GO:0002443 59 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
response to cytokine GO:0034097 232 0.021
regulation of interleukin 12 secretion GO:2001182 1 0.021
oxidation reduction process GO:0055114 396 0.021
regulation of leukocyte mediated immunity GO:0002703 38 0.021
nervous system development GO:0007399 293 0.021
antigen processing and presentation of exogenous antigen GO:0019884 4 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
transforming growth factor beta secretion GO:0038044 1 0.021
cellular response to lipid GO:0071396 127 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.020
negative regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell GO:2001189 1 0.020
positive regulation of apoptotic process GO:0043065 246 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
cytokine production involved in immune response GO:0002367 27 0.020
response to molecule of bacterial origin GO:0002237 82 0.020
central nervous system development GO:0007417 123 0.020
response to lipopolysaccharide GO:0032496 70 0.020
positive regulation of cell proliferation GO:0008284 301 0.019
regulation of endocytosis GO:0030100 72 0.019
cell type specific apoptotic process GO:0097285 125 0.019
cytoplasmic transport GO:0016482 379 0.019
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
regulation of locomotion GO:0040012 329 0.018
wound healing GO:0042060 115 0.018
humoral immune response GO:0006959 49 0.018
vitamin transmembrane transport GO:0035461 4 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.018
regulation of cytoskeleton organization GO:0051493 177 0.018
negative regulation of cell cycle GO:0045786 193 0.018
neuron differentiation GO:0030182 138 0.018
positive regulation of gtpase activity GO:0043547 166 0.018
regulation of body fluid levels GO:0050878 99 0.017
cellular response to dna damage stimulus GO:0006974 379 0.017
purine ribonucleotide catabolic process GO:0009154 404 0.017
regulation of acute inflammatory response to antigenic stimulus GO:0002864 1 0.017
regulation of exocytosis GO:0017157 46 0.017
negative regulation of leukocyte proliferation GO:0070664 16 0.017
determination of adult lifespan GO:0008340 2 0.017
regulation of gtpase activity GO:0043087 180 0.017
response to wounding GO:0009611 168 0.017
Rat
leukocyte chemotaxis GO:0030595 76 0.017
positive regulation of protein kinase activity GO:0045860 190 0.017
negative regulation of tumor necrosis factor production GO:0032720 20 0.017
mast cell activation involved in immune response GO:0002279 4 0.017
detection of triacyl bacterial lipopeptide GO:0042495 2 0.017
regulation of cytokine production involved in immune response GO:0002718 22 0.017
extrinsic apoptotic signaling pathway GO:0097191 119 0.017
female gamete generation GO:0007292 2 0.016
neurogenesis GO:0022008 169 0.016
positive regulation of catabolic process GO:0009896 310 0.016
intrinsic apoptotic signaling pathway GO:0097193 127 0.016
regulation of small gtpase mediated signal transduction GO:0051056 156 0.016
regulation of production of molecular mediator of immune response GO:0002700 25 0.016
positive regulation of immune effector process GO:0002699 40 0.016
biological adhesion GO:0022610 331 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
positive regulation of innate immune response GO:0045089 79 0.016
purine containing compound catabolic process GO:0072523 411 0.016
regulation of protein localization GO:0032880 296 0.016
negative regulation of cd8 positive alpha beta t cell activation GO:2001186 1 0.016
regulation of chemotaxis GO:0050920 74 0.016
generation of neurons GO:0048699 152 0.016
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
organelle localization GO:0051640 84 0.016
positive regulation of chemotaxis GO:0050921 57 0.016
neuron development GO:0048666 113 0.015
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
regulation of cytokine secretion GO:0050707 57 0.015
regulation of interleukin 10 secretion GO:2001179 4 0.015
interleukin 10 production GO:0032613 17 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.015
nk t cell activation GO:0051132 4 0.015
syncytium formation by plasma membrane fusion GO:0000768 2 0.015
positive regulation of mast cell activation GO:0033005 2 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
negative regulation of secretion GO:0051048 58 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
actin filament bundle assembly GO:0051017 54 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
regulation of protein ubiquitination GO:0031396 95 0.015
rho protein signal transduction GO:0007266 26 0.015
protein polymerization GO:0051258 71 0.015
hemopoiesis GO:0030097 180 0.015
chemotaxis GO:0006935 157 0.015
leukocyte activation involved in immune response GO:0002366 30 0.015
regulation of ras gtpase activity GO:0032318 128 0.014
establishment of protein localization to membrane GO:0090150 121 0.014
cellular macromolecule catabolic process GO:0044265 380 0.014
granulocyte chemotaxis GO:0071621 37 0.014
cellular response to molecule of bacterial origin GO:0071219 62 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.014
regulation of b cell receptor signaling pathway GO:0050855 4 0.014
positive regulation of behavior GO:0048520 60 0.014
negative regulation of secretion by cell GO:1903531 52 0.014
regulation of cell cycle process GO:0010564 266 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
regulation of kinase activity GO:0043549 314 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.014
regulation of transferase activity GO:0051338 355 0.014
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.014
positive regulation of secretion GO:0051047 116 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
protein catabolic process GO:0030163 325 0.014
tissue migration GO:0090130 119 0.014
neuromuscular junction development GO:0007528 3 0.014
negative regulation of cytokine production GO:0001818 82 0.013
regulation of cellular amino acid metabolic process GO:0006521 6 0.013
ameboidal type cell migration GO:0001667 135 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
regulation of leukocyte migration GO:0002685 63 0.013
defense response to virus GO:0051607 71 0.013
calcium mediated signaling GO:0019722 44 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
positive regulation of mononuclear cell proliferation GO:0032946 47 0.013
regulation of transforming growth factor beta secretion GO:2001201 1 0.013
response to inorganic substance GO:0010035 127 0.013
positive regulation of tumor necrosis factor production GO:0032760 21 0.013
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
regulation of rho gtpase activity GO:0032319 66 0.013
regulation of tumor necrosis factor production GO:0032680 43 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
Rat
myoblast fusion GO:0007520 1 0.013
regulation of rho protein signal transduction GO:0035023 79 0.013
response to radiation GO:0009314 151 0.012
cellular response to triacyl bacterial lipopeptide GO:0071727 2 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
secretion GO:0046903 254 0.012
taxis GO:0042330 157 0.012
regulation of nervous system development GO:0051960 88 0.012
coagulation GO:0050817 78 0.012
t cell tolerance induction GO:0002517 4 0.012
detection of stimulus GO:0051606 85 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
regulation of leukocyte apoptotic process GO:2000106 25 0.012
regulation of protein processing GO:0070613 150 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
astrocyte differentiation GO:0048708 4 0.012
organelle assembly GO:0070925 176 0.012
positive regulation of cell motility GO:2000147 177 0.012
negative regulation of protein maturation GO:1903318 142 0.012
regulation of interleukin 10 production GO:0032653 16 0.012
myeloid leukocyte differentiation GO:0002573 60 0.012
post embryonic organ development GO:0048569 1 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
positive regulation of t cell tolerance induction GO:0002666 2 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
regulation of peptidase activity GO:0052547 180 0.011
protein localization to organelle GO:0033365 280 0.011
intracellular protein transport GO:0006886 270 0.011
type i interferon secretion GO:0072641 1 0.011
carbohydrate metabolic process GO:0005975 207 0.011
osteoclast development GO:0036035 2 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
regulation of response to dna damage stimulus GO:2001020 94 0.011
hemostasis GO:0007599 76 0.011
regulation of innate immune response GO:0045088 97 0.011
positive regulation of b cell mediated immunity GO:0002714 4 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
cell activation involved in immune response GO:0002263 30 0.011
dephosphorylation GO:0016311 209 0.011
growth GO:0040007 202 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.011
cell part morphogenesis GO:0032990 137 0.011
mitotic nuclear division GO:0007067 119 0.010
purine nucleoside catabolic process GO:0006152 398 0.010
cellular response to abiotic stimulus GO:0071214 117 0.010
positive regulation of vasoconstriction GO:0045907 3 0.010
cellular protein catabolic process GO:0044257 261 0.010
negative regulation of ion transport GO:0043271 39 0.010
sulfur compound metabolic process GO:0006790 101 0.010
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.010
interferon beta production GO:0032608 23 0.010
positive regulation of leukocyte differentiation GO:1902107 37 0.010
regulation of protein maturation GO:1903317 150 0.010
calcium ion transport GO:0006816 147 0.010
spermatid development GO:0007286 4 0.010
positive regulation of proteolysis GO:0045862 142 0.010

AIF1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.013
sensory system disease DOID:0050155 203 0.011
eye and adnexa disease DOID:1492 150 0.011
nervous system disease DOID:863 431 0.011
eye disease DOID:5614 149 0.011