Homo sapiens

32 known processes

ORAI1

ORAI calcium release-activated calcium modulator 1

(Aliases: FLJ14466,CRACM1,ORAT1,TMEM142A)

ORAI1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of store operated calcium channel activity GO:1901341 4 0.756
cation transmembrane transport GO:0098655 238 0.446
cation transport GO:0006812 331 0.415
ion transmembrane transport GO:0034220 338 0.398
activation of store operated calcium channel activity GO:0032237 4 0.383
calcium ion transmembrane transport GO:0070588 76 0.351
transmembrane transport GO:0055085 399 0.333
regulation of calcium ion transport GO:0051924 79 0.316
inorganic cation transmembrane transport GO:0098662 194 0.306
inorganic ion transmembrane transport GO:0098660 231 0.305
divalent inorganic cation transport GO:0072511 158 0.298
positive regulation of calcium ion transport GO:0051928 51 0.286
divalent metal ion transport GO:0070838 152 0.273
positive regulation of ion transport GO:0043270 87 0.250
calcium ion transport GO:0006816 147 0.246
regulation of calcium ion transmembrane transporter activity GO:1901019 28 0.216
regulation of metal ion transport GO:0010959 120 0.204
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.183
regulation of transmembrane transport GO:0034762 139 0.157
metal ion homeostasis GO:0055065 169 0.156
positive regulation of transporter activity GO:0032411 32 0.155
regulation of transmembrane transporter activity GO:0022898 74 0.146
cation homeostasis GO:0055080 189 0.142
cellular ion homeostasis GO:0006873 168 0.138
positive regulation of transport GO:0051050 336 0.132
regulation of cation channel activity GO:2001257 33 0.131
detection of chemical stimulus GO:0009593 55 0.122
cellular homeostasis GO:0019725 196 0.121
cellular cation homeostasis GO:0030003 163 0.119
regulation of ion transmembrane transport GO:0034765 132 0.115
cellular metal ion homeostasis GO:0006875 146 0.107
ion homeostasis GO:0050801 230 0.104
regulation of ion transmembrane transporter activity GO:0032412 72 0.102
detection of stimulus GO:0051606 85 0.097
response to calcium ion GO:0051592 46 0.097
regulation of transporter activity GO:0032409 82 0.096
cellular divalent inorganic cation homeostasis GO:0072503 128 0.089
positive regulation of ion transmembrane transport GO:0034767 40 0.085
chemical homeostasis GO:0048878 306 0.082
regulation of calcium ion transmembrane transport GO:1903169 28 0.082
cellular calcium ion homeostasis GO:0006874 117 0.072
cellular chemical homeostasis GO:0055082 180 0.071
positive regulation of transmembrane transport GO:0034764 41 0.066
positive regulation of calcium ion transmembrane transporter activity GO:1901021 13 0.063
response to inorganic substance GO:0010035 127 0.061
post embryonic development GO:0009791 2 0.059
cellular amine metabolic process GO:0044106 41 0.057
regulation of cellular amine metabolic process GO:0033238 11 0.054
small gtpase mediated signal transduction GO:0007264 78 0.050
positive regulation of phosphorylation GO:0042327 394 0.045
multicellular organismal aging GO:0010259 3 0.042
amine metabolic process GO:0009308 44 0.041
cellular ketone metabolic process GO:0042180 80 0.040
cellular response to endogenous stimulus GO:0071495 336 0.040
regulation of cellular ketone metabolic process GO:0010565 50 0.040
positive regulation of cation channel activity GO:2001259 16 0.039
nucleoside triphosphate catabolic process GO:0009143 394 0.039
determination of adult lifespan GO:0008340 2 0.037
response to metal ion GO:0010038 84 0.036
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
ras protein signal transduction GO:0007265 73 0.034
metal ion transport GO:0030001 272 0.033
actin filament based process GO:0030029 224 0.032
nucleotide catabolic process GO:0009166 408 0.032
organophosphate catabolic process GO:0046434 430 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.030
purine ribonucleoside metabolic process GO:0046128 437 0.030
defense response GO:0006952 315 0.029
store operated calcium entry GO:0002115 3 0.029
Mouse Rat
cellular amino acid metabolic process GO:0006520 116 0.029
cellular response to oxygen containing compound GO:1901701 276 0.028
negative regulation of catalytic activity GO:0043086 335 0.028
nucleoside phosphate catabolic process GO:1901292 412 0.028
lipid metabolic process GO:0006629 381 0.027
locomotory behavior GO:0007626 1 0.027
glycosyl compound catabolic process GO:1901658 413 0.027
regulation of kinase activity GO:0043549 314 0.026
regulation of ion transport GO:0043269 189 0.026
positive regulation of protein phosphorylation GO:0001934 313 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.025
purine nucleoside catabolic process GO:0006152 398 0.025
ribonucleoside catabolic process GO:0042454 406 0.025
regulation of protein kinase activity GO:0045859 289 0.025
regulation of nucleoside metabolic process GO:0009118 209 0.025
purine nucleoside triphosphate catabolic process GO:0009146 392 0.025
regulation of cellular amino acid metabolic process GO:0006521 6 0.025
segmentation GO:0035282 4 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
system process GO:0003008 349 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
response to abiotic stimulus GO:0009628 336 0.024
positive regulation of catabolic process GO:0009896 310 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
cellular response to dna damage stimulus GO:0006974 379 0.024
immune response GO:0006955 307 0.024
signal transduction by phosphorylation GO:0023014 297 0.024
positive regulation of cellular component organization GO:0051130 376 0.023
mapk cascade GO:0000165 288 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
cytoplasmic transport GO:0016482 379 0.023
protein catabolic process GO:0030163 325 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
rho protein signal transduction GO:0007266 26 0.022
regulation of cytokine production GO:0001817 232 0.022
cell adhesion GO:0007155 325 0.022
nucleoside catabolic process GO:0009164 408 0.022
enzyme linked receptor protein signaling pathway GO:0007167 303 0.022
regulation of cellular response to stress GO:0080135 244 0.022
ribonucleoside triphosphate catabolic process GO:0009203 391 0.022
regulation of protein localization GO:0032880 296 0.022
positive regulation of transferase activity GO:0051347 227 0.022
female gamete generation GO:0007292 2 0.021
regulation of purine nucleotide metabolic process GO:1900542 264 0.021
anion transport GO:0006820 161 0.021
cellular macromolecule catabolic process GO:0044265 380 0.021
single organism cellular localization GO:1902580 332 0.021
intracellular protein transport GO:0006886 270 0.021
biological adhesion GO:0022610 331 0.020
response to external biotic stimulus GO:0043207 261 0.020
regeneration GO:0031099 4 0.020
purine nucleoside triphosphate metabolic process GO:0009144 412 0.020
detection of calcium ion GO:0005513 8 0.020
multi organism cellular process GO:0044764 156 0.020
positive regulation of immune system process GO:0002684 283 0.020
purine nucleotide catabolic process GO:0006195 405 0.020
guanosine containing compound metabolic process GO:1901068 244 0.020
purine containing compound catabolic process GO:0072523 411 0.020
innate immune response GO:0045087 178 0.020
cell morphogenesis GO:0000902 296 0.020
regulation of proteolysis GO:0030162 293 0.020
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
organonitrogen compound biosynthetic process GO:1901566 200 0.019
gtp catabolic process GO:0006184 237 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
regulation of cell cycle process GO:0010564 266 0.019
regulation of cell cycle GO:0051726 393 0.019
positive regulation of cellular component movement GO:0051272 181 0.019
regulation of nucleotide catabolic process GO:0030811 205 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
cellular protein catabolic process GO:0044257 261 0.018
response to oxygen containing compound GO:1901700 369 0.018
regulation of cell motility GO:2000145 299 0.018
mitotic cell cycle GO:0000278 326 0.018
anterior posterior axis specification GO:0009948 2 0.018
cellular response to nitrogen compound GO:1901699 144 0.018
nervous system development GO:0007399 293 0.018
cytokine production GO:0001816 247 0.018
membrane organization GO:0061024 292 0.018
protein maturation GO:0051604 233 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
response to biotic stimulus GO:0009607 276 0.018
response to nitrogen compound GO:1901698 184 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
maintenance of location GO:0051235 112 0.017
regulation of gtpase activity GO:0043087 180 0.017
interspecies interaction between organisms GO:0044419 156 0.017
histone modification GO:0016570 251 0.017
nucleoside triphosphate metabolic process GO:0009141 422 0.017
dephosphorylation GO:0016311 209 0.017
g protein coupled receptor signaling pathway GO:0007186 207 0.017
vesicle mediated transport GO:0016192 371 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
positive regulation of cell motility GO:2000147 177 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
regulation of cell differentiation GO:0045595 393 0.017
response to other organism GO:0051707 261 0.017
positive regulation of kinase activity GO:0033674 204 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
cellular component morphogenesis GO:0032989 314 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
negative regulation of cell proliferation GO:0008285 228 0.016
response to cytokine GO:0034097 232 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
regulation of cellular component movement GO:0051270 334 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
cellular response to organonitrogen compound GO:0071417 124 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
protein ubiquitination GO:0016567 314 0.016
purine ribonucleoside catabolic process GO:0046130 398 0.016
endosomal transport GO:0016197 129 0.016
single organism membrane organization GO:0044802 268 0.016
nuclear transport GO:0051169 179 0.016
cell growth GO:0016049 160 0.016
protein autophosphorylation GO:0046777 123 0.016
protein localization to organelle GO:0033365 280 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
adult locomotory behavior GO:0008344 1 0.015
apoptotic signaling pathway GO:0097190 268 0.015
secretion GO:0046903 254 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
cellular response to abiotic stimulus GO:0071214 117 0.015
negative regulation of multicellular organismal process GO:0051241 317 0.015
endomembrane system organization GO:0010256 196 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
regulation of response to external stimulus GO:0032101 222 0.015
regulation of protein catabolic process GO:0042176 155 0.015
memory GO:0007613 3 0.015
regulation of immune response GO:0050776 201 0.015
positive regulation of gtp catabolic process GO:0033126 166 0.015
covalent chromatin modification GO:0016569 254 0.015
neuromuscular junction development GO:0007528 3 0.015
spermatid differentiation GO:0048515 4 0.015
response to organonitrogen compound GO:0010243 156 0.015
oogenesis GO:0048477 2 0.015
cell projection organization GO:0030030 252 0.015
oxidation reduction process GO:0055114 396 0.015
response to hormone GO:0009725 175 0.015
positive regulation of cell migration GO:0030335 172 0.015
blastoderm segmentation GO:0007350 2 0.015
protein targeting GO:0006605 187 0.015
positive regulation of organelle organization GO:0010638 195 0.015
nucleocytoplasmic transport GO:0006913 176 0.015
alcohol metabolic process GO:0006066 114 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.015
response to growth factor GO:0070848 205 0.014
nitrogen compound transport GO:0071705 191 0.014
secretion by cell GO:0032940 226 0.014
positive regulation of mapk cascade GO:0043410 190 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
carbohydrate metabolic process GO:0005975 207 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
regulation of transferase activity GO:0051338 355 0.014
regulation of locomotion GO:0040012 329 0.014
hyperosmotic response GO:0006972 4 0.014
regulation of cell migration GO:0030334 289 0.014
tripartite regional subdivision GO:0007351 2 0.014
negative regulation of cell death GO:0060548 345 0.014
spermatid development GO:0007286 4 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
negative regulation of protein modification process GO:0031400 200 0.014
gtp metabolic process GO:0046039 239 0.014
protein processing GO:0016485 226 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
peripheral nervous system development GO:0007422 2 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
cell activation GO:0001775 213 0.013
actin cytoskeleton organization GO:0030036 207 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
microtubule based process GO:0007017 210 0.013
positive regulation of cell differentiation GO:0045597 211 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
mitotic cell cycle process GO:1903047 286 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
organelle assembly GO:0070925 176 0.013
regulation of actin filament based process GO:0032970 141 0.013
regulation of intracellular transport GO:0032386 195 0.013
epithelium development GO:0060429 227 0.013
negative regulation of cytokine production GO:0001818 82 0.013
compound eye development GO:0048749 1 0.013
response to fungus GO:0009620 4 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
response to salt stress GO:0009651 3 0.013
chromatin modification GO:0016568 298 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
cellular protein complex assembly GO:0043623 188 0.012
regulation of store operated calcium channel activity GO:1901339 4 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
epithelium migration GO:0090132 119 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
oocyte development GO:0048599 1 0.012
cell division GO:0051301 168 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
associative learning GO:0008306 1 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
defense response to fungus GO:0050832 4 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
negative regulation of cell cycle GO:0045786 193 0.012
organic anion transport GO:0015711 103 0.012
positive regulation of cell death GO:0010942 263 0.012
regulation of protein transport GO:0051223 213 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
peptidyl serine modification GO:0018209 106 0.012
neurological system process GO:0050877 163 0.012
regulation of cell adhesion GO:0030155 166 0.012
viral life cycle GO:0019058 132 0.012
epithelial cell migration GO:0010631 119 0.012
regulation of peptidase activity GO:0052547 180 0.012
regulation of cell growth GO:0001558 135 0.012
rna processing GO:0006396 255 0.012
regulation of mapk cascade GO:0043408 262 0.012
dna repair GO:0006281 198 0.012
head development GO:0060322 108 0.012
cell projection assembly GO:0030031 126 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
cellular response to cytokine stimulus GO:0071345 181 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.012
ameboidal type cell migration GO:0001667 135 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
response to lipid GO:0033993 206 0.012
rhythmic behavior GO:0007622 2 0.011
positive regulation of gtpase activity GO:0043547 166 0.011
protein acylation GO:0043543 138 0.011
positive regulation of proteolysis GO:0045862 142 0.011
negative regulation of transport GO:0051051 176 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
regulation of protein maturation GO:1903317 150 0.011
regulation of protein complex assembly GO:0043254 147 0.011
rab protein signal transduction GO:0032482 4 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
positive regulation of locomotion GO:0040017 186 0.011
response to axon injury GO:0048678 1 0.011
protein localization to membrane GO:0072657 160 0.011
cellular response to external stimulus GO:0071496 111 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
sequestering of metal ion GO:0051238 24 0.011
hindbrain development GO:0030902 3 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
endocytosis GO:0006897 159 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
oocyte differentiation GO:0009994 2 0.011
t cell differentiation in thymus GO:0033077 4 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
positive regulation of cell cycle GO:0045787 140 0.011
response to bacterium GO:0009617 144 0.011
circadian behavior GO:0048512 2 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
regulation of multi organism process GO:0043900 157 0.011
negative regulation of protein processing GO:0010955 142 0.011
response to wounding GO:0009611 168 0.011
nuclear import GO:0051170 106 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
viral process GO:0016032 146 0.011
immune effector process GO:0002252 159 0.010
modification dependent macromolecule catabolic process GO:0043632 212 0.010
cell cycle phase transition GO:0044770 173 0.010
protein import into nucleus GO:0006606 104 0.010
regulation of secretion by cell GO:1903530 177 0.010
regulation of synaptic plasticity GO:0048167 3 0.010
protein localization to nucleus GO:0034504 136 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
sequestering of calcium ion GO:0051208 17 0.010
mating GO:0007618 1 0.010
regulation of dna metabolic process GO:0051052 153 0.010
regulation of viral process GO:0050792 103 0.010
regulation of protein processing GO:0070613 150 0.010
response to organic cyclic compound GO:0014070 204 0.010
protein oligomerization GO:0051259 173 0.010
glycoprotein metabolic process GO:0009100 110 0.010
positive regulation of immune response GO:0050778 159 0.010
single organism cell adhesion GO:0098602 179 0.010
monovalent inorganic cation transport GO:0015672 128 0.010
immune system development GO:0002520 195 0.010
atp metabolic process GO:0046034 176 0.010
lens development in camera type eye GO:0002088 2 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010

ORAI1 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.023
disease of metabolism DOID:0014667 295 0.021
central nervous system disease DOID:331 186 0.021
nervous system disease DOID:863 431 0.021
inherited metabolic disorder DOID:655 242 0.018
disease of cellular proliferation DOID:14566 174 0.015
cancer DOID:162 167 0.015
organ system cancer DOID:0050686 164 0.015
neurodegenerative disease DOID:1289 102 0.014
sensory system disease DOID:0050155 203 0.013
immune system disease DOID:2914 155 0.012
connective tissue disease DOID:65 109 0.012
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
muscular disease DOID:0080000 114 0.010
muscle tissue disease DOID:66 113 0.010