IMP

Process View

Homo sapiens

4 genes annotated in human

hyperosmotic response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
MAPK1	mitogen-activated protein kinase 1	0.987
JUN	jun proto-oncogene	0.977
MAP2K4	mitogen-activated protein kinase kinase 4	0.933
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.907
MAPK8	mitogen-activated protein kinase 8	0.882	Yeast Worm
DUSP1	dual specificity phosphatase 1	0.821
ARRB2	arrestin, beta 2	0.589
MAPK14	mitogen-activated protein kinase 14	0.568	Yeast Worm
HDAC6	histone deacetylase 6	0.485
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.399
ATF2	activating transcription factor 2	0.374
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.360
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.308
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.222
CPNE6	copine VI (neuronal)	0.198
MAPK3	mitogen-activated protein kinase 3	0.196
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.185
PEA15	phosphoprotein enriched in astrocytes 15	0.168
IRF2	interferon regulatory factor 2	0.142
ARRB1	arrestin, beta 1	0.114
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.110
DUSP3	dual specificity phosphatase 3	0.106
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.101
FAM107A	family with sequence similarity 107, member A	0.096
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.090
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.089
PAX8	paired box 8	0.082
FLNB	filamin B, beta	0.081
PTPRR	protein tyrosine phosphatase, receptor type, R	0.081
DUSP7	dual specificity phosphatase 7	0.077
MAP2K6	mitogen-activated protein kinase kinase 6	0.075
MAPK9	mitogen-activated protein kinase 9	0.073	Yeast Worm
MAP2K1	mitogen-activated protein kinase kinase 1	0.072	Yeast
ZNF282	zinc finger protein 282	0.069
KCTD17	potassium channel tetramerisation domain containing 17	0.068
FBXO33	F-box protein 33	0.066
CARD11	caspase recruitment domain family, member 11	0.063
SOCS3	suppressor of cytokine signaling 3	0.062
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.060
ATF3	activating transcription factor 3	0.060
ADAMTSL4	ADAMTS-like 4	0.060
XPO7	exportin 7	0.057
UBXN6	UBX domain protein 6	0.048
SPRY2	sprouty homolog 2 (Drosophila)	0.048
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.046
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.046
SBF1	SET binding factor 1	0.043
C1orf93	chromosome 1 open reading frame 93	0.042
DUSP9	dual specificity phosphatase 9	0.038
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.038
GRIP1	glutamate receptor interacting protein 1	0.037
MAP1S	microtubule-associated protein 1S	0.034
MBP	myelin basic protein	0.034
ARHGAP9	Rho GTPase activating protein 9	0.033
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.032
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.032
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.032
MAPK15	mitogen-activated protein kinase 15	0.031
SPRR2D	small proline-rich protein 2D	0.031
TRIP6	thyroid hormone receptor interactor 6	0.030
PTN	pleiotrophin	0.029
PEBP4	phosphatidylethanolamine-binding protein 4	0.028
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.028
HSF1	heat shock transcription factor 1	0.028
CCDC85B	coiled-coil domain containing 85B	0.027
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.026
PDCD6IP	programmed cell death 6 interacting protein	0.025
C19orf25	chromosome 19 open reading frame 25	0.025
CREBBP	CREB binding protein	0.025
SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	0.025
ARR3	arrestin 3, retinal (X-arrestin)	0.025
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.024
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.024
NSF	N-ethylmaleimide-sensitive factor	0.024
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.024
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.024
CSDA	cold shock domain protein A	0.023
PRKCZ	protein kinase C, zeta	0.023
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.023
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.023
OBSL1	obscurin-like 1	0.022
GRIA1	glutamate receptor, ionotropic, AMPA 1	0.022
STAMBP	STAM binding protein	0.021
SH3KBP1	SH3-domain kinase binding protein 1	0.021
SH3RF3	SH3 domain containing ring finger 3	0.021
VEGFB	vascular endothelial growth factor B	0.021
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.021
CEP110	centrosomal protein 110kDa	0.020
C16orf74	chromosome 16 open reading frame 74	0.020
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.020
HMG20B	high mobility group 20B	0.020
SS18	synovial sarcoma translocation, chromosome 18	0.019
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.019
LRDD	leucine-rich repeats and death domain containing	0.019
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.018
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.018
CHN2	chimerin (chimaerin) 2	0.018
KTN1	kinectin 1 (kinesin receptor)	0.018
ACAN	aggrecan	0.018
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.017
JDP2	Jun dimerization protein 2	0.017
ELK1	ELK1, member of ETS oncogene family	0.017
DUSP4	dual specificity phosphatase 4	0.017
EPOR	erythropoietin receptor	0.017
CUL7	cullin 7	0.017
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.017
MTPN	myotrophin	0.017
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.017
ZNF219	zinc finger protein 219	0.017
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.016
FKBP8	FK506 binding protein 8, 38kDa	0.016
BAG1	BCL2-associated athanogene	0.016
CIZ1	CDKN1A interacting zinc finger protein 1	0.016
GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.016
PABPC3	poly(A) binding protein, cytoplasmic 3	0.016
ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	0.016
STXBP5	syntaxin binding protein 5 (tomosyn)	0.016
GADD45B	growth arrest and DNA-damage-inducible, beta	0.016
HOXA1	homeobox A1	0.015
DDN	dendrin	0.015
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.015
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.015
BTBD2	BTB (POZ) domain containing 2	0.015
PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.015
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.015
SLC17A1	solute carrier family 17 (sodium phosphate), member 1	0.015
DLG1	discs, large homolog 1 (Drosophila)	0.015
YBX1	Y box binding protein 1	0.015	Human
STAU2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.015
CATSPER1	cation channel, sperm associated 1	0.015
CDHR5	cadherin-related family member 5	0.015
NAP1L5	nucleosome assembly protein 1-like 5	0.014
DPP8	dipeptidyl-peptidase 8	0.014
USF2	upstream transcription factor 2, c-fos interacting	0.014
FAM124B	family with sequence similarity 124B	0.014
NKX2-8	NK2 homeobox 8	0.014
RALY	RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))	0.014
ORAI1	ORAI calcium release-activated calcium modulator 1	0.014
MAP2K3	mitogen-activated protein kinase kinase 3	0.014
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.014
UBASH3B	ubiquitin associated and SH3 domain containing B	0.014
FLII	flightless I homolog (Drosophila)	0.014
PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.014
TXNL1	thioredoxin-like 1	0.014
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.014
NCKAP1	NCK-associated protein 1	0.013
INPP5F	inositol polyphosphate-5-phosphatase F	0.013
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.013
SNCAIP	synuclein, alpha interacting protein	0.013
GNMT	glycine N-methyltransferase	0.013
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.013
ZBTB25	zinc finger and BTB domain containing 25	0.013
BSG	basigin (Ok blood group)	0.013
KIAA1712	KIAA1712	0.013
SYNJ2	synaptojanin 2	0.013
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.013
GNAS	GNAS complex locus	0.012
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.012
PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme	0.012	Worm
SIX1	SIX homeobox 1	0.012
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.012
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	0.012
ADRBK2	adrenergic, beta, receptor kinase 2	0.012	Worm
ZNF764	zinc finger protein 764	0.012
ADAM17	ADAM metallopeptidase domain 17	0.012
DUSP16	dual specificity phosphatase 16	0.012
ZFAND5	zinc finger, AN1-type domain 5	0.012
COL8A1	collagen, type VIII, alpha 1	0.012
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.012
DDIT3	DNA-damage-inducible transcript 3	0.012
CNOT3	CCR4-NOT transcription complex, subunit 3	0.012
RHOA	ras homolog gene family, member A	0.012
KLF5	Kruppel-like factor 5 (intestinal)	0.012
BTRC	beta-transducin repeat containing	0.012
ZRANB1	zinc finger, RAN-binding domain containing 1	0.012
LPHN3	latrophilin 3	0.012
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.012
POLH	polymerase (DNA directed), eta	0.012
LIMK1	LIM domain kinase 1	0.012
MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)	0.011
XIAP	X-linked inhibitor of apoptosis	0.011
RARA	retinoic acid receptor, alpha	0.011
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.011
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.011
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.011
HNF1B	HNF1 homeobox B	0.011
AQP6	aquaporin 6, kidney specific	0.011
HTT	huntingtin	0.011
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.011
C8orf48	chromosome 8 open reading frame 48	0.011
AES	amino-terminal enhancer of split	0.011
PEX14	peroxisomal biogenesis factor 14	0.011
PIAS2	protein inhibitor of activated STAT, 2	0.011
FBXW7	F-box and WD repeat domain containing 7	0.011
WDR62	WD repeat domain 62	0.011
ADRBK1	adrenergic, beta, receptor kinase 1	0.011	Worm
RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1	0.011
CNTFR	ciliary neurotrophic factor receptor	0.011
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.011
CCDC88C	coiled-coil domain containing 88C	0.011
GK	glycerol kinase	0.011
BCL2	B-cell CLL/lymphoma 2	0.011
VPS36	vacuolar protein sorting 36 homolog (S. cerevisiae)	0.011
FBP1	fructose-1,6-bisphosphatase 1	0.011
GTF2I	general transcription factor IIi	0.011
KIF26A	kinesin family member 26A	0.011
CEP170	centrosomal protein 170kDa	0.011
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.011
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.011
DDHD2	DDHD domain containing 2	0.011
IL12RB2	interleukin 12 receptor, beta 2	0.011
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.011
GPR116	G protein-coupled receptor 116	0.011
FHOD1	formin homology 2 domain containing 1	0.011
SMU1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.011
NCOA6	nuclear receptor coactivator 6	0.011
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.010
FPGS	folylpolyglutamate synthase	0.010
KAT2B	K(lysine) acetyltransferase 2B	0.010
CA4	carbonic anhydrase IV	0.010
HK1	hexokinase 1	0.010
KRT17	keratin 17	0.010
CLASP2	cytoplasmic linker associated protein 2	0.010
C3orf63	chromosome 3 open reading frame 63	0.010
LINGO1	leucine rich repeat and Ig domain containing 1	0.010
IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	0.010
AKAP11	A kinase (PRKA) anchor protein 11	0.010
COX7A1	cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)	0.010
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.010
THOC5	THO complex 5	0.010
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.010
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.010
C1orf65	chromosome 1 open reading frame 65	0.010
STON2	stonin 2	0.010
CCDC67	coiled-coil domain containing 67	0.010
GTF2F1	general transcription factor IIF, polypeptide 1, 74kDa	0.010
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.010
PANX2	pannexin 2	0.010