Homo sapiens

205 known processes

BCL2

B-cell CLL/lymphoma 2

(Aliases: Bcl-2)

BCL2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of release of cytochrome c from mitochondria GO:0090200 18 1.000
Human
neuron death in response to oxidative stress GO:0036475 9 1.000
Human
regulation of oxidative stress induced neuron death GO:1903203 9 1.000
Human
release of cytochrome c from mitochondria GO:0001836 35 1.000
Human Mouse
positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 4 1.000
Human
positive regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903378 2 1.000
Human
positive regulation of mitochondrion organization GO:0010822 30 1.000
Human Worm
regulation of execution phase of apoptosis GO:1900117 11 1.000
Human
apoptotic signaling pathway GO:0097190 268 1.000
regulation of peptidase activity GO:0052547 180 1.000
Human Zebrafish
positive regulation of apoptotic signaling pathway GO:2001235 70 1.000
Human
positive regulation of protein oligomerization GO:0032461 17 1.000
Human
regulation of endopeptidase activity GO:0052548 170 1.000
Human Zebrafish
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 1.000
Human
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 1.000
regulation of protein heterodimerization activity GO:0043497 5 1.000
regulation of release of cytochrome c from mitochondria GO:0090199 29 1.000
Human
regulation of protein oligomerization GO:0032459 26 1.000
Human
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 1.000
Human
positive regulation of response to oxidative stress GO:1902884 7 1.000
Human
modulation by symbiont of host cellular process GO:0044068 3 1.000
Human
apoptotic mitochondrial changes GO:0008637 57 1.000
Human Mouse
positive regulation of cellular response to oxidative stress GO:1900409 7 1.000
Human
mitochondrial fragmentation involved in apoptotic process GO:0043653 7 1.000
Human
regulation of cysteine type endopeptidase activity GO:2000116 127 1.000
Human Zebrafish
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 1.000
Human
modulation by organism of apoptotic process in other organism involved in symbiotic interaction GO:0052433 1 1.000
Human
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 1.000
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 1.000
Human
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 2 1.000
Human
modulation by symbiont of host apoptotic process GO:0052150 1 1.000
Human
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 7 1.000
Human
protein processing GO:0016485 226 1.000
Human Zebrafish
positive regulation of apoptotic dna fragmentation GO:1902512 1 1.000
Human
positive regulation of oxidative stress induced cell death GO:1903209 5 1.000
Human
regulation of mitochondrion organization GO:0010821 54 1.000
Human Worm
suppression by virus of host apoptotic process GO:0019050 1 1.000
Human
regulation of cellular ph reduction GO:0032847 1 1.000
modulation of programmed cell death in other organism GO:0044531 1 1.000
Human
positive regulation of cell death GO:0010942 263 1.000
Human
zymogen activation GO:0031638 70 1.000
Human
regulation of apoptotic signaling pathway GO:2001233 175 1.000
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 1.000
positive regulation of programmed cell death GO:0043068 249 1.000
Human
execution phase of apoptosis GO:0097194 32 1.000
Human
intrinsic apoptotic signaling pathway GO:0097193 127 1.000
modulation by virus of host process GO:0019054 2 1.000
Human
modulation of apoptotic process in other organism GO:0044532 1 1.000
Human
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 2 1.000
Human
positive regulation of apoptotic process GO:0043065 246 1.000
Human
positive regulation of endopeptidase activity GO:0010950 84 1.000
Human
positive regulation of neuron apoptotic process GO:0043525 8 1.000
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 1.000
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 3 1.000
single organism membrane fusion GO:0044801 37 1.000
Human Worm
negative regulation of cell death GO:0060548 345 1.000
mitochondrial membrane organization GO:0007006 40 1.000
Human Mouse
regulation of mitochondrial membrane permeability GO:0046902 25 1.000
Human Mouse
modulation by symbiont of host programmed cell death GO:0052040 1 1.000
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 1.000
Human Zebrafish
mitochondrial fusion GO:0008053 13 1.000
Human Worm
regulation of protein localization to plasma membrane GO:1903076 40 1.000
Human
regulation of proteolysis GO:0030162 293 1.000
Human Zebrafish
positive regulation of execution phase of apoptosis GO:1900119 5 1.000
Human
negative regulation of execution phase of apoptosis GO:1900118 6 0.999
Human
regulation of membrane permeability GO:0090559 25 0.999
Human Mouse
signal transduction in absence of ligand GO:0038034 22 0.999
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.999
Human
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.999
Human
cellular response to external stimulus GO:0071496 111 0.999
Mouse
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 2 0.999
modulation by virus of host apoptotic process GO:0039526 1 0.999
Human
activation of cysteine type endopeptidase activity GO:0097202 57 0.999
Human
regulation of apoptotic dna fragmentation GO:1902510 3 0.999
Human
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.999
positive regulation of proteolysis GO:0045862 142 0.999
Human
regulation of transmembrane transporter activity GO:0022898 74 0.999
mitochondrial transport GO:0006839 60 0.999
Human Mouse
regulation of mitochondrial fusion GO:0010635 5 0.999
Worm
positive regulation of peptidase activity GO:0010952 88 0.999
Human
regulation of protein localization GO:0032880 296 0.999
Human Mouse
positive regulation of organelle organization GO:0010638 195 0.999
Human Worm
release of matrix enzymes from mitochondria GO:0032976 1 0.999
Human
cellular response to mechanical stimulus GO:0071260 39 0.999
defense response to virus GO:0051607 71 0.998
negative regulation of apoptotic process GO:0043066 316 0.998
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.998
neuron apoptotic process GO:0051402 39 0.998
protein maturation GO:0051604 233 0.998
Human Zebrafish
cell type specific apoptotic process GO:0097285 125 0.998
positive regulation of oxidative stress induced neuron death GO:1903223 2 0.998
Human
negative regulation of neuron apoptotic process GO:0043524 23 0.998
retinal cell apoptotic process GO:1990009 1 0.997
Human
leukocyte apoptotic process GO:0071887 31 0.997
Human
positive regulation of protein homooligomerization GO:0032464 7 0.997
positive regulation of cellular component organization GO:0051130 376 0.997
Human Worm
apoptotic dna fragmentation GO:0006309 6 0.997
Human
negative regulation of apoptotic signaling pathway GO:2001234 97 0.997
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.997
Human
extrinsic apoptotic signaling pathway GO:0097191 119 0.996
negative regulation of anoikis GO:2000811 15 0.996
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.996
Human Mouse
regulation of oxidative stress induced cell death GO:1903201 24 0.996
Human
positive regulation of lymphocyte proliferation GO:0050671 46 0.995
regulation of neuron apoptotic process GO:0043523 35 0.995
protein homooligomerization GO:0051260 100 0.995
Human
regulation of cellular amine metabolic process GO:0033238 11 0.994
modification of morphology or physiology of other organism GO:0035821 43 0.994
Human
defense response to other organism GO:0098542 129 0.993
negative regulation of programmed cell death GO:0043069 321 0.993
mitochondrion organization GO:0007005 156 0.993
Human Mouse Worm
interaction with host GO:0051701 42 0.993
Human
endoplasmic reticulum unfolded protein response GO:0030968 16 0.993
Human
negative regulation of cell proliferation GO:0008285 228 0.992
Mouse
apoptotic process in bone marrow GO:0071839 1 0.992
transformed cell apoptotic process GO:0006927 3 0.992
Human
negative regulation of peptidase activity GO:0010466 91 0.992
Zebrafish
response to iron ion GO:0010039 6 0.991
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.990
apoptotic process involved in morphogenesis GO:0060561 3 0.990
response to inorganic substance GO:0010035 127 0.990
membrane organization GO:0061024 292 0.989
Human Mouse Worm
modification by symbiont of host morphology or physiology GO:0044003 12 0.988
Human
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 12 0.987
growth GO:0040007 202 0.987
regulation of cellular amino acid metabolic process GO:0006521 6 0.987
lymphocyte apoptotic process GO:0070227 20 0.986
Human
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.985
Zebrafish
positive regulation of mitochondrial membrane permeability GO:0035794 17 0.985
positive regulation of b cell activation GO:0050871 17 0.985
cellular cation homeostasis GO:0030003 163 0.984
response to decreased oxygen levels GO:0036293 96 0.984
Mouse Rat
positive regulation of cellular component biogenesis GO:0044089 158 0.984
Human
ph reduction GO:0045851 11 0.983
cellular calcium ion homeostasis GO:0006874 117 0.982
Mouse
signal transduction by p53 class mediator GO:0072331 72 0.982
positive regulation of leukocyte proliferation GO:0070665 48 0.981
negative regulation by symbiont of host programmed cell death GO:0052041 1 0.980
Human
mononuclear cell proliferation GO:0032943 71 0.980
modulation by virus of host morphology or physiology GO:0019048 10 0.980
Human
multi organism cellular process GO:0044764 156 0.980
Human Mouse
response to metal ion GO:0010038 84 0.978
mitotic cell cycle phase transition GO:0044772 162 0.977
Human Mouse
response to cycloheximide GO:0046898 1 0.976
response to nicotine GO:0035094 12 0.976
regulation of neuron death GO:1901214 56 0.972
b cell apoptotic process GO:0001783 6 0.971
Human
positive regulation of cell proliferation GO:0008284 301 0.969
response to electrical stimulus GO:0051602 1 0.969
Rat
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.968
Human
regulation of cell cycle process GO:0010564 266 0.968
Human Mouse
cellular chemical homeostasis GO:0055082 180 0.967
cellular response to uv GO:0034644 32 0.964
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.964
intracellular ph reduction GO:0051452 10 0.963
mitochondrion morphogenesis GO:0070584 8 0.962
negative regulation of endopeptidase activity GO:0010951 84 0.962
Zebrafish
regulation of lymphocyte proliferation GO:0050670 64 0.961
single organism cellular localization GO:1902580 332 0.960
Human
development of primary female sexual characteristics GO:0046545 10 0.959
Mouse Rat
cellular homeostasis GO:0019725 196 0.958
positive regulation of cellular catabolic process GO:0031331 284 0.956
Human Worm
regulation of establishment of protein localization GO:0070201 242 0.956
Human
calcium ion transport GO:0006816 147 0.955
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.952
female gonad development GO:0008585 10 0.951
Mouse Rat
cellular response to dna damage stimulus GO:0006974 379 0.949
chordate embryonic development GO:0043009 34 0.948
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.948
positive regulation of dna catabolic process GO:1903626 2 0.942
Human
regulation of membrane potential GO:0042391 95 0.941
Human Mouse
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 16 0.939
cellular ketone metabolic process GO:0042180 80 0.939
tube development GO:0035295 125 0.936
Mouse
establishment of protein localization to mitochondrion GO:0072655 22 0.932
response to oxidative stress GO:0006979 121 0.928
Human Mouse
mitochondrial outer membrane permeabilization GO:0097345 15 0.922
positive regulation of leukocyte activation GO:0002696 80 0.920
neuron death GO:0070997 65 0.917
response to abiotic stimulus GO:0009628 336 0.916
Mouse Rat
negative regulation of homeostatic process GO:0032845 59 0.915
positive regulation of fibroblast apoptotic process GO:2000271 6 0.914
regulation of mitotic cell cycle GO:0007346 189 0.911
Human Mouse
positive regulation of hydrolase activity GO:0051345 331 0.911
Human Worm
lymphocyte activation GO:0046649 133 0.911
response to hypoxia GO:0001666 96 0.910
Mouse Rat
protein insertion into mitochondrial membrane GO:0051204 3 0.909
defense response GO:0006952 315 0.907
regulation of ph GO:0006885 20 0.906
regulation of cell cycle phase transition GO:1901987 126 0.901
Human Mouse
cellular monovalent inorganic cation homeostasis GO:0030004 26 0.899
regulation of cellular response to stress GO:0080135 244 0.897
Human
regulation of ion transport GO:0043269 189 0.897
negative regulation of catalytic activity GO:0043086 335 0.894
Zebrafish
positive regulation of protein complex assembly GO:0031334 86 0.893
Human
lymphocyte proliferation GO:0046651 70 0.891
cellular response to abiotic stimulus GO:0071214 117 0.891
regulation of establishment of protein localization to plasma membrane GO:0090003 30 0.887
Human
mitotic cell cycle process GO:1903047 286 0.885
Human Mouse
negative regulation of neuron death GO:1901215 32 0.884
positive regulation of mononuclear cell proliferation GO:0032946 47 0.883
mitochondrial fission GO:0000266 14 0.881
Human
ion transmembrane transport GO:0034220 338 0.881
Human
monovalent inorganic cation homeostasis GO:0055067 37 0.879
positive regulation of neuron death GO:1901216 14 0.877
Human
divalent metal ion transport GO:0070838 152 0.875
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 1 0.870
response to cytokine GO:0034097 232 0.870
regulation of endoplasmic reticulum unfolded protein response GO:1900101 5 0.868
Human
positive regulation of growth GO:0045927 58 0.865
regulation of b cell activation GO:0050864 24 0.862
cellular amino acid metabolic process GO:0006520 116 0.861
activation of immune response GO:0002253 114 0.856
cell growth GO:0016049 160 0.853
regulation of ion homeostasis GO:2000021 73 0.852
multicellular organismal homeostasis GO:0048871 67 0.848
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.846
Zebrafish
negative regulation of protein localization to plasma membrane GO:1903077 13 0.845
Human
viral process GO:0016032 146 0.845
Human Mouse
response to alkaloid GO:0043279 20 0.844
cellular macromolecule catabolic process GO:0044265 380 0.835
Human
response to organic cyclic compound GO:0014070 204 0.833
regulation of cell cycle GO:0051726 393 0.831
Human Mouse
cellular response to starvation GO:0009267 58 0.828
Mouse
negative regulation of intracellular signal transduction GO:1902532 183 0.824
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.819
Human Mouse
protein oligomerization GO:0051259 173 0.818
Human
developmental programmed cell death GO:0010623 3 0.813
Mouse
response to virus GO:0009615 126 0.813
positive regulation of apoptotic process involved in morphogenesis GO:1902339 1 0.808
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.806
negative regulation of cell cycle process GO:0010948 121 0.805
Human Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.794
single organism membrane organization GO:0044802 268 0.794
Human Mouse Worm
regulation of b cell proliferation GO:0030888 18 0.792
regulation of leukocyte proliferation GO:0070663 67 0.791
cation homeostasis GO:0055080 189 0.790
positive regulation of b cell proliferation GO:0030890 12 0.788
regulation of mitotic cell cycle phase transition GO:1901990 118 0.786
Human Mouse
response to hormone GO:0009725 175 0.783
Mouse Rat
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.780
apoptotic nuclear changes GO:0030262 13 0.778
Human
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 16 0.777
response to oxygen levels GO:0070482 100 0.776
Mouse Rat
positive regulation of immune system process GO:0002684 283 0.774
positive regulation of cell cycle GO:0045787 140 0.773
regulation of cellular response to oxidative stress GO:1900407 26 0.772
Human
positive regulation of lymphocyte activation GO:0051251 73 0.770
immune response regulating signaling pathway GO:0002764 97 0.764
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 38 0.759
Human
regulation of epithelial cell proliferation GO:0050678 113 0.756
regulation of transporter activity GO:0032409 82 0.755
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.750
negative regulation of cell cycle phase transition GO:1901988 89 0.749
Human Mouse
cell activation GO:0001775 213 0.742
t cell apoptotic process GO:0070231 12 0.742
positive regulation of developmental pigmentation GO:0048087 2 0.741
Mouse
modulation of programmed cell death in other organism involved in symbiotic interaction GO:0052248 1 0.737
Human
regulation of mitochondrial membrane potential GO:0051881 23 0.736
Human Mouse
regulation of leukocyte activation GO:0002694 115 0.731
protein localization to plasma membrane GO:0072659 93 0.729
Human
organelle fusion GO:0048284 36 0.724
Human Worm
leukocyte proliferation GO:0070661 74 0.724
metal ion transport GO:0030001 272 0.724
membrane fusion GO:0061025 43 0.718
Human Worm
response to endoplasmic reticulum stress GO:0034976 49 0.711
response to nitrogen compound GO:1901698 184 0.711
cellular amine metabolic process GO:0044106 41 0.707
negative regulation of cell cycle GO:0045786 193 0.702
Human Mouse
cell cycle checkpoint GO:0000075 117 0.701
Human
dna catabolic process endonucleolytic GO:0000737 37 0.693
Human
regulation of protein complex assembly GO:0043254 147 0.692
Human
response to organonitrogen compound GO:0010243 156 0.690
regulation of intracellular ph GO:0051453 16 0.688
response to unfolded protein GO:0006986 24 0.687
Human
positive regulation of dna metabolic process GO:0051054 73 0.687
Human
dna catabolic process GO:0006308 49 0.674
Human
cellular response to virus GO:0098586 9 0.674
response to uv GO:0009411 73 0.673
Mouse
chemotaxis GO:0006935 157 0.673
cellular response to light stimulus GO:0071482 34 0.667
response to mechanical stimulus GO:0009612 51 0.666
positive regulation of cell growth GO:0030307 48 0.662
b cell homeostasis GO:0001782 1 0.656
Mouse
negative regulation of protein metabolic process GO:0051248 391 0.656
Zebrafish
positive regulation of catabolic process GO:0009896 310 0.654
Human Worm
regulation of homeostatic process GO:0032844 121 0.650
neural tube development GO:0021915 9 0.647
negative regulation of mitotic cell cycle GO:0045930 102 0.647
Human Mouse
protein localization to membrane GO:0072657 160 0.645
Human
thyroid gland development GO:0030878 5 0.642
regulation of lymphocyte activation GO:0051249 103 0.637
cellular response to endogenous stimulus GO:0071495 336 0.636
regulation of metal ion transport GO:0010959 120 0.636
urogenital system development GO:0001655 65 0.633
Mouse
regulation of calcium ion transport GO:0051924 79 0.633
response to biotic stimulus GO:0009607 276 0.632
anatomical structure homeostasis GO:0060249 100 0.631
Mouse
male sex differentiation GO:0046661 25 0.624
Mouse
mitotic cell cycle checkpoint GO:0007093 68 0.616
Human
positive regulation of cell activation GO:0050867 81 0.615
establishment of protein localization to plasma membrane GO:0090002 68 0.613
Human
b cell activation GO:0042113 33 0.607
regulation of anoikis GO:2000209 19 0.604
regulation of mitosis GO:0007088 63 0.592
antigen receptor mediated signaling pathway GO:0050851 38 0.591
response to axon injury GO:0048678 1 0.588
Mouse
regulation of protein processing GO:0070613 150 0.584
Zebrafish
regulation of cellular component biogenesis GO:0044087 281 0.584
Human
cardiovascular system development GO:0072358 262 0.580
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9 0.579
negative regulation of protein binding GO:0032091 35 0.577
Human
regulation of dna catabolic process GO:1903624 7 0.577
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.559
Human Mouse
regulation of protein maturation GO:1903317 150 0.559
Zebrafish
negative regulation of protein phosphorylation GO:0001933 140 0.558
negative regulation of establishment of protein localization to plasma membrane GO:0090005 9 0.557
Human
er nucleus signaling pathway GO:0006984 23 0.555
Human
regulation of mononuclear cell proliferation GO:0032944 65 0.552
immune response GO:0006955 307 0.546
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.535
Mouse
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.533
leukocyte differentiation GO:0002521 98 0.528
Mouse
anoikis GO:0043276 22 0.527
regulation of growth GO:0040008 165 0.522
negative regulation of binding GO:0051100 57 0.519
Human
cation transport GO:0006812 331 0.512
regulation of cell growth GO:0001558 135 0.509
plasma membrane organization GO:0007009 115 0.508
Human
renal system development GO:0072001 63 0.508
Mouse
ovulation cycle GO:0042698 9 0.501
Mouse Rat
negative regulation of transferase activity GO:0051348 124 0.500
epithelium development GO:0060429 227 0.499
Mouse
tissue homeostasis GO:0001894 63 0.495
Mouse
cellular ion homeostasis GO:0006873 168 0.493
cellular response to oxidative stress GO:0034599 85 0.486
Human Mouse
cytokinesis GO:0000910 96 0.484
Human
cellular component disassembly GO:0022411 92 0.481
Human
response to ionizing radiation GO:0010212 65 0.477
Mouse
response to alcohol GO:0097305 64 0.469
Rat
regulation of protein homooligomerization GO:0032462 11 0.464
response to radiation GO:0009314 151 0.461
Mouse
protein polyubiquitination GO:0000209 110 0.458
regulation of cell development GO:0060284 161 0.458
Mouse
cell division GO:0051301 168 0.457
Human
limbic system development GO:0021761 3 0.454
autophagy GO:0006914 88 0.454
response to transition metal nanoparticle GO:1990267 29 0.453
b cell receptor signaling pathway GO:0050853 18 0.449
cellular response to radiation GO:0071478 65 0.448
negative regulation of response to dna damage stimulus GO:2001021 33 0.447
Human
negative regulation of release of cytochrome c from mitochondria GO:0090201 11 0.447
Human
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901028 9 0.445
dephosphorylation GO:0016311 209 0.445
Mouse
sequestering of metal ion GO:0051238 24 0.442
cellular response to unfolded protein GO:0034620 16 0.440
Human
protein ubiquitination GO:0016567 314 0.439
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.432
negative regulation of mitochondrion organization GO:0010823 22 0.428
Human
amine metabolic process GO:0009308 44 0.420
negative regulation of cellular component organization GO:0051129 235 0.417
Human
regulation of dna metabolic process GO:0051052 153 0.415
Human
ion homeostasis GO:0050801 230 0.413
vacuole organization GO:0007033 44 0.412
regulation of cell activation GO:0050865 125 0.410
sequestering of calcium ion GO:0051208 17 0.404
digestive tract development GO:0048565 75 0.402
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.402
anatomical structure formation involved in morphogenesis GO:0048646 284 0.399
positive regulation of nucleoside metabolic process GO:0045979 186 0.398
Worm
regulation of cell cycle arrest GO:0071156 36 0.394
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.384
Human
positive regulation of immune response GO:0050778 159 0.382
chemical homeostasis GO:0048878 306 0.378
g1 s transition of mitotic cell cycle GO:0000082 78 0.374
Mouse
regulation of leukocyte apoptotic process GO:2000106 25 0.373
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 1 0.371
response to reactive oxygen species GO:0000302 61 0.370
Mouse
nucleotide catabolic process GO:0009166 408 0.367
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.358
Worm
regulation of multi organism process GO:0043900 157 0.356
Mouse
generation of neurons GO:0048699 152 0.352
Mouse
development of primary male sexual characteristics GO:0046546 23 0.348
Mouse
cell cycle phase transition GO:0044770 173 0.344
Human Mouse
negative regulation of protein modification process GO:0031400 200 0.343
response to lipid GO:0033993 206 0.342
Mouse Rat
neuron projection regeneration GO:0031102 1 0.339
Mouse
regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902229 20 0.331
Human
gland development GO:0048732 48 0.328
Mouse
proteasomal protein catabolic process GO:0010498 176 0.328
interspecies interaction between organisms GO:0044419 156 0.326
Human Mouse
epithelial cell proliferation GO:0050673 128 0.323
establishment of protein localization to organelle GO:0072594 172 0.314
negative regulation of phosphorylation GO:0042326 174 0.314
establishment of protein localization to membrane GO:0090150 121 0.313
Human
negative regulation of proteolysis GO:0045861 132 0.312
Zebrafish
response to steroid hormone GO:0048545 80 0.307
Mouse Rat
negative regulation of phosphorus metabolic process GO:0010563 267 0.306
lymphocyte homeostasis GO:0002260 4 0.305
Mouse
cellular response to alkaloid GO:0071312 11 0.301
regulation of cell differentiation GO:0045595 393 0.300
Mouse
immune response activating signal transduction GO:0002757 90 0.300
positive regulation of cell cycle arrest GO:0071158 23 0.299
negative regulation of hydrolase activity GO:0051346 182 0.297
Zebrafish
response to drug GO:0042493 81 0.297
purine containing compound catabolic process GO:0072523 411 0.295
Worm
thymocyte apoptotic process GO:0070242 2 0.294
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.292
Zebrafish
regeneration GO:0031099 4 0.278
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.278
regulation of anatomical structure morphogenesis GO:0022603 286 0.277
Mouse Worm
lipid metabolic process GO:0006629 381 0.274
maintenance of location GO:0051235 112 0.274
cell fate determination GO:0001709 3 0.271
regulation of protein kinase activity GO:0045859 289 0.267
regulation of autophagy GO:0010506 52 0.264
collateral sprouting GO:0048668 2 0.264
cell development GO:0048468 328 0.264
Mouse
cellular component morphogenesis GO:0032989 314 0.261
Mouse
regulation of nucleoside metabolic process GO:0009118 209 0.261
Worm
regulation of protein dephosphorylation GO:0035304 18 0.260
cellular response to oxygen levels GO:0071453 55 0.259
Mouse
peptidyl serine modification GO:0018209 106 0.256
Mouse
hindbrain development GO:0030902 3 0.255
Mouse
immune effector process GO:0002252 159 0.255
regulation of proteasomal protein catabolic process GO:0061136 87 0.254
response to oxygen containing compound GO:1901700 369 0.254
Mouse Rat
thymus development GO:0048538 3 0.254
Mouse
oogenesis GO:0048477 2 0.250
Mouse
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.249
negative regulation of organelle organization GO:0010639 126 0.246
Human
protein dephosphorylation GO:0006470 81 0.246
Mouse
female gamete generation GO:0007292 2 0.245
Mouse
peptidyl tyrosine phosphorylation GO:0018108 170 0.244
pattern specification process GO:0007389 43 0.243
macroautophagy GO:0016236 39 0.241
cellular response to organonitrogen compound GO:0071417 124 0.238
negative regulation of phosphate metabolic process GO:0045936 267 0.238
male gonad development GO:0008584 23 0.237
Mouse
glial cell apoptotic process GO:0034349 7 0.236
Rat
regulation of lymphocyte apoptotic process GO:0070228 15 0.234
mitotic cell cycle GO:0000278 326 0.234
Human Mouse
response to external biotic stimulus GO:0043207 261 0.233
negative regulation of protein maturation GO:1903318 142 0.230
Zebrafish
response to hydrogen peroxide GO:0042542 40 0.230
Mouse
embryo development GO:0009790 123 0.224
Worm
endoplasmic reticulum calcium ion homeostasis GO:0032469 9 0.219
Mouse
spermatid differentiation GO:0048515 4 0.218
cellular response to nitrogen compound GO:1901699 144 0.218
dna damage checkpoint GO:0000077 68 0.211
myeloid cell homeostasis GO:0002262 34 0.209
embryo development ending in birth or egg hatching GO:0009792 34 0.209
Worm
response to topologically incorrect protein GO:0035966 29 0.205
Human
negative regulation of protein processing GO:0010955 142 0.205
Zebrafish
circulatory system development GO:0072359 262 0.203
cellular response to topologically incorrect protein GO:0035967 19 0.202
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.202
taxis GO:0042330 157 0.202
cellular response to hypoxia GO:0071456 51 0.201
Mouse
regulation of b cell apoptotic process GO:0002902 5 0.198
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.198
regulation of response to oxidative stress GO:1902882 26 0.195
Human
protein catabolic process GO:0030163 325 0.193
endocrine system development GO:0035270 26 0.192
fibroblast apoptotic process GO:0044346 8 0.191
determination of adult lifespan GO:0008340 2 0.189
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.188
Mouse
regulation of fibroblast apoptotic process GO:2000269 8 0.184
kidney development GO:0001822 53 0.177
Mouse
response to peptide GO:1901652 65 0.176
Rat
monosaccharide metabolic process GO:0005996 74 0.176
cell projection organization GO:0030030 252 0.174
Mouse
signal transduction in response to dna damage GO:0042770 57 0.168
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 3 0.167
regulation of cellular ph GO:0030641 17 0.167
regulation of response to external stimulus GO:0032101 222 0.167
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 4 0.166
response to peptide hormone GO:0043434 61 0.166
Rat
tube morphogenesis GO:0035239 95 0.164
Mouse
cytoplasmic transport GO:0016482 379 0.163
Mouse
hematopoietic or lymphoid organ development GO:0048534 186 0.162
Mouse
positive regulation of transport GO:0051050 336 0.162
mitotic nuclear division GO:0007067 119 0.161
organ morphogenesis GO:0009887 147 0.158
Mouse
regulation of lipid metabolic process GO:0019216 96 0.156
t cell homeostasis GO:0043029 3 0.156
Mouse
cellular response to metal ion GO:0071248 43 0.155
organelle fission GO:0048285 149 0.155
Human
regulation of transmembrane transport GO:0034762 139 0.152
positive regulation of killing of cells of other organism GO:0051712 4 0.152
multicellular organismal aging GO:0010259 3 0.148
female sex differentiation GO:0046660 12 0.146
Mouse Rat
regulation of kinase activity GO:0043549 314 0.145
signal transduction by phosphorylation GO:0023014 297 0.143
positive regulation of multi organism process GO:0043902 56 0.142
regulation of protein homodimerization activity GO:0043496 9 0.142
regulation of sequestering of calcium ion GO:0051282 41 0.141
gtp catabolic process GO:0006184 237 0.140
Worm
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.139
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.137
Human

BCL2 disease predictions

Disease DO term ID Size Probability Func Analog Org