Homo sapiens

90 known processes

COPS8

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

(Aliases: SGN8,COP9,CSN8,MGC1297,MGC43256)

COPS8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deneddylation GO:0000338 10 0.989
cullin deneddylation GO:0010388 9 0.880
cytokinesis GO:0000910 96 0.744
protein modification by small protein removal GO:0070646 92 0.697
cellular response to dna damage stimulus GO:0006974 379 0.635
regulation of protein stability GO:0031647 87 0.632
dna damage checkpoint GO:0000077 68 0.595
regulation of cell cycle phase transition GO:1901987 126 0.582
protein stabilization GO:0050821 64 0.579
g2 dna damage checkpoint GO:0031572 26 0.562
mitotic cell cycle phase transition GO:0044772 162 0.556
post embryonic development GO:0009791 2 0.547
cell cycle phase transition GO:0044770 173 0.533
cell division GO:0051301 168 0.472
mitotic dna damage checkpoint GO:0044773 28 0.471
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.436
regulation of cell cycle process GO:0010564 266 0.416
negative regulation of cell cycle phase transition GO:1901988 89 0.406
mitotic cell cycle GO:0000278 326 0.394
cellular macromolecule catabolic process GO:0044265 380 0.322
negative regulation of cell cycle process GO:0010948 121 0.313
modification dependent macromolecule catabolic process GO:0043632 212 0.310
cyclin catabolic process GO:0008054 6 0.300
cellular protein catabolic process GO:0044257 261 0.296
protein catabolic process GO:0030163 325 0.287
negative regulation of mitotic cell cycle GO:0045930 102 0.271
reproductive process GO:0022414 106 0.269
ubiquitin dependent protein catabolic process GO:0006511 206 0.263
posttranscriptional regulation of gene expression GO:0010608 213 0.250
single organism cellular localization GO:1902580 332 0.249
nervous system development GO:0007399 293 0.241
mitotic cell cycle checkpoint GO:0007093 68 0.230
endocytosis GO:0006897 159 0.207
regulation of mitotic cell cycle phase transition GO:1901990 118 0.207
modification dependent protein catabolic process GO:0019941 209 0.193
mitotic cell cycle process GO:1903047 286 0.192
dna integrity checkpoint GO:0031570 71 0.191
cell cycle checkpoint GO:0000075 117 0.162
regulation of cell cycle GO:0051726 393 0.155
glial cell migration GO:0008347 4 0.148
negative regulation of proteolysis GO:0045861 132 0.140
reproductive structure development GO:0048608 55 0.135
regulation of mitotic cell cycle GO:0007346 189 0.130
microtubule cytoskeleton organization GO:0000226 176 0.128
regulation of proteasomal protein catabolic process GO:0061136 87 0.126
regulation of proteolysis GO:0030162 293 0.125
vesicle mediated transport GO:0016192 371 0.123
protein localization to organelle GO:0033365 280 0.112
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.097
segmentation GO:0035282 4 0.097
embryo development GO:0009790 123 0.097
multicellular organismal aging GO:0010259 3 0.096
lipid biosynthetic process GO:0008610 177 0.089
female gamete generation GO:0007292 2 0.088
anterior posterior axis specification embryo GO:0008595 2 0.088
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.088
sex differentiation GO:0007548 45 0.087
negative regulation of protein maturation GO:1903318 142 0.084
embryo development ending in birth or egg hatching GO:0009792 34 0.084
regulation of protein maturation GO:1903317 150 0.080
negative regulation of cell cycle GO:0045786 193 0.076
negative regulation of cellular protein metabolic process GO:0032269 353 0.074
positive regulation of catabolic process GO:0009896 310 0.074
mitotic dna integrity checkpoint GO:0044774 30 0.071
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.066
organelle localization GO:0051640 84 0.064
cell projection organization GO:0030030 252 0.063
secretion GO:0046903 254 0.063
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.062
regulation of cellular protein catabolic process GO:1903362 96 0.061
mitotic g2 m transition checkpoint GO:0044818 9 0.060
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.060
positive regulation of protein catabolic process GO:0045732 75 0.058
neuron differentiation GO:0030182 138 0.057
purine ribonucleoside metabolic process GO:0046128 437 0.057
proteasomal protein catabolic process GO:0010498 176 0.056
anterior posterior axis specification GO:0009948 2 0.053
adult locomotory behavior GO:0008344 1 0.052
positive regulation of cell death GO:0010942 263 0.051
regulation of protein processing GO:0070613 150 0.050
negative regulation of protein processing GO:0010955 142 0.050
protein modification by small protein conjugation GO:0032446 342 0.050
negative regulation of cellular protein catabolic process GO:1903363 38 0.050
negative regulation of protein catabolic process GO:0042177 59 0.047
nucleoside catabolic process GO:0009164 408 0.047
regulation of mitosis GO:0007088 63 0.046
protein processing GO:0016485 226 0.046
protein maturation GO:0051604 233 0.045
mitotic g2 dna damage checkpoint GO:0007095 7 0.044
oogenesis GO:0048477 2 0.044
regulation of protein catabolic process GO:0042176 155 0.043
mapk cascade GO:0000165 288 0.042
internal peptidyl lysine acetylation GO:0018393 97 0.041
neuron projection development GO:0031175 106 0.041
negative regulation of catabolic process GO:0009895 104 0.041
cellular amine metabolic process GO:0044106 41 0.040
cellular macromolecular complex assembly GO:0034622 324 0.038
regulation of protein localization GO:0032880 296 0.038
cellular protein complex assembly GO:0043623 188 0.038
intracellular protein transport GO:0006886 270 0.037
chromatin organization GO:0006325 351 0.037
development of primary sexual characteristics GO:0045137 35 0.037
regulation of cellular amine metabolic process GO:0033238 11 0.037
cytoplasmic transport GO:0016482 379 0.036
determination of adult lifespan GO:0008340 2 0.035
regulation of cellular ketone metabolic process GO:0010565 50 0.035
organic hydroxy compound metabolic process GO:1901615 147 0.035
establishment of nucleus localization GO:0040023 1 0.035
protein targeting GO:0006605 187 0.034
response to organic cyclic compound GO:0014070 204 0.034
chromosome segregation GO:0007059 114 0.033
single organism membrane organization GO:0044802 268 0.033
cell morphogenesis involved in differentiation GO:0000904 144 0.032
purine nucleotide catabolic process GO:0006195 405 0.032
nucleotide catabolic process GO:0009166 408 0.031
positive regulation of phosphorylation GO:0042327 394 0.030
positive regulation of cell cycle GO:0045787 140 0.030
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.030
nuclear migration GO:0007097 1 0.030
regulation of protein serine threonine kinase activity GO:0071900 179 0.030
nucleoside triphosphate catabolic process GO:0009143 394 0.029
positive regulation of organelle organization GO:0010638 195 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
guanosine containing compound catabolic process GO:1901069 239 0.028
protein localization to nucleus GO:0034504 136 0.027
nitrogen compound transport GO:0071705 191 0.027
generation of neurons GO:0048699 152 0.027
membrane organization GO:0061024 292 0.027
negative regulation of cellular component organization GO:0051129 235 0.026
protein import GO:0017038 130 0.026
positive regulation of alcohol biosynthetic process GO:1902932 9 0.026
behavior GO:0007610 112 0.025
developmental process involved in reproduction GO:0003006 66 0.025
protein polyubiquitination GO:0000209 110 0.025
reproduction GO:0000003 63 0.024
neurogenesis GO:0022008 169 0.024
regulation of intracellular protein transport GO:0033157 123 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
microtubule based process GO:0007017 210 0.023
blastoderm segmentation GO:0007350 2 0.023
regulation of establishment of protein localization GO:0070201 242 0.023
gonad development GO:0008406 34 0.023
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.023
small molecule biosynthetic process GO:0044283 157 0.022
mitotic cytokinesis GO:0000281 19 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
lipid metabolic process GO:0006629 381 0.022
purine ribonucleoside catabolic process GO:0046130 398 0.021
negative regulation of cellular catabolic process GO:0031330 83 0.021
cellular component morphogenesis GO:0032989 314 0.021
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.020
negative regulation of phosphate metabolic process GO:0045936 267 0.020
mitotic nuclear division GO:0007067 119 0.020
regulation of locomotion GO:0040012 329 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
nucleus localization GO:0051647 1 0.020
regulation of protein transport GO:0051223 213 0.019
multicellular organismal reproductive process GO:0048609 40 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
cellular lipid metabolic process GO:0044255 303 0.019
establishment of protein localization to organelle GO:0072594 172 0.019
taxis GO:0042330 157 0.019
single organism reproductive process GO:0044702 98 0.019
stress activated protein kinase signaling cascade GO:0031098 94 0.018
tripartite regional subdivision GO:0007351 2 0.018
cell cell signaling GO:0007267 155 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
peptidyl lysine modification GO:0018205 144 0.018
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
organophosphate catabolic process GO:0046434 430 0.018
cell part morphogenesis GO:0032990 137 0.018
purine containing compound catabolic process GO:0072523 411 0.018
positive regulation of proteolysis GO:0045862 142 0.017
defense response to other organism GO:0098542 129 0.017
protein import into nucleus GO:0006606 104 0.017
secretion by cell GO:0032940 226 0.017
internal protein amino acid acetylation GO:0006475 101 0.017
regulation of apoptotic signaling pathway GO:2001233 175 0.017
positive regulation of cellular protein catabolic process GO:1903364 37 0.017
reproductive system development GO:0061458 56 0.017
alcohol metabolic process GO:0006066 114 0.017
regulation of meiotic cell cycle GO:0051445 4 0.016
positive regulation of meiotic cell cycle GO:0051446 2 0.016
nuclear import GO:0051170 106 0.016
establishment of protein localization to membrane GO:0090150 121 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
rna interference GO:0016246 4 0.016
chemotaxis GO:0006935 157 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
positive regulation of cell cycle process GO:0090068 106 0.016
response to oxidative stress GO:0006979 121 0.015
chordate embryonic development GO:0043009 34 0.015
cytoskeleton dependent cytokinesis GO:0061640 22 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
meiotic chromosome segregation GO:0045132 4 0.015
locomotory behavior GO:0007626 1 0.015
regulation of cellular response to stress GO:0080135 244 0.015
purine nucleoside triphosphate catabolic process GO:0009146 392 0.015
positive regulation of steroid metabolic process GO:0045940 13 0.015
mitochondrial transport GO:0006839 60 0.015
response to other organism GO:0051707 261 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
protein dna complex subunit organization GO:0071824 80 0.015
regulation of transferase activity GO:0051338 355 0.015
multi organism reproductive process GO:0044703 54 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
organelle assembly GO:0070925 176 0.014
atp metabolic process GO:0046034 176 0.014
response to external biotic stimulus GO:0043207 261 0.014
cell morphogenesis GO:0000902 296 0.014
receptor mediated endocytosis GO:0006898 84 0.014
transmembrane transport GO:0055085 399 0.014
response to virus GO:0009615 126 0.014
protein import into mitochondrial matrix GO:0030150 1 0.013
amine metabolic process GO:0009308 44 0.013
regulation of intracellular transport GO:0032386 195 0.013
positive regulation of transferase activity GO:0051347 227 0.013
response to lipid GO:0033993 206 0.013
gtp metabolic process GO:0046039 239 0.013
toxin transport GO:1901998 4 0.013
regulation of sister chromatid segregation GO:0033045 27 0.013
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
endomembrane system organization GO:0010256 196 0.012
neuron development GO:0048666 113 0.012
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.012
establishment of organelle localization GO:0051656 59 0.012
cellular ketone metabolic process GO:0042180 80 0.012
protein ubiquitination GO:0016567 314 0.012
stress activated mapk cascade GO:0051403 93 0.012
monocarboxylic acid biosynthetic process GO:0072330 67 0.012
regulation of alcohol biosynthetic process GO:1902930 22 0.012
spermatid differentiation GO:0048515 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
cell projection morphogenesis GO:0048858 129 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
glycosyl compound catabolic process GO:1901658 413 0.011
single organism nuclear import GO:1902593 104 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.011
regulation of cytokine production GO:0001817 232 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
negative regulation of catalytic activity GO:0043086 335 0.010
multicellular organism reproduction GO:0032504 42 0.010
response to cytokine GO:0034097 232 0.010
signal transduction by phosphorylation GO:0023014 297 0.010
negative regulation of cell proliferation GO:0008285 228 0.010

COPS8 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.033
nervous system disease DOID:863 431 0.033
central nervous system disease DOID:331 186 0.020
brain disease DOID:936 73 0.020
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012