Homo sapiens

39 known processes

CXCR4

chemokine (C-X-C motif) receptor 4

(Aliases: LCR1,NPYY3R,WHIM,HM89,LAP3,NPYRL,FB22,D2S201E,NPYR,NPY3R,LESTR,HSY3RR,CD184)

CXCR4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
dendritic cell antigen processing and presentation GO:0002468 1 0.995
positive regulation of neutrophil chemotaxis GO:0090023 7 0.783
Human
regulation of leukocyte chemotaxis GO:0002688 46 0.614
Human Zebrafish
granulocyte chemotaxis GO:0071621 37 0.591
Human Zebrafish
granulocyte migration GO:0097530 40 0.577
Human Zebrafish
positive regulation of cytokine production GO:0001819 167 0.573
regulation of cellular ketone metabolic process GO:0010565 50 0.563
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.529
regulation of locomotion GO:0040012 329 0.503
regulation of cellular component movement GO:0051270 334 0.502
Human Zebrafish Mouse
positive regulation of mapk cascade GO:0043410 190 0.500
Human
positive regulation of astrocyte chemotaxis GO:2000464 1 0.497
Human
negative regulation of programmed cell death GO:0043069 321 0.472
Human
chemokine c c motif ligand 19 signaling pathway GO:0038115 1 0.467
Human
regulation of chemotaxis GO:0050920 74 0.457
positive regulation of cellular amine metabolic process GO:0033240 7 0.456
t cell differentiation in thymus GO:0033077 4 0.442
amine metabolic process GO:0009308 44 0.437
leukocyte activation GO:0045321 164 0.437
Human Mouse
positive regulation of cell differentiation GO:0045597 211 0.433
Human Mouse
positive regulation of neutrophil migration GO:1902624 7 0.431
Human
positive regulation of myeloid leukocyte cytokine production involved in immune response GO:0061081 1 0.429
cellular amine metabolic process GO:0044106 41 0.427
taxis GO:0042330 157 0.427
cellular amino acid metabolic process GO:0006520 116 0.417
regulation of cellular amino acid metabolic process GO:0006521 6 0.416
positive regulation of behavior GO:0048520 60 0.415
Human Zebrafish
regulation of leukocyte migration GO:0002685 63 0.400
Human Zebrafish
leukocyte apoptotic process GO:0071887 31 0.377
cytokine production GO:0001816 247 0.366
Human
b cell homeostasis GO:0001782 1 0.366
neutrophil chemotaxis GO:0030593 24 0.365
Human Zebrafish
positive regulation of immune system process GO:0002684 283 0.364
Human
peptidyl tyrosine phosphorylation GO:0018108 170 0.361
leukocyte differentiation GO:0002521 98 0.361
Human
regulation of cell differentiation GO:0045595 393 0.355
Human Zebrafish Mouse
astrocyte chemotaxis GO:0035700 1 0.353
Human
cellular ketone metabolic process GO:0042180 80 0.353
leukocyte chemotaxis GO:0030595 76 0.349
Human Zebrafish
leukocyte migration GO:0050900 107 0.345
Human Zebrafish
regulation of granulocyte chemotaxis GO:0071622 16 0.343
Human Zebrafish
cell type specific apoptotic process GO:0097285 125 0.335
positive regulation of developmental process GO:0051094 314 0.326
Human Mouse
cell activation GO:0001775 213 0.320
Human Mouse
positive regulation of granulocyte chemotaxis GO:0071624 9 0.317
Human
cell chemotaxis GO:0060326 112 0.316
Human Zebrafish
regulation of mapk cascade GO:0043408 262 0.311
Human
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.308
Human
positive regulation of phosphorylation GO:0042327 394 0.299
Human
hematopoietic or lymphoid organ development GO:0048534 186 0.289
Human
immune system development GO:0002520 195 0.286
Human
cell development GO:0048468 328 0.278
Zebrafish Mouse Rat
lymphocyte homeostasis GO:0002260 4 0.274
regulation of cellular amine metabolic process GO:0033238 11 0.267
regulation of cytokine production GO:0001817 232 0.265
positive regulation of leukocyte chemotaxis GO:0002690 38 0.246
Human
positive regulation of leukocyte differentiation GO:1902107 37 0.241
Human
positive regulation of cell proliferation GO:0008284 301 0.241
Human
monocarboxylic acid metabolic process GO:0032787 185 0.232
signal transduction by phosphorylation GO:0023014 297 0.224
Human
negative regulation of leukocyte apoptotic process GO:2000107 16 0.216
hemopoiesis GO:0030097 180 0.215
Human
peptidyl tyrosine modification GO:0018212 170 0.213
positive regulation of cellular component movement GO:0051272 181 0.209
Human
positive regulation of protein phosphorylation GO:0001934 313 0.208
negative regulation of immune system process GO:0002683 136 0.206
Zebrafish
response to cytokine GO:0034097 232 0.204
negative regulation of cell proliferation GO:0008285 228 0.200
Human
biological adhesion GO:0022610 331 0.194
g protein coupled receptor signaling pathway GO:0007186 207 0.193
negative regulation of cell differentiation GO:0045596 171 0.191
regulation of protein kinase activity GO:0045859 289 0.187
regulation of kinase activity GO:0043549 314 0.185
positive regulation of leukocyte proliferation GO:0070665 48 0.179
behavior GO:0007610 112 0.178
regulation of defense response GO:0031347 154 0.176
regulation of leukocyte apoptotic process GO:2000106 25 0.172
regulation of cell migration GO:0030334 289 0.167
Human Zebrafish Mouse
cytokine mediated signaling pathway GO:0019221 109 0.167
Human Rat
defense response GO:0006952 315 0.165
Human
positive regulation of kinase activity GO:0033674 204 0.164
positive regulation of cell motility GO:2000147 177 0.163
Human
regulation of leukocyte differentiation GO:1902105 61 0.163
Human
erk1 and erk2 cascade GO:0070371 104 0.161
Human
nervous system development GO:0007399 293 0.158
Zebrafish Mouse Rat
lymphocyte apoptotic process GO:0070227 20 0.156
unsaturated fatty acid biosynthetic process GO:0006636 21 0.155
regulation of dendritic cell antigen processing and presentation GO:0002604 1 0.154
neutrophil migration GO:1990266 25 0.150
Human Zebrafish
regulation of cell cycle GO:0051726 393 0.149
Human
positive regulation of transferase activity GO:0051347 227 0.147
immune response GO:0006955 307 0.147
Human
response to abiotic stimulus GO:0009628 336 0.147
regulation of protein serine threonine kinase activity GO:0071900 179 0.147
regulation of peptidase activity GO:0052547 180 0.145
negative regulation of cell death GO:0060548 345 0.143
Human
negative regulation of homeostatic process GO:0032845 59 0.141
Human
regulation of immune response GO:0050776 201 0.140
lymphocyte activation GO:0046649 133 0.135
Mouse
intrinsic apoptotic signaling pathway GO:0097193 127 0.134
cell projection organization GO:0030030 252 0.133
Zebrafish Mouse
neuron projection development GO:0031175 106 0.133
Zebrafish Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.131
fatty acid metabolic process GO:0006631 115 0.131
cellular lipid metabolic process GO:0044255 303 0.128
regulation of erk1 and erk2 cascade GO:0070372 99 0.128
Human
activation of protein kinase activity GO:0032147 90 0.128
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.128
t cell selection GO:0045058 4 0.126
cellular response to cytokine stimulus GO:0071345 181 0.126
carboxylic acid biosynthetic process GO:0046394 97 0.124
t cell activation GO:0042110 99 0.124
Mouse
regulation of transferase activity GO:0051338 355 0.122
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.122
chemokine production GO:0032602 32 0.121
Human
lymphocyte proliferation GO:0046651 70 0.120
Mouse
regulation of behavior GO:0050795 82 0.120
positive regulation of leukocyte migration GO:0002687 46 0.118
Human
negative regulation of cell adhesion GO:0007162 64 0.117
negative regulation of protein metabolic process GO:0051248 391 0.117
negative regulation of peptidase activity GO:0010466 91 0.114
positive thymic t cell selection GO:0045059 1 0.114
negative regulation of developmental process GO:0051093 247 0.113
Human
negative regulation of catalytic activity GO:0043086 335 0.112
response to hyperoxia GO:0055093 4 0.109
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.108
positive regulation of protein kinase activity GO:0045860 190 0.108
immune effector process GO:0002252 159 0.107
monocarboxylic acid biosynthetic process GO:0072330 67 0.107
regulation of apoptotic signaling pathway GO:2001233 175 0.104
activation of mapk activity GO:0000187 45 0.103
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.103
thymic t cell selection GO:0045061 2 0.102
generation of neurons GO:0048699 152 0.101
Zebrafish Mouse Rat
fatty acid biosynthetic process GO:0006633 46 0.101
negative regulation of apoptotic process GO:0043066 316 0.101
Human
purine ribonucleoside metabolic process GO:0046128 437 0.098
lymphocyte differentiation GO:0030098 35 0.097
small molecule biosynthetic process GO:0044283 157 0.097
response to hypoxia GO:0001666 96 0.097
lipid biosynthetic process GO:0008610 177 0.096
regulation of anatomical structure morphogenesis GO:0022603 286 0.096
Human Zebrafish
cellular response to dna damage stimulus GO:0006974 379 0.096
regulation of cell motility GO:2000145 299 0.095
Human Zebrafish Mouse
fatty acid derivative metabolic process GO:1901568 35 0.094
unsaturated fatty acid metabolic process GO:0033559 37 0.094
positive regulation of t cell differentiation GO:0045582 11 0.093
regulation of lymphocyte apoptotic process GO:0070228 15 0.093
fatty acid derivative biosynthetic process GO:1901570 18 0.092
organic acid biosynthetic process GO:0016053 97 0.091
blood vessel development GO:0001568 172 0.090
Human Zebrafish Mouse
protein processing GO:0016485 226 0.088
system process GO:0003008 349 0.086
Rat
actin filament based process GO:0030029 224 0.086
Zebrafish
myeloid leukocyte migration GO:0097529 62 0.086
Human Zebrafish
positive regulation of acute inflammatory response GO:0002675 2 0.085
negative regulation of endopeptidase activity GO:0010951 84 0.084
prostanoid metabolic process GO:0006692 17 0.084
regulation of protein maturation GO:1903317 150 0.084
positive regulation of antigen processing and presentation GO:0002579 1 0.083
negative regulation of myeloid cell apoptotic process GO:0033033 4 0.081
negative regulation of protein processing GO:0010955 142 0.081
regulation of cell cycle process GO:0010564 266 0.080
Human
secretion GO:0046903 254 0.080
Human
regulation of response to external stimulus GO:0032101 222 0.080
negative regulation of transport GO:0051051 176 0.079
negative regulation of proteolysis GO:0045861 132 0.078
negative regulation of apoptotic signaling pathway GO:2001234 97 0.078
nucleotide catabolic process GO:0009166 408 0.078
regulation of protein processing GO:0070613 150 0.078
nucleoside phosphate catabolic process GO:1901292 412 0.077
ribonucleoside triphosphate metabolic process GO:0009199 412 0.077
negative regulation of hydrolase activity GO:0051346 182 0.076
response to increased oxygen levels GO:0036296 4 0.075
signal transduction in response to dna damage GO:0042770 57 0.075
protein maturation GO:0051604 233 0.074
negative regulation of cell substrate adhesion GO:0010812 24 0.073
regulation of cell projection organization GO:0031344 107 0.072
Zebrafish
purine containing compound catabolic process GO:0072523 411 0.072
cyclic nucleotide metabolic process GO:0009187 82 0.072
Human
negative regulation of multicellular organismal process GO:0051241 317 0.071
Human
intracellular protein transport GO:0006886 270 0.071
purine nucleoside catabolic process GO:0006152 398 0.070
nitrogen compound transport GO:0071705 191 0.070
cellular macromolecule catabolic process GO:0044265 380 0.069
regulation of cellular response to stress GO:0080135 244 0.069
organophosphate catabolic process GO:0046434 430 0.069
de novo protein folding GO:0006458 2 0.068
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.067
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.067
glycosyl compound catabolic process GO:1901658 413 0.067
ribonucleoside triphosphate catabolic process GO:0009203 391 0.066
apoptotic signaling pathway GO:0097190 268 0.066
positive regulation of lymphocyte differentiation GO:0045621 13 0.065
nucleoside catabolic process GO:0009164 408 0.065
positive regulation of immune response GO:0050778 159 0.065
negative regulation of intracellular signal transduction GO:1902532 183 0.065
lipid metabolic process GO:0006629 381 0.065
t cell differentiation GO:0030217 29 0.064
regulation of proteolysis GO:0030162 293 0.064
cellular response to oxygen containing compound GO:1901701 276 0.064
Human
inflammatory response to antigenic stimulus GO:0002437 4 0.063
cellular protein complex assembly GO:0043623 188 0.063
anatomical structure formation involved in morphogenesis GO:0048646 284 0.062
Human Zebrafish Mouse
response to oxygen containing compound GO:1901700 369 0.061
Human Zebrafish
fibroblast proliferation GO:0048144 33 0.061
regulation of neuron projection development GO:0010975 57 0.061
Zebrafish
icosanoid metabolic process GO:0006690 35 0.060
response to oxygen levels GO:0070482 100 0.060
negative regulation of protein maturation GO:1903318 142 0.060
inflammatory cell apoptotic process GO:0006925 3 0.060
positive regulation of lymphocyte proliferation GO:0050671 46 0.060
regulation of secretion GO:0051046 194 0.060
ribonucleotide catabolic process GO:0009261 405 0.059
purine nucleoside triphosphate catabolic process GO:0009146 392 0.059
cellular defense response GO:0006968 2 0.059
Human
ion homeostasis GO:0050801 230 0.059
Human
cell substrate adhesion GO:0031589 132 0.058
ras protein signal transduction GO:0007265 73 0.058
negative regulation of cellular component organization GO:0051129 235 0.057
purine nucleotide catabolic process GO:0006195 405 0.057
neurological system process GO:0050877 163 0.057
receptor metabolic process GO:0043112 81 0.057
Human
regulation of cell activation GO:0050865 125 0.056
neuron differentiation GO:0030182 138 0.056
Zebrafish Mouse Rat
growth GO:0040007 202 0.056
Zebrafish
rho protein signal transduction GO:0007266 26 0.055
regulation of cell adhesion GO:0030155 166 0.055
positive regulation of t cell activation GO:0050870 54 0.055
post embryonic development GO:0009791 2 0.054
regulation of response to dna damage stimulus GO:2001020 94 0.054
cell morphogenesis GO:0000902 296 0.054
Zebrafish Mouse
regulation of cell substrate adhesion GO:0010810 68 0.053
regulation of peptide transport GO:0090087 62 0.053
positive regulation of fibroblast proliferation GO:0048146 21 0.052
cation transport GO:0006812 331 0.052
Human Rat
mononuclear cell proliferation GO:0032943 71 0.052
Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.052
positive regulation of locomotion GO:0040017 186 0.051
Human Zebrafish
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.051
nucleoside triphosphate metabolic process GO:0009141 422 0.051
cytokine production involved in immune response GO:0002367 27 0.050
nucleoside triphosphate catabolic process GO:0009143 394 0.050
regulation of endopeptidase activity GO:0052548 170 0.050
purine ribonucleotide catabolic process GO:0009154 404 0.050
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.050
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.049
small gtpase mediated signal transduction GO:0007264 78 0.049
regulation of homeostatic process GO:0032844 121 0.048
Human
negative regulation of b cell apoptotic process GO:0002903 4 0.048
negative regulation of secretion GO:0051048 58 0.048
actin filament based movement GO:0030048 17 0.047
regulation of signal transduction by p53 class mediator GO:1901796 26 0.047
de novo posttranslational protein folding GO:0051084 2 0.047
response to oxidative stress GO:0006979 121 0.047
chemokine c x c motif ligand 2 production GO:0072567 3 0.047
cellular response to endogenous stimulus GO:0071495 336 0.046
icosanoid biosynthetic process GO:0046456 18 0.046
immune response regulating signaling pathway GO:0002764 97 0.046
response to inorganic substance GO:0010035 127 0.046
ribonucleoside catabolic process GO:0042454 406 0.045
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.045
cardiovascular system development GO:0072358 262 0.045
Human Zebrafish Mouse
response to organonitrogen compound GO:0010243 156 0.044
transmembrane transport GO:0055085 399 0.044
positive regulation of cellular catabolic process GO:0031331 284 0.044
purine nucleoside triphosphate metabolic process GO:0009144 412 0.044
response to other organism GO:0051707 261 0.044
Human Zebrafish
receptor internalization GO:0031623 43 0.043
Human
positive regulation of catabolic process GO:0009896 310 0.043
cellular macromolecular complex assembly GO:0034622 324 0.043
positive regulation of immune effector process GO:0002699 40 0.042
regulation of cytokine mediated signaling pathway GO:0001959 41 0.041
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.041
myeloid dendritic cell chemotaxis GO:0002408 3 0.041
Human
negative regulation of neurogenesis GO:0050768 26 0.040
response to molecule of bacterial origin GO:0002237 82 0.040
Human Zebrafish
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.040
angiogenesis GO:0001525 147 0.040
Human Zebrafish Mouse
positive regulation of cell activation GO:0050867 81 0.039
actin cytoskeleton organization GO:0030036 207 0.039
Zebrafish
vesicle mediated transport GO:0016192 371 0.038
Human
mapk cascade GO:0000165 288 0.038
Human
regeneration GO:0031099 4 0.038
Zebrafish
female gamete generation GO:0007292 2 0.038
regulation of cell division GO:0051302 116 0.037
Human
secretion by cell GO:0032940 226 0.037
Human
cell adhesion GO:0007155 325 0.037
positive regulation of lymphocyte activation GO:0051251 73 0.037
positive regulation of response to external stimulus GO:0032103 88 0.037
Human Zebrafish
negative regulation of biomineral tissue development GO:0070168 8 0.037
Human
b cell proliferation GO:0042100 22 0.037
regulation of nucleoside metabolic process GO:0009118 209 0.036
b cell activation GO:0042113 33 0.036
purine ribonucleoside catabolic process GO:0046130 398 0.036
regulation of nucleotide metabolic process GO:0006140 269 0.036
Human
positive regulation of t cell proliferation GO:0042102 33 0.036
positive regulation of hydrolase activity GO:0051345 331 0.035
divalent inorganic cation homeostasis GO:0072507 136 0.035
Human
regulation of b cell activation GO:0050864 24 0.035
vasculature development GO:0001944 181 0.035
Human Zebrafish Mouse
positive regulation of cell migration GO:0030335 172 0.035
Human
positive regulation of defense response GO:0031349 87 0.034
positive regulation of cellular component organization GO:0051130 376 0.034
oogenesis GO:0048477 2 0.034
regulation of ion transport GO:0043269 189 0.034
Human Rat
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.034
regulation of chemokine c x c motif ligand 2 production GO:2000341 2 0.034
regulation of t cell differentiation GO:0045580 19 0.034
epithelium migration GO:0090132 119 0.034
Zebrafish
peptide transport GO:0015833 74 0.034
regulation of neuron differentiation GO:0045664 70 0.034
Zebrafish
negative regulation of cell development GO:0010721 48 0.034
positive regulation of gtp catabolic process GO:0033126 166 0.033
positive regulation of interferon gamma production GO:0032729 26 0.033
positive regulation of transport GO:0051050 336 0.032
Human
guanosine containing compound catabolic process GO:1901069 239 0.032
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.032
epithelial cell differentiation GO:0030855 141 0.032
Rat
response to bacterium GO:0009617 144 0.032
Human Zebrafish
blood vessel remodeling GO:0001974 2 0.032
epithelium development GO:0060429 227 0.032
Mouse Rat
positive regulation of map kinase activity GO:0043406 80 0.032
regulation of bone mineralization GO:0030500 29 0.031
Human
regulation of cell development GO:0060284 161 0.031
Zebrafish Mouse
cellular homeostasis GO:0019725 196 0.031
Human
eosinophil activation involved in immune response GO:0002278 2 0.031
maintenance of location GO:0051235 112 0.030
Human
cytokinesis GO:0000910 96 0.030
Human
regulation of gtp catabolic process GO:0033124 180 0.030
innate immune response GO:0045087 178 0.030
response to organic cyclic compound GO:0014070 204 0.030
Human
cell growth GO:0016049 160 0.030
Zebrafish
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.029
regulation of macrophage cytokine production GO:0010935 4 0.029
gtp metabolic process GO:0046039 239 0.029
myeloid leukocyte activation GO:0002274 34 0.029
Human
cellular response to lipid GO:0071396 127 0.029
Human
regulation of leukocyte activation GO:0002694 115 0.028
response to metal ion GO:0010038 84 0.028
multicellular organismal aging GO:0010259 3 0.028
regulation of gtpase activity GO:0043087 180 0.028
negative regulation of phosphorus metabolic process GO:0010563 267 0.028
regulation of mononuclear cell proliferation GO:0032944 65 0.028
positive regulation of camp metabolic process GO:0030816 41 0.028
Human
cation homeostasis GO:0055080 189 0.028
Human
guanosine containing compound metabolic process GO:1901068 244 0.028
epithelial cell proliferation GO:0050673 128 0.028
Human
actin mediated cell contraction GO:0070252 12 0.028
regulation of purine nucleotide metabolic process GO:1900542 264 0.028
Human
regulation of nucleotide catabolic process GO:0030811 205 0.027
camp mediated signaling GO:0019933 23 0.027
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.027
negative regulation of response to dna damage stimulus GO:2001021 33 0.027
cellular response to ammonium ion GO:0071242 4 0.027
cellular extravasation GO:0045123 21 0.027
macrophage cytokine production GO:0010934 4 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.027
blood vessel morphogenesis GO:0048514 162 0.027
Human Zebrafish Mouse
activation of immune response GO:0002253 114 0.026
divalent metal ion transport GO:0070838 152 0.026
Human Rat
regulation of epithelial cell proliferation GO:0050678 113 0.026
Human
negative regulation of neuron differentiation GO:0045665 21 0.026
response to biotic stimulus GO:0009607 276 0.026
Human Zebrafish
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.026
Human
regulation of cytokine production involved in immune response GO:0002718 22 0.026
lymphocyte mediated immunity GO:0002449 48 0.026
positive regulation of cell division GO:0051781 59 0.026
Human
gtp catabolic process GO:0006184 237 0.026
signal transduction by p53 class mediator GO:0072331 72 0.026
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.026
regulation of fibroblast proliferation GO:0048145 32 0.026
positive regulation of nucleotide catabolic process GO:0030813 185 0.026
regulation of camp mediated signaling GO:0043949 13 0.026
Human
regulation of b cell proliferation GO:0030888 18 0.026
neurogenesis GO:0022008 169 0.025
Zebrafish Mouse Rat
chemokine c c motif ligand 11 production GO:0071954 1 0.025
Human
positive regulation of b cell activation GO:0050871 17 0.025
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.025
Human
mitotic cell cycle GO:0000278 326 0.025
protein ubiquitination GO:0016567 314 0.025
cellular protein catabolic process GO:0044257 261 0.025
chemotaxis GO:0006935 157 0.025
protein folding GO:0006457 38 0.025
protein catabolic process GO:0030163 325 0.025
immune response activating signal transduction GO:0002757 90 0.025
nuclear import GO:0051170 106 0.025
positive t cell selection GO:0043368 2 0.024
calcium ion homeostasis GO:0055074 122 0.024
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.024
locomotory behavior GO:0007626 1 0.024
regulation of neutrophil migration GO:1902622 10 0.024
Human Zebrafish
posttranscriptional regulation of gene expression GO:0010608 213 0.024
regulation of purine nucleotide catabolic process GO:0033121 205 0.024
negative regulation of phosphorylation GO:0042326 174 0.024
determination of adult lifespan GO:0008340 2 0.024
execution phase of apoptosis GO:0097194 32 0.024
Human
cytoplasmic transport GO:0016482 379 0.024
Human
response to nitrogen compound GO:1901698 184 0.023
regulation of map kinase activity GO:0043405 108 0.023
negative regulation of neuron projection development GO:0010977 15 0.023
positive regulation of protein transport GO:0051222 135 0.023
adaptive immune response GO:0002250 49 0.023
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.023
regulation of t cell activation GO:0050863 77 0.023
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.023
positive regulation of cell death GO:0010942 263 0.023
Human
regulation of actin filament based process GO:0032970 141 0.023
cellular response to oxidative stress GO:0034599 85 0.023
negative regulation of blood vessel morphogenesis GO:2000181 41 0.023
Human
cell morphogenesis involved in differentiation GO:0000904 144 0.023
Zebrafish Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.023
Human
receptor mediated endocytosis GO:0006898 84 0.023
Human
memory GO:0007613 3 0.023
second messenger mediated signaling GO:0019932 78 0.023
regulation of ossification GO:0030278 58 0.023
Human
endocytosis GO:0006897 159 0.022
Human
b cell apoptotic process GO:0001783 6 0.022
regulation of neurogenesis GO:0050767 82 0.022
Zebrafish Mouse
segmentation GO:0035282 4 0.022
myeloid cell differentiation GO:0030099 117 0.022
Human
eosinophil degranulation GO:0043308 2 0.022
negative regulation of cell activation GO:0050866 33 0.022
sequestering of metal ion GO:0051238 24 0.022
Human
positive regulation of b cell proliferation GO:0030890 12 0.022
ameboidal type cell migration GO:0001667 135 0.022
Zebrafish Mouse
regulation of vasculature development GO:1901342 97 0.022
Human
positive regulation of gtpase activity GO:0043547 166 0.022
tumor necrosis factor production GO:0032640 43 0.022
positive regulation of programmed cell death GO:0043068 249 0.021
Human
azole transport GO:0045117 4 0.021
carbohydrate derivative biosynthetic process GO:1901137 207 0.021
positive regulation of nucleoside metabolic process GO:0045979 186 0.021
regulation of calcium ion transport GO:0051924 79 0.021
Human Rat
regulation of b cell apoptotic process GO:0002902 5 0.021
regulation of lymphocyte activation GO:0051249 103 0.021
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.021
Human
regulation of ion transmembrane transport GO:0034765 132 0.020
chemical homeostasis GO:0048878 306 0.020
Human
regulation of immune effector process GO:0002697 91 0.020
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.020
tissue migration GO:0090130 119 0.020
Zebrafish
reactive oxygen species metabolic process GO:0072593 75 0.020
cytosolic calcium ion homeostasis GO:0051480 89 0.020
Human
peptide secretion GO:0002790 51 0.020
leukocyte proliferation GO:0070661 74 0.020
Mouse
regulation of ras gtpase activity GO:0032318 128 0.020
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.020
regulation of lymphocyte differentiation GO:0045619 22 0.020
positive regulation of nucleotide metabolic process GO:0045981 230 0.020
Human
sensory perception GO:0007600 103 0.020
microtubule based process GO:0007017 210 0.020
cellular cation homeostasis GO:0030003 163 0.020
Human
modification dependent protein catabolic process GO:0019941 209 0.020
response to salt stress GO:0009651 3 0.020
negative regulation of protein modification process GO:0031400 200 0.020
cytosolic calcium ion transport GO:0060401 48 0.020
Human
ion transmembrane transport GO:0034220 338 0.019
cyclic nucleotide mediated signaling GO:0019935 26 0.019
Human
syncytium formation by plasma membrane fusion GO:0000768 2 0.019
positive regulation of leukocyte activation GO:0002696 80 0.019
cardiac muscle cell contraction GO:0086003 4 0.019
mitotic cell cycle process GO:1903047 286 0.019
modification dependent macromolecule catabolic process GO:0043632 212 0.019
leukocyte mediated immunity GO:0002443 59 0.019
cellular response to organonitrogen compound GO:0071417 124 0.019
positive regulation of type 2 immune response GO:0002830 2 0.019
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.019
cellular metal ion homeostasis GO:0006875 146 0.019
Human
regulation of establishment of protein localization GO:0070201 242 0.019
rhythmic behavior GO:0007622 2 0.019
regulation of tumor necrosis factor production GO:0032680 43 0.019
negative regulation of protein phosphorylation GO:0001933 140 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
regulation of antigen processing and presentation of peptide antigen via mhc class ii GO:0002586 3 0.018
regulation of monocyte chemotaxis GO:0090025 11 0.018
Human
negative regulation of vasculature development GO:1901343 43 0.018
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.018
leukocyte homeostasis GO:0001776 7 0.018
humoral immune response GO:0006959 49 0.018
neuromuscular junction development GO:0007528 3 0.018
positive regulation of cytokinesis GO:0032467 29 0.018
Human
regulation of actin cytoskeleton organization GO:0032956 116 0.018
single organism nuclear import GO:1902593 104 0.018
response to decreased oxygen levels GO:0036293 96 0.018
epithelial cell migration GO:0010631 119 0.018
Zebrafish
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 4 0.018
regulation of cell growth GO:0001558 135 0.018
Zebrafish
actin filament organization GO:0007015 128 0.018

CXCR4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease by infectious agent DOID:0050117 34 0.031
Human
immune system disease DOID:2914 155 0.020
hypersensitivity reaction disease DOID:0060056 25 0.020
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
organ system cancer DOID:0050686 164 0.019