Homo sapiens

122 known processes

HNF4A

hepatocyte nuclear factor 4, alpha

(Aliases: HNF4a9,HNF4a8,FLJ39654,HNF4a7,HNF4alpha,TCF14,MODY1,MODY,TCF,NR2A1,HNF4,NR2A21)

HNF4A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of bile acid biosynthetic process GO:0070858 3 1.000
bile acid metabolic process GO:0008206 14 1.000
steroid metabolic process GO:0008202 94 1.000
drug catabolic process GO:0042737 10 1.000
intracellular bile acid receptor signaling pathway GO:0038185 1 0.999
monocarboxylic acid metabolic process GO:0032787 185 0.999
Rat Worm
steroid biosynthetic process GO:0006694 46 0.999
lipid biosynthetic process GO:0008610 177 0.999
Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.999
Human
cholesterol homeostasis GO:0042632 28 0.999
Mouse
organic acid biosynthetic process GO:0016053 97 0.998
Rat
organic hydroxy compound metabolic process GO:1901615 147 0.998
cellular ketone metabolic process GO:0042180 80 0.998
Rat Worm
organic hydroxy compound biosynthetic process GO:1901617 71 0.997
monocarboxylic acid biosynthetic process GO:0072330 67 0.997
Rat
lipid metabolic process GO:0006629 381 0.996
regulation of hormone levels GO:0010817 125 0.996
Mouse
chemical homeostasis GO:0048878 306 0.993
peptide secretion GO:0002790 51 0.988
Mouse
regulation of lipid biosynthetic process GO:0046890 47 0.988
Rat
bile acid biosynthetic process GO:0006699 10 0.985
endocrine system development GO:0035270 26 0.980
atrial cardiac muscle tissue morphogenesis GO:0055009 1 0.979
regulation of cellular ketone metabolic process GO:0010565 50 0.976
Rat Worm
response to low density lipoprotein particle GO:0055098 4 0.976
peptide transport GO:0015833 74 0.974
Mouse
lipid transport GO:0006869 90 0.972
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.971
Rat
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.970
Rat
embryonic camera type eye development GO:0031076 2 0.963
pancreas development GO:0031016 19 0.963
small molecule biosynthetic process GO:0044283 157 0.961
Rat
cellular lipid metabolic process GO:0044255 303 0.957
Rat Worm Fly
regulation of cholesterol storage GO:0010885 8 0.947
regulation of lipid metabolic process GO:0019216 96 0.946
atrial cardiac muscle tissue development GO:0003228 1 0.946
forebrain generation of neurons GO:0021872 3 0.930
oxidation reduction process GO:0055114 396 0.928
Fly
response to hormone GO:0009725 175 0.923
epithelium development GO:0060429 227 0.922
Human
glandular epithelial cell differentiation GO:0002067 6 0.913
embryonic eye morphogenesis GO:0048048 2 0.911
vitamin d receptor signaling pathway GO:0070561 4 0.909
embryonic camera type eye formation GO:0060900 2 0.889
carboxylic acid biosynthetic process GO:0046394 97 0.880
Rat
amide transport GO:0042886 76 0.875
Mouse
regulation of transcription involved in lymphatic endothelial cell fate commitment GO:0060849 2 0.865
Human
exogenous drug catabolic process GO:0042738 8 0.858
myeloid cell differentiation GO:0030099 117 0.858
single organism carbohydrate metabolic process GO:0044723 193 0.853
Rat
hindbrain development GO:0030902 3 0.848
response to xenobiotic stimulus GO:0009410 30 0.836
endocrine pancreas development GO:0031018 11 0.834
regulation of steroid metabolic process GO:0019218 32 0.826
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.824
glycolytic process GO:0006096 17 0.801
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter GO:0072366 1 0.794
pyruvate metabolic process GO:0006090 26 0.790
system process GO:0003008 349 0.786
carbohydrate metabolic process GO:0005975 207 0.781
Rat
negative regulation of lipid biosynthetic process GO:0051055 22 0.780
regulation of carbohydrate metabolic process GO:0006109 54 0.778
Rat
drug metabolic process GO:0017144 19 0.759
regulation of smooth muscle cell proliferation GO:0048660 28 0.757
response to steroid hormone GO:0048545 80 0.757
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.755
regulation of transcription involved in cell fate commitment GO:0060850 6 0.745
Human
embryonic camera type eye morphogenesis GO:0048596 2 0.735
regulation of secretion GO:0051046 194 0.735
Mouse
regulation of cell differentiation GO:0045595 393 0.728
response to organic cyclic compound GO:0014070 204 0.719
Rat
response to drug GO:0042493 81 0.710
Rat
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.705
positive regulation of cell death GO:0010942 263 0.701
response to thyroid hormone GO:0097066 9 0.697
regulation of cellular component biogenesis GO:0044087 281 0.695
Rat
signal release GO:0023061 70 0.677
Mouse
lymphatic endothelial cell fate commitment GO:0060838 2 0.671
Human
peptide hormone secretion GO:0030072 50 0.663
Mouse
intracellular receptor signaling pathway GO:0030522 104 0.662
Human
positive regulation of oxidoreductase activity GO:0051353 26 0.662
negative regulation of cell differentiation GO:0045596 171 0.661
negative regulation of cholesterol storage GO:0010887 4 0.651
positive regulation of developmental process GO:0051094 314 0.630
muscle tissue development GO:0060537 62 0.622
lipid homeostasis GO:0055088 39 0.621
monosaccharide metabolic process GO:0005996 74 0.618
Rat
regulation of locomotion GO:0040012 329 0.610
Human
response to inorganic substance GO:0010035 127 0.607
regulation of oxidoreductase activity GO:0051341 43 0.606
response to monosaccharide GO:0034284 20 0.597
Mouse Rat
cellular carbohydrate metabolic process GO:0044262 84 0.596
Rat
epithelial cell differentiation GO:0030855 141 0.583
Human
cellular response to oxygen containing compound GO:1901701 276 0.577
regulation of bile acid biosynthetic process GO:0070857 5 0.573
positive regulation of homeostatic process GO:0032846 47 0.573
Mouse
cellular hormone metabolic process GO:0034754 41 0.567
regulation of lipid transport by regulation of transcription from rna polymerase ii promoter GO:0072367 4 0.565
regulation of cell migration GO:0030334 289 0.564
Human
response to estrogen GO:0043627 47 0.558
cardiac chamber development GO:0003205 30 0.558
sterol homeostasis GO:0055092 28 0.555
Mouse
flavonoid metabolic process GO:0009812 8 0.552
epithelial cell fate commitment GO:0072148 3 0.550
Human
myeloid leukocyte differentiation GO:0002573 60 0.550
lipid oxidation GO:0034440 33 0.539
Fly
response to organonitrogen compound GO:0010243 156 0.535
Rat
lens morphogenesis in camera type eye GO:0002089 2 0.524
cardiac atrium development GO:0003230 10 0.523
regulation of steroid biosynthetic process GO:0050810 23 0.522
response to oxygen containing compound GO:1901700 369 0.522
Human Mouse Rat
regulation of growth GO:0040008 165 0.522
response to abiotic stimulus GO:0009628 336 0.516
negative regulation of lipid metabolic process GO:0045833 38 0.516
regulation of lipid transport GO:0032368 44 0.513
maintenance of location GO:0051235 112 0.507
Worm
leukocyte differentiation GO:0002521 98 0.506
cell fate determination GO:0001709 3 0.497
renal system development GO:0072001 63 0.490
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.485
xenobiotic transport GO:0042908 1 0.484
forebrain neuron differentiation GO:0021879 3 0.478
nitrogen compound transport GO:0071705 191 0.472
Mouse
cellular response to prostaglandin stimulus GO:0071379 4 0.471
gland development GO:0048732 48 0.469
positive regulation of cellular component organization GO:0051130 376 0.461
tube development GO:0035295 125 0.459
Mouse
cardiovascular system development GO:0072358 262 0.453
Human
positive regulation of organelle organization GO:0010638 195 0.449
regulation of peptidase activity GO:0052547 180 0.446
regulation of male gonad development GO:2000018 4 0.439
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.435
response to lipid GO:0033993 206 0.433
Human
response to nitrogen compound GO:1901698 184 0.431
Rat
venous blood vessel development GO:0060841 2 0.429
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.426
cellular response to endogenous stimulus GO:0071495 336 0.424
organ morphogenesis GO:0009887 147 0.419
regulation of endopeptidase activity GO:0052548 170 0.415
response to nutrient GO:0007584 20 0.413
trophectodermal cell differentiation GO:0001829 3 0.411
positive regulation of cholesterol storage GO:0010886 4 0.407
organic anion transport GO:0015711 103 0.407
interspecies interaction between organisms GO:0044419 156 0.407
Human
hemopoiesis GO:0030097 180 0.404
lens development in camera type eye GO:0002088 2 0.403
positive regulation of sarcomere organization GO:0060298 2 0.403
viral process GO:0016032 146 0.402
Human
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.390
stem cell development GO:0048864 69 0.388
anion transport GO:0006820 161 0.387
hepaticobiliary system development GO:0061008 10 0.384
regulation of proteolysis GO:0030162 293 0.379
innate immune response GO:0045087 178 0.376
negative regulation of cell proliferation GO:0008285 228 0.375
positive regulation of fatty acid metabolic process GO:0045923 11 0.369
Rat
hormone transport GO:0009914 68 0.368
Mouse
cell development GO:0048468 328 0.367
cellular response to nutrient GO:0031670 12 0.367
regulation of immune response GO:0050776 201 0.363
limbic system development GO:0021761 3 0.363
positive regulation of programmed cell death GO:0043068 249 0.359
endothelial cell fate commitment GO:0060839 3 0.356
Human
regulation of viral process GO:0050792 103 0.356
viral life cycle GO:0019058 132 0.356
rhythmic process GO:0048511 31 0.353
muscle cell proliferation GO:0033002 35 0.350
circulatory system development GO:0072359 262 0.348
Human
generation of precursor metabolites and energy GO:0006091 68 0.344
organophosphate biosynthetic process GO:0090407 163 0.343
positive regulation of neural precursor cell proliferation GO:2000179 2 0.342
ion homeostasis GO:0050801 230 0.335
Mouse
positive regulation of cell proliferation GO:0008284 301 0.333
regulation of heart growth GO:0060420 4 0.332
lipid catabolic process GO:0016042 84 0.322
Fly
fatty acid metabolic process GO:0006631 115 0.319
Rat Worm
pronephros morphogenesis GO:0072114 1 0.318
response to metal ion GO:0010038 84 0.317
cellular response to organonitrogen compound GO:0071417 124 0.315
reproductive system development GO:0061458 56 0.313
metencephalon development GO:0022037 2 0.312
positive regulation of male gonad development GO:2000020 3 0.311
cardiac ventricle development GO:0003231 23 0.309
response to hypoxia GO:0001666 96 0.305
insulin secretion GO:0030073 39 0.303
Mouse
blastocyst formation GO:0001825 3 0.298
single organism carbohydrate catabolic process GO:0044724 33 0.294
response to acid chemical GO:0001101 66 0.294
Human
regulation of cell motility GO:2000145 299 0.291
Human
regulation of homeostatic process GO:0032844 121 0.290
Mouse
smooth muscle cell proliferation GO:0048659 28 0.289
alcohol metabolic process GO:0006066 114 0.287
inner ear morphogenesis GO:0042472 4 0.284
blood vessel development GO:0001568 172 0.284
otic vesicle development GO:0071599 1 0.283
drug transport GO:0015893 8 0.283
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 15 0.283
regulation of cysteine type endopeptidase activity GO:2000116 127 0.282
regulation of glucose metabolic process GO:0010906 28 0.276
Rat
regulation of insulin secretion GO:0050796 33 0.275
Mouse
interferon gamma mediated signaling pathway GO:0060333 7 0.275
cellular response to insulin stimulus GO:0032869 41 0.275
secretion GO:0046903 254 0.274
Mouse
regulation of neural precursor cell proliferation GO:2000177 4 0.274
regulation of cellular carbohydrate catabolic process GO:0043471 11 0.272
blastocyst development GO:0001824 3 0.270
tissue morphogenesis GO:0048729 96 0.268
positive regulation of protein phosphorylation GO:0001934 313 0.264
Rat
vasculature development GO:0001944 181 0.263
Human
regulation of blood pressure GO:0008217 30 0.262
ectodermal placode formation GO:0060788 1 0.261
atp metabolic process GO:0046034 176 0.261
negative regulation of immune system process GO:0002683 136 0.260
single organism reproductive process GO:0044702 98 0.255
negative regulation of developmental process GO:0051093 247 0.255
response to fatty acid GO:0070542 13 0.253
epidermal cell differentiation GO:0009913 45 0.252
placenta development GO:0001890 10 0.248
response to glucose GO:0009749 19 0.248
Mouse Rat
endothelial cell migration GO:0043542 86 0.247
Human
response to extracellular stimulus GO:0009991 85 0.247
sequestering of triglyceride GO:0030730 11 0.246
response to alcohol GO:0097305 64 0.243
regulation of sequestering of triglyceride GO:0010889 8 0.241
hematopoietic or lymphoid organ development GO:0048534 186 0.239
development of primary male sexual characteristics GO:0046546 23 0.237
regulation of circadian rhythm GO:0042752 11 0.236
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.235
morphogenesis of embryonic epithelium GO:0016331 4 0.235
secretion by cell GO:0032940 226 0.234
Mouse
cellular response to thyroid hormone stimulus GO:0097067 9 0.232
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 3 0.227
cerebellum development GO:0021549 2 0.225
cellular component morphogenesis GO:0032989 314 0.224
muscle structure development GO:0061061 98 0.222
regulation of cytoskeleton organization GO:0051493 177 0.219
positive regulation of endopeptidase activity GO:0010950 84 0.216
hepatocyte differentiation GO:0070365 1 0.215
maternal placenta development GO:0001893 5 0.214
negative regulation of apoptotic process GO:0043066 316 0.213
reproductive structure development GO:0048608 55 0.212
ventricular cardiac muscle cell differentiation GO:0055012 1 0.212
purine ribonucleotide biosynthetic process GO:0009152 79 0.211
response to decreased oxygen levels GO:0036293 96 0.207
liver development GO:0001889 9 0.207
cell morphogenesis GO:0000902 296 0.206
carbohydrate derivative biosynthetic process GO:1901137 207 0.205
regulation of viral genome replication GO:0045069 48 0.200
stem cell differentiation GO:0048863 93 0.199
cellular response to organic cyclic compound GO:0071407 127 0.199
cardiac septum morphogenesis GO:0060411 9 0.199
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.198
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.198
Rat
tissue migration GO:0090130 119 0.197
Human
regulation of transporter activity GO:0032409 82 0.196
immune response GO:0006955 307 0.195
glucose homeostasis GO:0042593 31 0.195
Mouse
cardiac chamber morphogenesis GO:0003206 26 0.194
cellular response to nutrient levels GO:0031669 69 0.193
regulation of ion transport GO:0043269 189 0.192
response to oxidative stress GO:0006979 121 0.191
glutamate receptor signaling pathway GO:0007215 23 0.190
positive regulation of phosphorylation GO:0042327 394 0.189
Rat
carbohydrate catabolic process GO:0016052 36 0.186
cellular homeostasis GO:0019725 196 0.185
organonitrogen compound biosynthetic process GO:1901566 200 0.184
cholesterol storage GO:0010878 9 0.183
negative regulation of response to interferon gamma GO:0060331 2 0.182
response to oxygen levels GO:0070482 100 0.182
skeletal muscle thin filament assembly GO:0030240 3 0.180
cellular response to acid chemical GO:0071229 44 0.180
ventricular cardiac muscle tissue development GO:0003229 14 0.178
cardiocyte differentiation GO:0035051 23 0.178
positive regulation of kinase activity GO:0033674 204 0.178
Rat
cellular response to cytokine stimulus GO:0071345 181 0.177
regulation of kidney size GO:0035564 2 0.175
regulation of transmembrane transporter activity GO:0022898 74 0.173
androgen metabolic process GO:0008209 9 0.172
nucleoside phosphate biosynthetic process GO:1901293 109 0.171
positive regulation of hormone secretion GO:0046887 25 0.170
positive regulation of peptidase activity GO:0010952 88 0.168
regulation of cell development GO:0060284 161 0.168
reactive oxygen species metabolic process GO:0072593 75 0.167
ureteric bud elongation GO:0060677 2 0.167
energy derivation by oxidation of organic compounds GO:0015980 43 0.166
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.166
receptor biosynthetic process GO:0032800 18 0.165
hexose metabolic process GO:0019318 55 0.165
Rat
negative regulation of transport GO:0051051 176 0.162
Rat
response to vitamin d GO:0033280 10 0.160
response to nutrient levels GO:0031667 81 0.160
cardiac ventricle morphogenesis GO:0003208 20 0.160
urogenital system development GO:0001655 65 0.160
cellular response to hormone stimulus GO:0032870 125 0.158
positive regulation of transport GO:0051050 336 0.157
positive regulation of cell development GO:0010720 92 0.156
regulation of lipid storage GO:0010883 21 0.155
response to carbohydrate GO:0009743 21 0.155
Mouse Rat
viral genome replication GO:0019079 50 0.154
negative regulation of icosanoid secretion GO:0032304 2 0.153
positive regulation of cellular component movement GO:0051272 181 0.153
response to activity GO:0014823 0 0.152
muscle organ morphogenesis GO:0048644 19 0.152
mesonephric duct development GO:0072177 3 0.151
epithelial cell proliferation GO:0050673 128 0.151
Human
cell differentiation in hindbrain GO:0021533 1 0.148
regulation of kinase activity GO:0043549 314 0.147
Human Rat
regulation of cellular component movement GO:0051270 334 0.147
Human
purine nucleotide biosynthetic process GO:0006164 84 0.147
morphogenesis of a branching epithelium GO:0061138 20 0.146
cellular response to interferon gamma GO:0071346 24 0.146
vitamin e metabolic process GO:0042360 1 0.145
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.144
protein maturation GO:0051604 233 0.144
negative regulation of protein maturation GO:1903318 142 0.144
hormone mediated signaling pathway GO:0009755 22 0.144
negative regulation of locomotion GO:0040013 118 0.143
Human
embryonic retina morphogenesis in camera type eye GO:0060059 1 0.143
cellular response to decreased oxygen levels GO:0036294 51 0.143
cellular response to oxidative stress GO:0034599 85 0.142
negative regulation of cellular component organization GO:0051129 235 0.142
regulation of innate immune response GO:0045088 97 0.140
growth GO:0040007 202 0.139
cellular amine metabolic process GO:0044106 41 0.139
regulation of hormone secretion GO:0046883 57 0.139
Mouse
skeletal system development GO:0001501 79 0.137
sensory organ morphogenesis GO:0090596 21 0.136
chromatin organization GO:0006325 351 0.136
regulation of secretion by cell GO:1903530 177 0.136
Mouse
lipid modification GO:0030258 84 0.136
Fly
mitochondrion organization GO:0007005 156 0.135
cranial nerve development GO:0021545 4 0.134
regulation of fatty acid metabolic process GO:0019217 24 0.132
Rat Worm
regulation of cholesterol homeostasis GO:2000188 2 0.132
Mouse
regulation of glycolytic process GO:0006110 10 0.131
monocyte differentiation GO:0030224 15 0.130
positive regulation of cellular component biogenesis GO:0044089 158 0.129
reactive oxygen species biosynthetic process GO:1903409 4 0.129
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.129
negative regulation of smooth muscle cell proliferation GO:0048662 14 0.127
ventricular septum development GO:0003281 5 0.126
ribonucleotide biosynthetic process GO:0009260 81 0.126
negative regulation of steroid biosynthetic process GO:0010894 15 0.126
locomotory behavior GO:0007626 1 0.125
positive regulation of cytoskeleton organization GO:0051495 83 0.125
embryonic organ morphogenesis GO:0048562 24 0.125
cellular response to extracellular stimulus GO:0031668 72 0.124
cellular carbohydrate catabolic process GO:0044275 17 0.123
cellular response to fatty acid GO:0071398 8 0.122
post embryonic development GO:0009791 2 0.122
Worm
cytokine mediated signaling pathway GO:0019221 109 0.121
cellular response to nitrogen compound GO:1901699 144 0.120
positive regulation of vitamin d 24 hydroxylase activity GO:0010980 3 0.120
regulation of organelle assembly GO:1902115 40 0.119
glucose metabolic process GO:0006006 45 0.119
Rat
regulation of cell cycle GO:0051726 393 0.118
Human Rat
striated muscle tissue development GO:0014706 59 0.118
lipid localization GO:0010876 106 0.117
Worm
immune system development GO:0002520 195 0.117
negative regulation of viral process GO:0048525 66 0.117
regulation of protein kinase activity GO:0045859 289 0.117
Human Rat
positive regulation of cell migration GO:0030335 172 0.117
alanine metabolic process GO:0006522 4 0.116
cell type specific apoptotic process GO:0097285 125 0.116
positive regulation of organ growth GO:0046622 2 0.115
regeneration GO:0031099 4 0.115
heart development GO:0007507 95 0.114
ectodermal placode development GO:0071696 1 0.114
embryonic morphogenesis GO:0048598 85 0.113
Mouse
positive regulation of locomotion GO:0040017 186 0.112
ameboidal type cell migration GO:0001667 135 0.112
Human
embryo development GO:0009790 123 0.111
Mouse Worm
gland morphogenesis GO:0022612 8 0.110
protein processing GO:0016485 226 0.110
response to insulin GO:0032868 45 0.110
keratinocyte proliferation GO:0043616 17 0.110
hormone secretion GO:0046879 65 0.109
Mouse
cellular response to peptide GO:1901653 59 0.109
cellular response to inorganic substance GO:0071241 45 0.108
epithelial cell development GO:0002064 34 0.107
pyruvate family amino acid metabolic process GO:0009078 4 0.107
organic acid transport GO:0015849 65 0.107
hippocampus development GO:0021766 1 0.107
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.106
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.106
regulation of generation of precursor metabolites and energy GO:0043467 27 0.106
drug export GO:0046618 1 0.105
enteroendocrine cell differentiation GO:0035883 6 0.105
cellular response to oxygen levels GO:0071453 55 0.104
response to hexose GO:0009746 20 0.104
Mouse Rat
energy homeostasis GO:0097009 3 0.103
ribose phosphate biosynthetic process GO:0046390 82 0.103
endothelial cell proliferation GO:0001935 65 0.103
Human
negative regulation of cell death GO:0060548 345 0.103
regulation of sarcomere organization GO:0060297 3 0.103
regulation of endothelial cell proliferation GO:0001936 56 0.102
Human
positive regulation of striated muscle cell differentiation GO:0051155 9 0.102
negative regulation of programmed cell death GO:0043069 321 0.101
response to cytokine GO:0034097 232 0.100
regulation of cytokine mediated signaling pathway GO:0001959 41 0.097
purine ribonucleoside biosynthetic process GO:0046129 23 0.097
nucleoside monophosphate metabolic process GO:0009123 191 0.096
negative regulation of response to cytokine stimulus GO:0060761 25 0.095
regulation of anatomical structure morphogenesis GO:0022603 286 0.095
Mouse
regulation of response to interferon gamma GO:0060330 7 0.094
defense response GO:0006952 315 0.094
circadian rhythm GO:0007623 21 0.094
transmembrane transport GO:0055085 399 0.092
regulation of receptor biosynthetic process GO:0010869 15 0.091
negative regulation of protein processing GO:0010955 142 0.091
morphogenesis of a branching structure GO:0001763 21 0.091
regulation of peptide hormone secretion GO:0090276 41 0.091
Mouse
nervous system development GO:0007399 293 0.091
positive regulation of lipid storage GO:0010884 10 0.091
positive regulation of epithelial cell differentiation GO:0030858 14 0.090
sex differentiation GO:0007548 45 0.090
Mouse
respiratory tube development GO:0030323 20 0.090
negative regulation of smooth muscle cell migration GO:0014912 7 0.090
circadian regulation of gene expression GO:0032922 8 0.089
epidermis development GO:0008544 59 0.089
negative regulation of viral genome replication GO:0045071 35 0.089
actin filament based process GO:0030029 224 0.088
cardiac septum development GO:0003279 13 0.088
ribonucleoside triphosphate metabolic process GO:0009199 412 0.088
regulation of protein complex assembly GO:0043254 147 0.088
multicellular organismal homeostasis GO:0048871 67 0.087
negative regulation of steroid metabolic process GO:0045939 15 0.086
cellular response to vitamin d GO:0071305 5 0.086
organic hydroxy compound transport GO:0015850 63 0.086
regulation of ion transmembrane transport GO:0034765 132 0.086
cellular response to lipid GO:0071396 127 0.086
muscle organ development GO:0007517 56 0.086
cellular response to hypoxia GO:0071456 51 0.085
metal ion homeostasis GO:0055065 169 0.085
hepatocyte proliferation GO:0072574 1 0.085
positive regulation of cell differentiation GO:0045597 211 0.085
regulation of glycolytic by positive regulation of transcription from rna polymerase ii promoter GO:0072363 1 0.085
determination of adult lifespan GO:0008340 2 0.084
Worm
skeletal myofibril assembly GO:0014866 3 0.084
cellular ion homeostasis GO:0006873 168 0.083
nicotinate transport GO:2001142 1 0.083
circulatory system process GO:0003013 113 0.082
negative regulation of sequestering of triglyceride GO:0010891 5 0.082
apoptotic signaling pathway GO:0097190 268 0.082
aorta morphogenesis GO:0035909 1 0.082
pallium development GO:0021543 10 0.081
actin filament organization GO:0007015 128 0.080
cardiac atrium morphogenesis GO:0003209 7 0.080
anatomical structure formation involved in morphogenesis GO:0048646 284 0.080
regulation of epidermal cell differentiation GO:0045604 15 0.080
purine nucleoside triphosphate metabolic process GO:0009144 412 0.079
cholesterol transport GO:0030301 39 0.079
purine containing compound biosynthetic process GO:0072522 88 0.079
acylglycerol homeostasis GO:0055090 14 0.079
Mouse
pancreatic a cell differentiation GO:0003310 1 0.079
kidney development GO:0001822 53 0.078
sterol transport GO:0015918 39 0.078
purine nucleoside biosynthetic process GO:0042451 23 0.078
regulation of carbohydrate catabolic process GO:0043470 11 0.078
purine nucleoside monophosphate metabolic process GO:0009126 186 0.078
dna templated transcription initiation GO:0006352 35 0.078
negative regulation of epithelial cell proliferation GO:0050680 48 0.077
Human
ventricular cardiac muscle tissue morphogenesis GO:0055010 14 0.077
negative regulation of catalytic activity GO:0043086 335 0.077
Human
cellular response to vitamin GO:0071295 6 0.077
response to peptide GO:1901652 65 0.077
thymus development GO:0048538 3 0.076
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.076
epithelial cell migration GO:0010631 119 0.076
Human
positive regulation of muscle cell differentiation GO:0051149 15 0.076
negative regulation of response to wounding GO:1903035 47 0.076
zymogen activation GO:0031638 70 0.075
artery morphogenesis GO:0048844 7 0.075
positive regulation of protein complex assembly GO:0031334 86 0.075
regulation of muscle tissue development GO:1901861 26 0.075
cellular response to growth factor stimulus GO:0071363 197 0.074
negative regulation of peptidase activity GO:0010466 91 0.074
bile acid signaling pathway GO:0038183 3 0.074
nucleoside triphosphate metabolic process GO:0009141 422 0.074
positive regulation of nervous system development GO:0051962 54 0.074
positive regulation of proteolysis GO:0045862 142 0.074
retinoic acid receptor signaling pathway GO:0048384 13 0.073
Human
positive regulation of apoptotic process GO:0043065 246 0.073
decidualization GO:0046697 4 0.072
cardiac muscle cell differentiation GO:0055007 15 0.072
vitamin k catabolic process GO:0042377 2 0.072

HNF4A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.985
acquired metabolic disease DOID:0060158 58 0.932
obesity DOID:9970 16 0.649
nutrition disease DOID:374 17 0.649
overnutrition DOID:654 17 0.649
diabetes mellitus DOID:9351 31 0.564
carbohydrate metabolism disease DOID:0050013 32 0.564
glucose metabolism disease DOID:4194 32 0.564
type 2 diabetes mellitus DOID:9352 28 0.166
cancer DOID:162 167 0.145
disease of cellular proliferation DOID:14566 174 0.145
organ system cancer DOID:0050686 164 0.145