Homo sapiens

58 known processes

HSPA4

heat shock 70kDa protein 4

(Aliases: hsp70RY,MGC131852,RY,APG-2,hsp70,HS24/P52)

HSPA4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein refolding GO:0042026 14 0.999
Yeast
protein ubiquitination GO:0016567 314 0.995
protein folding GO:0006457 38 0.990
Yeast
post embryonic development GO:0009791 2 0.937
Worm
protein modification by small protein conjugation GO:0032446 342 0.914
negative regulation of programmed cell death GO:0043069 321 0.911
Rat
regulation of cellular component biogenesis GO:0044087 281 0.890
protein catabolic process GO:0030163 325 0.861
ubiquitin dependent protein catabolic process GO:0006511 206 0.835
determination of adult lifespan GO:0008340 2 0.818
Worm
establishment of protein localization to organelle GO:0072594 172 0.812
cellular macromolecule catabolic process GO:0044265 380 0.799
negative regulation of cell death GO:0060548 345 0.788
Rat
modification dependent protein catabolic process GO:0019941 209 0.786
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.775
nucleoside monophosphate metabolic process GO:0009123 191 0.745
Yeast
cytoplasmic transport GO:0016482 379 0.741
de novo posttranslational protein folding GO:0051084 2 0.725
chaperone cofactor dependent protein refolding GO:0070389 4 0.711
multicellular organismal aging GO:0010259 3 0.676
Worm
purine ribonucleotide catabolic process GO:0009154 404 0.670
Yeast
intracellular protein transmembrane transport GO:0065002 24 0.669
de novo protein folding GO:0006458 2 0.661
modification dependent macromolecule catabolic process GO:0043632 212 0.648
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.647
nucleoside catabolic process GO:0009164 408 0.634
Yeast
nucleoside phosphate catabolic process GO:1901292 412 0.619
Yeast
purine nucleoside monophosphate catabolic process GO:0009128 158 0.609
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 158 0.591
Yeast
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.581
Yeast
negative regulation of cellular protein metabolic process GO:0032269 353 0.574
Rat
translation GO:0006412 132 0.566
receptor mediated endocytosis GO:0006898 84 0.564
Worm
cellular macromolecular complex assembly GO:0034622 324 0.561
protein processing GO:0016485 226 0.556
cellular protein catabolic process GO:0044257 261 0.547
negative regulation of apoptotic process GO:0043066 316 0.520
Rat
positive regulation of apoptotic process GO:0043065 246 0.508
purine ribonucleoside metabolic process GO:0046128 437 0.508
Yeast
regulation of proteasomal protein catabolic process GO:0061136 87 0.508
negative regulation of protein metabolic process GO:0051248 391 0.504
Rat
ribonucleotide catabolic process GO:0009261 405 0.500
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.497
Yeast
chromatin modification GO:0016568 298 0.470
aging GO:0007568 66 0.464
Worm
immune response GO:0006955 307 0.460
protein targeting GO:0006605 187 0.453
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.445
purine nucleoside triphosphate metabolic process GO:0009144 412 0.406
Yeast
nuclear transport GO:0051169 179 0.395
nucleocytoplasmic transport GO:0006913 176 0.378
ribonucleoside triphosphate metabolic process GO:0009199 412 0.371
Yeast
posttranscriptional regulation of gene expression GO:0010608 213 0.364
regulation of protein ubiquitination GO:0031396 95 0.364
intracellular protein transport GO:0006886 270 0.359
nucleoside triphosphate catabolic process GO:0009143 394 0.347
Yeast
chaperone mediated protein folding requiring cofactor GO:0051085 1 0.338
regulation of protein transport GO:0051223 213 0.322
purine nucleotide catabolic process GO:0006195 405 0.302
Yeast
defense response GO:0006952 315 0.300
nucleotide catabolic process GO:0009166 408 0.300
Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.280
Yeast
single organism reproductive process GO:0044702 98 0.280
Worm
purine containing compound catabolic process GO:0072523 411 0.263
Yeast
cellular protein complex assembly GO:0043623 188 0.259
regulation of binding GO:0051098 111 0.257
Rat
negative regulation of phosphate metabolic process GO:0045936 267 0.254
Rat
atp metabolic process GO:0046034 176 0.249
Yeast
protein localization to organelle GO:0033365 280 0.248
cell type specific apoptotic process GO:0097285 125 0.247
response to radiation GO:0009314 151 0.242
protein oligomerization GO:0051259 173 0.237
positive regulation of dna metabolic process GO:0051054 73 0.235
covalent chromatin modification GO:0016569 254 0.233
proteasomal protein catabolic process GO:0010498 176 0.229
purine nucleoside catabolic process GO:0006152 398 0.218
Yeast
positive regulation of cellular catabolic process GO:0031331 284 0.216
actin filament based process GO:0030029 224 0.213
purine nucleoside triphosphate catabolic process GO:0009146 392 0.210
Yeast
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.209
regulation of protein kinase activity GO:0045859 289 0.205
glycosyl compound catabolic process GO:1901658 413 0.196
Yeast
protein targeting to nucleus GO:0044744 104 0.193
positive regulation of cell death GO:0010942 263 0.183
negative regulation of intracellular signal transduction GO:1902532 183 0.180
purine ribonucleoside catabolic process GO:0046130 398 0.179
Yeast
organelle assembly GO:0070925 176 0.170
single organism cellular localization GO:1902580 332 0.163
purine nucleoside monophosphate metabolic process GO:0009126 186 0.162
Yeast
regulation of gene expression epigenetic GO:0040029 73 0.161
regulation of peptidase activity GO:0052547 180 0.156
negative regulation of protein processing GO:0010955 142 0.154
negative regulation of proteolysis GO:0045861 132 0.153
positive regulation of proteolysis GO:0045862 142 0.153
endocytosis GO:0006897 159 0.151
Worm
regulation of proteolysis GO:0030162 293 0.150
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.146
response to abiotic stimulus GO:0009628 336 0.146
Rat
positive regulation of hydrolase activity GO:0051345 331 0.145
vesicle mediated transport GO:0016192 371 0.143
Worm
negative regulation of protein modification process GO:0031400 200 0.136
Rat
cellular response to dna damage stimulus GO:0006974 379 0.136
nucleoside monophosphate catabolic process GO:0009125 159 0.135
Yeast
regulation of intracellular transport GO:0032386 195 0.131
regulation of dna metabolic process GO:0051052 153 0.130
regulation of transferase activity GO:0051338 355 0.126
ribonucleoside catabolic process GO:0042454 406 0.124
Yeast
negative regulation of cellular component organization GO:0051129 235 0.121
reproduction GO:0000003 63 0.113
Worm
cell development GO:0048468 328 0.113
protein maturation GO:0051604 233 0.108
regulation of nucleocytoplasmic transport GO:0046822 98 0.107
protein import GO:0017038 130 0.106
regulation of kinase activity GO:0043549 314 0.102
sex differentiation GO:0007548 45 0.102
Worm
regulation of cytoplasmic transport GO:1903649 149 0.102
positive regulation of programmed cell death GO:0043068 249 0.102
regeneration GO:0031099 4 0.101
embryo development GO:0009790 123 0.101
Worm
regulation of establishment of protein localization GO:0070201 242 0.100
ribonucleoside triphosphate catabolic process GO:0009203 391 0.095
Yeast
regulation of apoptotic signaling pathway GO:2001233 175 0.093
regulation of protein maturation GO:1903317 150 0.093
embryo development ending in birth or egg hatching GO:0009792 34 0.091
Worm
protein deubiquitination GO:0016579 79 0.089
single organism nuclear import GO:1902593 104 0.089
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.089
Yeast
single organism membrane organization GO:0044802 268 0.088
regulation of cellular response to stress GO:0080135 244 0.086
reproductive structure development GO:0048608 55 0.086
Worm
negative regulation of catalytic activity GO:0043086 335 0.086
regulation of protein localization GO:0032880 296 0.086
positive regulation of protein catabolic process GO:0045732 75 0.085
positive regulation of catabolic process GO:0009896 310 0.085
regulation of endopeptidase activity GO:0052548 170 0.085
negative regulation of protein ubiquitination GO:0031397 35 0.084
apoptotic signaling pathway GO:0097190 268 0.084
histone modification GO:0016570 251 0.081
rna interference GO:0016246 4 0.080
atp catabolic process GO:0006200 157 0.080
Yeast
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.079
regulation of protein import into nucleus GO:0042306 78 0.078
mitochondrial transport GO:0006839 60 0.078
immune system development GO:0002520 195 0.078
negative regulation of hydrolase activity GO:0051346 182 0.076
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.074
chromatin organization GO:0006325 351 0.074
regulation of protein complex assembly GO:0043254 147 0.073
regulation of viral process GO:0050792 103 0.072
negative regulation of phosphorus metabolic process GO:0010563 267 0.072
Rat
positive regulation of transport GO:0051050 336 0.069
regulation of mitotic spindle checkpoint GO:1903504 8 0.068
cellular response to cytokine stimulus GO:0071345 181 0.068
anatomical structure formation involved in morphogenesis GO:0048646 284 0.067
Rat
positive regulation of developmental process GO:0051094 314 0.067
Rat
regulation of cytokine production GO:0001817 232 0.065
regulation of protein targeting GO:1903533 91 0.065
reproductive system development GO:0061458 56 0.064
Worm
positive regulation of cellular component organization GO:0051130 376 0.062
cellular amino acid metabolic process GO:0006520 116 0.062
female gamete generation GO:0007292 2 0.061
protein import into nucleus GO:0006606 104 0.061
cardiovascular system development GO:0072358 262 0.061
Rat
chordate embryonic development GO:0043009 34 0.060
positive regulation of protein complex assembly GO:0031334 86 0.060
response to external biotic stimulus GO:0043207 261 0.059
growth GO:0040007 202 0.059
response to oxygen containing compound GO:1901700 369 0.059
response to nitrogen compound GO:1901698 184 0.056
trna metabolic process GO:0006399 35 0.056
regulation of protein processing GO:0070613 150 0.056
chaperone mediated protein complex assembly GO:0051131 9 0.054
response to light stimulus GO:0009416 87 0.053
microtubule cytoskeleton organization GO:0000226 176 0.052
nucleoside triphosphate metabolic process GO:0009141 422 0.051
Yeast
cellular component morphogenesis GO:0032989 314 0.050
cytoplasmic translation GO:0002181 8 0.050
spermatid differentiation GO:0048515 4 0.049
toxin transport GO:1901998 4 0.048
positive regulation of cellular component biogenesis GO:0044089 158 0.047
response to topologically incorrect protein GO:0035966 29 0.046
Worm
regulation of purine nucleotide metabolic process GO:1900542 264 0.046
protein localization to membrane GO:0072657 160 0.046
multicellular organism reproduction GO:0032504 42 0.046
striated muscle cell apoptotic process GO:0010658 3 0.046
positive regulation of protein ubiquitination GO:0031398 53 0.045
negative regulation of protein phosphorylation GO:0001933 140 0.045
Rat
response to organic cyclic compound GO:0014070 204 0.044
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.043
regulation of purine nucleotide catabolic process GO:0033121 205 0.043
chaperone mediated protein folding GO:0061077 13 0.042
organophosphate catabolic process GO:0046434 430 0.041
Yeast
regulation of translation GO:0006417 89 0.041
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.041
negative regulation of peptidase activity GO:0010466 91 0.040
secretion GO:0046903 254 0.040
establishment of protein localization to membrane GO:0090150 121 0.039
nuclear import GO:0051170 106 0.039
mapk cascade GO:0000165 288 0.037
signal transduction by phosphorylation GO:0023014 297 0.036
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.036
amine metabolic process GO:0009308 44 0.035
intracellular protein transmembrane import GO:0044743 23 0.035
regulation of cellular protein catabolic process GO:1903362 96 0.035
regulation of innate immune response GO:0045088 97 0.035
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.034
protein localization to nucleus GO:0034504 136 0.033
negative regulation of protein kinase activity GO:0006469 98 0.033
positive regulation of nucleotide metabolic process GO:0045981 230 0.033
immune effector process GO:0002252 159 0.033
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.033
cellular amine metabolic process GO:0044106 41 0.032
regulation of protein serine threonine kinase activity GO:0071900 179 0.032
regulation of mitotic cell cycle GO:0007346 189 0.031
microtubule based process GO:0007017 210 0.031
regulation of ion transport GO:0043269 189 0.031
tissue regeneration GO:0042246 3 0.031
positive regulation of protein transport GO:0051222 135 0.031
negative regulation of binding GO:0051100 57 0.031
Rat
ribonucleoprotein complex subunit organization GO:0071826 81 0.031
negative regulation of protein maturation GO:1903318 142 0.030
oogenesis GO:0048477 2 0.029
developmental process involved in reproduction GO:0003006 66 0.029
Worm
negative regulation of apoptotic signaling pathway GO:2001234 97 0.029
spermatid development GO:0007286 4 0.029
regulation of nucleotide metabolic process GO:0006140 269 0.028
innate immune response GO:0045087 178 0.027
sexual reproduction GO:0019953 37 0.027
regulation of cell cycle GO:0051726 393 0.027
development of primary sexual characteristics GO:0045137 35 0.027
Worm
protein localization to mitochondrion GO:0070585 25 0.027
ribonucleoside monophosphate metabolic process GO:0009161 187 0.026
Yeast
meiosis i GO:0007127 4 0.026
regulation of intracellular protein transport GO:0033157 123 0.026
rna catabolic process GO:0006401 71 0.026
response to other organism GO:0051707 261 0.026
dephosphorylation GO:0016311 209 0.026
regulation of nucleotide catabolic process GO:0030811 205 0.026
regulation of t cell activation GO:0050863 77 0.025
mitotic cell cycle GO:0000278 326 0.025
dna repair GO:0006281 198 0.025
multicellular organismal reproductive process GO:0048609 40 0.024
negative regulation of growth GO:0045926 97 0.024
multi organism cellular process GO:0044764 156 0.024
negative regulation of phosphorylation GO:0042326 174 0.024
Rat
reactive oxygen species metabolic process GO:0072593 75 0.024
small gtpase mediated signal transduction GO:0007264 78 0.023
regulation of cell growth GO:0001558 135 0.023
positive regulation of peptidase activity GO:0010952 88 0.023
actin cytoskeleton organization GO:0030036 207 0.023
detection of stimulus GO:0051606 85 0.023
system process GO:0003008 349 0.023
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.022
protein dna complex subunit organization GO:0071824 80 0.022
negative regulation of organelle organization GO:0010639 126 0.022
response to organonitrogen compound GO:0010243 156 0.022
cellular response to uv GO:0034644 32 0.022
extrinsic apoptotic signaling pathway GO:0097191 119 0.021
regulation of mapk cascade GO:0043408 262 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.021
positive regulation of apoptotic signaling pathway GO:2001235 70 0.021
spindle assembly GO:0051225 29 0.020
mitochondrion organization GO:0007005 156 0.020
ncrna processing GO:0034470 83 0.020
secretion by cell GO:0032940 226 0.020
regulation of growth GO:0040008 165 0.020
fertilization GO:0009566 12 0.020
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.019
cellular response to oxidative stress GO:0034599 85 0.019
actin filament organization GO:0007015 128 0.019
negative regulation of kinase activity GO:0033673 106 0.019
rna processing GO:0006396 255 0.019
small nucleolar ribonucleoprotein complex assembly GO:0000491 3 0.019
organelle localization GO:0051640 84 0.019
gonad development GO:0008406 34 0.018
Worm
reproductive process GO:0022414 106 0.018
Worm
regulation of viral genome replication GO:0045069 48 0.018
regulation of protein localization to nucleus GO:1900180 85 0.018
mitochondrial membrane organization GO:0007006 40 0.018
regulation of immune response GO:0050776 201 0.018
anterior posterior axis specification embryo GO:0008595 2 0.018
gamete generation GO:0007276 25 0.017
regulation of protein binding GO:0043393 66 0.017
Rat
response to unfolded protein GO:0006986 24 0.017
regulation of cell differentiation GO:0045595 393 0.017
gene silencing GO:0016458 49 0.017
oocyte differentiation GO:0009994 2 0.017
regulation of protein catabolic process GO:0042176 155 0.016
response to peptide GO:1901652 65 0.016
positive regulation of cell cycle GO:0045787 140 0.016
response to cytokine GO:0034097 232 0.016
regulation of multi organism process GO:0043900 157 0.015
positive regulation of mrna metabolic process GO:1903313 19 0.015
response to wounding GO:0009611 168 0.015
posttranscriptional gene silencing GO:0016441 25 0.015
regulation of defense response GO:0031347 154 0.015
positive regulation of organelle organization GO:0010638 195 0.014
establishment of protein localization to mitochondrial membrane GO:0090151 7 0.014
divalent inorganic cation transport GO:0072511 158 0.014
negative regulation of cell growth GO:0030308 83 0.014
locomotory behavior GO:0007626 1 0.014
cell cycle phase transition GO:0044770 173 0.014
calcium ion transport GO:0006816 147 0.014
macromolecular complex disassembly GO:0032984 60 0.014
response to bacterium GO:0009617 144 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.013
myosin filament organization GO:0031033 2 0.013
regulation of small gtpase mediated signal transduction GO:0051056 156 0.013
gtp metabolic process GO:0046039 239 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.013
myeloid cell differentiation GO:0030099 117 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
positive regulation of cytokine production GO:0001819 167 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
regulation of atp metabolic process GO:1903578 29 0.012
negative regulation of transferase activity GO:0051348 124 0.012
cell growth GO:0016049 160 0.012
positive regulation of atp catabolic process GO:1903291 19 0.012
nervous system development GO:0007399 293 0.012
segmentation GO:0035282 4 0.012
neurological system process GO:0050877 163 0.012
cell division GO:0051301 168 0.012
cellular component disassembly GO:0022411 92 0.012
negative regulation of neuron apoptotic process GO:0043524 23 0.012
response to lipid GO:0033993 206 0.012
negative regulation of protein transport GO:0051224 75 0.011
oocyte development GO:0048599 1 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
intracellular receptor signaling pathway GO:0030522 104 0.011
sperm motility GO:0030317 6 0.011
mrna catabolic process GO:0006402 56 0.011
spermatogenesis GO:0007283 22 0.011
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.011
negative regulation of neuron death GO:1901215 32 0.011
cell aging GO:0007569 52 0.011
macromolecule methylation GO:0043414 97 0.011
cell morphogenesis GO:0000902 296 0.010
positive regulation of kinase activity GO:0033674 204 0.010
cell cell signaling GO:0007267 155 0.010
cellular response to organonitrogen compound GO:0071417 124 0.010
regulation of dna replication GO:0006275 68 0.010
muscle structure development GO:0061061 98 0.010

HSPA4 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.016
nervous system disease DOID:863 431 0.016