Homo sapiens

108 known processes

MAP3K4

mitogen-activated protein kinase kinase kinase 4

(Aliases: MTK1,KIAA0213,MEKK4,FLJ42439,MAPKKK4,PRO0412)

MAP3K4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule catabolic process GO:0044265 380 0.446
positive regulation of cell death GO:0010942 263 0.395
positive regulation of protein phosphorylation GO:0001934 313 0.395
mapk cascade GO:0000165 288 0.356
signal transduction by phosphorylation GO:0023014 297 0.352
stress activated protein kinase signaling cascade GO:0031098 94 0.333
regulation of mapk cascade GO:0043408 262 0.311
positive regulation of mapk cascade GO:0043410 190 0.307
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.295
negative regulation of phosphorylation GO:0042326 174 0.281
regulation of protein complex assembly GO:0043254 147 0.262
post embryonic development GO:0009791 2 0.258
positive regulation of p38mapk cascade GO:1900745 8 0.252
negative regulation of protein metabolic process GO:0051248 391 0.235
regulation of cellular amine metabolic process GO:0033238 11 0.229
positive regulation of kinase activity GO:0033674 204 0.218
regulation of cellular component biogenesis GO:0044087 281 0.193
Fly
response to radiation GO:0009314 151 0.186
p38mapk cascade GO:0038066 9 0.172
positive regulation of immune system process GO:0002684 283 0.167
stress activated mapk cascade GO:0051403 93 0.164
cellular response to abiotic stimulus GO:0071214 117 0.158
Fly
negative regulation of cellular protein metabolic process GO:0032269 353 0.158
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.153
positive regulation of cellular component organization GO:0051130 376 0.152
negative regulation of catalytic activity GO:0043086 335 0.143
organophosphate catabolic process GO:0046434 430 0.142
ubiquitin dependent protein catabolic process GO:0006511 206 0.142
regulation of stress activated mapk cascade GO:0032872 84 0.141
modification dependent protein catabolic process GO:0019941 209 0.140
protein catabolic process GO:0030163 325 0.135
nucleoside triphosphate metabolic process GO:0009141 422 0.131
cellular protein catabolic process GO:0044257 261 0.130
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.127
cellular response to mechanical stimulus GO:0071260 39 0.125
activation of protein kinase activity GO:0032147 90 0.125
regulation of protein serine threonine kinase activity GO:0071900 179 0.122
cellular response to external stimulus GO:0071496 111 0.121
lung growth GO:0060437 2 0.121
nucleoside triphosphate catabolic process GO:0009143 394 0.113
negative regulation of protein modification process GO:0031400 200 0.113
response to abiotic stimulus GO:0009628 336 0.112
regulation of cytoskeleton organization GO:0051493 177 0.110
cytoplasmic transport GO:0016482 379 0.109
secretion GO:0046903 254 0.108
ribonucleoside catabolic process GO:0042454 406 0.106
regulation of reactive oxygen species metabolic process GO:2000377 41 0.104
ribonucleoside triphosphate catabolic process GO:0009203 391 0.102
positive regulation of transport GO:0051050 336 0.097
negative regulation of cellular amine metabolic process GO:0033239 3 0.096
protein targeting GO:0006605 187 0.093
regulation of protein kinase activity GO:0045859 289 0.092
multicellular organismal aging GO:0010259 3 0.091
somitogenesis GO:0001756 2 0.090
positive regulation of organelle organization GO:0010638 195 0.090
regulation of intracellular transport GO:0032386 195 0.090
positive regulation of transferase activity GO:0051347 227 0.089
nucleoside catabolic process GO:0009164 408 0.087
modification dependent macromolecule catabolic process GO:0043632 212 0.086
regulation of organelle assembly GO:1902115 40 0.081
enzyme linked receptor protein signaling pathway GO:0007167 303 0.079
activation of mapkkk activity GO:0000185 7 0.078
protein ubiquitination GO:0016567 314 0.075
ossification GO:0001503 121 0.074
defense response to other organism GO:0098542 129 0.073
single organism cellular localization GO:1902580 332 0.072
chromatin organization GO:0006325 351 0.072
Fly
negative regulation of cytoskeleton organization GO:0051494 45 0.071
positive regulation of jnk cascade GO:0046330 52 0.071
regulation of map kinase activity GO:0043405 108 0.071
regulation of protein catabolic process GO:0042176 155 0.069
positive regulation of protein complex assembly GO:0031334 86 0.068
positive regulation of nucleotide metabolic process GO:0045981 230 0.066
carbohydrate metabolic process GO:0005975 207 0.066
cellular response to dna damage stimulus GO:0006974 379 0.065
guanosine containing compound metabolic process GO:1901068 244 0.064
gtp catabolic process GO:0006184 237 0.064
reactive oxygen species metabolic process GO:0072593 75 0.062
associative learning GO:0008306 1 0.061
negative regulation of organelle organization GO:0010639 126 0.061
Fly
regulation of jnk cascade GO:0046328 73 0.061
cellular amino acid metabolic process GO:0006520 116 0.061
nucleotide catabolic process GO:0009166 408 0.061
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.060
purine nucleotide catabolic process GO:0006195 405 0.060
mitotic cell cycle process GO:1903047 286 0.060
glycosyl compound catabolic process GO:1901658 413 0.059
determination of adult lifespan GO:0008340 2 0.059
posttranscriptional regulation of gene expression GO:0010608 213 0.058
actin cytoskeleton organization GO:0030036 207 0.058
vesicle mediated transport GO:0016192 371 0.058
Fly
cell morphogenesis GO:0000902 296 0.056
positive regulation of cellular component biogenesis GO:0044089 158 0.055
actin filament based process GO:0030029 224 0.055
actin filament organization GO:0007015 128 0.054
negative regulation of protein phosphorylation GO:0001933 140 0.054
cellular response to radiation GO:0071478 65 0.051
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.051
purine ribonucleotide catabolic process GO:0009154 404 0.051
regulation of cell projection organization GO:0031344 107 0.051
synaptic vesicle recycling GO:0036465 3 0.051
regulation of cellular ketone metabolic process GO:0010565 50 0.051
purine ribonucleoside catabolic process GO:0046130 398 0.050
defense response to bacterium GO:0042742 63 0.050
positive regulation of phosphorylation GO:0042327 394 0.049
protein oligomerization GO:0051259 173 0.049
cellular amine metabolic process GO:0044106 41 0.049
protein modification by small protein conjugation GO:0032446 342 0.048
regulation of cell cycle GO:0051726 393 0.047
regulation of stress fiber assembly GO:0051492 32 0.047
cell division GO:0051301 168 0.047
positive regulation of gtp catabolic process GO:0033126 166 0.047
segmentation GO:0035282 4 0.046
lipid metabolic process GO:0006629 381 0.046
positive regulation of programmed cell death GO:0043068 249 0.046
chromatin modification GO:0016568 298 0.046
Fly
cdc42 protein signal transduction GO:0032488 4 0.046
muscle contraction GO:0006936 73 0.046
positive regulation of protein kinase activity GO:0045860 190 0.045
purine containing compound catabolic process GO:0072523 411 0.045
negative regulation of catabolic process GO:0009895 104 0.045
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.044
membrane organization GO:0061024 292 0.044
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.043
jnk cascade GO:0007254 80 0.043
synaptic vesicle endocytosis GO:0048488 2 0.043
regulation of vesicle mediated transport GO:0060627 130 0.043
purine nucleoside triphosphate catabolic process GO:0009146 392 0.042
negative regulation of kinase activity GO:0033673 106 0.042
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.041
positive regulation of synaptic transmission GO:0050806 4 0.040
rna transport GO:0050658 39 0.040
establishment of rna localization GO:0051236 39 0.039
protein localization to organelle GO:0033365 280 0.039
proteasomal protein catabolic process GO:0010498 176 0.039
response to inorganic substance GO:0010035 127 0.039
Fly
response to oxygen containing compound GO:1901700 369 0.039
guanosine containing compound catabolic process GO:1901069 239 0.038
epithelium development GO:0060429 227 0.037
establishment of protein localization to organelle GO:0072594 172 0.037
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.037
gtp metabolic process GO:0046039 239 0.036
regulation of protein transport GO:0051223 213 0.036
dna repair GO:0006281 198 0.036
intracellular protein transport GO:0006886 270 0.036
positive regulation of apoptotic process GO:0043065 246 0.035
negative regulation of transferase activity GO:0051348 124 0.035
negative regulation of hydrolase activity GO:0051346 182 0.035
regulation of multi organism process GO:0043900 157 0.035
replacement ossification GO:0036075 1 0.035
single organism membrane organization GO:0044802 268 0.035
organelle fission GO:0048285 149 0.035
microtubule cytoskeleton organization GO:0000226 176 0.035
positive regulation of icosanoid secretion GO:0032305 3 0.034
protein processing GO:0016485 226 0.034
small gtpase mediated signal transduction GO:0007264 78 0.034
protein import GO:0017038 130 0.034
single organism carbohydrate metabolic process GO:0044723 193 0.034
ribonucleoside triphosphate metabolic process GO:0009199 412 0.033
positive regulation of developmental process GO:0051094 314 0.033
negative regulation of intracellular signal transduction GO:1902532 183 0.033
cell projection organization GO:0030030 252 0.033
regulation of kinase activity GO:0043549 314 0.033
purine ribonucleoside metabolic process GO:0046128 437 0.033
positive regulation of nucleotide catabolic process GO:0030813 185 0.033
regulation of behavior GO:0050795 82 0.033
cellular ketone metabolic process GO:0042180 80 0.033
female gamete generation GO:0007292 2 0.032
organic anion transport GO:0015711 103 0.032
anion transport GO:0006820 161 0.032
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.032
positive regulation of cellular catabolic process GO:0031331 284 0.031
regulation of establishment of protein localization GO:0070201 242 0.031
organelle localization GO:0051640 84 0.031
negative regulation of phosphate metabolic process GO:0045936 267 0.031
negative regulation of protein maturation GO:1903318 142 0.031
anatomical structure formation involved in morphogenesis GO:0048646 284 0.030
regulation of gtp catabolic process GO:0033124 180 0.030
regulation of icosanoid secretion GO:0032303 4 0.030
positive regulation of protein catabolic process GO:0045732 75 0.030
response to uv GO:0009411 73 0.030
negative regulation of phosphorus metabolic process GO:0010563 267 0.030
negative regulation of cellular component organization GO:0051129 235 0.030
Fly
rna localization GO:0006403 41 0.030
single organism cell adhesion GO:0098602 179 0.030
transmembrane transport GO:0055085 399 0.030
cilium assembly GO:0042384 63 0.029
purine ribonucleotide biosynthetic process GO:0009152 79 0.029
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.029
myeloid cell differentiation GO:0030099 117 0.029
actin filament bundle organization GO:0061572 54 0.028
regulation of cell differentiation GO:0045595 393 0.028
neuromuscular junction development GO:0007528 3 0.028
regulation of dna metabolic process GO:0051052 153 0.028
Fly
regulation of cell morphogenesis GO:0022604 153 0.028
regulation of transferase activity GO:0051338 355 0.028
nitrogen compound transport GO:0071705 191 0.028
protein complex disassembly GO:0043241 52 0.027
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 3 0.027
regulation of cellular protein catabolic process GO:1903362 96 0.027
cilium organization GO:0044782 68 0.027
positive regulation of cellular amine metabolic process GO:0033240 7 0.027
regulation of secretion GO:0051046 194 0.027
positive regulation of organic acid transport GO:0032892 3 0.026
establishment of organelle localization GO:0051656 59 0.026
cellular response to ionizing radiation GO:0071479 32 0.026
ribonucleotide catabolic process GO:0009261 405 0.026
nuclear import GO:0051170 106 0.026
activation of immune response GO:0002253 114 0.026
positive regulation of nucleoside metabolic process GO:0045979 186 0.025
negative regulation of proteolysis GO:0045861 132 0.025
organic acid transport GO:0015849 65 0.025
response to mechanical stimulus GO:0009612 51 0.025
positive regulation of ras gtpase activity GO:0032320 117 0.025
negative regulation of protein processing GO:0010955 142 0.025
striated muscle contraction GO:0006941 52 0.025
regulation of cellular response to stress GO:0080135 244 0.025
organonitrogen compound biosynthetic process GO:1901566 200 0.025
spermatid differentiation GO:0048515 4 0.025
lipid localization GO:0010876 106 0.025
microtubule based process GO:0007017 210 0.024
response to drug GO:0042493 81 0.024
positive regulation of defense response GO:0031349 87 0.024
small molecule biosynthetic process GO:0044283 157 0.024
embryo development GO:0009790 123 0.023
nuclear division GO:0000280 128 0.023
regulation of protein maturation GO:1903317 150 0.023
positive regulation of secretion GO:0051047 116 0.023
actomyosin structure organization GO:0031032 59 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.023
negative regulation of protein kinase activity GO:0006469 98 0.023
system process GO:0003008 349 0.022
mitotic nuclear division GO:0007067 119 0.022
response to heat GO:0009408 21 0.022
Fly
mitotic cell cycle GO:0000278 326 0.022
vacuole organization GO:0007033 44 0.022
regulation of mitotic cell cycle GO:0007346 189 0.022
endomembrane system organization GO:0010256 196 0.022
positive regulation of cytoplasmic transport GO:1903651 82 0.022
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.021
regulation of protein localization to nucleus GO:1900180 85 0.021
interspecies interaction between organisms GO:0044419 156 0.021
protein localization to membrane GO:0072657 160 0.021
positive regulation of catabolic process GO:0009896 310 0.021
regulation of protein localization GO:0032880 296 0.021
regulation of protein processing GO:0070613 150 0.021
regulation of anatomical structure morphogenesis GO:0022603 286 0.021
cellular response to oxygen containing compound GO:1901701 276 0.021
negative regulation of apoptotic process GO:0043066 316 0.021
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.021
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.021
protein modification by small protein removal GO:0070646 92 0.021
cellular carbohydrate metabolic process GO:0044262 84 0.021
regulation of microtubule based process GO:0032886 74 0.020
negative regulation of cellular catabolic process GO:0031330 83 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
positive regulation of behavior GO:0048520 60 0.020
cellular component disassembly GO:0022411 92 0.020
regulation of proteasomal protein catabolic process GO:0061136 87 0.020
regulation of microtubule cytoskeleton organization GO:0070507 61 0.020
cell cell signaling GO:0007267 155 0.020
organelle assembly GO:0070925 176 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
regulation of protein ubiquitination GO:0031396 95 0.020
histone modification GO:0016570 251 0.020
activation of mapk activity GO:0000187 45 0.020
cilium morphogenesis GO:0060271 75 0.020
regulation of actin cytoskeleton organization GO:0032956 116 0.020
cellular protein complex assembly GO:0043623 188 0.020
negative regulation of developmental process GO:0051093 247 0.020
cell projection assembly GO:0030031 126 0.020
negative regulation of interleukin 6 biosynthetic process GO:0045409 3 0.019
oogenesis GO:0048477 2 0.019
organic hydroxy compound metabolic process GO:1901615 147 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.019
lipid transport GO:0006869 90 0.019
regulation of nuclear division GO:0051783 65 0.019
negative regulation of mapk cascade GO:0043409 56 0.019
nucleobase containing compound transport GO:0015931 51 0.019
defense response to gram positive bacterium GO:0050830 29 0.019
regulation of intracellular protein transport GO:0033157 123 0.019
alcohol metabolic process GO:0006066 114 0.018
regulation of protein targeting GO:1903533 91 0.018
positive regulation of protein localization to nucleus GO:1900182 48 0.018
covalent chromatin modification GO:0016569 254 0.018
lymphocyte activation GO:0046649 133 0.018
actin filament bundle assembly GO:0051017 54 0.018
rna processing GO:0006396 255 0.018
regulation of nucleotide metabolic process GO:0006140 269 0.018
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.018
regulation of proteolysis GO:0030162 293 0.018
mononuclear cell proliferation GO:0032943 71 0.018
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.018
regulation of actin filament based process GO:0032970 141 0.017
rho protein signal transduction GO:0007266 26 0.017
cellular response to nitrogen compound GO:1901699 144 0.017
stress fiber assembly GO:0043149 40 0.017
regulation of nucleocytoplasmic transport GO:0046822 98 0.017
oocyte development GO:0048599 1 0.017
response to osmotic stress GO:0006970 17 0.017
Fly
protein targeting to nucleus GO:0044744 104 0.017
male meiosis GO:0007140 1 0.017
response to tumor necrosis factor GO:0034612 76 0.017
tissue homeostasis GO:0001894 63 0.017
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.017
purine nucleotide biosynthetic process GO:0006164 84 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.016
positive regulation of cellular protein catabolic process GO:1903364 37 0.016
reproductive process GO:0022414 106 0.016
Mouse
nuclear transport GO:0051169 179 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.016
spindle assembly GO:0051225 29 0.016
behavior GO:0007610 112 0.016
notch signaling pathway GO:0007219 31 0.016
endochondral bone morphogenesis GO:0060350 3 0.016
regulation of innate immune response GO:0045088 97 0.016
protein import into nucleus GO:0006606 104 0.016
oocyte differentiation GO:0009994 2 0.016
positive regulation of hydrolase activity GO:0051345 331 0.016
response to growth factor GO:0070848 205 0.016
response to light stimulus GO:0009416 87 0.016
negative regulation of multicellular organismal process GO:0051241 317 0.015
anatomical structure homeostasis GO:0060249 100 0.015
negative regulation of apoptotic signaling pathway GO:2001234 97 0.015
mitotic spindle elongation GO:0000022 4 0.015
regulation of small gtpase mediated signal transduction GO:0051056 156 0.015
negative regulation of cell cycle GO:0045786 193 0.015
negative regulation of cell proliferation GO:0008285 228 0.015
wound healing GO:0042060 115 0.015
negative regulation of transport GO:0051051 176 0.015
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.015
nucleic acid transport GO:0050657 39 0.015
regulation of cell cycle process GO:0010564 266 0.015
response to reactive oxygen species GO:0000302 61 0.015
positive regulation of protein transport GO:0051222 135 0.015
multi organism reproductive process GO:0044703 54 0.015
polyol metabolic process GO:0019751 32 0.015
platelet activation GO:0030168 44 0.015
inner ear morphogenesis GO:0042472 4 0.015
protein localization to nucleus GO:0034504 136 0.015
neurotransmitter secretion GO:0007269 4 0.015
response to wounding GO:0009611 168 0.015
blood coagulation GO:0007596 76 0.014
negative regulation of actin filament bundle assembly GO:0032232 9 0.014
single organism nuclear import GO:1902593 104 0.014
translation GO:0006412 132 0.014
positive regulation of gtpase activity GO:0043547 166 0.014
multi organism cellular process GO:0044764 156 0.014
response to transforming growth factor beta GO:0071559 94 0.014
positive regulation of secretion by cell GO:1903532 108 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
positive regulation of map kinase activity GO:0043406 80 0.014
endochondral ossification GO:0001958 1 0.014
single organism reproductive process GO:0044702 98 0.014
Mouse
viral life cycle GO:0019058 132 0.014
response to metal ion GO:0010038 84 0.014
Fly
nucleoside phosphate catabolic process GO:1901292 412 0.014
cell part morphogenesis GO:0032990 137 0.014
prostaglandin secretion GO:0032310 2 0.014
cellular component morphogenesis GO:0032989 314 0.014
locomotory behavior GO:0007626 1 0.014
coagulation GO:0050817 78 0.014
response to ionizing radiation GO:0010212 65 0.014
peptidyl serine modification GO:0018209 106 0.014
negative regulation of map kinase activity GO:0043407 27 0.014
positive regulation of cell cycle process GO:0090068 106 0.013
positive regulation of cell projection organization GO:0031346 64 0.013
spermatid development GO:0007286 4 0.013
purine containing compound biosynthetic process GO:0072522 88 0.013
regulation of protein oligomerization GO:0032459 26 0.013
peptidyl lysine modification GO:0018205 144 0.013
mrna transport GO:0051028 30 0.013
innate immune response GO:0045087 178 0.013
regulation of purine nucleotide metabolic process GO:1900542 264 0.013
protein maturation GO:0051604 233 0.013
regulation of protein stability GO:0031647 87 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
cellular chemical homeostasis GO:0055082 180 0.013
secretion by cell GO:0032940 226 0.013
pattern specification process GO:0007389 43 0.013
mrna export from nucleus GO:0006406 29 0.013
sister chromatid segregation GO:0000819 54 0.013
response to transition metal nanoparticle GO:1990267 29 0.013
cyclic nucleotide metabolic process GO:0009187 82 0.013
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
reproductive system development GO:0061458 56 0.012
Mouse
regulation of actin filament bundle assembly GO:0032231 36 0.012
regulation of mitosis GO:0007088 63 0.012
spindle elongation GO:0051231 4 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
potassium ion transport GO:0006813 62 0.012
neurogenesis GO:0022008 169 0.012
mitotic sister chromatid separation GO:0051306 18 0.012
ribose phosphate biosynthetic process GO:0046390 82 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
monocarboxylic acid transport GO:0015718 32 0.012
organelle inheritance GO:0048308 2 0.012
protein deubiquitination GO:0016579 79 0.012
negative regulation of myeloid cell differentiation GO:0045638 42 0.012
regulation of protein import into nucleus GO:0042306 78 0.012
regulation of rho protein signal transduction GO:0035023 79 0.012
positive regulation of exosomal secretion GO:1903543 12 0.012
endosome to lysosome transport GO:0008333 21 0.012
cytokinesis GO:0000910 96 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
cell cycle checkpoint GO:0000075 117 0.012
oocyte maturation GO:0001556 1 0.012
negative regulation of multi organism process GO:0043901 92 0.012
arf protein signal transduction GO:0032011 0 0.012
regulation of translation GO:0006417 89 0.012
response to endoplasmic reticulum stress GO:0034976 49 0.012
Fly
regulation of cytoplasmic transport GO:1903649 149 0.012
embryo development ending in birth or egg hatching GO:0009792 34 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
regulation of growth GO:0040008 165 0.011
regulation of cell activation GO:0050865 125 0.011
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.011
negative regulation of neurotrophin trk receptor signaling pathway GO:0051387 2 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
neural tube patterning GO:0021532 2 0.011
protein acetylation GO:0006473 116 0.011
spindle organization GO:0007051 53 0.011
compound eye development GO:0048749 1 0.011
macromolecular complex disassembly GO:0032984 60 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
cyclic purine nucleotide metabolic process GO:0052652 60 0.011
positive regulation of intracellular transport GO:0032388 104 0.011
behavioral response to ethanol GO:0048149 2 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
branch elongation of an epithelium GO:0060602 3 0.011
response to nitrogen compound GO:1901698 184 0.011
cell adhesion GO:0007155 325 0.011
cellular protein complex disassembly GO:0043624 36 0.011
interleukin 8 production GO:0032637 51 0.011
reproductive structure development GO:0048608 55 0.011
Mouse
regulation of carbohydrate metabolic process GO:0006109 54 0.011
ras protein signal transduction GO:0007265 73 0.011
chromosome separation GO:0051304 23 0.011
rna export from nucleus GO:0006405 33 0.011
cellular lipid metabolic process GO:0044255 303 0.011
positive regulation of growth GO:0045927 58 0.011
regulation of chromosome organization GO:0033044 103 0.011
Fly
negative regulation of protein catabolic process GO:0042177 59 0.011
regulation of cell projection assembly GO:0060491 47 0.011
thymus development GO:0048538 3 0.011
single organismal cell cell adhesion GO:0016337 148 0.011
regulation of chromosome segregation GO:0051983 44 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
negative regulation of cell death GO:0060548 345 0.011
plasma membrane organization GO:0007009 115 0.011
signal transduction in response to dna damage GO:0042770 57 0.011
nucleocytoplasmic transport GO:0006913 176 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.010
regulation of cytokine production GO:0001817 232 0.010
blastoderm segmentation GO:0007350 2 0.010
nucleotide biosynthetic process GO:0009165 109 0.010
intracellular receptor signaling pathway GO:0030522 104 0.010
positive regulation of aldosterone metabolic process GO:0032346 2 0.010
protein depolymerization GO:0051261 30 0.010
positive regulation of multi organism process GO:0043902 56 0.010
regulation of meiosis GO:0040020 3 0.010
sensory perception GO:0007600 103 0.010
developmental process involved in reproduction GO:0003006 66 0.010
Mouse
regulation of secretion by cell GO:1903530 177 0.010
mitochondrion distribution GO:0048311 3 0.010
cell cycle phase transition GO:0044770 173 0.010
negative regulation of growth GO:0045926 97 0.010
ribonucleoprotein complex subunit organization GO:0071826 81 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
neutrophil differentiation GO:0030223 2 0.010
negative regulation of protein transport GO:0051224 75 0.010

MAP3K4 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.111
connective tissue disease DOID:65 109 0.077
bone disease DOID:0080001 88 0.040
central nervous system disease DOID:331 186 0.032
neurodegenerative disease DOID:1289 102 0.032
nervous system disease DOID:863 431 0.032
osteochondrodysplasia DOID:2256 35 0.025
bone development disease DOID:0080006 55 0.025
myopathy DOID:423 104 0.018
muscular disease DOID:0080000 114 0.018
muscle tissue disease DOID:66 113 0.018
neuropathy DOID:870 52 0.015
neuromuscular disease DOID:440 38 0.011
charcot marie tooth disease DOID:10595 33 0.011