IMP

Process View

Homo sapiens

1 genes annotated in human

Multi-species View

replacement ossification

GO:0036075

Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "replacement ossification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "replacement ossification" (in gray)

Name	Description	Probability	Func Analog Organism
ANGPT2	angiopoietin 2	0.863
BCAR1	breast cancer anti-estrogen resistance 1	0.641
ANGPT1	angiopoietin 1	0.370
COL6A1	collagen, type VI, alpha 1	0.369
HDAC4	histone deacetylase 4	0.366
LIMK1	LIM domain kinase 1	0.355
COL1A2	collagen, type I, alpha 2	0.290
SORBS3	sorbin and SH3 domain containing 3	0.227
IGFBP3	insulin-like growth factor binding protein 3	0.194
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.173
IL4R	interleukin 4 receptor	0.163
COL3A1	collagen, type III, alpha 1	0.146
SLAMF1	signaling lymphocytic activation molecule family member 1	0.144
BMP1	bone morphogenetic protein 1	0.125
SMAD3	SMAD family member 3	0.112
EPOR	erythropoietin receptor	0.096
C17orf28	chromosome 17 open reading frame 28	0.084
SPTBN1	spectrin, beta, non-erythrocytic 1	0.075
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.068
NID2	nidogen 2 (osteonidogen)	0.065
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.064
HDAC9	histone deacetylase 9	0.059
ZFYVE9	zinc finger, FYVE domain containing 9	0.057
COL5A1	collagen, type V, alpha 1	0.054
COL6A2	collagen, type VI, alpha 2	0.053
FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	0.053
LRP1	low density lipoprotein receptor-related protein 1	0.052
FURIN	furin (paired basic amino acid cleaving enzyme)	0.051
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.051	Mouse
COL7A1	collagen, type VII, alpha 1	0.050
COL4A1	collagen, type IV, alpha 1	0.042
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.040
LUM	lumican	0.036
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.035
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.035
PTPRB	protein tyrosine phosphatase, receptor type, B	0.034
ARRB1	arrestin, beta 1	0.034
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.033
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.031
MRC2	mannose receptor, C type 2	0.031
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.031
SORBS1	sorbin and SH3 domain containing 1	0.030
MFAP2	microfibrillar-associated protein 2	0.029
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.029
SH2D1B	SH2 domain containing 1B	0.029
FKBP10	FK506 binding protein 10, 65 kDa	0.026
FN1	fibronectin 1	0.025
TIMP2	TIMP metallopeptidase inhibitor 2	0.024
DUSP23	dual specificity phosphatase 23	0.022
MSX2	msh homeobox 2	0.022
COL1A1	collagen, type I, alpha 1	0.022	Mouse
INPPL1	inositol polyphosphate phosphatase-like 1	0.022
AUH	AU RNA binding protein/enoyl-CoA hydratase	0.022
EPAS1	endothelial PAS domain protein 1	0.021
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.020
DOK3	docking protein 3	0.020
LOXL2	lysyl oxidase-like 2	0.020
MAPK7	mitogen-activated protein kinase 7	0.019
LOX	lysyl oxidase	0.019
NRP2	neuropilin 2	0.019
BGN	biglycan	0.019
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.019
THY1	Thy-1 cell surface antigen	0.019
DDR2	discoidin domain receptor tyrosine kinase 2	0.018
MSX1	msh homeobox 1	0.018
ADAM12	ADAM metallopeptidase domain 12	0.018
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.018
VWF	von Willebrand factor	0.018
IGFBP5	insulin-like growth factor binding protein 5	0.018
FBLN1	fibulin 1	0.017
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.017
FYN	FYN oncogene related to SRC, FGR, YES	0.016
MYO1C	myosin IC	0.016
RTKN	rhotekin	0.016
RAB7A	RAB7A, member RAS oncogene family	0.016
DLG5	discs, large homolog 5 (Drosophila)	0.015
RUNX1	runt-related transcription factor 1	0.015
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.015
SOCS7	suppressor of cytokine signaling 7	0.015
COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	0.015
CTGF	connective tissue growth factor	0.015
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015
EHD2	EH-domain containing 2	0.015
WISP1	WNT1 inducible signaling pathway protein 1	0.015
CDH5	cadherin 5, type 2 (vascular endothelium)	0.015
IL4	interleukin 4	0.015
PRMT6	protein arginine methyltransferase 6	0.015
PXDN	peroxidasin homolog (Drosophila)	0.015
BMP2	bone morphogenetic protein 2	0.015
PDGFA	platelet-derived growth factor alpha polypeptide	0.014
TNC	tenascin C	0.014
PTRF	polymerase I and transcript release factor	0.014
COL11A1	collagen, type XI, alpha 1	0.014
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.014
BDNF	brain-derived neurotrophic factor	0.014
HMGA2	high mobility group AT-hook 2	0.014
SOX11	SRY (sex determining region Y)-box 11	0.014
COL8A2	collagen, type VIII, alpha 2	0.014
NBL1	neuroblastoma, suppression of tumorigenicity 1	0.014
FOXF2	forkhead box F2	0.013
HDAC5	histone deacetylase 5	0.013
GLI3	GLI family zinc finger 3	0.013
COL18A1	collagen, type XVIII, alpha 1	0.013
UNC5B	unc-5 homolog B (C. elegans)	0.013
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.013
ECE1	endothelin converting enzyme 1	0.013
CSPG4	chondroitin sulfate proteoglycan 4	0.013
ECM1	extracellular matrix protein 1	0.012
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.012
TMEM128	transmembrane protein 128	0.012
CRABP2	cellular retinoic acid binding protein 2	0.012
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.012
DENND4B	DENN/MADD domain containing 4B	0.012
RARG	retinoic acid receptor, gamma	0.012
ITGB4	integrin, beta 4	0.012
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.012
FGF7	fibroblast growth factor 7	0.011
PHYH	phytanoyl-CoA 2-hydroxylase	0.011
CNN1	calponin 1, basic, smooth muscle	0.011
SH2D1A	SH2 domain containing 1A	0.011
SH3GL3	SH3-domain GRB2-like 3	0.011
CELF2	CUGBP, Elav-like family member 2	0.011
SH3GL1	SH3-domain GRB2-like 1	0.011
PIGP	phosphatidylinositol glycan anchor biosynthesis, class P	0.011
VEGFA	vascular endothelial growth factor A	0.011
FNDC1	fibronectin type III domain containing 1	0.010
COL13A1	collagen, type XIII, alpha 1	0.010	Mouse
ATP5S	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)	0.010
COL10A1	collagen, type X, alpha 1	0.010
COL16A1	collagen, type XVI, alpha 1	0.010
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.010
PTK7	PTK7 protein tyrosine kinase 7	0.010
SH3KBP1	SH3-domain kinase binding protein 1	0.010
LTBP4	latent transforming growth factor beta binding protein 4	0.010
GSTCD	glutathione S-transferase, C-terminal domain containing	0.010
MYH10	myosin, heavy chain 10, non-muscle	0.010
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.010