Homo sapiens

205 known processes

NKX2-5

NK2 transcription factor related, locus 5 (Drosophila)

(Aliases: FLJ99536,FLJ97166,NKX2.5,FLJ52202,NKX2E,FLJ97197,FLJ97195,CHNG5,NKX4-1,CSX,CSX1)

NKX2-5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cardioblast differentiation GO:0051891 2 1.000
Mouse
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 1 1.000
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 1.000
luteinizing hormone secretion GO:0032275 1 1.000
foramen ovale closure GO:0035922 1 1.000
pulmonary vein morphogenesis GO:0060577 1 1.000
follicle stimulating hormone secretion GO:0046884 3 1.000
limb bud formation GO:0060174 1 1.000
outflow tract septum morphogenesis GO:0003148 4 1.000
cardiac ventricle formation GO:0003211 2 1.000
Mouse
cardiac atrium morphogenesis GO:0003209 7 1.000
regulation of cardioblast differentiation GO:0051890 4 1.000
Mouse
heart formation GO:0060914 2 1.000
cardiac chamber formation GO:0003207 2 1.000
Mouse
regulation of thyroid hormone generation GO:2000609 2 1.000
aortic valve development GO:0003176 3 1.000
soft palate development GO:0060023 3 0.999
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 3 0.999
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.999
cardiac cell fate determination GO:0060913 3 0.999
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 0.999
organ formation GO:0048645 3 0.999
atrial septum morphogenesis GO:0060413 5 0.998
cardiac conduction system development GO:0003161 2 0.998
forelimb morphogenesis GO:0035136 4 0.998
cardiac right ventricle morphogenesis GO:0003215 3 0.998
cardiac muscle cell proliferation GO:0060038 6 0.997
Mouse
endocardial cushion development GO:0003197 3 0.997
cardiac left ventricle formation GO:0003218 1 0.996
cranial nerve development GO:0021545 4 0.995
eosinophil differentiation GO:0030222 2 0.994
cd8 positive alpha beta t cell activation GO:0036037 3 0.993
regulation of heart growth GO:0060420 4 0.992
Mouse
regulation of cardiac muscle tissue development GO:0055024 13 0.991
Mouse
endocrine system development GO:0035270 26 0.990
negative regulation of cardiac muscle tissue development GO:0055026 7 0.988
atrial septum development GO:0003283 8 0.988
embryonic viscerocranium morphogenesis GO:0048703 1 0.987
cardiac septum morphogenesis GO:0060411 9 0.984
cardiac ventricle morphogenesis GO:0003208 20 0.983
cardiac atrium development GO:0003230 10 0.983
embryonic heart tube morphogenesis GO:0003143 8 0.981
Mouse
pericardium development GO:0060039 2 0.979
male genitalia development GO:0030539 1 0.975
atrioventricular valve morphogenesis GO:0003181 2 0.974
ventricular cardiac muscle tissue development GO:0003229 14 0.974
atrioventricular valve development GO:0003171 3 0.972
mesenchyme development GO:0060485 59 0.968
Human Mouse
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.967
regulation of stem cell differentiation GO:2000736 56 0.963
Human Mouse
thymus development GO:0048538 3 0.956
cardiac chamber morphogenesis GO:0003206 26 0.952
positive regulation of stem cell differentiation GO:2000738 29 0.952
Mouse
cardiac muscle tissue development GO:0048738 39 0.951
positive regulation of cardiac muscle tissue growth GO:0055023 2 0.951
cardiac chamber development GO:0003205 30 0.949
aortic valve morphogenesis GO:0003180 3 0.949
regulation of muscle cell differentiation GO:0051147 31 0.939
heart valve formation GO:0003188 2 0.938
positive regulation of heart growth GO:0060421 2 0.937
blastoderm segmentation GO:0007350 2 0.936
negative regulation of heart growth GO:0061117 2 0.935
lymphocyte migration GO:0072676 28 0.935
muscle cell proliferation GO:0033002 35 0.934
Mouse
negative regulation of striated muscle tissue development GO:0045843 11 0.930
anterior posterior axis specification embryo GO:0008595 2 0.923
venous blood vessel development GO:0060841 2 0.920
Mouse
segmentation GO:0035282 4 0.919
regulation of organ formation GO:0003156 4 0.919
optic nerve development GO:0021554 2 0.917
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.915
heart morphogenesis GO:0003007 48 0.914
embryonic digit morphogenesis GO:0042733 6 0.912
pharyngeal system development GO:0060037 2 0.907
Mouse
regulation of heart morphogenesis GO:2000826 4 0.904
cardiocyte differentiation GO:0035051 23 0.900
Mouse Rat
organ morphogenesis GO:0009887 147 0.897
regulation of striated muscle cell differentiation GO:0051153 25 0.896
positive regulation of muscle organ development GO:0048636 7 0.891
septum secundum development GO:0003285 2 0.890
regulation of striated muscle tissue development GO:0016202 26 0.886
Mouse
tube development GO:0035295 125 0.880
Human Mouse Worm
negative regulation of cellular component movement GO:0051271 106 0.877
Human
cardiac muscle tissue growth GO:0055017 6 0.876
Mouse
embryonic cranial skeleton morphogenesis GO:0048701 6 0.861
cell fate determination GO:0001709 3 0.858
cd8 positive alpha beta t cell differentiation GO:0043374 1 0.856
cardiac ventricle development GO:0003231 23 0.850
regulation of hormone levels GO:0010817 125 0.849
positive regulation of interleukin 5 production GO:0032754 3 0.843
epithelium development GO:0060429 227 0.840
Human Mouse
cardiac muscle cell differentiation GO:0055007 15 0.830
Mouse Rat
regulation of cell differentiation GO:0045595 393 0.827
heart growth GO:0060419 6 0.819
Mouse
transdifferentiation GO:0060290 2 0.816
heart development GO:0007507 95 0.803
female genitalia development GO:0030540 2 0.788
circulatory system development GO:0072359 262 0.779
leukocyte migration GO:0050900 107 0.764
stem cell differentiation GO:0048863 93 0.757
Human Mouse
atrioventricular valve formation GO:0003190 1 0.756
negative regulation of cell differentiation GO:0045596 171 0.755
negative regulation of muscle organ development GO:0048635 12 0.749
cardiac septum development GO:0003279 13 0.740
heart looping GO:0001947 7 0.739
Mouse
epithelial tube morphogenesis GO:0060562 38 0.739
Human Mouse
negative regulation of developmental process GO:0051093 247 0.732
skeletal system development GO:0001501 79 0.711
negative regulation of cell motility GO:2000146 104 0.706
Human
positive regulation of organ growth GO:0046622 2 0.695
negative regulation of muscle tissue development GO:1901862 11 0.684
embryonic morphogenesis GO:0048598 85 0.674
Mouse
negative regulation of cell death GO:0060548 345 0.667
positive regulation of cell proliferation GO:0008284 301 0.665
Mouse
secretion GO:0046903 254 0.663
cellular ketone metabolic process GO:0042180 80 0.659
tube morphogenesis GO:0035239 95 0.656
Human Mouse
hormone secretion GO:0046879 65 0.655
anterior posterior axis specification GO:0009948 2 0.650
vasculature development GO:0001944 181 0.639
Mouse
regulation of cell development GO:0060284 161 0.637
regulation of cell cycle GO:0051726 393 0.633
blood vessel morphogenesis GO:0048514 162 0.631
Mouse
negative regulation of cardiac muscle tissue growth GO:0055022 2 0.626
heart valve morphogenesis GO:0003179 8 0.623
positive regulation of cardiac muscle tissue development GO:0055025 6 0.614
regulation of anatomical structure morphogenesis GO:0022603 286 0.613
Human
determination of bilateral symmetry GO:0009855 15 0.609
Mouse
cell proliferation involved in heart morphogenesis GO:0061323 1 0.608
venous blood vessel morphogenesis GO:0048845 1 0.602
male sex differentiation GO:0046661 25 0.602
negative regulation of multicellular organismal process GO:0051241 317 0.595
Human
kidney development GO:0001822 53 0.595
heart valve development GO:0003170 8 0.593
negative regulation of cell proliferation GO:0008285 228 0.590
amine metabolic process GO:0009308 44 0.587
cardioblast differentiation GO:0010002 8 0.580
Mouse
negative regulation of cell migration GO:0030336 102 0.578
Human
regulation of cell migration GO:0030334 289 0.576
Human
cardiovascular system development GO:0072358 262 0.574
regulation of myoblast differentiation GO:0045661 12 0.572
immune system development GO:0002520 195 0.572
tripartite regional subdivision GO:0007351 2 0.571
spinal cord development GO:0021510 4 0.570
cellular amine metabolic process GO:0044106 41 0.567
muscle cell development GO:0055001 29 0.563
Mouse
positive regulation of cell cycle GO:0045787 140 0.556
cell development GO:0048468 328 0.556
muscle structure development GO:0061061 98 0.553
cell cell signaling GO:0007267 155 0.551
striated muscle tissue development GO:0014706 59 0.549
morphogenesis of an epithelium GO:0002009 60 0.545
Human Mouse
cellular senescence GO:0090398 34 0.542
renal system development GO:0072001 63 0.540
positive regulation of cell differentiation GO:0045597 211 0.537
striated muscle cell differentiation GO:0051146 43 0.536
hematopoietic or lymphoid organ development GO:0048534 186 0.533
regulation of cellular amine metabolic process GO:0033238 11 0.531
blood vessel development GO:0001568 172 0.531
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 284 0.530
Mouse
ventricular septum development GO:0003281 5 0.529
response to biotic stimulus GO:0009607 276 0.517
digestive system development GO:0055123 75 0.515
Worm
positive regulation of developmental process GO:0051094 314 0.515
embryonic skeletal system development GO:0048706 13 0.512
regulation of cardiac muscle tissue growth GO:0055021 4 0.511
Mouse
regulation of myotube differentiation GO:0010830 18 0.504
embryonic limb morphogenesis GO:0030326 9 0.504
regulation of muscle tissue development GO:1901861 26 0.503
Mouse
regulation of cell motility GO:2000145 299 0.498
Human
hormone transport GO:0009914 68 0.488
blood circulation GO:0008015 113 0.474
Mouse
immune effector process GO:0002252 159 0.466
embryonic skeletal system morphogenesis GO:0048704 9 0.463
chordate embryonic development GO:0043009 34 0.459
Mouse
outflow tract morphogenesis GO:0003151 10 0.456
formation of primary germ layer GO:0001704 42 0.452
hemopoiesis GO:0030097 180 0.450
Mouse
gland development GO:0048732 48 0.449
myoblast differentiation GO:0045445 21 0.446
muscle cell differentiation GO:0042692 63 0.444
enzyme linked receptor protein signaling pathway GO:0007167 303 0.443
Human Mouse
embryonic appendage morphogenesis GO:0035113 9 0.438
skeletal system morphogenesis GO:0048705 24 0.438
interleukin 13 secretion GO:0072611 2 0.436
specification of symmetry GO:0009799 16 0.432
Mouse
muscle contraction GO:0006936 73 0.429
Mouse
immune response GO:0006955 307 0.428
cardiac muscle cell myoblast differentiation GO:0060379 5 0.424
palate development GO:0060021 13 0.424
signal release GO:0023061 70 0.423
amide biosynthetic process GO:0043604 15 0.419
lung development GO:0030324 20 0.413
Human
specification of organ identity GO:0010092 3 0.407
basophil differentiation GO:0030221 2 0.404
pattern specification process GO:0007389 43 0.402
Mouse
muscle organ development GO:0007517 56 0.400
cell activation GO:0001775 213 0.396
determination of left right symmetry GO:0007368 11 0.394
Mouse
regulation of locomotion GO:0040012 329 0.393
Human
positive regulation of striated muscle tissue development GO:0045844 7 0.392
leukocyte differentiation GO:0002521 98 0.389
cardiac muscle adaptation GO:0014887 4 0.387
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.386
response to other organism GO:0051707 261 0.385
regulation of secretion by cell GO:1903530 177 0.382
negative regulation of growth GO:0045926 97 0.382
regulation of organ morphogenesis GO:2000027 24 0.381
tissue morphogenesis GO:0048729 96 0.380
positive regulation of tooth mineralization GO:0070172 2 0.378
secretion by cell GO:0032940 226 0.377
response to external biotic stimulus GO:0043207 261 0.374
muscle organ morphogenesis GO:0048644 19 0.367
system process GO:0003008 349 0.366
Mouse
digestive tract development GO:0048565 75 0.364
Worm
cardiac cell fate commitment GO:0060911 7 0.363
Mouse
positive regulation of transport GO:0051050 336 0.358
Mouse
appendage morphogenesis GO:0035107 16 0.358
forebrain regionalization GO:0021871 3 0.349
t cell activation GO:0042110 99 0.347
cellular response to endogenous stimulus GO:0071495 336 0.343
Human
cell aging GO:0007569 52 0.337
negative regulation of locomotion GO:0040013 118 0.335
Human
nervous system development GO:0007399 293 0.334
regulation of cell proliferation involved in heart morphogenesis GO:2000136 1 0.333
cellular component disassembly GO:0022411 92 0.326
apoptotic nuclear changes GO:0030262 13 0.321
skeletal muscle fiber development GO:0048741 12 0.317
embryonic forelimb morphogenesis GO:0035115 4 0.314
regulation of cellular component movement GO:0051270 334 0.313
Human
alpha beta t cell differentiation GO:0046632 7 0.312
response to wounding GO:0009611 168 0.309
morphogenesis of an epithelial sheet GO:0002011 12 0.307
eosinophil fate commitment GO:0035854 2 0.304
sensory organ morphogenesis GO:0090596 21 0.300
cardiac muscle hypertrophy in response to stress GO:0014898 4 0.298
bmp signaling pathway GO:0030509 49 0.297
Mouse
endoderm formation GO:0001706 33 0.295
respiratory system development GO:0060541 22 0.290
Human
alpha beta t cell differentiation involved in immune response GO:0002293 5 0.285
cell differentiation in spinal cord GO:0021515 1 0.280
negative regulation of apoptotic process GO:0043066 316 0.274
embryonic organ development GO:0048568 36 0.272
Human Mouse
determination of heart left right asymmetry GO:0061371 8 0.272
Mouse
parathyroid gland development GO:0060017 2 0.270
cardioblast cell fate commitment GO:0042684 1 0.269
head development GO:0060322 108 0.269
Human
hemostasis GO:0007599 76 0.268
cardiac muscle tissue morphogenesis GO:0055008 18 0.267
regeneration GO:0031099 4 0.266
platelet formation GO:0030220 4 0.264
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.263
Human Mouse
appendage development GO:0048736 23 0.260
mesonephric duct development GO:0072177 3 0.260
thyroid hormone generation GO:0006590 2 0.257
positive regulation of cell motility GO:2000147 177 0.245
mesenchymal cell development GO:0014031 50 0.243
Human
regulation of protein transport GO:0051223 213 0.238
regulation of interleukin 5 secretion GO:2000662 2 0.237
embryonic heart tube development GO:0035050 9 0.236
Human Mouse
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 6 0.233
generation of neurons GO:0048699 152 0.232
regulation of muscle organ development GO:0048634 27 0.232
Mouse
organonitrogen compound biosynthetic process GO:1901566 200 0.230
cell morphogenesis GO:0000902 296 0.230
Human
striated muscle cell development GO:0055002 27 0.227
Mouse
mammary gland development GO:0030879 17 0.226
regionalization GO:0003002 29 0.220
Mouse
regulation of hormone metabolic process GO:0032350 14 0.219
endoderm development GO:0007492 33 0.218
positive regulation of erythrocyte differentiation GO:0045648 11 0.218
mesoderm development GO:0007498 14 0.217
carbohydrate derivative biosynthetic process GO:1901137 207 0.213
organ growth GO:0035265 12 0.212
Mouse
positive regulation of secretion by cell GO:1903532 108 0.211
muscle fiber development GO:0048747 16 0.208
brain development GO:0007420 97 0.207
Human
lymphocyte activation GO:0046649 133 0.203
interleukin 5 secretion GO:0072603 2 0.202
leukocyte activation GO:0045321 164 0.200
negative regulation of myoblast differentiation GO:0045662 7 0.199
positive regulation of cell migration GO:0030335 172 0.197
skeletal muscle organ development GO:0060538 26 0.196
peptidyl tyrosine modification GO:0018212 170 0.195
blood coagulation GO:0007596 76 0.193
extraocular skeletal muscle development GO:0002074 1 0.192
limb development GO:0060173 23 0.192
wnt signaling pathway GO:0016055 156 0.189
Mouse
central nervous system development GO:0007417 123 0.187
Human
coagulation GO:0050817 78 0.185
myotube differentiation GO:0014902 22 0.184
actin filament based movement GO:0030048 17 0.184
execution phase of apoptosis GO:0097194 32 0.183
cytokine production GO:0001816 247 0.181
muscle tissue development GO:0060537 62 0.180
alpha beta t cell activation involved in immune response GO:0002287 5 0.179
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.179
epithelial cell migration GO:0010631 119 0.177
regulation of skeletal muscle fiber development GO:0048742 12 0.176
ameboidal type cell migration GO:0001667 135 0.174
positive regulation of thyroid hormone generation GO:2000611 2 0.173
striated muscle cell proliferation GO:0014855 7 0.173
Mouse
sensory organ development GO:0007423 52 0.172
limb morphogenesis GO:0035108 16 0.172
actin mediated cell contraction GO:0070252 12 0.172
cardiac left ventricle morphogenesis GO:0003214 6 0.171
regulation of multi organism process GO:0043900 157 0.168
embryo development GO:0009790 123 0.166
Human Mouse
regulation of cytokine production GO:0001817 232 0.165
neurogenesis GO:0022008 169 0.164
menstrual cycle phase GO:0022601 2 0.163
response to cytokine GO:0034097 232 0.162
regulation of epithelial cell migration GO:0010632 93 0.161
tissue migration GO:0090130 119 0.155
embryonic digestive tract morphogenesis GO:0048557 2 0.154
regulation of interleukin 5 production GO:0032674 6 0.153
glucose homeostasis GO:0042593 31 0.153
cell fate commitment GO:0045165 27 0.153
Mouse
cell morphogenesis involved in differentiation GO:0000904 144 0.150
Human
response to abiotic stimulus GO:0009628 336 0.150
t cell differentiation involved in immune response GO:0002292 7 0.150
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.149
skeletal muscle tissue development GO:0007519 24 0.148
glycoprotein biosynthetic process GO:0009101 91 0.148
growth GO:0040007 202 0.146
Mouse
regulation of growth GO:0040008 165 0.144
Mouse
striated muscle contraction GO:0006941 52 0.144
Mouse
digestive tract morphogenesis GO:0048546 56 0.143
regulation of male gonad development GO:2000018 4 0.140
camera type eye development GO:0043010 25 0.138
chemical homeostasis GO:0048878 306 0.137
hair follicle morphogenesis GO:0031069 2 0.137
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.136
positive regulation of interleukin 5 secretion GO:2000664 1 0.135
tissue remodeling GO:0048771 16 0.134
negative regulation of programmed cell death GO:0043069 321 0.133
regulation of defense response GO:0031347 154 0.133
gastrulation GO:0007369 51 0.133
positive regulation of cellular component movement GO:0051272 181 0.132
regulation of muscle system process GO:0090257 53 0.131
Mouse
regulation of heart contraction GO:0008016 50 0.128
Mouse
embryonic pattern specification GO:0009880 5 0.128
defense response GO:0006952 315 0.127
myeloid cell differentiation GO:0030099 117 0.126
positive regulation of protein transport GO:0051222 135 0.124
fat cell proliferation GO:0070341 2 0.124
regulation of antimicrobial humoral response GO:0002759 1 0.124
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.121
cellular response to cytokine stimulus GO:0071345 181 0.120
positive regulation of cell development GO:0010720 92 0.119
single organismal cell cell adhesion GO:0016337 148 0.118
regulation of dermatome development GO:0061183 3 0.117
cell activation involved in immune response GO:0002263 30 0.117
positive regulation of protein secretion GO:0050714 60 0.116
forebrain generation of neurons GO:0021872 3 0.115
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.115
retina development in camera type eye GO:0060041 15 0.115
humoral immune response GO:0006959 49 0.113
angiogenesis GO:0001525 147 0.111
cardiac muscle contraction GO:0060048 34 0.110
Mouse
regulation of protein localization GO:0032880 296 0.109
pituitary gland development GO:0021983 2 0.108
cell adhesion GO:0007155 325 0.107
positive regulation of odontogenesis GO:0042482 3 0.107
female sex differentiation GO:0046660 12 0.106
reproductive structure development GO:0048608 55 0.106
leukocyte activation involved in immune response GO:0002366 30 0.106
regulation of apoptotic signaling pathway GO:2001233 175 0.104
wnt signaling pathway involved in wound healing spreading of epidermal cells GO:0035659 1 0.104
cell type specific apoptotic process GO:0097285 125 0.104
regulation of definitive erythrocyte differentiation GO:0010724 2 0.103
regulation of cellular amino acid metabolic process GO:0006521 6 0.103
thyroid hormone metabolic process GO:0042403 4 0.103
organic hydroxy compound metabolic process GO:1901615 147 0.103
apoptotic signaling pathway GO:0097190 268 0.102
negative regulation of cell cycle GO:0045786 193 0.102
post embryonic development GO:0009791 2 0.102
cellular response to gonadotropin stimulus GO:0071371 4 0.101
response to oxygen containing compound GO:1901700 369 0.101
Rat
cellular modified amino acid metabolic process GO:0006575 64 0.099
positive regulation of secretion GO:0051047 116 0.098
hindbrain development GO:0030902 3 0.098
dermatome development GO:0061054 3 0.098
stem cell development GO:0048864 69 0.097
Human
regulation of binding GO:0051098 111 0.097
positive regulation of epithelial cell migration GO:0010634 55 0.096
male gonad development GO:0008584 23 0.096
positive regulation of homeostatic process GO:0032846 47 0.096
tissue regeneration GO:0042246 3 0.096
erythrocyte development GO:0048821 3 0.095
heart process GO:0003015 62 0.095
Mouse
epidermis morphogenesis GO:0048730 3 0.093
negative regulation of binding GO:0051100 57 0.091
heart field specification GO:0003128 2 0.091
epithelial cell development GO:0002064 34 0.091
eye morphogenesis GO:0048592 16 0.090
cell projection organization GO:0030030 252 0.089
response to steroid hormone GO:0048545 80 0.089
Rat
biological adhesion GO:0022610 331 0.088
reproductive process GO:0022414 106 0.088
positive regulation of developmental growth GO:0048639 16 0.088
epithelial cell differentiation GO:0030855 141 0.087
response to lipid GO:0033993 206 0.087
Rat
regulation of transcription regulatory region dna binding GO:2000677 15 0.087
regulation of vasculature development GO:1901342 97 0.086
regulation of skeletal muscle tissue development GO:0048641 15 0.085
sex differentiation GO:0007548 45 0.085
cellular response to oxygen containing compound GO:1901701 276 0.085
regulation of striated muscle contraction GO:0006942 37 0.085
Mouse
cell proliferation in forebrain GO:0021846 1 0.084
bmp signaling pathway involved in heart development GO:0061312 3 0.084
endodermal cell fate commitment GO:0001711 4 0.084
response to growth factor GO:0070848 205 0.084
Human Rat
single organism reproductive process GO:0044702 98 0.083
neuron projection development GO:0031175 106 0.082
forebrain neuron differentiation GO:0021879 3 0.082
negative regulation of organ growth GO:0046621 5 0.081
positive regulation of apoptotic process GO:0043065 246 0.081
hematopoietic progenitor cell differentiation GO:0002244 38 0.079
negative regulation of fat cell proliferation GO:0070345 1 0.079
development of primary male sexual characteristics GO:0046546 23 0.079
signal transduction in absence of ligand GO:0038034 22 0.078
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.076
metencephalon development GO:0022037 2 0.076
platelet morphogenesis GO:0036344 4 0.075
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.075
cellular response to tumor necrosis factor GO:0071356 63 0.075
canonical wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 2 0.074
forebrain dorsal ventral pattern formation GO:0021798 1 0.074
positive regulation of cell death GO:0010942 263 0.073
negative regulation of neural precursor cell proliferation GO:2000178 1 0.073
cartilage condensation GO:0001502 1 0.073
negative regulation of response to external stimulus GO:0032102 83 0.073
cellular amino acid metabolic process GO:0006520 116 0.073
t cell differentiation GO:0030217 29 0.072
odontogenesis GO:0042476 25 0.072
cellular response to abiotic stimulus GO:0071214 117 0.071
chromatin organization GO:0006325 351 0.071
neuron development GO:0048666 113 0.071
atrial septum secundum morphogenesis GO:0003290 1 0.070
negative regulation of epithelial cell proliferation GO:0050680 48 0.070
myotube cell development GO:0014904 14 0.069
negative regulation of cell development GO:0010721 48 0.068
Human
negative regulation of developmental growth GO:0048640 10 0.068
negative regulation of apoptotic signaling pathway GO:2001234 97 0.068
regulation of cytokine secretion GO:0050707 57 0.067
neuron fate commitment GO:0048663 2 0.067
regulation of cellular ketone metabolic process GO:0010565 50 0.067
amide transport GO:0042886 76 0.065
ribonucleotide catabolic process GO:0009261 405 0.065
pancreas development GO:0031016 19 0.064
endodermal cell fate specification GO:0001714 4 0.064
ribonucleoside catabolic process GO:0042454 406 0.064
lymphocyte activation involved in immune response GO:0002285 20 0.064
lymphocyte differentiation GO:0030098 35 0.064
regulation of muscle contraction GO:0006937 45 0.063
Mouse
positive regulation of growth GO:0045927 58 0.063
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.063
anterior posterior pattern specification GO:0009952 9 0.062
platelet activation GO:0030168 44 0.062
regulation of bmp signaling pathway GO:0030510 27 0.062
kidney epithelium development GO:0072073 25 0.062
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.062
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.062
regulation of homeostatic process GO:0032844 121 0.061
single organism cell adhesion GO:0098602 179 0.061
inner ear morphogenesis GO:0042472 4 0.061
reproductive system development GO:0061458 56 0.060
peptide metabolic process GO:0006518 51 0.060
cytokine secretion GO:0050663 64 0.060
signal transduction by phosphorylation GO:0023014 297 0.060
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.059
regulation of mitotic cell cycle GO:0007346 189 0.059
regulation of proteolysis GO:0030162 293 0.058
nucleotide catabolic process GO:0009166 408 0.058
regulation of cellular response to x ray GO:2000683 2 0.058
atrial septum primum morphogenesis GO:0003289 1 0.058
positive regulation of immune system process GO:0002684 283 0.058
regulation of inflammatory response GO:0050727 46 0.056
ribonucleoside triphosphate metabolic process GO:0009199 412 0.056
regulation of actin filament based process GO:0032970 141 0.055
negative regulation of stem cell differentiation GO:2000737 22 0.055
Human
mapk cascade GO:0000165 288 0.055
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.054
t cell activation involved in immune response GO:0002286 13 0.054
regulation of nervous system development GO:0051960 88 0.054
nucleoside phosphate catabolic process GO:1901292 412 0.054
right ventricular cardiac muscle tissue morphogenesis GO:0003221 2 0.053

NKX2-5 disease predictions

Disease DO term ID Size Probability Func Analog Org
congenital heart disease DOID:1682 16 0.958
heart septal defect DOID:1681 14 0.958
heart disease DOID:114 68 0.958
cardiovascular system disease DOID:1287 106 0.958
atrial heart septal defect DOID:1882 8 0.790
tetralogy of fallot DOID:6419 7 0.611
disease of metabolism DOID:0014667 295 0.099
musculoskeletal system disease DOID:17 223 0.059