Homo sapiens

205 known processes

PINK1

PTEN induced putative kinase 1

(Aliases: PARK6,BRPK,FLJ27236)

PINK1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
autophagy GO:0006914 88 0.958
protein modification by small protein conjugation GO:0032446 342 0.834
regulation of kinase activity GO:0043549 314 0.717
protein localization to organelle GO:0033365 280 0.676
protein localization to mitochondrion GO:0070585 25 0.634
mitochondrion degradation GO:0000422 8 0.626
regulation of transferase activity GO:0051338 355 0.572
negative regulation of developmental process GO:0051093 247 0.424
Fly
cellular amino acid metabolic process GO:0006520 116 0.421
negative regulation of protein metabolic process GO:0051248 391 0.417
mitochondrial transport GO:0006839 60 0.402
single organism membrane organization GO:0044802 268 0.375
Fly
negative regulation of organelle organization GO:0010639 126 0.369
Fly
small molecule biosynthetic process GO:0044283 157 0.345
negative regulation of cellular component organization GO:0051129 235 0.318
Fly
regulation of protein kinase activity GO:0045859 289 0.302
negative regulation of mitochondrial fusion GO:0010637 4 0.293
Fly
mitochondrion organization GO:0007005 156 0.286
cellular response to external stimulus GO:0071496 111 0.280
cellular ketone metabolic process GO:0042180 80 0.277
cellular lipid metabolic process GO:0044255 303 0.274
cellular protein catabolic process GO:0044257 261 0.274
Fly
amine metabolic process GO:0009308 44 0.257
regulation of carbohydrate metabolic process GO:0006109 54 0.254
intracellular protein transport GO:0006886 270 0.252
regulation of oxidative stress induced neuron death GO:1903203 9 0.252
regulation of cellular amino acid metabolic process GO:0006521 6 0.245
regulation of cellular ketone metabolic process GO:0010565 50 0.228
negative regulation of cellular protein metabolic process GO:0032269 353 0.222
establishment of protein localization to mitochondrion GO:0072655 22 0.218
cellular response to oxidative stress GO:0034599 85 0.214
system process GO:0003008 349 0.213
regulation of binding GO:0051098 111 0.205
response to extracellular stimulus GO:0009991 85 0.201
cytoplasmic transport GO:0016482 379 0.199
negative regulation of cell death GO:0060548 345 0.196
dopamine uptake involved in synaptic transmission GO:0051583 4 0.192
positive regulation of catabolic process GO:0009896 310 0.181
negative regulation of transferase activity GO:0051348 124 0.180
neurotransmitter secretion GO:0007269 4 0.179
regulation of autophagy GO:0010506 52 0.178
cellular amine metabolic process GO:0044106 41 0.177
negative regulation of phosphate metabolic process GO:0045936 267 0.175
regulation of cellular response to oxidative stress GO:1900407 26 0.175
regulation of neurotransmitter secretion GO:0046928 3 0.175
negative regulation of programmed cell death GO:0043069 321 0.166
single organism cellular localization GO:1902580 332 0.158
regulation of cellular amine metabolic process GO:0033238 11 0.157
neuron death in response to oxidative stress GO:0036475 9 0.155
negative regulation of kinase activity GO:0033673 106 0.154
negative regulation of protein phosphorylation GO:0001933 140 0.153
locomotory behavior GO:0007626 1 0.153
lipid metabolic process GO:0006629 381 0.152
hematopoietic or lymphoid organ development GO:0048534 186 0.148
Zebrafish
cell death in response to oxidative stress GO:0036473 29 0.147
chemical homeostasis GO:0048878 306 0.147
regulation of cellular component biogenesis GO:0044087 281 0.146
cation transport GO:0006812 331 0.141
Mouse
adult locomotory behavior GO:0008344 1 0.141
organelle fusion GO:0048284 36 0.140
Fly
negative regulation of phosphorylation GO:0042326 174 0.137
negative regulation of cytoskeleton organization GO:0051494 45 0.132
musculoskeletal movement GO:0050881 17 0.132
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.131
macroautophagy GO:0016236 39 0.129
regulation of oxidative stress induced cell death GO:1903201 24 0.128
monocarboxylic acid metabolic process GO:0032787 185 0.127
regulation of response to oxidative stress GO:1902882 26 0.127
positive regulation of cellular catabolic process GO:0031331 284 0.126
post embryonic development GO:0009791 2 0.125
cellular carbohydrate metabolic process GO:0044262 84 0.124
vacuole organization GO:0007033 44 0.122
membrane organization GO:0061024 292 0.120
Fly
negative regulation of phosphorus metabolic process GO:0010563 267 0.119
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.118
single organism membrane fusion GO:0044801 37 0.117
Fly
oogenesis GO:0048477 2 0.113
membrane fusion GO:0061025 43 0.112
Fly
establishment of protein localization to organelle GO:0072594 172 0.110
negative regulation of cellular response to oxidative stress GO:1900408 18 0.107
cellular homeostasis GO:0019725 196 0.105
regulation of cellular response to stress GO:0080135 244 0.105
regulation of protein serine threonine kinase activity GO:0071900 179 0.105
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.104
female gamete generation GO:0007292 2 0.100
negative regulation of cellular amine metabolic process GO:0033239 3 0.099
negative regulation of catalytic activity GO:0043086 335 0.098
cellular response to starvation GO:0009267 58 0.096
organic hydroxy compound metabolic process GO:1901615 147 0.096
multicellular organismal movement GO:0050879 17 0.093
positive regulation of developmental process GO:0051094 314 0.089
Fly
negative regulation of mitotic cell cycle GO:0045930 102 0.088
regulation of cell cycle GO:0051726 393 0.087
negative regulation of multicellular organismal process GO:0051241 317 0.087
determination of adult lifespan GO:0008340 2 0.085
catecholamine uptake involved in synaptic transmission GO:0051934 4 0.084
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.080
regulation of protein catabolic process GO:0042176 155 0.080
protein targeting GO:0006605 187 0.080
negative regulation of leukocyte differentiation GO:1902106 24 0.077
carboxylic acid biosynthetic process GO:0046394 97 0.076
carbohydrate metabolic process GO:0005975 207 0.075
positive regulation of protein phosphorylation GO:0001934 313 0.074
response to nutrient levels GO:0031667 81 0.074
single organism carbohydrate metabolic process GO:0044723 193 0.073
regulation of cytoskeleton organization GO:0051493 177 0.073
sulfur compound biosynthetic process GO:0044272 38 0.072
cellular response to cytokine stimulus GO:0071345 181 0.072
regulation of proteasomal protein catabolic process GO:0061136 87 0.072
regulation of stress activated mapk cascade GO:0032872 84 0.071
protein polyubiquitination GO:0000209 110 0.071
regulation of cell cycle process GO:0010564 266 0.071
modification dependent macromolecule catabolic process GO:0043632 212 0.070
Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.070
Fly
regulation of leukocyte differentiation GO:1902105 61 0.069
regulation of glucokinase activity GO:0033131 2 0.069
protein targeting to mitochondrion GO:0006626 19 0.069
catecholamine uptake GO:0090493 4 0.068
ubiquitin dependent protein catabolic process GO:0006511 206 0.066
Fly
regulation of actin cytoskeleton organization GO:0032956 116 0.065
positive regulation of autophagy GO:0010508 24 0.064
organophosphate biosynthetic process GO:0090407 163 0.064
signal transduction by phosphorylation GO:0023014 297 0.063
secretion GO:0046903 254 0.063
Mouse
apoptotic signaling pathway GO:0097190 268 0.062
organic acid biosynthetic process GO:0016053 97 0.062
negative regulation of apoptotic signaling pathway GO:2001234 97 0.061
behavior GO:0007610 112 0.060
regulation of cell activation GO:0050865 125 0.060
cellular response to extracellular stimulus GO:0031668 72 0.059
lipid biosynthetic process GO:0008610 177 0.058
multicellular organismal aging GO:0010259 3 0.057
negative regulation of response to oxidative stress GO:1902883 18 0.056
regulation of protein binding GO:0043393 66 0.056
regulation of cell differentiation GO:0045595 393 0.055
regulation of mapk cascade GO:0043408 262 0.055
regulation of jnk cascade GO:0046328 73 0.055
cell cycle g1 s phase transition GO:0044843 80 0.055
response to lipid GO:0033993 206 0.055
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.054
small molecule catabolic process GO:0044282 92 0.054
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.054
negative regulation of protein kinase activity GO:0006469 98 0.052
negative regulation of oxidative stress induced cell death GO:1903202 17 0.052
positive regulation of cell death GO:0010942 263 0.052
internal peptidyl lysine acetylation GO:0018393 97 0.051
organelle assembly GO:0070925 176 0.049
regulation of leukocyte activation GO:0002694 115 0.048
glucose metabolic process GO:0006006 45 0.048
negative regulation of leukocyte activation GO:0002695 26 0.047
regulation of lipid metabolic process GO:0019216 96 0.047
cellular macromolecule catabolic process GO:0044265 380 0.046
Fly
sulfur compound metabolic process GO:0006790 101 0.046
cellular chemical homeostasis GO:0055082 180 0.046
regulation of protein complex assembly GO:0043254 147 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
i kappab kinase nf kappab signaling GO:0007249 166 0.045
leukocyte activation GO:0045321 164 0.045
positive regulation of phosphorylation GO:0042327 394 0.045
positive regulation of protein kinase activity GO:0045860 190 0.045
mitotic cell cycle process GO:1903047 286 0.044
positive regulation of proteolysis GO:0045862 142 0.044
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.044
internal protein amino acid acetylation GO:0006475 101 0.044
growth GO:0040007 202 0.044
Worm
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.043
positive regulation of kinase activity GO:0033674 204 0.042
chromatin modification GO:0016568 298 0.042
regulation of proteolysis GO:0030162 293 0.042
response to external biotic stimulus GO:0043207 261 0.042
coenzyme metabolic process GO:0006732 65 0.042
actin filament organization GO:0007015 128 0.042
response to hormone GO:0009725 175 0.041
response to toxic substance GO:0009636 37 0.041
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 41 0.041
hexose metabolic process GO:0019318 55 0.041
regulation of actin filament based process GO:0032970 141 0.040
metal ion homeostasis GO:0055065 169 0.040
regulation of ion transport GO:0043269 189 0.040
Mouse
catecholamine transport GO:0051937 6 0.039
Mouse
protein ubiquitination GO:0016567 314 0.039
glycerolipid metabolic process GO:0046486 107 0.039
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.039
ion homeostasis GO:0050801 230 0.038
cellular response to nutrient levels GO:0031669 69 0.037
cellular response to oxygen containing compound GO:1901701 276 0.037
apoptotic mitochondrial changes GO:0008637 57 0.037
dopamine transport GO:0015872 5 0.037
Mouse
cofactor metabolic process GO:0051186 87 0.037
response to endoplasmic reticulum stress GO:0034976 49 0.037
Worm
mitotic cell cycle phase transition GO:0044772 162 0.037
negative regulation of cell cycle process GO:0010948 121 0.037
response to cytokine GO:0034097 232 0.036
regulation of neuron apoptotic process GO:0043523 35 0.035
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
immune system development GO:0002520 195 0.035
Zebrafish
purine ribonucleoside metabolic process GO:0046128 437 0.035
regulation of protein stability GO:0031647 87 0.035
positive regulation of cellular component organization GO:0051130 376 0.035
inclusion body assembly GO:0070841 17 0.035
regulation of cell cycle phase transition GO:1901987 126 0.034
regulation of lymphocyte activation GO:0051249 103 0.034
startle response GO:0001964 3 0.034
response to oxidative stress GO:0006979 121 0.034
protein acylation GO:0043543 138 0.034
proteasomal protein catabolic process GO:0010498 176 0.033
positive regulation of apoptotic process GO:0043065 246 0.033
positive regulation of protein catabolic process GO:0045732 75 0.033
positive regulation of organelle organization GO:0010638 195 0.033
cellular ion homeostasis GO:0006873 168 0.032
regulation of mitotic cell cycle phase transition GO:1901990 118 0.032
response to other organism GO:0051707 261 0.032
negative regulation of neuron death GO:1901215 32 0.032
nucleoside phosphate catabolic process GO:1901292 412 0.032
regulation of secretion GO:0051046 194 0.031
Mouse
cation homeostasis GO:0055080 189 0.031
protein acetylation GO:0006473 116 0.031
posttranscriptional regulation of gene expression GO:0010608 213 0.031
Mouse
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.031
organelle fission GO:0048285 149 0.031
Fly
leukocyte differentiation GO:0002521 98 0.031
organelle localization GO:0051640 84 0.031
g1 s transition of mitotic cell cycle GO:0000082 78 0.030
negative regulation of protein modification process GO:0031400 200 0.030
monosaccharide metabolic process GO:0005996 74 0.030
oxidation reduction process GO:0055114 396 0.030
Mouse
negative regulation of apoptotic process GO:0043066 316 0.030
peptidyl serine modification GO:0018209 106 0.030
alcohol metabolic process GO:0006066 114 0.029
chromatin organization GO:0006325 351 0.029
regulation of cell cycle g1 s phase transition GO:1902806 42 0.029
autophagic vacuole assembly GO:0000045 19 0.029
nucleoside phosphate biosynthetic process GO:1901293 109 0.029
divalent inorganic cation homeostasis GO:0072507 136 0.029
regulation of cellular protein catabolic process GO:1903362 96 0.029
anatomical structure homeostasis GO:0060249 100 0.028
cellular component morphogenesis GO:0032989 314 0.028
Worm
protein catabolic process GO:0030163 325 0.028
Fly
positive regulation of binding GO:0051099 45 0.028
organonitrogen compound biosynthetic process GO:1901566 200 0.027
regulation of glucose metabolic process GO:0010906 28 0.027
regulation of anatomical structure size GO:0090066 101 0.027
response to starvation GO:0042594 59 0.027
actin filament capping GO:0051693 4 0.027
reactive oxygen species metabolic process GO:0072593 75 0.027
peptidyl lysine modification GO:0018205 144 0.027
nitrogen compound transport GO:0071705 191 0.026
Mouse
jnk cascade GO:0007254 80 0.026
cell morphogenesis GO:0000902 296 0.026
Worm
somatic muscle development GO:0007525 1 0.026
response to organic cyclic compound GO:0014070 204 0.026
regulation of histone modification GO:0031056 47 0.026
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.025
cellular amino acid biosynthetic process GO:0008652 30 0.025
fatty acid metabolic process GO:0006631 115 0.025
negative regulation of protein processing GO:0010955 142 0.025
protein autoubiquitination GO:0051865 37 0.025
negative regulation of cell cycle GO:0045786 193 0.025
regulation of secretion by cell GO:1903530 177 0.025
Mouse
cell type specific apoptotic process GO:0097285 125 0.025
neurological system process GO:0050877 163 0.025
activation of protein kinase activity GO:0032147 90 0.025
stress activated protein kinase signaling cascade GO:0031098 94 0.024
regulation of protein processing GO:0070613 150 0.024
embryo development GO:0009790 123 0.024
neuron apoptotic process GO:0051402 39 0.024
purine containing compound catabolic process GO:0072523 411 0.024
regulation of nucleotide metabolic process GO:0006140 269 0.024
regulation of metal ion transport GO:0010959 120 0.024
maintenance of location GO:0051235 112 0.024
cell activation GO:0001775 213 0.024
phospholipid metabolic process GO:0006644 99 0.024
response to inorganic substance GO:0010035 127 0.024
protein polymerization GO:0051258 71 0.024
establishment of vesicle localization GO:0051650 23 0.024
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.024
positive regulation of cellular protein catabolic process GO:1903364 37 0.024
fatty acid biosynthetic process GO:0006633 46 0.023
protein oligomerization GO:0051259 173 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
cellular response to oxygen levels GO:0071453 55 0.023
negative regulation of cell differentiation GO:0045596 171 0.023
positive regulation of synaptic transmission GO:0050806 4 0.022
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 412 0.022
positive regulation of gtpase activity GO:0043547 166 0.022
mapk cascade GO:0000165 288 0.022
positive regulation of cellular response to oxidative stress GO:1900409 7 0.022
mitochondrial fusion GO:0008053 13 0.022
Fly
positive regulation of programmed cell death GO:0043068 249 0.022
negative regulation of intracellular signal transduction GO:1902532 183 0.022
peptidyl serine phosphorylation GO:0018105 101 0.021
covalent chromatin modification GO:0016569 254 0.021
actin cytoskeleton organization GO:0030036 207 0.021
protein homooligomerization GO:0051260 100 0.021
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.021
neurotransmitter uptake GO:0001504 5 0.021
cellular component disassembly GO:0022411 92 0.021
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.021
negative regulation of secretion by cell GO:1903531 52 0.021
cell projection morphogenesis GO:0048858 129 0.021
Worm
defense response GO:0006952 315 0.021
regulation of apoptotic signaling pathway GO:2001233 175 0.020
cellular component assembly involved in morphogenesis GO:0010927 73 0.020
stress activated mapk cascade GO:0051403 93 0.020
cell cycle phase transition GO:0044770 173 0.020
dephosphorylation GO:0016311 209 0.020
Mouse
zinc ion homeostasis GO:0055069 12 0.020
monocarboxylic acid biosynthetic process GO:0072330 67 0.020
actin filament based process GO:0030029 224 0.019
immune response GO:0006955 307 0.019
response to biotic stimulus GO:0009607 276 0.019
negative regulation of secretion GO:0051048 58 0.019
nucleoside triphosphate metabolic process GO:0009141 422 0.019
cellular response to hormone stimulus GO:0032870 125 0.019
nervous system development GO:0007399 293 0.019
Zebrafish Worm
response to abiotic stimulus GO:0009628 336 0.019
defense response to other organism GO:0098542 129 0.019
cellular response to tumor necrosis factor GO:0071356 63 0.019
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.019
negative regulation of cell cycle phase transition GO:1901988 89 0.019
establishment of protein localization to membrane GO:0090150 121 0.019
negative regulation of cell activation GO:0050866 33 0.019
mucus secretion GO:0070254 1 0.019
protein monoubiquitination GO:0006513 39 0.019
negative regulation of cellular carbohydrate metabolic process GO:0010677 14 0.019
negative regulation of transport GO:0051051 176 0.019
memory GO:0007613 3 0.019
regulation of growth GO:0040008 165 0.019
histone acetylation GO:0016573 93 0.018
positive regulation of transferase activity GO:0051347 227 0.018
positive regulation of gtp catabolic process GO:0033126 166 0.018
inorganic ion transmembrane transport GO:0098660 231 0.018
positive regulation of nucleotide catabolic process GO:0030813 185 0.018
cellular response to nitrogen compound GO:1901699 144 0.018
lymphocyte differentiation GO:0030098 35 0.018
negative regulation of hormone secretion GO:0046888 15 0.018
norepinephrine metabolic process GO:0042415 1 0.018
generation of neurons GO:0048699 152 0.018
Zebrafish Worm
ribonucleotide catabolic process GO:0009261 405 0.018
muscle structure development GO:0061061 98 0.018
synaptic transmission GO:0007268 61 0.018
Mouse Fly
response to fungus GO:0009620 4 0.017
regulation of lymphocyte differentiation GO:0045619 22 0.017
regulation of mitotic cell cycle GO:0007346 189 0.017
cell projection organization GO:0030030 252 0.017
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.017
regulation of endopeptidase activity GO:0052548 170 0.017
regulation of peptidyl lysine acetylation GO:2000756 22 0.017
divalent inorganic cation transport GO:0072511 158 0.017
protein targeting to membrane GO:0006612 42 0.017
mitotic cell cycle GO:0000278 326 0.017
negative regulation of carbohydrate metabolic process GO:0045912 20 0.017
regulation of membrane potential GO:0042391 95 0.017
calcium ion transport GO:0006816 147 0.017
regulation of dna binding GO:0051101 37 0.017
neuron cellular homeostasis GO:0070050 3 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
Fly
macromolecular complex disassembly GO:0032984 60 0.016
short term memory GO:0007614 1 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
response to oxygen levels GO:0070482 100 0.016
actomyosin structure organization GO:0031032 59 0.016
protein depolymerization GO:0051261 30 0.016
regulation of peptide transport GO:0090087 62 0.016
cell development GO:0048468 328 0.016
Zebrafish Worm Fly
neuron death GO:0070997 65 0.016
microtubule based process GO:0007017 210 0.016
negative regulation of synaptic transmission GO:0050805 2 0.016
cell cell signaling GO:0007267 155 0.016
Mouse Fly
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
cofactor biosynthetic process GO:0051188 31 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
neurogenesis GO:0022008 169 0.016
Zebrafish Worm
regulation of meiotic cell cycle GO:0051445 4 0.016
actin filament bundle organization GO:0061572 54 0.015
negative regulation of mitochondrion organization GO:0010823 22 0.015
Fly
lipoprotein metabolic process GO:0042157 42 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.015
cilium morphogenesis GO:0060271 75 0.015
cell part morphogenesis GO:0032990 137 0.015
Worm
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
ketone catabolic process GO:0042182 3 0.015
signal release GO:0023061 70 0.015
hormone secretion GO:0046879 65 0.015
cellular response to organic cyclic compound GO:0071407 127 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
regulation of hormone secretion GO:0046883 57 0.015
cognition GO:0050890 43 0.015
negative regulation of stress activated mapk cascade GO:0032873 19 0.015
mitochondrial membrane organization GO:0007006 40 0.015
regulation of cytokine mediated signaling pathway GO:0001959 41 0.015
negative regulation of proteolysis GO:0045861 132 0.015
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 7 0.014
protein k48 linked ubiquitination GO:0070936 38 0.014
regulation of neuron death GO:1901214 56 0.014
response to tumor necrosis factor GO:0034612 76 0.014
epithelial cell differentiation GO:0030855 141 0.014
response to organonitrogen compound GO:0010243 156 0.014
response to nitrogen compound GO:1901698 184 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.014
peripheral nervous system development GO:0007422 2 0.014
negative regulation of protein complex disassembly GO:0043242 20 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
regulation of neurotransmitter levels GO:0001505 15 0.014
lymphocyte activation GO:0046649 133 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
protein complex disassembly GO:0043241 52 0.014
positive regulation of cell development GO:0010720 92 0.014
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 15 0.014
regulation of mitochondrial fusion GO:0010635 5 0.014
Fly
protein maturation GO:0051604 233 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
long term synaptic potentiation GO:0060291 1 0.014
negative regulation of actin filament bundle assembly GO:0032232 9 0.013
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.013
regulation of intracellular transport GO:0032386 195 0.013
neuron differentiation GO:0030182 138 0.013
Zebrafish Worm
regulation of chromatin organization GO:1902275 56 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
neutral lipid metabolic process GO:0006638 27 0.013
secretion by cell GO:0032940 226 0.013
Mouse
sequestering of calcium ion GO:0051208 17 0.013
negative regulation of chromosome organization GO:2001251 48 0.013
regeneration GO:0031099 4 0.013
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 0.013
nucleoside catabolic process GO:0009164 408 0.013
negative regulation of protein complex assembly GO:0031333 43 0.013
protein k63 linked ubiquitination GO:0070534 31 0.013
modification dependent protein catabolic process GO:0019941 209 0.012
Fly
response to bacterium GO:0009617 144 0.012
multi organism cellular process GO:0044764 156 0.012
regulation of gtpase activity GO:0043087 180 0.012
response to acid chemical GO:0001101 66 0.012
vesicle mediated transport GO:0016192 371 0.012
gtp metabolic process GO:0046039 239 0.012
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.012
Fly
sequestering of metal ion GO:0051238 24 0.012
regulation of map kinase activity GO:0043405 108 0.012
transmembrane transport GO:0055085 399 0.012
myeloid cell differentiation GO:0030099 117 0.012
Zebrafish
regulation of ion homeostasis GO:2000021 73 0.012
cellular response to lipid GO:0071396 127 0.012
response to oxygen containing compound GO:1901700 369 0.012
glycerophospholipid metabolic process GO:0006650 84 0.012
organophosphate catabolic process GO:0046434 430 0.012
long term memory GO:0007616 2 0.012
negative regulation of mapk cascade GO:0043409 56 0.012
regulation of membrane permeability GO:0090559 25 0.012
innate immune response GO:0045087 178 0.012
cellular metal ion homeostasis GO:0006875 146 0.011
acyl coa metabolic process GO:0006637 23 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 19 0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.011
protein processing GO:0016485 226 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
nonribosomal peptide biosynthetic process GO:0019184 4 0.011
glutathione biosynthetic process GO:0006750 4 0.011
purine nucleotide catabolic process GO:0006195 405 0.011
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.011
receptor metabolic process GO:0043112 81 0.011
oocyte development GO:0048599 1 0.011
regulation of dephosphorylation GO:0035303 96 0.011
Mouse
negative regulation of jnk cascade GO:0046329 16 0.011
regulation of cell development GO:0060284 161 0.011
gtp catabolic process GO:0006184 237 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
cerebellum development GO:0021549 2 0.011
cellular protein complex disassembly GO:0043624 36 0.011
regulation of body fluid levels GO:0050878 99 0.011

PINK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.971
nervous system disease DOID:863 431 0.971
parkinson s disease DOID:14330 18 0.965
synucleinopathy DOID:0050890 22 0.965
neurodegenerative disease DOID:1289 102 0.965
cancer DOID:162 167 0.065
disease of cellular proliferation DOID:14566 174 0.065
organ system cancer DOID:0050686 164 0.065
disease by infectious agent DOID:0050117 34 0.056
cardiovascular system disease DOID:1287 106 0.041
hypertension DOID:10763 13 0.039
artery disease DOID:0050828 23 0.039
vascular disease DOID:178 25 0.039
essential hypertension DOID:10825 8 0.039
sensory system disease DOID:0050155 203 0.028
disease of metabolism DOID:0014667 295 0.026
eye and adnexa disease DOID:1492 150 0.020
eye disease DOID:5614 149 0.020
inherited metabolic disorder DOID:655 242 0.019
musculoskeletal system disease DOID:17 223 0.018
connective tissue disease DOID:65 109 0.014
respiratory system cancer DOID:0050615 16 0.011