IMP
Process View
positive regulation of intrinsic apoptotic signaling pathway
Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of intrinsic apoptotic signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BCL2L1 | BCL2-like 1 | 1.000 | Human | |
| BCL2 | B-cell CLL/lymphoma 2 | 1.000 | Human | |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 1.000 | ||
| BAX | BCL2-associated X protein | 0.998 | ||
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.984 | ||
| S100A6 | S100 calcium binding protein A6 | 0.955 | Human | |
| S100A8 | S100 calcium binding protein A8 | 0.943 | ||
| MDM2 | Mdm2 p53 binding protein homolog (mouse) | 0.928 | ||
| BAD | BCL2-associated agonist of cell death | 0.928 | ||
| BID | BH3 interacting domain death agonist | 0.924 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.908 | ||
| S100A9 | S100 calcium binding protein A9 | 0.880 | ||
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.867 | ||
| SYK | spleen tyrosine kinase | 0.789 | ||
| SFPQ | splicing factor proline/glutamine-rich | 0.750 | ||
| S100A14 | S100 calcium binding protein A14 | 0.732 | ||
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.708 | ||
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.689 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.659 | ||
| SEPT2 | septin 2 | 0.657 | Human | |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 0.655 | ||
| SMCR7L | Smith-Magenis syndrome chromosome region, candidate 7-like | 0.638 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.598 | Human | |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.578 | ||
| CUL1 | cullin 1 | 0.526 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.525 | ||
| WBP4 | WW domain binding protein 4 (formin binding protein 21) | 0.501 | ||
| S100B | S100 calcium binding protein B | 0.486 | Human | |
| TP53 | tumor protein p53 | 0.485 | ||
| HCK | hemopoietic cell kinase | 0.484 | Human | |
| SKP1 | S-phase kinase-associated protein 1 | 0.447 | ||
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.421 | ||
| S100A4 | S100 calcium binding protein A4 | 0.415 | Human | |
| BAK1 | BCL2-antagonist/killer 1 | 0.411 | Human | |
| EGFR | epidermal growth factor receptor | 0.387 | ||
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.386 | ||
| TOP1 | topoisomerase (DNA) I | 0.381 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.325 | ||
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.308 | ||
| SOD1 | superoxide dismutase 1, soluble | 0.281 | ||
| ZNF746 | zinc finger protein 746 | 0.278 | ||
| S100A10 | S100 calcium binding protein A10 | 0.273 | Human | |
| DAZAP2 | DAZ associated protein 2 | 0.268 | ||
| S100A11 | S100 calcium binding protein A11 | 0.255 | Human | |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.251 | ||
| SEPT11 | septin 11 | 0.214 | ||
| MDM4 | Mdm4 p53 binding protein homolog (mouse) | 0.205 | ||
| SPRR2A | small proline-rich protein 2A | 0.202 | ||
| SNW1 | SNW domain containing 1 | 0.201 | ||
| BCAP31 | B-cell receptor-associated protein 31 | 0.194 | ||
| BLNK | B-cell linker | 0.190 | ||
| DAXX | death-domain associated protein | 0.182 | ||
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.178 | ||
| FUS | fused in sarcoma | 0.178 | ||
| AREG | amphiregulin | 0.177 | ||
| UBE2I | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 0.170 | ||
| KRT5 | keratin 5 | 0.168 | ||
| WWOX | WW domain containing oxidoreductase | 0.165 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.161 | Human | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.161 | ||
| S100A1 | S100 calcium binding protein A1 | 0.154 | Human | |
| BECN1 | beclin 1, autophagy related | 0.151 | ||
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.146 | ||
| ANXA1 | annexin A1 | 0.144 | ||
| SMCR7 | Smith-Magenis syndrome chromosome region, candidate 7 | 0.142 | ||
| PTEN | phosphatase and tensin homolog | 0.136 | ||
| YAP1 | Yes-associated protein 1 | 0.132 | ||
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | 0.121 | ||
| FKBP8 | FK506 binding protein 8, 38kDa | 0.097 | ||
| PARK7 | Parkinson disease (autosomal recessive, early onset) 7 | 0.093 | Mouse | |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.090 | ||
| SLC9A3R2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 | 0.087 | Human | |
| S100P | S100 calcium binding protein P | 0.087 | Human | |
| FBXW11 | F-box and WD repeat domain containing 11 | 0.087 | ||
| ANXA2 | annexin A2 | 0.086 | ||
| BTRC | beta-transducin repeat containing | 0.085 | ||
| BIRC3 | baculoviral IAP repeat containing 3 | 0.085 | ||
| NCK1 | NCK adaptor protein 1 | 0.081 | ||
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.079 | ||
| FADD | Fas (TNFRSF6)-associated via death domain | 0.079 | ||
| SH3RF1 | SH3 domain containing ring finger 1 | 0.077 | ||
| SEPT7 | septin 7 | 0.077 | Human | |
| PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | 0.077 | ||
| PML | promyelocytic leukemia | 0.075 | ||
| ZFYVE1 | zinc finger, FYVE domain containing 1 | 0.075 | ||
| NCOA3 | nuclear receptor coactivator 3 | 0.075 | ||
| GAS7 | growth arrest-specific 7 | 0.074 | ||
| PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme | 0.068 | ||
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.067 | ||
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.067 | ||
| PRDX1 | peroxiredoxin 1 | 0.064 | ||
| BBC3 | BCL2 binding component 3 | 0.063 | ||
| SRRM1 | serine/arginine repetitive matrix 1 | 0.062 | ||
| RYBP | RING1 and YY1 binding protein | 0.060 | ||
| SUMO2 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) | 0.059 | ||
| HSPA8 | heat shock 70kDa protein 8 | 0.059 | ||
| S100A2 | S100 calcium binding protein A2 | 0.058 | Human | |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.058 | ||
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.058 | ||
| CANX | calnexin | 0.055 | ||
| RXRB | retinoid X receptor, beta | 0.055 | ||
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 0.054 | ||
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.051 | ||
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.051 | ||
| MAPK8 | mitogen-activated protein kinase 8 | 0.050 | ||
| SPDEF | SAM pointed domain containing ets transcription factor | 0.050 | ||
| FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.050 | Human | |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.050 | ||
| CRY1 | cryptochrome 1 (photolyase-like) | 0.048 | ||
| THRAP3 | thyroid hormone receptor associated protein 3 | 0.047 | ||
| KRT6C | keratin 6C | 0.047 | ||
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.046 | ||
| NONO | non-POU domain containing, octamer-binding | 0.046 | Human | |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.045 | ||
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.044 | ||
| SNIP1 | Smad nuclear interacting protein 1 | 0.042 | ||
| CAPRIN1 | cell cycle associated protein 1 | 0.042 | ||
| CSTA | cystatin A (stefin A) | 0.041 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.039 | ||
| AR | androgen receptor | 0.038 | ||
| HDAC1 | histone deacetylase 1 | 0.037 | ||
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.037 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.035 | ||
| RANBP2 | RAN binding protein 2 | 0.034 | ||
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.033 | ||
| ITK | IL2-inducible T-cell kinase | 0.032 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.031 | ||
| CAV2 | caveolin 2 | 0.031 | Human | |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.031 | ||
| CACYBP | calcyclin binding protein | 0.031 | ||
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.031 | ||
| SNX9 | sorting nexin 9 | 0.030 | ||
| TRAF1 | TNF receptor-associated factor 1 | 0.029 | ||
| S100A12 | S100 calcium binding protein A12 | 0.029 | Human | |
| PRKCDBP | protein kinase C, delta binding protein | 0.029 | ||
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.029 | ||
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.029 | Human | |
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.029 | ||
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.029 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.028 | ||
| CDC5L | CDC5 cell division cycle 5-like (S. pombe) | 0.028 | ||
| HIPK3 | homeodomain interacting protein kinase 3 | 0.027 | ||
| CASC5 | cancer susceptibility candidate 5 | 0.026 | ||
| HTATSF1 | HIV-1 Tat specific factor 1 | 0.026 | ||
| PPID | peptidylprolyl isomerase D | 0.026 | ||
| CCNE1 | cyclin E1 | 0.026 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.025 | ||
| SATB2 | SATB homeobox 2 | 0.025 | ||
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.025 | ||
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.025 | ||
| DICER1 | dicer 1, ribonuclease type III | 0.025 | ||
| CCDC6 | coiled-coil domain containing 6 | 0.024 | ||
| SLC26A3 | solute carrier family 26, member 3 | 0.024 | ||
| AGER | advanced glycosylation end product-specific receptor | 0.024 | ||
| PINK1 | PTEN induced putative kinase 1 | 0.024 | ||
| MSX2 | msh homeobox 2 | 0.023 | Human | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.023 | ||
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.023 | ||
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.023 | ||
| FES | feline sarcoma oncogene | 0.023 | ||
| AHNAK | AHNAK nucleoprotein | 0.022 | ||
| FBXW2 | F-box and WD repeat domain containing 2 | 0.022 | ||
| SQSTM1 | sequestosome 1 | 0.022 | ||
| TNS4 | tensin 4 | 0.022 | ||
| XIAP | X-linked inhibitor of apoptosis | 0.022 | ||
| HDAC2 | histone deacetylase 2 | 0.022 | ||
| C4orf14 | chromosome 4 open reading frame 14 | 0.022 | ||
| MSX1 | msh homeobox 1 | 0.021 | ||
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.021 | ||
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.021 | ||
| TBC1D10A | TBC1 domain family, member 10A | 0.020 | ||
| SP1 | Sp1 transcription factor | 0.020 | ||
| CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 0.020 | ||
| PTRF | polymerase I and transcript release factor | 0.020 | ||
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 0.020 | ||
| SMAD1 | SMAD family member 1 | 0.020 | ||
| DAD1 | defender against cell death 1 | 0.019 | ||
| F2R | coagulation factor II (thrombin) receptor | 0.019 | ||
| SEPT6 | septin 6 | 0.019 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.019 | ||
| PI3 | peptidase inhibitor 3, skin-derived | 0.019 | ||
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.019 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.019 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.019 | ||
| AMOTL1 | angiomotin like 1 | 0.018 | ||
| HUS1 | HUS1 checkpoint homolog (S. pombe) | 0.018 | ||
| ESR1 | estrogen receptor 1 | 0.018 | ||
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.018 | ||
| SUMO1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | 0.018 | ||
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.018 | ||
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.018 | ||
| SAP18 | Sin3A-associated protein, 18kDa | 0.018 | ||
| MYD88 | myeloid differentiation primary response gene (88) | 0.017 | ||
| GOPC | golgi-associated PDZ and coiled-coil motif containing | 0.017 | ||
| ZFP28 | zinc finger protein 28 homolog (mouse) | 0.017 | ||
| SPC24 | SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) | 0.017 | ||
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 0.017 | ||
| CAPG | capping protein (actin filament), gelsolin-like | 0.017 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.017 | ||
| SUMO3 | SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) | 0.016 | ||
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.016 | ||
| CLU | clusterin | 0.016 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.015 | ||
| ZNF207 | zinc finger protein 207 | 0.015 | ||
| BCL2L2 | BCL2-like 2 | 0.015 | Human | |
| FBXO7 | F-box protein 7 | 0.015 | ||
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.015 | ||
| RAD17 | RAD17 homolog (S. pombe) | 0.015 | ||
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.015 | ||
| FBXO33 | F-box protein 33 | 0.015 | ||
| RGS2 | regulator of G-protein signaling 2, 24kDa | 0.015 | ||
| CTSB | cathepsin B | 0.014 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.014 | ||
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.014 | ||
| ZNF512B | zinc finger protein 512B | 0.014 | ||
| PRKRA | protein kinase, interferon-inducible double stranded RNA dependent activator | 0.014 | Mouse | |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 0.014 | ||
| TRAF3 | TNF receptor-associated factor 3 | 0.014 | ||
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.014 | ||
| HNRNPCL1 | heterogeneous nuclear ribonucleoprotein C-like 1 | 0.014 | ||
| CLSPN | claspin | 0.013 | ||
| SPNS1 | spinster homolog 1 (Drosophila) | 0.013 | ||
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.013 | ||
| LCK | lymphocyte-specific protein tyrosine kinase | 0.013 | ||
| SUGT1 | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 0.013 | ||
| PTPLB | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b | 0.013 | ||
| EMP3 | epithelial membrane protein 3 | 0.013 | ||
| CUL3 | cullin 3 | 0.013 | ||
| PRDX5 | peroxiredoxin 5 | 0.013 | ||
| PPHLN1 | periphilin 1 | 0.013 | ||
| SEC61B | Sec61 beta subunit | 0.012 | ||
| HSPA1L | heat shock 70kDa protein 1-like | 0.012 | ||
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.012 | ||
| CD63 | CD63 molecule | 0.012 | ||
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.012 | ||
| MATR3 | matrin 3 | 0.012 | ||
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.012 | ||
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 0.012 | ||
| VAV2 | vav 2 guanine nucleotide exchange factor | 0.012 | ||
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | 0.012 | ||
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.012 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.011 | ||
| IL8 | interleukin 8 | 0.011 | ||
| NCF2 | neutrophil cytosolic factor 2 | 0.011 | ||
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.011 | ||
| NRG1 | neuregulin 1 | 0.011 | ||
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.011 | ||
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.011 | ||
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 0.011 | ||
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.011 | ||
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.011 | ||
| GRB7 | growth factor receptor-bound protein 7 | 0.011 | ||
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.011 | ||
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.011 | ||
| DLX2 | distal-less homeobox 2 | 0.011 | ||
| EMP1 | epithelial membrane protein 1 | 0.011 | ||
| PRKCQ | protein kinase C, theta | 0.011 | ||
| ZBP1 | Z-DNA binding protein 1 | 0.011 | ||
| PPP1R13B | protein phosphatase 1, regulatory (inhibitor) subunit 13B | 0.011 | ||
| CSTB | cystatin B (stefin B) | 0.011 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.011 | ||
| C1orf9 | chromosome 1 open reading frame 9 | 0.010 | ||
| TADA3 | transcriptional adaptor 3 | 0.010 | ||
| S100A13 | S100 calcium binding protein A13 | 0.010 | ||
| TXNRD1 | thioredoxin reductase 1 | 0.010 | ||
| PIGA | phosphatidylinositol glycan anchor biosynthesis, class A | 0.010 | ||
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.010 | ||
| BUB1B | budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.010 | ||
| SMAD7 | SMAD family member 7 | 0.010 | ||
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.010 | ||
| CD2AP | CD2-associated protein | 0.010 |