Homo sapiens

40 known processes

PRF1

perforin 1 (pore forming protein)

(Aliases: FLH2,P1,PFN1,HPLH2,PFP,MGC65093)

PRF1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of deoxyribonuclease activity GO:0032076 1 0.997
negative regulation of nuclease activity GO:0032074 2 0.990
interleukin 1 beta biosynthetic process GO:0050720 2 0.988
negative regulation of endodeoxyribonuclease activity GO:0032078 1 0.988
interleukin 1 biosynthetic process GO:0042222 2 0.775
negative regulation of dna catabolic process GO:1903625 2 0.732
immune response GO:0006955 307 0.471
Mouse
cell killing GO:0001906 34 0.446
foramen ovale closure GO:0035922 1 0.428
phagocytosis recognition GO:0006910 3 0.426
leukocyte activation GO:0045321 164 0.304
positive regulation of apoptotic process GO:0043065 246 0.289
regulation of endodeoxyribonuclease activity GO:0032071 3 0.261
regulation of nuclease activity GO:0032069 11 0.245
regulation of immune response GO:0050776 201 0.239
positive regulation of programmed cell death GO:0043068 249 0.232
negative regulation of catalytic activity GO:0043086 335 0.228
negative regulation of t helper 1 cell activation GO:2000518 1 0.223
interleukin 1 beta production GO:0032611 22 0.214
negative regulation of t cell cytokine production GO:0002725 4 0.212
regulation of cellular amino acid metabolic process GO:0006521 6 0.206
negative regulation of hydrolase activity GO:0051346 182 0.202
lymphocyte activation GO:0046649 133 0.198
response to other organism GO:0051707 261 0.197
Mouse
regulation of secretion GO:0051046 194 0.177
positive regulation of immune system process GO:0002684 283 0.175
lymphocyte mediated immunity GO:0002449 48 0.172
defense response GO:0006952 315 0.166
Mouse
cytokine mediated signaling pathway GO:0019221 109 0.157
secretion by cell GO:0032940 226 0.149
vesicle mediated transport GO:0016192 371 0.149
cellular protein catabolic process GO:0044257 261 0.144
regulation of cellular ketone metabolic process GO:0010565 50 0.140
cell activation GO:0001775 213 0.130
interleukin 1 production GO:0032612 26 0.129
t cell activation GO:0042110 99 0.117
negative regulation of dna metabolic process GO:0051053 57 0.115
positive regulation of cell death GO:0010942 263 0.114
cytokine production GO:0001816 247 0.113
regulation of leukocyte mediated immunity GO:0002703 38 0.112
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.111
leukocyte migration GO:0050900 107 0.109
regulation of secretion by cell GO:1903530 177 0.105
negative regulation of cell proliferation GO:0008285 228 0.104
positive regulation of cell proliferation GO:0008284 301 0.101
cellular amino acid metabolic process GO:0006520 116 0.098
eosinophil activation GO:0043307 3 0.097
negative regulation of binding GO:0051100 57 0.096
immune effector process GO:0002252 159 0.095
Mouse
amine metabolic process GO:0009308 44 0.093
negative regulation of multicellular organismal process GO:0051241 317 0.093
immune system development GO:0002520 195 0.092
cellular amine metabolic process GO:0044106 41 0.091
negative regulation of programmed cell death GO:0043069 321 0.091
positive regulation of macrophage chemotaxis GO:0010759 3 0.089
leukocyte mediated immunity GO:0002443 59 0.089
regulation of dna metabolic process GO:0051052 153 0.089
positive regulation of secretion GO:0051047 116 0.083
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.082
positive regulation of hydrolase activity GO:0051345 331 0.082
regulation of protein localization GO:0032880 296 0.080
hemopoiesis GO:0030097 180 0.080
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.079
cytokine metabolic process GO:0042107 38 0.078
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.077
dna catabolic process GO:0006308 49 0.076
protein catabolic process GO:0030163 325 0.075
secretion GO:0046903 254 0.074
lymphocyte proliferation GO:0046651 70 0.072
post embryonic development GO:0009791 2 0.071
regulation of binding GO:0051098 111 0.070
cytokine secretion GO:0050663 64 0.070
positive regulation of phosphorylation GO:0042327 394 0.070
cellular macromolecule catabolic process GO:0044265 380 0.069
regulation of immune effector process GO:0002697 91 0.069
peptidyl tyrosine modification GO:0018212 170 0.066
chemokine c c motif ligand 19 signaling pathway GO:0038115 1 0.065
negative regulation of catabolic process GO:0009895 104 0.064
negative regulation of cellular catabolic process GO:0031330 83 0.064
leukocyte mediated cytotoxicity GO:0001909 27 0.063
positive regulation of leukocyte mediated immunity GO:0002705 24 0.062
response to biotic stimulus GO:0009607 276 0.062
Mouse
regulation of establishment of protein localization GO:0070201 242 0.062
regulation of nucleotide catabolic process GO:0030811 205 0.062
regulation of dna binding GO:0051101 37 0.061
signal transduction by phosphorylation GO:0023014 297 0.060
regulation of cell motility GO:2000145 299 0.059
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.055
positive regulation of immune response GO:0050778 159 0.054
negative regulation of cell death GO:0060548 345 0.054
cytokine biosynthetic process GO:0042089 37 0.053
glycosyl compound catabolic process GO:1901658 413 0.053
regulation of lymphocyte activation GO:0051249 103 0.050
nucleoside triphosphate catabolic process GO:0009143 394 0.050
apoptotic signaling pathway GO:0097190 268 0.049
innate immune response GO:0045087 178 0.048
regulation of anatomical structure morphogenesis GO:0022603 286 0.048
purine ribonucleoside catabolic process GO:0046130 398 0.047
positive regulation of cd8 positive alpha beta t cell proliferation GO:2000566 1 0.047
regulation of response to external stimulus GO:0032101 222 0.046
regulation of biomineral tissue development GO:0070167 31 0.045
positive regulation of cellular amine metabolic process GO:0033240 7 0.045
purine nucleoside catabolic process GO:0006152 398 0.044
regulation of oxidoreductase activity GO:0051341 43 0.044
response to external biotic stimulus GO:0043207 261 0.044
Mouse
positive regulation of cytokine production GO:0001819 167 0.043
immune response activating signal transduction GO:0002757 90 0.043
regulation of cell differentiation GO:0045595 393 0.043
negative regulation of cytokine production involved in immune response GO:0002719 13 0.043
chemokine c c motif ligand 11 production GO:0071954 1 0.042
negative regulation of immune system process GO:0002683 136 0.042
nucleoside triphosphate metabolic process GO:0009141 422 0.042
regulation of c c chemokine binding GO:2001263 1 0.042
cellular ketone metabolic process GO:0042180 80 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.042
purine nucleoside triphosphate catabolic process GO:0009146 392 0.041
positive regulation of transport GO:0051050 336 0.041
regulation of cellular component movement GO:0051270 334 0.040
negative regulation of developmental process GO:0051093 247 0.040
regulation of intracellular transport GO:0032386 195 0.039
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.038
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.038
regulation of cytokine production GO:0001817 232 0.038
protein localization to nucleus GO:0034504 136 0.038
ribonucleoside catabolic process GO:0042454 406 0.037
regulation of leukocyte apoptotic process GO:2000106 25 0.037
purine ribonucleotide catabolic process GO:0009154 404 0.037
regulation of cellular amine metabolic process GO:0033238 11 0.037
regulation of lymphocyte mediated immunity GO:0002706 33 0.037
negative regulation of cellular component organization GO:0051129 235 0.037
negative regulation of apoptotic process GO:0043066 316 0.036
multicellular organismal aging GO:0010259 3 0.035
small gtpase mediated signal transduction GO:0007264 78 0.034
nervous system development GO:0007399 293 0.034
i kappab kinase nf kappab signaling GO:0007249 166 0.033
cellular homeostasis GO:0019725 196 0.032
response to oxygen containing compound GO:1901700 369 0.032
Rat
cytoplasmic transport GO:0016482 379 0.032
negative regulation of dna binding GO:0043392 18 0.032
response to virus GO:0009615 126 0.032
Mouse
actin filament based process GO:0030029 224 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.032
regulation of purine nucleotide metabolic process GO:1900542 264 0.031
cell projection organization GO:0030030 252 0.031
adaptive immune response GO:0002250 49 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.031
negative regulation of protein metabolic process GO:0051248 391 0.031
protein targeting GO:0006605 187 0.031
determination of adult lifespan GO:0008340 2 0.031
regulation of multi organism process GO:0043900 157 0.031
embryonic viscerocranium morphogenesis GO:0048703 1 0.030
regulation of locomotion GO:0040012 329 0.030
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
negative regulation of cell differentiation GO:0045596 171 0.030
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.030
regulation of astrocyte chemotaxis GO:2000458 1 0.030
hematopoietic or lymphoid organ development GO:0048534 186 0.030
positive regulation of cardioblast differentiation GO:0051891 2 0.030
regulation of cell migration GO:0030334 289 0.030
divalent inorganic cation transport GO:0072511 158 0.029
positive regulation of innate immune response GO:0045089 79 0.029
nucleoside catabolic process GO:0009164 408 0.029
cellular response to lipopolysaccharide GO:0071222 57 0.029
guanosine containing compound catabolic process GO:1901069 239 0.029
single organismal cell cell adhesion GO:0016337 148 0.028
regulation of nucleotide metabolic process GO:0006140 269 0.028
peptidyl tyrosine phosphorylation GO:0018108 170 0.028
mononuclear cell proliferation GO:0032943 71 0.028
innate immune response activating cell surface receptor signaling pathway GO:0002220 2 0.028
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.028
purine nucleotide catabolic process GO:0006195 405 0.028
leukocyte differentiation GO:0002521 98 0.028
protein localization to organelle GO:0033365 280 0.028
regulation of transferase activity GO:0051338 355 0.027
ribonucleotide catabolic process GO:0009261 405 0.027
positive regulation of defense response GO:0031349 87 0.027
single organism membrane organization GO:0044802 268 0.027
neuromuscular junction development GO:0007528 3 0.027
organophosphate catabolic process GO:0046434 430 0.027
cell development GO:0048468 328 0.027
regulation of lymphocyte proliferation GO:0050670 64 0.027
blood vessel development GO:0001568 172 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
cellular component morphogenesis GO:0032989 314 0.026
single organism cellular localization GO:1902580 332 0.026
cation transport GO:0006812 331 0.026
myeloid leukocyte activation GO:0002274 34 0.026
intracellular protein transport GO:0006886 270 0.026
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
epithelial cell proliferation GO:0050673 128 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
regulation of protein kinase activity GO:0045859 289 0.025
gtp catabolic process GO:0006184 237 0.025
regulation of protein transport GO:0051223 213 0.025
chemotaxis GO:0006935 157 0.025
positive regulation of developmental process GO:0051094 314 0.025
actin filament polymerization GO:0030041 45 0.025
response to bacterium GO:0009617 144 0.025
viral process GO:0016032 146 0.025
membrane organization GO:0061024 292 0.025
response to growth factor GO:0070848 205 0.024
dephosphorylation GO:0016311 209 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
positive regulation of leukocyte activation GO:0002696 80 0.024
reactive oxygen species biosynthetic process GO:1903409 4 0.024
positive regulation of nucleotide catabolic process GO:0030813 185 0.024
regulation of cell activation GO:0050865 125 0.024
positive regulation of leukocyte proliferation GO:0070665 48 0.024
regulation of sensory perception GO:0051931 3 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
second messenger mediated signaling GO:0019932 78 0.024
cell adhesion GO:0007155 325 0.024
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.024
cellular ion homeostasis GO:0006873 168 0.023
actin cytoskeleton organization GO:0030036 207 0.023
regulation of peptidase activity GO:0052547 180 0.023
regulation of protein secretion GO:0050708 86 0.023
maintenance of location GO:0051235 112 0.023
g protein coupled receptor signaling pathway GO:0007186 207 0.023
peptide transport GO:0015833 74 0.022
regulation of cellular component biogenesis GO:0044087 281 0.022
positive regulation of catabolic process GO:0009896 310 0.022
positive regulation of jak stat cascade GO:0046427 35 0.022
granulocyte migration GO:0097530 40 0.022
regulation of cytokine secretion GO:0050707 57 0.022
inflammatory response GO:0006954 79 0.022
eosinophil degranulation GO:0043308 2 0.021
camp metabolic process GO:0046058 61 0.021
response to cytokine GO:0034097 232 0.021
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.021
protein maturation GO:0051604 233 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.021
erk1 and erk2 cascade GO:0070371 104 0.021
negative regulation of cell cycle GO:0045786 193 0.021
regulation of innate immune response GO:0045088 97 0.021
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.021
nucleoside phosphate catabolic process GO:1901292 412 0.021
purine ribonucleoside metabolic process GO:0046128 437 0.021
cellular response to dna damage stimulus GO:0006974 379 0.020
guanosine containing compound metabolic process GO:1901068 244 0.020
calcium mediated signaling GO:0019722 44 0.020
negative regulation of oxidoreductase activity GO:0051354 17 0.020
lymphocyte apoptotic process GO:0070227 20 0.020
regulation of chemokine mediated signaling pathway GO:0070099 6 0.020
regulation of gtp catabolic process GO:0033124 180 0.020
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.020
cardiovascular system development GO:0072358 262 0.020
cellular response to cytokine stimulus GO:0071345 181 0.020
eosinophil mediated immunity GO:0002447 2 0.020
regulation of leukocyte differentiation GO:1902105 61 0.020
segmentation GO:0035282 4 0.020
lipid metabolic process GO:0006629 381 0.020
regulation of proteolysis GO:0030162 293 0.020
positive regulation of protein secretion GO:0050714 60 0.020
positive regulation of protein transport GO:0051222 135 0.020
taxis GO:0042330 157 0.020
negative regulation of cell motility GO:2000146 104 0.020
regulation of viral process GO:0050792 103 0.020
purine containing compound catabolic process GO:0072523 411 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.019
positive regulation of cell killing GO:0031343 19 0.019
stress activated mapk cascade GO:0051403 93 0.019
positive regulation of transferase activity GO:0051347 227 0.019
sensory perception GO:0007600 103 0.019
cell morphogenesis GO:0000902 296 0.019
positive regulation of organelle organization GO:0010638 195 0.019
endocytosis GO:0006897 159 0.019
ras protein signal transduction GO:0007265 73 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
activation of innate immune response GO:0002218 55 0.019
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.019
regulation of cell cycle GO:0051726 393 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.019
negative regulation of c c chemokine binding GO:2001264 1 0.018
regulation of angiogenesis GO:0045765 92 0.018
regulation of myeloid leukocyte differentiation GO:0002761 39 0.018
calcium ion transport GO:0006816 147 0.018
myeloid leukocyte migration GO:0097529 62 0.018
positive regulation of granzyme b production GO:0071663 1 0.018
reactive nitrogen species metabolic process GO:2001057 3 0.018
regulation of cell cycle process GO:0010564 266 0.018
mapk cascade GO:0000165 288 0.018
regulation of vesicle mediated transport GO:0060627 130 0.018
regulation of endopeptidase activity GO:0052548 170 0.018
metal ion transport GO:0030001 272 0.018
positive regulation of cellular component organization GO:0051130 376 0.018
regulation of mapk cascade GO:0043408 262 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
regulation of natural killer cell mediated immunity GO:0002715 16 0.018
bone mineralization GO:0030282 34 0.018
eosinophil chemotaxis GO:0048245 8 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
glial cell migration GO:0008347 4 0.017
positive regulation of neutrophil migration GO:1902624 7 0.017
t cell mediated cytotoxicity GO:0001913 9 0.017
system process GO:0003008 349 0.017
innate immune response activating signal transduction GO:0002758 48 0.017
viral life cycle GO:0019058 132 0.017
negative regulation of viral process GO:0048525 66 0.017
positive regulation of cytoskeleton organization GO:0051495 83 0.017
positive regulation of protein phosphorylation GO:0001934 313 0.017
organic hydroxy compound metabolic process GO:1901615 147 0.017
response to nitric oxide GO:0071731 4 0.017
oogenesis GO:0048477 2 0.017
protein targeting to nucleus GO:0044744 104 0.017
protein processing GO:0016485 226 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
positive regulation of nucleoside metabolic process GO:0045979 186 0.017
negative regulation of cytokine production GO:0001818 82 0.017
positive regulation of leukocyte chemotaxis GO:0002690 38 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
cellular protein complex assembly GO:0043623 188 0.016
regulation of actin filament polymerization GO:0030833 50 0.016
regulation of protein complex assembly GO:0043254 147 0.016
nitrogen compound transport GO:0071705 191 0.016
blastoderm segmentation GO:0007350 2 0.016
female gamete generation GO:0007292 2 0.016
nucleotide catabolic process GO:0009166 408 0.016
regulation of defense response GO:0031347 154 0.016
immune response regulating signaling pathway GO:0002764 97 0.016
regulation of epithelial cell proliferation GO:0050678 113 0.016
rho protein signal transduction GO:0007266 26 0.016
negative regulation of proteolysis GO:0045861 132 0.016
negative regulation of cell migration GO:0030336 102 0.016
nucleocytoplasmic transport GO:0006913 176 0.016
myeloid cell differentiation GO:0030099 117 0.016
regulation of rho protein signal transduction GO:0035023 79 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.016
natural killer cell mediated cytotoxicity GO:0042267 23 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.016
regulation of protein polymerization GO:0032271 63 0.016
protein localization to membrane GO:0072657 160 0.016
interspecies interaction between organisms GO:0044419 156 0.015
extrinsic apoptotic signaling pathway GO:0097191 119 0.015
reactive oxygen species metabolic process GO:0072593 75 0.015
negative regulation of cellular component movement GO:0051271 106 0.015
protein import into nucleus GO:0006606 104 0.015
glycerolipid metabolic process GO:0046486 107 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
positive regulation of cell cycle GO:0045787 140 0.015
neuron development GO:0048666 113 0.015
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.015
protein import GO:0017038 130 0.015
endomembrane system organization GO:0010256 196 0.015
positive regulation of necrotic cell death GO:0010940 4 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
positive regulation of secretion by cell GO:1903532 108 0.015
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
cellular cation homeostasis GO:0030003 163 0.015
regulation of kinase activity GO:0043549 314 0.015
regulation of protein processing GO:0070613 150 0.015
neurogenesis GO:0022008 169 0.015
neuron differentiation GO:0030182 138 0.015
pattern recognition receptor signaling pathway GO:0002221 48 0.015
cellular response to biotic stimulus GO:0071216 71 0.015
granzyme a production GO:0035746 1 0.015
regulation of cd8 positive alpha beta t cell activation GO:2001185 2 0.015
programmed necrotic cell death GO:0097300 18 0.015
regulation of erk1 and erk2 cascade GO:0070372 99 0.015
positive regulation of stress activated mapk cascade GO:0032874 60 0.015
cell projection assembly GO:0030031 126 0.014
regulation of cellular response to stress GO:0080135 244 0.014
generation of neurons GO:0048699 152 0.014
defense response to bacterium GO:0042742 63 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
t helper 1 cell activation GO:0035711 1 0.014
regulation of dephosphorylation GO:0035303 96 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.014
regulation of phosphatase activity GO:0010921 81 0.014
regulation of cell development GO:0060284 161 0.014
positive regulation of epithelial cell proliferation GO:0050679 65 0.014
cellular chemical homeostasis GO:0055082 180 0.014
eosinophil activation involved in immune response GO:0002278 2 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
regulation of dna catabolic process GO:1903624 7 0.014
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.014
positive regulation of proteolysis GO:0045862 142 0.014
regulation of protein maturation GO:1903317 150 0.014
interferon gamma production GO:0032609 39 0.014
sequestering of calcium ion GO:0051208 17 0.014
oocyte development GO:0048599 1 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.014
oocyte differentiation GO:0009994 2 0.013
cellular response to ammonium ion GO:0071242 4 0.013
endothelial cell proliferation GO:0001935 65 0.013
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.013
positive regulation of locomotion GO:0040017 186 0.013
tumor necrosis factor production GO:0032640 43 0.013
regulation of vasculature development GO:1901342 97 0.013
positive regulation of immune effector process GO:0002699 40 0.013
positive regulation of gtpase activity GO:0043547 166 0.013
regulation of cell adhesion GO:0030155 166 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
protein autophosphorylation GO:0046777 123 0.013
cell fate determination GO:0001709 3 0.013
negative regulation of protein maturation GO:1903318 142 0.013
small molecule biosynthetic process GO:0044283 157 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
regulation of leukocyte migration GO:0002685 63 0.013
response to tumor necrosis factor GO:0034612 76 0.013
mitotic cell cycle process GO:1903047 286 0.013
jak stat cascade GO:0007259 46 0.013
circulatory system development GO:0072359 262 0.013
natural killer cell mediated immunity GO:0002228 23 0.013
single organism cell adhesion GO:0098602 179 0.013
regulation of reactive oxygen species metabolic process GO:2000377 41 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
microtubule based process GO:0007017 210 0.013
amide transport GO:0042886 76 0.013
protein polymerization GO:0051258 71 0.013
glycoprotein metabolic process GO:0009100 110 0.013
ion transmembrane transport GO:0034220 338 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
regulation of gtpase activity GO:0043087 180 0.013
regulation of actin filament based process GO:0032970 141 0.013
regulation of ion transport GO:0043269 189 0.013
tripartite regional subdivision GO:0007351 2 0.012
regulation of calcium ion transport into cytosol GO:0010522 33 0.012
positive regulation of phospholipase activity GO:0010518 22 0.012
negative regulation of multi organism process GO:0043901 92 0.012
negative regulation of endopeptidase activity GO:0010951 84 0.012
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
epithelium development GO:0060429 227 0.012
metal ion homeostasis GO:0055065 169 0.012
protein localization to plasma membrane GO:0072659 93 0.012
response to organic cyclic compound GO:0014070 204 0.012
chemical homeostasis GO:0048878 306 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
positive regulation of ion transport GO:0043270 87 0.012
anatomical structure homeostasis GO:0060249 100 0.012
protein secretion GO:0009306 98 0.012
response to salt stress GO:0009651 3 0.012
negative regulation of transport GO:0051051 176 0.012
t cell differentiation in thymus GO:0033077 4 0.012
negative regulation of protein transport GO:0051224 75 0.012
cell division GO:0051301 168 0.012
divalent metal ion transport GO:0070838 152 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
organelle assembly GO:0070925 176 0.012
regulation of metal ion transport GO:0010959 120 0.012
positive regulation of mapk cascade GO:0043410 190 0.012
positive regulation of acute inflammatory response GO:0002675 2 0.012
negative regulation of eosinophil migration GO:2000417 2 0.012
multi organism cellular process GO:0044764 156 0.012
osteoblast differentiation GO:0001649 92 0.012
cell type specific apoptotic process GO:0097285 125 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
blood vessel morphogenesis GO:0048514 162 0.012
positive regulation of kinase activity GO:0033674 204 0.012
negative regulation of protein modification process GO:0031400 200 0.012
forelimb morphogenesis GO:0035136 4 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
single organism nuclear import GO:1902593 104 0.011
negative regulation of locomotion GO:0040013 118 0.011
actin filament organization GO:0007015 128 0.011
cellular defense response GO:0006968 2 0.011
positive regulation of cell cycle process GO:0090068 106 0.011
cell projection morphogenesis GO:0048858 129 0.011
post embryonic organ development GO:0048569 1 0.011
positive regulation of cell activation GO:0050867 81 0.011
alcohol metabolic process GO:0006066 114 0.011
positive regulation of cytokine secretion GO:0050715 42 0.011
positive regulation of protein kinase b signaling GO:0051897 42 0.011
activation of phospholipase d activity GO:0031584 3 0.011
cellular calcium ion homeostasis GO:0006874 117 0.011
activation of immune response GO:0002253 114 0.011
regulation of protein kinase b signaling GO:0051896 61 0.011
nuclear import GO:0051170 106 0.011
ossification GO:0001503 121 0.011
regulation of cell projection organization GO:0031344 107 0.011
t cell mediated immunity GO:0002456 25 0.011
sensory perception of pain GO:0019233 4 0.011
locomotory behavior GO:0007626 1 0.011
positive regulation of ras gtpase activity GO:0032320 117 0.011
microtubule cytoskeleton organization GO:0000226 176 0.011
response to lipopolysaccharide GO:0032496 70 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
cell part morphogenesis GO:0032990 137 0.011
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.011
negative regulation of phosphatase activity GO:0010923 61 0.011
mitotic cell cycle GO:0000278 326 0.011
positive regulation of ion transmembrane transport GO:0034767 40 0.011
negative regulation of cd4 positive alpha beta t cell proliferation GO:2000562 1 0.011
sex determination GO:0007530 3 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011

PRF1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.020
cancer DOID:162 167 0.012
disease of cellular proliferation DOID:14566 174 0.012