|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.959
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.929
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.912
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.911
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.872
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.867
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.857
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.847
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.831
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.828
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.827
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.824
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.816
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.804
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.803
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.785
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.771
|
Fly |
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.759
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.750
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.742
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.730
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.727
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.721
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.711
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.709
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.703
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.703
|
Fly |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.702
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.692
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.692
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.685
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.679
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.670
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.636
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.626
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.624
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.614
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.601
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.595
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.590
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.589
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.587
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.576
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.573
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.572
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.569
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.562
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.560
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.555
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.552
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.551
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.550
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.548
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.547
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.544
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.543
|
Fly |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.542
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.541
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.534
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.534
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.530
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.529
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.524
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.523
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.520
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.517
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.508
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.505
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.503
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.488
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.482
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.481
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.479
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.474
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.471
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.458
|
Fly |
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.458
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.454
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.432
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.423
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.413
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.403
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.403
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.401
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.388
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.384
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.382
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.376
|
Fly |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.373
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.373
|
|
|
|
regulation of glial cell proliferation
|
GO:0060251 |
4 |
0.370
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.365
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.360
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.359
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.351
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.349
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.349
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.343
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.338
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.332
|
Fly |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.325
|
Human |
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.324
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.320
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.317
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.313
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.311
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.309
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.308
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.305
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.304
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.303
|
Human |
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.300
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.300
|
|
|
|
positive regulation of gliogenesis
|
GO:0014015 |
4 |
0.300
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.299
|
Fly |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.296
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.290
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.287
|
|
|
|
cellular polysaccharide biosynthetic process
|
GO:0033692 |
21 |
0.278
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.268
|
Fly |
|
|
oogenesis
|
GO:0048477 |
2 |
0.268
|
Fly |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.266
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.264
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.259
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.255
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.243
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.243
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.241
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.239
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.236
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.227
|
Human |
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.226
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.225
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.224
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.223
|
|
|
|
regulation of glycogen biosynthetic process
|
GO:0005979 |
14 |
0.221
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.219
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.215
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.212
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.211
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.208
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.205
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.203
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.203
|
|
|
|
phospholipid catabolic process
|
GO:0009395 |
12 |
0.201
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.200
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.199
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.199
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.199
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.193
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.192
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.192
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.191
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.191
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.191
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.190
|
|
|
|
regulation of lipid catabolic process
|
GO:0050994 |
23 |
0.190
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.186
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.186
|
Fly |
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.184
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.184
|
Human |
|
|
cell competition in a multicellular organism
|
GO:0035212 |
1 |
0.182
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.178
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.177
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.175
|
|
|
|
system process
|
GO:0003008 |
349 |
0.175
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.172
|
|
|
|
startle response
|
GO:0001964 |
3 |
0.171
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.170
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.169
|
|
|
|
monosaccharide metabolic process
|
GO:0005996 |
74 |
0.168
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.168
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.168
|
|
|
|
regulation of chemotaxis
|
GO:0050920 |
74 |
0.168
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.165
|
Fly |
|
|
cell development
|
GO:0048468 |
328 |
0.164
|
Fly |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.162
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.162
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.162
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.162
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.160
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.160
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.160
|
|
|
|
monosaccharide transport
|
GO:0015749 |
32 |
0.158
|
|
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.157
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.157
|
|
|
|
regulation of axon regeneration
|
GO:0048679 |
1 |
0.157
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.157
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.156
|
|
|
|
growth
|
GO:0040007 |
202 |
0.156
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.154
|
|
|
|
cellular carbohydrate biosynthetic process
|
GO:0034637 |
21 |
0.154
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.152
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.149
|
Fly |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.148
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.145
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.145
|
|
|
|
cellular polysaccharide metabolic process
|
GO:0044264 |
27 |
0.145
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.143
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.141
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.141
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.140
|
|
|
|
energy reserve metabolic process
|
GO:0006112 |
22 |
0.139
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.139
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.138
|
|
|
|
organic acid catabolic process
|
GO:0016054 |
71 |
0.137
|
|
|
|
regulation of neuron projection regeneration
|
GO:0070570 |
1 |
0.134
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.131
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.130
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.130
|
Fly |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.129
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.126
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.124
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.124
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.124
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.123
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.123
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.123
|
Fly |
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.122
|
Fly |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.121
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.121
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.120
|
|
|
|
lipid modification
|
GO:0030258 |
84 |
0.120
|
|
|
|
ribonucleoprotein complex biogenesis
|
GO:0022613 |
116 |
0.120
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.118
|
|
|
|
regulation of dendrite development
|
GO:0050773 |
18 |
0.117
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.117
|
|
|
|
termination of signal transduction
|
GO:0023021 |
3 |
0.117
|
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
2 |
0.116
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.115
|
|
|
|
behavioral response to ethanol
|
GO:0048149 |
2 |
0.114
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
63 |
0.114
|
|
|
|
negative regulation of phosphatase activity
|
GO:0010923 |
61 |
0.113
|
Human |
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
3 |
0.113
|
Fly |
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.112
|
|
|
|
phospholipid transport
|
GO:0015914 |
23 |
0.111
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.111
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.111
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.110
|
|
|
|
organic hydroxy compound catabolic process
|
GO:1901616 |
22 |
0.110
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.109
|
|
|
|
regulation of cellular response to insulin stimulus
|
GO:1900076 |
17 |
0.109
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.109
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.109
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.108
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.108
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.108
|
|
|
|
organophosphate ester transport
|
GO:0015748 |
32 |
0.108
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.107
|
|
|
|
ribonucleoprotein complex assembly
|
GO:0022618 |
78 |
0.107
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
4 |
0.107
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.106
|
|
|
|
anion transmembrane transport
|
GO:0098656 |
76 |
0.105
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.105
|
|
|
|
response to activity
|
GO:0014823 |
0 |
0.104
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.104
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.104
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.103
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.103
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.103
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.102
|
|
|
|
lipid catabolic process
|
GO:0016042 |
84 |
0.102
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.101
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.101
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.101
|
Fly |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.101
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.100
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.099
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.099
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.099
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.099
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.099
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.099
|
|
|
|
generation of precursor metabolites and energy
|
GO:0006091 |
68 |
0.098
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.098
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.096
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.096
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.096
|
|
|
|
forebrain neuron development
|
GO:0021884 |
2 |
0.096
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.095
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.095
|
|
|
|
olfactory bulb development
|
GO:0021772 |
5 |
0.094
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.094
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.094
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.094
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.094
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.093
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.092
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.092
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
23 |
0.091
|
|
|
|
glucan metabolic process
|
GO:0044042 |
22 |
0.091
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.090
|
|
|
|
t cell homeostasis
|
GO:0043029 |
3 |
0.088
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.087
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.087
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.087
|
Fly |
|
|
glycogen metabolic process
|
GO:0005977 |
22 |
0.086
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.085
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.085
|
|
|
|
small molecule catabolic process
|
GO:0044282 |
92 |
0.085
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.085
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.084
|
|
|
|
negative regulation of synaptic transmission
|
GO:0050805 |
2 |
0.084
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
13 |
0.084
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.083
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.083
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.083
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.083
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.083
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.082
|
|
|
|
polysaccharide metabolic process
|
GO:0005976 |
33 |
0.082
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.082
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.082
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.081
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.080
|
|
|
|
somatic muscle development
|
GO:0007525 |
1 |
0.080
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.079
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.079
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.079
|
|
|
|
regulation of glucose import
|
GO:0046324 |
21 |
0.079
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.078
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.077
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.077
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.076
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.076
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.075
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.075
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.075
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.074
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.074
|
Fly |
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.072
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.072
|
|
|
|
peroxisome degradation
|
GO:0030242 |
1 |
0.071
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.071
|
Fly |
|
|
response to radiation
|
GO:0009314 |
151 |
0.071
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.071
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.070
|
|
|
|
post embryonic organ development
|
GO:0048569 |
1 |
0.070
|
|
|
|
glycogen biosynthetic process
|
GO:0005978 |
16 |
0.069
|
|
|
|
positive regulation of collateral sprouting
|
GO:0048672 |
2 |
0.069
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.069
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.069
|
|
|
|
regulation of polysaccharide biosynthetic process
|
GO:0032885 |
20 |
0.069
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.068
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.068
|
|
|
|
cellular biogenic amine metabolic process
|
GO:0006576 |
34 |
0.067
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.067
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.066
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.066
|
Fly |
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.066
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.066
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.065
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.065
|
|
|
|
organic acid transport
|
GO:0015849 |
65 |
0.065
|
|
|
|
regulation of axon extension involved in axon guidance
|
GO:0048841 |
2 |
0.064
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.064
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.063
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.063
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.062
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.062
|
|
|
|
rna catabolic process
|
GO:0006401 |
71 |
0.062
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.062
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.062
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
31 |
0.062
|
Fly |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.062
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.062
|
|
|
|
forebrain neuron differentiation
|
GO:0021879 |
3 |
0.061
|
|
|
|
regulation of glycogen metabolic process
|
GO:0070873 |
15 |
0.061
|
|
|
|
establishment of protein localization to plasma membrane
|
GO:0090002 |
68 |
0.061
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.060
|
|
|
|
regulation of carbohydrate metabolic process
|
GO:0006109 |
54 |
0.060
|
|
|
|
positive regulation of glycogen biosynthetic process
|
GO:0045725 |
10 |
0.060
|
|
|
|
negative regulation of alkaline phosphatase activity
|
GO:0010693 |
2 |
0.060
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.060
|
|
|
|
regulation of blood vessel endothelial cell migration
|
GO:0043535 |
30 |
0.060
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.060
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.060
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.060
|
|
|
|
carboxylic acid catabolic process
|
GO:0046395 |
71 |
0.059
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.059
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.059
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.059
|
Fly |
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.058
|
|
|
|
monocarboxylic acid catabolic process
|
GO:0072329 |
37 |
0.058
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.058
|
|
|
|
positive regulation of cellular response to insulin stimulus
|
GO:1900078 |
6 |
0.057
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.057
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.057
|
|
|
|
cellular lipid catabolic process
|
GO:0044242 |
65 |
0.057
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.056
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.056
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.056
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.056
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.055
|
Fly |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.055
|
|
|
|
regulation of cellular carbohydrate metabolic process
|
GO:0010675 |
47 |
0.055
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.055
|
|
|
|
sphingolipid metabolic process
|
GO:0006665 |
38 |
0.055
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.055
|
|
|
|
positive regulation of cell growth
|
GO:0030307 |
48 |
0.054
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.054
|
|
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.054
|
|
|
|
peroxisome organization
|
GO:0007031 |
28 |
0.054
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.054
|
|
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
55 |
0.054
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.054
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.054
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.054
|
|
|
|
negative regulation of lipid catabolic process
|
GO:0050995 |
9 |
0.054
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.054
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.054
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.054
|
|
|
|
positive regulation of organ growth
|
GO:0046622 |
2 |
0.054
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.053
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.053
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.053
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.052
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.052
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.051
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.051
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.051
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.051
|
|
|
|
regulation of polysaccharide metabolic process
|
GO:0032881 |
21 |
0.051
|
|
|
|
regulation of axon guidance
|
GO:1902667 |
3 |
0.051
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.051
|
Fly |
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.051
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.051
|
|
|
|
ceramide metabolic process
|
GO:0006672 |
25 |
0.051
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.051
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.051
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.050
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.049
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.049
|
|
|
|
liposaccharide metabolic process
|
GO:1903509 |
27 |
0.049
|
|
|
|
brain morphogenesis
|
GO:0048854 |
1 |
0.049
|
|
|
|
response to fluid shear stress
|
GO:0034405 |
14 |
0.049
|
|
|
|
regulation of neuron migration
|
GO:2001222 |
3 |
0.049
|
|
|
|
ethanolamine containing compound metabolic process
|
GO:0042439 |
26 |
0.049
|
|
|
|
collateral sprouting
|
GO:0048668 |
2 |
0.049
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.048
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.048
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.048
|
|
|
|
ral protein signal transduction
|
GO:0032484 |
1 |
0.048
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.048
|
|
|
|
regulation of glucan biosynthetic process
|
GO:0010962 |
14 |
0.048
|
|
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.048
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.048
|
|
|
|
positive regulation of carbohydrate metabolic process
|
GO:0045913 |
21 |
0.047
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.047
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.047
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.046
|
Fly |
|
|
autophagy
|
GO:0006914 |
88 |
0.046
|
|
|
|
schwann cell development
|
GO:0014044 |
1 |
0.046
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.046
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.046
|
|
|
|
positive regulation of protein targeting to membrane
|
GO:0090314 |
8 |
0.046
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.046
|
|
|
|
regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay
|
GO:1900151 |
8 |
0.046
|
|
|
|
positive regulation of superoxide anion generation
|
GO:0032930 |
4 |
0.046
|
|
|
|
positive regulation of chemotaxis
|
GO:0050921 |
57 |
0.046
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.046
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.046
|
|
|
|
regulation of alkaline phosphatase activity
|
GO:0010692 |
2 |
0.046
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.045
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.045
|
|
|
|
positive regulation of vesicle fusion
|
GO:0031340 |
4 |
0.045
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.045
|
|
|
|
cerebral cortex cell migration
|
GO:0021795 |
3 |
0.045
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.045
|
Fly |
|
|
membrane lipid metabolic process
|
GO:0006643 |
53 |
0.044
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.044
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.044
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
23 |
0.044
|
|
|
|
polysaccharide biosynthetic process
|
GO:0000271 |
27 |
0.044
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.044
|
|
|
|
positive regulation of fat cell differentiation
|
GO:0045600 |
12 |
0.044
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.044
|
|
|
|
regulation of ral protein signal transduction
|
GO:0032485 |
1 |
0.044
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.044
|
|
|
|
positive regulation of response to dna damage stimulus
|
GO:2001022 |
43 |
0.044
|
|
|
|
ribonucleoprotein complex subunit organization
|
GO:0071826 |
81 |
0.044
|
|
|
|
regulation of glucosylceramide catabolic process
|
GO:2000752 |
1 |
0.043
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.043
|
|
|
|
primary neural tube formation
|
GO:0014020 |
3 |
0.043
|
|
|
|
positive regulation of growth
|
GO:0045927 |
58 |
0.043
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.042
|
Fly |
|
|
negative regulation of posttranscriptional gene silencing
|
GO:0060149 |
3 |
0.042
|
|
|
|
positive regulation of ral gtpase activity
|
GO:0032852 |
1 |
0.042
|
|
|
|
positive regulation of monooxygenase activity
|
GO:0032770 |
14 |
0.042
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.042
|
|
|
|
positive regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045737 |
15 |
0.042
|
|
|
|
positive regulation of developmental growth
|
GO:0048639 |
16 |
0.042
|
|
