IMP

Process View

Homo sapiens

34 genes annotated in human

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular senescence"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular senescence" (in gray)

Name	Description	Probability	Func Analog Organism
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.970
MAPK14	mitogen-activated protein kinase 14	0.944
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.939
RB1	retinoblastoma 1	0.897
CDK6	cyclin-dependent kinase 6	0.892
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.845
CREBBP	CREB binding protein	0.820
PML	promyelocytic leukemia	0.816
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.814
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.796
RUNX1	runt-related transcription factor 1	0.793
SMC6	structural maintenance of chromosomes 6	0.748
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.739
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.722
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.654
CTAG1B	cancer/testis antigen 1B	0.594
MAPK1	mitogen-activated protein kinase 1	0.554
EP300	E1A binding protein p300	0.543
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.542
CCND1	cyclin D1	0.433
NOXA1	NADPH oxidase activator 1	0.414
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.413
NCF1	neutrophil cytosolic factor 1	0.408
CCND3	cyclin D3	0.382
EID2	EP300 interacting inhibitor of differentiation 2	0.375
MAGEA3	melanoma antigen family A, 3	0.365
HSPB1	heat shock 27kDa protein 1	0.322
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.298
TP53	tumor protein p53	0.294
HSF1	heat shock transcription factor 1	0.277
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.263
TEKT4	tektin 4	0.261
NAP1L5	nucleosome assembly protein 1-like 5	0.259
DAXX	death-domain associated protein	0.253
BMP2	bone morphogenetic protein 2	0.245
TAL1	T-cell acute lymphocytic leukemia 1	0.243	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.233
KAT2B	K(lysine) acetyltransferase 2B	0.232
DUSP1	dual specificity phosphatase 1	0.217
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.190
PKM2	pyruvate kinase, muscle	0.166
NCOR2	nuclear receptor corepressor 2	0.158
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.150
ATF2	activating transcription factor 2	0.128
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.126	Human
GATA4	GATA binding protein 4	0.122
CPNE6	copine VI (neuronal)	0.119
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.117
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.115
MYOD1	myogenic differentiation 1	0.111
SETD8	SET domain containing (lysine methyltransferase) 8	0.108
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.104	Human
MKL1	megakaryoblastic leukemia (translocation) 1	0.103
UBE3A	ubiquitin protein ligase E3A	0.101
CLOCK	clock homolog (mouse)	0.100
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.098
HIPK2	homeodomain interacting protein kinase 2	0.094
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.091
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.090
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.089	Human
TNIP1	TNFAIP3 interacting protein 1	0.085
ARRB1	arrestin, beta 1	0.083
PRKCZ	protein kinase C, zeta	0.079	Human
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.079
MAP2K1	mitogen-activated protein kinase kinase 1	0.076
PEBP4	phosphatidylethanolamine-binding protein 4	0.076
JUN	jun proto-oncogene	0.073
SP1	Sp1 transcription factor	0.072
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.071
NCOR1	nuclear receptor corepressor 1	0.070
RALBP1	ralA binding protein 1	0.069
SMAD3	SMAD family member 3	0.068
RHEB	Ras homolog enriched in brain	0.067
SMAD7	SMAD family member 7	0.067
WWOX	WW domain containing oxidoreductase	0.066
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.063
CNBP	CCHC-type zinc finger, nucleic acid binding protein	0.063
YAP1	Yes-associated protein 1	0.062
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.061
DUSP9	dual specificity phosphatase 9	0.061
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.058
SH3RF1	SH3 domain containing ring finger 1	0.056
MAGEA5	melanoma antigen family A, 5	0.055
SATB2	SATB homeobox 2	0.055
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.051
EID2B	EP300 interacting inhibitor of differentiation 2B	0.049
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.049
MAGEA12	melanoma antigen family A, 12	0.049	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.048
SOS1	son of sevenless homolog 1 (Drosophila)	0.048
MAGEA2	melanoma antigen family A, 2	0.047
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.046
ARRB2	arrestin, beta 2	0.045
MYOCD	myocardin	0.043
GATA2	GATA binding protein 2	0.042
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.042
MAPK8	mitogen-activated protein kinase 8	0.042	Human
SMN1	survival of motor neuron 1, telomeric	0.041
NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	0.040
LNX1	ligand of numb-protein X 1	0.039
TRIM69	tripartite motif containing 69	0.039
YY1	YY1 transcription factor	0.039
FOXO3	forkhead box O3	0.037
BCL2	B-cell CLL/lymphoma 2	0.036
KRT5	keratin 5	0.036
MAGEA6	melanoma antigen family A, 6	0.035	Human
ZNF420	zinc finger protein 420	0.034
TCF12	transcription factor 12	0.034
BAG1	BCL2-associated athanogene	0.034
TP53BP2	tumor protein p53 binding protein, 2	0.033
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.033	Human
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.032
TSC22D1	TSC22 domain family, member 1	0.032
PAWR	PRKC, apoptosis, WT1, regulator	0.032
BTBD2	BTB (POZ) domain containing 2	0.032
MAPK6	mitogen-activated protein kinase 6	0.031
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.031
TRIM28	tripartite motif containing 28	0.031
GLRX3	glutaredoxin 3	0.031
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.030
CABLES1	Cdk5 and Abl enzyme substrate 1	0.030
TGIF1	TGFB-induced factor homeobox 1	0.030
EID1	EP300 interacting inhibitor of differentiation 1	0.030
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.030
HDAC3	histone deacetylase 3	0.030
WRN	Werner syndrome, RecQ helicase-like	0.030
SPRR2A	small proline-rich protein 2A	0.030
SMAD4	SMAD family member 4	0.030
PDPK1	3-phosphoinositide dependent protein kinase-1	0.029
MAPK3	mitogen-activated protein kinase 3	0.029
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.029
CCL14	chemokine (C-C motif) ligand 14	0.028
MOAP1	modulator of apoptosis 1	0.028
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.028
PDIA3	protein disulfide isomerase family A, member 3	0.027
RAP1A	RAP1A, member of RAS oncogene family	0.027
HCFC1	host cell factor C1 (VP16-accessory protein)	0.027
CP110	CP110 protein	0.027
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.026
MAGEB2	melanoma antigen family B, 2	0.026	Human
FGF3	fibroblast growth factor 3	0.026
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.026
PJA1	praja ring finger 1	0.025
CUL7	cullin 7	0.025
SETDB1	SET domain, bifurcated 1	0.025
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.025
TP73	tumor protein p73	0.025	Human
RBBP5	retinoblastoma binding protein 5	0.024
EID3	EP300 interacting inhibitor of differentiation 3	0.024
HIPK1	homeodomain interacting protein kinase 1	0.024
BANP	BTG3 associated nuclear protein	0.024
PEBP1	phosphatidylethanolamine binding protein 1	0.023
LIMK1	LIM domain kinase 1	0.023
FGF18	fibroblast growth factor 18	0.023
MAGEA4	melanoma antigen family A, 4	0.022	Human
WASF1	WAS protein family, member 1	0.022
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.022
HMGA1	high mobility group AT-hook 1	0.022
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.022
MYST1	MYST histone acetyltransferase 1	0.021
NDNL2	necdin-like 2	0.021	Human
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.021	Human
WNT10A	wingless-type MMTV integration site family, member 10A	0.021	Human
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.021
NUMB	numb homolog (Drosophila)	0.021
S100A4	S100 calcium binding protein A4	0.021
DLG1	discs, large homolog 1 (Drosophila)	0.021
CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.021
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.020
EGR1	early growth response 1	0.020
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.020
CDCP1	CUB domain containing protein 1	0.020
HTT	huntingtin	0.020
ZMYND11	zinc finger, MYND-type containing 11	0.020
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.020
CCND2	cyclin D2	0.020
MAPK7	mitogen-activated protein kinase 7	0.019
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.019
CTAG1A	cancer/testis antigen 1A	0.019
BMP4	bone morphogenetic protein 4	0.019
MAPK9	mitogen-activated protein kinase 9	0.018	Human
ZNF71	zinc finger protein 71	0.018
RALGDS	ral guanine nucleotide dissociation stimulator	0.018
CYBA	cytochrome b-245, alpha polypeptide	0.018
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.018
SOX1	SRY (sex determining region Y)-box 1	0.018
MAGEA9B	melanoma antigen family A, 9B	0.017	Human
BTRC	beta-transducin repeat containing	0.017
HDAC9	histone deacetylase 9	0.017
S1PR5	sphingosine-1-phosphate receptor 5	0.017
POU4F2	POU class 4 homeobox 2	0.017
MYO10	myosin X	0.017
WNT1	wingless-type MMTV integration site family, member 1	0.017	Human
MAGEA11	melanoma antigen family A, 11	0.017
ILK	integrin-linked kinase	0.017
ELF4	E74-like factor 4 (ets domain transcription factor)	0.017
PEA15	phosphoprotein enriched in astrocytes 15	0.016
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.016
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.016
KRT15	keratin 15	0.016
PHOX2A	paired-like homeobox 2a	0.016
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.016
BNC1	basonuclin 1	0.016
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.016	Mouse
PKN1	protein kinase N1	0.016
HDAC10	histone deacetylase 10	0.016
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.016
CCDC115	coiled-coil domain containing 115	0.015
SLC25A36	solute carrier family 25, member 36	0.015
FYN	FYN oncogene related to SRC, FGR, YES	0.015
SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	0.015
SIX6	SIX homeobox 6	0.015
KRT6C	keratin 6C	0.015
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.015
LMX1A	LIM homeobox transcription factor 1, alpha	0.015
FKBP8	FK506 binding protein 8, 38kDa	0.014
PRMT6	protein arginine methyltransferase 6	0.014
PYY	peptide YY	0.014
NPAS1	neuronal PAS domain protein 1	0.014
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.014
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.014
MAPK15	mitogen-activated protein kinase 15	0.014
MAGEA8	melanoma antigen family A, 8	0.014	Human
NFYA	nuclear transcription factor Y, alpha	0.014
PTPRR	protein tyrosine phosphatase, receptor type, R	0.014
CHUK	conserved helix-loop-helix ubiquitous kinase	0.014
MAGED1	melanoma antigen family D, 1	0.014
SQSTM1	sequestosome 1	0.014
GCM2	glial cells missing homolog 2 (Drosophila)	0.014
HES2	hairy and enhancer of split 2 (Drosophila)	0.014
SSX2B	synovial sarcoma, X breakpoint 2B	0.014
PDX1	pancreatic and duodenal homeobox 1	0.014
RIN1	Ras and Rab interactor 1	0.014
TPTE	transmembrane phosphatase with tensin homology	0.014
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.014
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.014
GLP1R	glucagon-like peptide 1 receptor	0.013
SMAD1	SMAD family member 1	0.013
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.013
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.013
PHOX2B	paired-like homeobox 2b	0.013
FGF8	fibroblast growth factor 8 (androgen-induced)	0.013
MKL2	MKL/myocardin-like 2	0.013
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.013
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.013
RFWD2	ring finger and WD repeat domain 2	0.013
APP	amyloid beta (A4) precursor protein	0.013
AMOTL1	angiomotin like 1	0.013
CTAG2	cancer/testis antigen 2	0.013
HDAC5	histone deacetylase 5	0.013
DUSP7	dual specificity phosphatase 7	0.013
SFRP1	secreted frizzled-related protein 1	0.013
BAG3	BCL2-associated athanogene 3	0.013
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.013
MSX1	msh homeobox 1	0.013
FOXF2	forkhead box F2	0.013
SETD7	SET domain containing (lysine methyltransferase) 7	0.013
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.013
SSX4B	synovial sarcoma, X breakpoint 4B	0.012
HAP1	huntingtin-associated protein 1	0.012
PAX2	paired box 2	0.012
PIAS2	protein inhibitor of activated STAT, 2	0.012
ARNT	aryl hydrocarbon receptor nuclear translocator	0.012
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.012
ZNF282	zinc finger protein 282	0.012
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.012
FSTL1	follistatin-like 1	0.012
CAPNS1	calpain, small subunit 1	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
FOXL1	forkhead box L1	0.012
GATA5	GATA binding protein 5	0.012
DCBLD1	discoidin, CUB and LCCL domain containing 1	0.012
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.012
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.012
TRIM37	tripartite motif containing 37	0.012
LDLR	low density lipoprotein receptor	0.012
PPARA	peroxisome proliferator-activated receptor alpha	0.012
COL2A1	collagen, type II, alpha 1	0.012
SCARF2	scavenger receptor class F, member 2	0.012
SSX3	synovial sarcoma, X breakpoint 3	0.011
GAGE3	G antigen 3	0.011
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.011
PICK1	protein interacting with PRKCA 1	0.011
CRY1	cryptochrome 1 (photolyase-like)	0.011
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.011
GAGE12D	G antigen 12D	0.011
TBX1	T-box 1	0.011	Human
RAB2A	RAB2A, member RAS oncogene family	0.011
ZNF148	zinc finger protein 148	0.011
TERT	telomerase reverse transcriptase	0.011
OPTN	optineurin	0.011
BCOR	BCL6 corepressor	0.011
FOXO1	forkhead box O1	0.011
SIRT1	sirtuin 1	0.011
PRLHR	prolactin releasing hormone receptor	0.011
WNT6	wingless-type MMTV integration site family, member 6	0.011	Human
MAGEC1	melanoma antigen family C, 1	0.011	Human
PAX5	paired box 5	0.011
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.011
HOXD13	homeobox D13	0.011
LMO2	LIM domain only 2 (rhombotin-like 1)	0.011
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.011
LMO1	LIM domain only 1 (rhombotin 1)	0.011
SMAD6	SMAD family member 6	0.011
NEUROD2	neurogenic differentiation 2	0.011	Human
SOX18	SRY (sex determining region Y)-box 18	0.011
EMX1	empty spiracles homeobox 1	0.010
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.010
WIF1	WNT inhibitory factor 1	0.010
SUPV3L1	suppressor of var1, 3-like 1 (S. cerevisiae)	0.010
NMNAT1	nicotinamide nucleotide adenylyltransferase 1	0.010
MSH4	mutS homolog 4 (E. coli)	0.010
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.010
OBSL1	obscurin-like 1	0.010
SSX1	synovial sarcoma, X breakpoint 1	0.010
DUSP3	dual specificity phosphatase 3	0.010
SHOX2	short stature homeobox 2	0.010
PGR	progesterone receptor	0.010
VSX1	visual system homeobox 1	0.010