|
|
scf dependent proteasomal ubiquitin dependent protein catabolic process
|
GO:0031146 |
15 |
1.000
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
1.000
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
1.000
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
1.000
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
1.000
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
1.000
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
1.000
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.999
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.999
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.999
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.998
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.997
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.996
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.994
|
|
|
|
g2 m transition of mitotic cell cycle
|
GO:0000086 |
41 |
0.985
|
Yeast |
|
|
negative regulation of glial cell proliferation
|
GO:0060253 |
2 |
0.975
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.972
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.963
|
Yeast Worm Fly |
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.949
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.941
|
Fly |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.941
|
Fly |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.920
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.919
|
|
|
|
neuron remodeling
|
GO:0016322 |
2 |
0.912
|
Fly |
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.906
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.902
|
Worm Fly |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.901
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.896
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.893
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.882
|
Fly |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.872
|
Fly |
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
2 |
0.861
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.846
|
Yeast |
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.820
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.812
|
Fly |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.808
|
Worm |
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.807
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.803
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.791
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.790
|
Fly |
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.774
|
Yeast |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.762
|
Yeast Fly |
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.743
|
Fly |
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.730
|
Fly |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.701
|
Worm |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.692
|
Yeast Worm Fly |
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.675
|
|
|
|
negative regulation of tor signaling
|
GO:0032007 |
11 |
0.667
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.666
|
Fly |
|
|
regulation of ubiquitin protein transferase activity
|
GO:0051438 |
28 |
0.659
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.650
|
Fly |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.636
|
Fly |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.635
|
Fly |
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.631
|
|
|
|
cell cycle g2 m phase transition
|
GO:0044839 |
43 |
0.618
|
Yeast |
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.611
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.597
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.594
|
Yeast Worm Fly |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.593
|
Worm |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.584
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.583
|
Worm Fly |
|
|
canonical wnt signaling pathway involved in negative regulation of apoptotic process
|
GO:0044336 |
2 |
0.579
|
|
|
|
regulation of heart induction
|
GO:0090381 |
2 |
0.575
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.541
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.532
|
Yeast Worm Fly |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.523
|
Worm Fly |
|
|
nephron tubule epithelial cell differentiation
|
GO:0072160 |
3 |
0.519
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.518
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.515
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.511
|
Fly |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.505
|
Yeast Fly |
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.482
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.469
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.467
|
Yeast |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.460
|
Yeast Fly |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.455
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.455
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.447
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.438
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.436
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.435
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.416
|
Worm |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.416
|
Fly |
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.415
|
Worm |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.399
|
Fly |
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.393
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
13 |
0.390
|
Worm |
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.389
|
Fly |
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.377
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.376
|
|
|
|
regulation of centrosome cycle
|
GO:0046605 |
15 |
0.372
|
Fly |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.371
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.371
|
Fly |
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.364
|
Fly |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.361
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.351
|
Yeast |
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.350
|
|
|
|
cerebral cortex radially oriented cell migration
|
GO:0021799 |
1 |
0.349
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.329
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.328
|
Yeast Fly |
|
|
regulation of microtubule based process
|
GO:0032886 |
74 |
0.326
|
Fly |
|
|
regulation of triglyceride metabolic process
|
GO:0090207 |
11 |
0.322
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.321
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.321
|
|
|
|
negative regulation of cellular protein catabolic process
|
GO:1903363 |
38 |
0.320
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.315
|
|
|
|
negative regulation of gliogenesis
|
GO:0014014 |
3 |
0.314
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.308
|
Worm |
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.289
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.286
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.276
|
Fly |
|
|
nf kappab import into nucleus
|
GO:0042348 |
22 |
0.274
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.270
|
|
|
|
metaphase anaphase transition of cell cycle
|
GO:0044784 |
21 |
0.269
|
|
|
|
smoothened signaling pathway
|
GO:0007224 |
14 |
0.264
|
|
|
|
cellular response to lithium ion
|
GO:0071285 |
2 |
0.252
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.251
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.246
|
Yeast Worm Fly |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.233
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.230
|
Fly |
|
|
amide transport
|
GO:0042886 |
76 |
0.230
|
|
|
|
regulation of nf kappab import into nucleus
|
GO:0042345 |
22 |
0.229
|
|
|
|
regulation of glial cell proliferation
|
GO:0060251 |
4 |
0.227
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.225
|
Fly |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.224
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.219
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.214
|
|
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.213
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.208
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.205
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.203
|
Worm |
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.202
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.194
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.194
|
Yeast |
|
|
reproductive system development
|
GO:0061458 |
56 |
0.193
|
Worm |
|
|
regulation of smooth muscle cell proliferation
|
GO:0048660 |
28 |
0.192
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.188
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.188
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.187
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.185
|
|
|
|
negative regulation of intracellular protein transport
|
GO:0090317 |
42 |
0.183
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.181
|
Fly |
|
|
embryonic forelimb morphogenesis
|
GO:0035115 |
4 |
0.177
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.176
|
Fly |
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.175
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.170
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.168
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.166
|
Fly |
|
|
system process
|
GO:0003008 |
349 |
0.165
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.163
|
Fly |
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.162
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.160
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.158
|
|
|
|
regulation of microtubule cytoskeleton organization
|
GO:0070507 |
61 |
0.157
|
Fly |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.156
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.153
|
Fly |
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.152
|
Fly |
|
|
histone monoubiquitination
|
GO:0010390 |
20 |
0.150
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.149
|
|
|
|
cell death in response to oxidative stress
|
GO:0036473 |
29 |
0.148
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.148
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.147
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.147
|
Worm |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.147
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.146
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.143
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.138
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.138
|
|
|
|
negative regulation of smoothened signaling pathway
|
GO:0045879 |
3 |
0.136
|
|
|
|
centrosome cycle
|
GO:0007098 |
32 |
0.135
|
Fly |
|
|
dna replication
|
GO:0006260 |
116 |
0.135
|
Fly |
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.133
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.132
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.132
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.131
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.130
|
Fly |
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.126
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.125
|
Worm |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.125
|
Fly |
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.125
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.124
|
Fly |
|
|
negative regulation of protein import into nucleus
|
GO:0042308 |
30 |
0.123
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.123
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.123
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.122
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.122
|
|
|
|
cerebral cortex radial glia guided migration
|
GO:0021801 |
1 |
0.120
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.120
|
Yeast |
|
|
generation of neurons
|
GO:0048699 |
152 |
0.120
|
Fly |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.120
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.116
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.115
|
|
|
|
granulocyte differentiation
|
GO:0030851 |
16 |
0.114
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
36 |
0.114
|
|
|
|
regulation of metaphase anaphase transition of cell cycle
|
GO:1902099 |
26 |
0.114
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.113
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.111
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.109
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.108
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.107
|
Fly |
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.107
|
|
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
47 |
0.107
|
|
|
|
negative regulation of camp mediated signaling
|
GO:0043951 |
4 |
0.107
|
|
|
|
positive regulation of glycoprotein metabolic process
|
GO:1903020 |
8 |
0.104
|
|
|
|
histone h2a ubiquitination
|
GO:0033522 |
17 |
0.103
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.103
|
Yeast |
|
|
defense response to virus
|
GO:0051607 |
71 |
0.103
|
|
|
|
autophagic cell death
|
GO:0048102 |
3 |
0.103
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.101
|
|
|
|
stem cell proliferation
|
GO:0072089 |
25 |
0.099
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.099
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.097
|
|
|
|
cyclin catabolic process
|
GO:0008054 |
6 |
0.097
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.096
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.095
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.095
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.095
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.091
|
Worm |
|
|
response to lithium ion
|
GO:0010226 |
2 |
0.091
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.090
|
Fly |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.090
|
Worm |
|
|
oogenesis
|
GO:0048477 |
2 |
0.088
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.088
|
Worm |
|
|
segmentation
|
GO:0035282 |
4 |
0.087
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.086
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.085
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.084
|
Fly |
|
|
neutral lipid metabolic process
|
GO:0006638 |
27 |
0.084
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.083
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.082
|
Yeast |
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
55 |
0.081
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.079
|
|
|
|
stem cell development
|
GO:0048864 |
69 |
0.077
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.077
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.076
|
Fly |
|
|
negative regulation of mitotic anaphase promoting complex activity
|
GO:0060564 |
4 |
0.076
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.075
|
Fly |
|
|
negative regulation of protein localization to nucleus
|
GO:1900181 |
34 |
0.075
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.075
|
Fly |
|
|
negative regulation of myeloid leukocyte differentiation
|
GO:0002762 |
16 |
0.074
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.074
|
Fly |
|
|
protein neddylation
|
GO:0045116 |
7 |
0.074
|
Yeast |
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.073
|
Worm |
|
|
regulation of g1 s transition of mitotic cell cycle
|
GO:2000045 |
40 |
0.073
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.072
|
Fly |
|
|
histone h2a monoubiquitination
|
GO:0035518 |
11 |
0.071
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.071
|
|
|
|
cellular response to toxic substance
|
GO:0097237 |
4 |
0.071
|
|
|
|
cerebral cortex cell migration
|
GO:0021795 |
3 |
0.071
|
|
|
|
negative regulation of cytoplasmic transport
|
GO:1903650 |
46 |
0.070
|
|
|
|
blastocyst development
|
GO:0001824 |
3 |
0.070
|
|
|
|
protein destabilization
|
GO:0031648 |
12 |
0.070
|
|
|
|
neuron maturation
|
GO:0042551 |
5 |
0.068
|
Fly |
|
|
regulation of embryonic development
|
GO:0045995 |
20 |
0.068
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.068
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.067
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.066
|
Worm |
|
|
regeneration
|
GO:0031099 |
4 |
0.065
|
|
|
|
regulation of triglyceride catabolic process
|
GO:0010896 |
6 |
0.064
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.063
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.062
|
Fly |
|
|
positive regulation of nf kappab import into nucleus
|
GO:0042346 |
13 |
0.062
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.062
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.062
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.061
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.060
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.060
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.060
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.059
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.059
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.059
|
Fly |
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
54 |
0.059
|
|
|
|
regulation of organelle assembly
|
GO:1902115 |
40 |
0.058
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.058
|
Fly |
|
|
nuclear import
|
GO:0051170 |
106 |
0.058
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.057
|
Worm |
|
|
regulation of mitotic sister chromatid segregation
|
GO:0033047 |
27 |
0.057
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.056
|
Fly |
|
|
regulation of kidney development
|
GO:0090183 |
10 |
0.056
|
|
|
|
positive regulation of transcription factor import into nucleus
|
GO:0042993 |
25 |
0.056
|
|
|
|
mitotic dna damage checkpoint
|
GO:0044773 |
28 |
0.056
|
Fly |
|
|
cell fate determination
|
GO:0001709 |
3 |
0.055
|
|
|
|
neutral lipid biosynthetic process
|
GO:0046460 |
11 |
0.055
|
|
|
|
g1 dna damage checkpoint
|
GO:0044783 |
18 |
0.054
|
|
|
|
regulation of smoothened signaling pathway
|
GO:0008589 |
6 |
0.054
|
|
|
|
spindle organization
|
GO:0007051 |
53 |
0.054
|
|
|
|
regulation of intracellular steroid hormone receptor signaling pathway
|
GO:0033143 |
32 |
0.054
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.054
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.053
|
Fly |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.053
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.053
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.052
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.052
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.052
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.052
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.052
|
|
|
|
canonical wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
|
GO:0044334 |
2 |
0.051
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.051
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
13 |
0.050
|
Fly |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.050
|
|
|
|
sex differentiation
|
GO:0007548 |
45 |
0.050
|
Worm |
|
|
centrosome organization
|
GO:0051297 |
58 |
0.050
|
Fly |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.049
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.048
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.048
|
|
|
|
protein export from nucleus
|
GO:0006611 |
29 |
0.048
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.048
|
Worm |
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.047
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.047
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.046
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.046
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.046
|
|
|
|
regulation of cellular response to insulin stimulus
|
GO:1900076 |
17 |
0.046
|
Fly |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.046
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.046
|
|
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.046
|
|
|
|
regulation of heparan sulfate proteoglycan biosynthetic process
|
GO:0010908 |
3 |
0.045
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.045
|
|
|
|
embryonic eye morphogenesis
|
GO:0048048 |
2 |
0.045
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.044
|
|
|
|
androgen receptor signaling pathway
|
GO:0030521 |
34 |
0.043
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.041
|
|
|
|
negative regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0045736 |
15 |
0.041
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.041
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.041
|
Yeast Fly |
|
|
vasculature development
|
GO:0001944 |
181 |
0.041
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.040
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.040
|
|
|
|
positive regulation of ubiquitin protein transferase activity
|
GO:0051443 |
18 |
0.040
|
|
|
|
growth
|
GO:0040007 |
202 |
0.040
|
Fly |
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.039
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.039
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.038
|
Worm |
|
|
iron ion homeostasis
|
GO:0055072 |
15 |
0.038
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.038
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.037
|
Fly |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.037
|
|
|
|
cyclic nucleotide mediated signaling
|
GO:0019935 |
26 |
0.037
|
|
|
|
acylglycerol biosynthetic process
|
GO:0046463 |
11 |
0.037
|
|
|
|
negative regulation of chromosome organization
|
GO:2001251 |
48 |
0.037
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.036
|
|
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.036
|
|
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.036
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
44 |
0.036
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.035
|
Worm |
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.035
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.035
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.035
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.035
|
Worm |
|
|
protein processing
|
GO:0016485 |
226 |
0.035
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.034
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
29 |
0.034
|
|
|
|
negative regulation of heart induction by canonical wnt signaling pathway
|
GO:0003136 |
1 |
0.034
|
|
|
|
mitotic sister chromatid separation
|
GO:0051306 |
18 |
0.034
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.033
|
|
|
|
pharynx development
|
GO:0060465 |
1 |
0.033
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
40 |
0.033
|
|
|
|
positive regulation of proteoglycan biosynthetic process
|
GO:1902730 |
3 |
0.033
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.033
|
|
|
|
negative regulation of nucleocytoplasmic transport
|
GO:0046823 |
37 |
0.033
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.033
|
|
|
|
mitotic g1 s transition checkpoint
|
GO:0044819 |
17 |
0.033
|
|
|
|
negative regulation of glial cell differentiation
|
GO:0045686 |
1 |
0.032
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.032
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.032
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
35 |
0.032
|
|
|
|
aging
|
GO:0007568 |
66 |
0.032
|
Worm |
|
|
positive regulation of protein polyubiquitination
|
GO:1902916 |
3 |
0.032
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.032
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.032
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.031
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.031
|
|
|
|
memory
|
GO:0007613 |
3 |
0.031
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.031
|
|
|
|
regulation of mitotic sister chromatid separation
|
GO:0010965 |
27 |
0.031
|
|
|
|
lipoprotein particle mediated signaling
|
GO:0055095 |
1 |
0.031
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.031
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.031
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.031
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.031
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
48 |
0.030
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.030
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.030
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.030
|
Worm |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.029
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.029
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.029
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
7 |
0.029
|
|
|
|
neural tube patterning
|
GO:0021532 |
2 |
0.029
|
|
|
|
positive regulation of cellular response to oxidative stress
|
GO:1900409 |
7 |
0.029
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.029
|
|
|
|
negative regulation of cell fate commitment
|
GO:0010454 |
3 |
0.028
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.028
|
|
|
|
sister chromatid cohesion
|
GO:0007062 |
24 |
0.028
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.028
|
Fly |
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.028
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.028
|
|
|
|
metanephric nephron epithelium development
|
GO:0072243 |
4 |
0.028
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
10 |
0.028
|
Worm |
|
|
regulation of glycoprotein biosynthetic process
|
GO:0010559 |
14 |
0.028
|
|
|
|
sprouting angiogenesis
|
GO:0002040 |
29 |
0.028
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.028
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.028
|
Yeast |
|
|
regulation of g2 m transition of mitotic cell cycle
|
GO:0010389 |
20 |
0.027
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.027
|
Yeast Fly |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.027
|
|
|
|
centrosome duplication
|
GO:0051298 |
28 |
0.027
|
Fly |
|
|
negative regulation of catagen
|
GO:0051796 |
1 |
0.027
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.027
|
|
|
|
negative regulation of interleukin 4 production
|
GO:0032713 |
3 |
0.027
|
|
|
|
ectoderm development
|
GO:0007398 |
3 |
0.027
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.027
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.026
|
|
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.026
|
|
|
|
positive regulation of circadian rhythm
|
GO:0042753 |
1 |
0.026
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.026
|
Yeast |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.025
|
Fly |
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.025
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.025
|
|
|
|
prostate gland development
|
GO:0030850 |
3 |
0.025
|
|
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.025
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.024
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.024
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.024
|
|
|
|
telomere maintenance
|
GO:0000723 |
32 |
0.024
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.024
|
|
|
|
negative regulation of transcription factor import into nucleus
|
GO:0042992 |
17 |
0.024
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.024
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.024
|
|
|
|
male gamete generation
|
GO:0048232 |
22 |
0.024
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.023
|
|
|
|
nucleus localization
|
GO:0051647 |
1 |
0.023
|
|
|
|
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway
|
GO:1902177 |
4 |
0.023
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.023
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.023
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.023
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.023
|
|
|
|
negative regulation of reproductive process
|
GO:2000242 |
7 |
0.022
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
23 |
0.022
|
Fly |
|
|
sensory perception
|
GO:0007600 |
103 |
0.022
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.022
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.022
|
Fly |
|
|
cellular response to inorganic substance
|
GO:0071241 |
45 |
0.022
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.022
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.022
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.022
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.022
|
|
|
|
regulation of chromatin organization
|
GO:1902275 |
56 |
0.022
|
|
|
|
regulation of nephron tubule epithelial cell differentiation
|
GO:0072182 |
3 |
0.021
|
|
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
102 |
0.021
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.021
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.021
|
Fly |
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.021
|
|
|
|
centriole replication
|
GO:0007099 |
13 |
0.021
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.021
|
Yeast |
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.021
|
|
|
|
cardiac muscle cell cardiac muscle cell adhesion
|
GO:0086042 |
1 |
0.021
|
|
|
|
negative regulation of nf kappab import into nucleus
|
GO:0042347 |
12 |
0.021
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.021
|
|
|
|
spermatogenesis
|
GO:0007283 |
22 |
0.021
|
|
|
|
insulin secretion
|
GO:0030073 |
39 |
0.020
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.020
|
|
|
|
regulation of organ formation
|
GO:0003156 |
4 |
0.020
|
|
|
|
regulation of metanephros development
|
GO:0072215 |
4 |
0.020
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.020
|
Worm |
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.020
|
|
|
|
regulation of cell cycle g2 m phase transition
|
GO:1902749 |
22 |
0.020
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.020
|
|
|
|
positive regulation of metaphase anaphase transition of cell cycle
|
GO:1902101 |
6 |
0.020
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.020
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.020
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.019
|
|
|
|
regulation of mitotic metaphase anaphase transition
|
GO:0030071 |
26 |
0.019
|
|
|
|
establishment of endothelial blood brain barrier
|
GO:0014045 |
1 |
0.019
|
|
|
|
canonical wnt signaling pathway involved in regulation of cell proliferation
|
GO:0044340 |
2 |
0.019
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.019
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.019
|
|
|
|
negative regulation of gene expression epigenetic
|
GO:0045814 |
19 |
0.019
|
|
|
|
regulation of cardioblast differentiation
|
GO:0051890 |
4 |
0.019
|
|
|
|
regulation of determination of dorsal identity
|
GO:2000015 |
2 |
0.019
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.018
|
Fly |
|
|
sensory perception of sound
|
GO:0007605 |
37 |
0.018
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.018
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.018
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.018
|
|
|
|
cognition
|
GO:0050890 |
43 |
0.018
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.018
|
Worm |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.018
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.018
|
|
|
|
negative regulation of cellular response to insulin stimulus
|
GO:1900077 |
8 |
0.018
|
Fly |
|
|
chromosome separation
|
GO:0051304 |
23 |
0.018
|
|
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.018
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.018
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.018
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.017
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.017
|
|
