IMP

Process View

Homo sapiens

18 genes annotated in human

g1 dna damage checkpoint

A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "g1 dna damage checkpoint"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "g1 dna damage checkpoint" (in gray)

Name	Description	Probability	Func Analog Organism
TP53	tumor protein p53	1.000
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.995
XIAP	X-linked inhibitor of apoptosis	0.983
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.974	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.903	Human
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.815
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.711
RB1	retinoblastoma 1	0.670
CDK6	cyclin-dependent kinase 6	0.606
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.518
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.470
CCND3	cyclin D3	0.367	Human
APAF1	apoptotic peptidase activating factor 1	0.337
PAX3	paired box 3	0.332
LRDD	leucine-rich repeats and death domain containing	0.228
IER3	immediate early response 3	0.223
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.209
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.203
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.189
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.185
FAS	Fas (TNF receptor superfamily, member 6)	0.171
CFLAR	CASP8 and FADD-like apoptosis regulator	0.146
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.141	Human
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.138	Human
CDK2	cyclin-dependent kinase 2	0.134
NLRC4	NLR family, CARD domain containing 4	0.126
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.123
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.121	Human
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.110
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.101
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.101	Human
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.087	Yeast
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.087
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.076
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.073
STRN3	striatin, calmodulin binding protein 3	0.071
BCL2	B-cell CLL/lymphoma 2	0.067
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.063	Human
FADD	Fas (TNFRSF6)-associated via death domain	0.058
FASLG	Fas ligand (TNF superfamily, member 6)	0.058
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.055
SKP1	S-phase kinase-associated protein 1	0.054
RPA1	replication protein A1, 70kDa	0.054
HIPK2	homeodomain interacting protein kinase 2	0.053
POU3F2	POU class 3 homeobox 2	0.052
CCND1	cyclin D1	0.051
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.050
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.044	Human
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.044
KRT5	keratin 5	0.043
SMAD7	SMAD family member 7	0.040
RBL1	retinoblastoma-like 1 (p107)	0.036
DAXX	death-domain associated protein	0.033
WWOX	WW domain containing oxidoreductase	0.033
RNF20	ring finger protein 20	0.031
MKRN1	makorin ring finger protein 1	0.030
MED1	mediator complex subunit 1	0.030
BRCA1	breast cancer 1, early onset	0.029
BIRC2	baculoviral IAP repeat containing 2	0.029
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.029	Human
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.028
CABLES1	Cdk5 and Abl enzyme substrate 1	0.027
CCNE1	cyclin E1	0.027
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.026
POU5F1	POU class 5 homeobox 1	0.026
NOTCH1	notch 1	0.026
SKP2	S-phase kinase-associated protein 2 (p45)	0.025
RAD18	RAD18 homolog (S. cerevisiae)	0.025
CCND2	cyclin D2	0.024	Human
SATB2	SATB homeobox 2	0.024
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.023	Human
RYBP	RING1 and YY1 binding protein	0.022
MARCKSL1	MARCKS-like 1	0.022
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.021
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.020
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.020
SALL2	sal-like 2 (Drosophila)	0.019
CSNK1A1	casein kinase 1, alpha 1	0.019
FOXD3	forkhead box D3	0.018
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.018
RIPK2	receptor-interacting serine-threonine kinase 2	0.018
CCNA1	cyclin A1	0.018
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.018
GORAB	golgin, RAB6-interacting	0.018
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.017
YAP1	Yes-associated protein 1	0.017
RPA2	replication protein A2, 32kDa	0.017
PCGF2	polycomb group ring finger 2	0.016
TERT	telomerase reverse transcriptase	0.016
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
RBL2	retinoblastoma-like 2 (p130)	0.015
EP300	E1A binding protein p300	0.015
PPME1	protein phosphatase methylesterase 1	0.015
BTRC	beta-transducin repeat containing	0.014
DZIP1	DAZ interacting protein 1	0.014
CUX1	cut-like homeobox 1	0.013
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.013
SIAH1	seven in absentia homolog 1 (Drosophila)	0.013
CASP8AP2	caspase 8 associated protein 2	0.013
NBN	nibrin	0.013
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.013
YY1	YY1 transcription factor	0.013
KAT2B	K(lysine) acetyltransferase 2B	0.012
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.012
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.012
RIOK3	RIO kinase 3 (yeast)	0.012
POLH	polymerase (DNA directed), eta	0.011
USP2	ubiquitin specific peptidase 2	0.011
MDFI	MyoD family inhibitor	0.011
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.011
S100A2	S100 calcium binding protein A2	0.011
KRT6C	keratin 6C	0.011
IFI16	interferon, gamma-inducible protein 16	0.011
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.011
S1PR5	sphingosine-1-phosphate receptor 5	0.011
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.010
SMC1A	structural maintenance of chromosomes 1A	0.010
UNG	uracil-DNA glycosylase	0.010
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.010