Homo sapiens

96 known processes

TARDBP

TAR DNA binding protein

(Aliases: TDP-43,ALS10)

TARDBP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna processing GO:0006396 255 0.995
female gamete generation GO:0007292 2 0.976
posttranscriptional regulation of gene expression GO:0010608 213 0.954
post embryonic development GO:0009791 2 0.934
translation GO:0006412 132 0.890
oogenesis GO:0048477 2 0.857
regulation of mrna splicing via spliceosome GO:0048024 32 0.745
embryo development GO:0009790 123 0.736
mrna metabolic process GO:0016071 175 0.731
mrna processing GO:0006397 133 0.702
posttranscriptional gene silencing by rna GO:0035194 25 0.701
determination of adult lifespan GO:0008340 2 0.683
cellular macromolecule catabolic process GO:0044265 380 0.593
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.572
oocyte development GO:0048599 1 0.556
multicellular organismal aging GO:0010259 3 0.551
negative regulation of gene silencing by rna GO:0060967 3 0.533
ribonucleoprotein complex biogenesis GO:0022613 116 0.514
cell development GO:0048468 328 0.513
Zebrafish Fly
rna catabolic process GO:0006401 71 0.501
spermatid development GO:0007286 4 0.483
regulation of rna splicing GO:0043484 62 0.475
posttranscriptional gene silencing GO:0016441 25 0.386
regulation of meiotic cell cycle GO:0051445 4 0.368
intracellular mrna localization GO:0008298 1 0.367
oocyte differentiation GO:0009994 2 0.343
negative regulation of developmental process GO:0051093 247 0.338
Fly
regulation of rna stability GO:0043487 23 0.333
response to abiotic stimulus GO:0009628 336 0.330
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.329
regulation of meiosis GO:0040020 3 0.328
negative regulation of cell differentiation GO:0045596 171 0.320
regulation of translation GO:0006417 89 0.314
ribonucleoside monophosphate metabolic process GO:0009161 187 0.311
nucleobase containing compound transport GO:0015931 51 0.311
embryo development ending in birth or egg hatching GO:0009792 34 0.306
nucleic acid transport GO:0050657 39 0.305
regulation of mrna metabolic process GO:1903311 53 0.304
negative regulation of cellular protein metabolic process GO:0032269 353 0.301
establishment of rna localization GO:0051236 39 0.300
crd mediated mrna stabilization GO:0070934 5 0.290
mitotic cell cycle process GO:1903047 286 0.276
reproduction GO:0000003 63 0.272
alternative mrna splicing via spliceosome GO:0000380 27 0.258
negative regulation of rna splicing GO:0033119 15 0.249
histone methylation GO:0016571 60 0.241
nuclear division GO:0000280 128 0.239
circadian regulation of translation GO:0097167 1 0.228
regulation of growth GO:0040008 165 0.226
Fly
rna localization GO:0006403 41 0.197
regulation of cell cycle GO:0051726 393 0.191
mitotic cell cycle GO:0000278 326 0.185
mrna splicing via spliceosome GO:0000398 89 0.182
gene silencing by rna GO:0031047 26 0.179
rna splicing via transesterification reactions GO:0000375 90 0.176
ribonucleoprotein complex assembly GO:0022618 78 0.176
reproductive process GO:0022414 106 0.170
positive regulation of cell proliferation GO:0008284 301 0.168
stem cell differentiation GO:0048863 93 0.164
rna interference GO:0016246 4 0.155
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.154
spermatid differentiation GO:0048515 4 0.151
regulation of gene expression epigenetic GO:0040029 73 0.148
neurogenesis GO:0022008 169 0.147
Zebrafish Fly
nuclear export GO:0051168 69 0.144
stem cell development GO:0048864 69 0.132
regulation of cell cycle process GO:0010564 266 0.127
growth GO:0040007 202 0.118
Zebrafish Fly
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 23 0.116
single organism cellular localization GO:1902580 332 0.115
rna splicing GO:0008380 131 0.114
ribonucleoprotein complex subunit organization GO:0071826 81 0.108
cytoplasmic transport GO:0016482 379 0.108
regulation of mrna processing GO:0050684 48 0.096
methylation GO:0032259 106 0.093
positive regulation of developmental process GO:0051094 314 0.091
regionalization GO:0003002 29 0.090
behavior GO:0007610 112 0.089
Zebrafish Fly
nervous system development GO:0007399 293 0.088
Zebrafish Fly
glycosyl compound catabolic process GO:1901658 413 0.084
vesicle mediated transport GO:0016192 371 0.082
negative regulation of programmed cell death GO:0043069 321 0.076
purine nucleoside monophosphate catabolic process GO:0009128 158 0.072
sexual reproduction GO:0019953 37 0.070
response to biotic stimulus GO:0009607 276 0.066
mrna export from nucleus GO:0006406 29 0.066
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.064
regulation of mrna stability GO:0043488 23 0.064
purine ribonucleoside catabolic process GO:0046130 398 0.063
gene silencing GO:0016458 49 0.063
negative regulation of apoptotic process GO:0043066 316 0.063
negative regulation of protein metabolic process GO:0051248 391 0.062
nuclear transcribed mrna catabolic process GO:0000956 48 0.061
segmentation GO:0035282 4 0.060
rna transport GO:0050658 39 0.059
protein acylation GO:0043543 138 0.059
lipid localization GO:0010876 106 0.058
anterior posterior axis specification embryo GO:0008595 2 0.055
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.055
endocytosis GO:0006897 159 0.055
mrna catabolic process GO:0006402 56 0.054
epithelium development GO:0060429 227 0.054
single organism reproductive process GO:0044702 98 0.054
cell division GO:0051301 168 0.053
organelle assembly GO:0070925 176 0.053
positive regulation of translation GO:0045727 35 0.052
pattern specification process GO:0007389 43 0.052
rna polyadenylation GO:0043631 14 0.052
hemidesmosome assembly GO:0031581 5 0.052
gene silencing by mirna GO:0035195 23 0.051
negative regulation of translation GO:0017148 37 0.051
negative regulation of mrna splicing via spliceosome GO:0048025 11 0.050
stem cell division GO:0017145 2 0.049
ncrna metabolic process GO:0034660 108 0.048
cellular component morphogenesis GO:0032989 314 0.047
Zebrafish Fly
cell junction organization GO:0034330 79 0.047
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.046
cellular amine metabolic process GO:0044106 41 0.046
multi organism reproductive process GO:0044703 54 0.045
muscle contraction GO:0006936 73 0.045
chromatin modification GO:0016568 298 0.045
response to nutrient levels GO:0031667 81 0.045
viral life cycle GO:0019058 132 0.043
response to external biotic stimulus GO:0043207 261 0.042
rna phosphodiester bond hydrolysis GO:0090501 35 0.042
regulation of cellular response to stress GO:0080135 244 0.041
blastoderm segmentation GO:0007350 2 0.041
protein alkylation GO:0008213 74 0.040
histone modification GO:0016570 251 0.040
regulation of cell division GO:0051302 116 0.040
negative regulation of cell death GO:0060548 345 0.039
nuclear transport GO:0051169 179 0.039
organelle fission GO:0048285 149 0.039
multicellular organism reproduction GO:0032504 42 0.039
amine metabolic process GO:0009308 44 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.038
osteoblast differentiation GO:0001649 92 0.038
gamete generation GO:0007276 25 0.038
response to oxygen containing compound GO:1901700 369 0.037
ribonucleoside catabolic process GO:0042454 406 0.037
purine nucleoside monophosphate metabolic process GO:0009126 186 0.037
aging GO:0007568 66 0.036
positive regulation of cellular catabolic process GO:0031331 284 0.036
tripartite regional subdivision GO:0007351 2 0.035
cell junction assembly GO:0034329 67 0.035
nucleocytoplasmic transport GO:0006913 176 0.032
negative regulation of cell cycle process GO:0010948 121 0.032
apoptotic signaling pathway GO:0097190 268 0.032
negative regulation of mrna metabolic process GO:1903312 15 0.032
meiotic nuclear division GO:0007126 10 0.032
ribonucleoside triphosphate metabolic process GO:0009199 412 0.031
regulation of cell differentiation GO:0045595 393 0.031
microtubule cytoskeleton organization GO:0000226 176 0.031
negative regulation of epidermal cell differentiation GO:0045605 4 0.031
positive regulation of cell activation GO:0050867 81 0.031
positive regulation of dna metabolic process GO:0051054 73 0.030
macromolecule methylation GO:0043414 97 0.030
response to cytokine GO:0034097 232 0.029
regeneration GO:0031099 4 0.029
positive regulation of organelle organization GO:0010638 195 0.029
female sex differentiation GO:0046660 12 0.028
reproductive structure development GO:0048608 55 0.028
production of mirnas involved in gene silencing by mirna GO:0035196 12 0.028
anterior posterior axis specification GO:0009948 2 0.028
protein stabilization GO:0050821 64 0.028
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.027
nucleoside monophosphate catabolic process GO:0009125 159 0.026
embryonic morphogenesis GO:0048598 85 0.025
multicellular organismal reproductive process GO:0048609 40 0.025
cellular response to oxygen containing compound GO:1901701 276 0.025
ras protein signal transduction GO:0007265 73 0.025
intrinsic apoptotic signaling pathway GO:0097193 127 0.025
spliceosomal complex assembly GO:0000245 17 0.024
atp metabolic process GO:0046034 176 0.024
positive regulation of proteolysis GO:0045862 142 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
cell substrate junction assembly GO:0007044 35 0.024
spermatogenesis GO:0007283 22 0.024
protein methylation GO:0006479 74 0.024
rna 3 end processing GO:0031123 35 0.023
nucleoside catabolic process GO:0009164 408 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.023
positive regulation of chromatin assembly or disassembly GO:0045799 2 0.023
purine nucleotide catabolic process GO:0006195 405 0.023
regulation of nervous system development GO:0051960 88 0.023
Fly
negative regulation of cell cycle GO:0045786 193 0.023
regulation of mitotic cell cycle GO:0007346 189 0.023
regulation of endopeptidase activity GO:0052548 170 0.022
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.022
signal transduction by p53 class mediator GO:0072331 72 0.022
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.022
dorsal ventral pattern formation GO:0009953 15 0.022
response to extracellular stimulus GO:0009991 85 0.022
organophosphate catabolic process GO:0046434 430 0.022
cellular macromolecular complex assembly GO:0034622 324 0.021
response to heat GO:0009408 21 0.021
vasculature development GO:0001944 181 0.021
regulation of viral process GO:0050792 103 0.021
interspecies interaction between organisms GO:0044419 156 0.021
positive regulation of transport GO:0051050 336 0.021
nuclear import GO:0051170 106 0.021
regulation of chromatin modification GO:1903308 51 0.021
rna export from nucleus GO:0006405 33 0.020
regulation of developmental growth GO:0048638 30 0.020
Fly
positive regulation of cellular component organization GO:0051130 376 0.020
circulatory system development GO:0072359 262 0.020
positive regulation of cell cycle GO:0045787 140 0.020
response to starvation GO:0042594 59 0.020
blastocyst development GO:0001824 3 0.020
response to nitrogen compound GO:1901698 184 0.020
dna replication GO:0006260 116 0.019
protein localization to organelle GO:0033365 280 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
nitrogen compound transport GO:0071705 191 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
negative regulation of peptidase activity GO:0010466 91 0.018
regulation of cell cycle phase transition GO:1901987 126 0.018
small molecule biosynthetic process GO:0044283 157 0.018
cell growth GO:0016049 160 0.017
Zebrafish
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.017
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 14 0.017
positive regulation of mrna processing GO:0050685 17 0.017
atp catabolic process GO:0006200 157 0.017
regulation of apoptotic signaling pathway GO:2001233 175 0.017
regulation of translational initiation GO:0006446 24 0.017
regulation of viral genome replication GO:0045069 48 0.016
cell projection organization GO:0030030 252 0.016
Zebrafish Fly
immune response GO:0006955 307 0.016
neuron projection development GO:0031175 106 0.016
Zebrafish Fly
regulation of dna metabolic process GO:0051052 153 0.016
angiogenesis GO:0001525 147 0.016
blood vessel morphogenesis GO:0048514 162 0.016
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
cell cycle checkpoint GO:0000075 117 0.015
ribonucleoside monophosphate catabolic process GO:0009158 158 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
generation of neurons GO:0048699 152 0.015
Zebrafish Fly
developmental process involved in reproduction GO:0003006 66 0.015
regulation of cellular ketone metabolic process GO:0010565 50 0.015
ncrna processing GO:0034470 83 0.014
germ cell development GO:0007281 8 0.014
tissue regeneration GO:0042246 3 0.014
ossification GO:0001503 121 0.014
dosage compensation GO:0007549 3 0.014
response to drug GO:0042493 81 0.014
positive regulation of growth GO:0045927 58 0.014
cell cycle phase transition GO:0044770 173 0.014
covalent chromatin modification GO:0016569 254 0.014
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.014
mrna transport GO:0051028 30 0.013
muscle system process GO:0003012 81 0.013
cellular component disassembly GO:0022411 92 0.013
chordate embryonic development GO:0043009 34 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
organelle localization GO:0051640 84 0.013
ribonucleoside triphosphate catabolic process GO:0009203 391 0.013
organ morphogenesis GO:0009887 147 0.013
development of primary sexual characteristics GO:0045137 35 0.013
regulation of immune effector process GO:0002697 91 0.013
regulation of peptidase activity GO:0052547 180 0.013
cell part morphogenesis GO:0032990 137 0.013
Zebrafish Fly
protein ubiquitination GO:0016567 314 0.013
heart morphogenesis GO:0003007 48 0.013
response to temperature stimulus GO:0009266 22 0.013
regulation of chromosome organization GO:0033044 103 0.013
developmental growth GO:0048589 48 0.012
Zebrafish Fly
regulation of lymphocyte activation GO:0051249 103 0.012
microtubule based process GO:0007017 210 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
regulation of leukocyte mediated immunity GO:0002703 38 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.012
negative regulation of mrna processing GO:0050686 12 0.012
response to lipid GO:0033993 206 0.012
nuclear migration GO:0007097 1 0.012
protein targeting to nucleus GO:0044744 104 0.012
chemotaxis GO:0006935 157 0.012
mrna 3 end processing GO:0031124 24 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
Fly
regulation of nuclear division GO:0051783 65 0.011
response to interferon gamma GO:0034341 39 0.011
system process GO:0003008 349 0.011
cellular ketone metabolic process GO:0042180 80 0.011
receptor mediated endocytosis GO:0006898 84 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
nucleoside triphosphate metabolic process GO:0009141 422 0.011
mitotic sister chromatid segregation GO:0000070 53 0.011
regulation of protein stability GO:0031647 87 0.011
defense response GO:0006952 315 0.011
regulation of protein complex assembly GO:0043254 147 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
chromatin organization GO:0006325 351 0.011
dna geometric change GO:0032392 32 0.010
positive regulation of leukocyte mediated immunity GO:0002705 24 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010
innate immune response GO:0045087 178 0.010
cellular amino acid metabolic process GO:0006520 116 0.010
nucleotide catabolic process GO:0009166 408 0.010
regulation of histone modification GO:0031056 47 0.010
protein maturation GO:0051604 233 0.010
regulation of protein transport GO:0051223 213 0.010
negative regulation of cell growth GO:0030308 83 0.010
regulation of cellular component biogenesis GO:0044087 281 0.010
Fly
sex differentiation GO:0007548 45 0.010

TARDBP disease predictions

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 104 0.875
muscular disease DOID:0080000 114 0.875
musculoskeletal system disease DOID:17 223 0.875
muscle tissue disease DOID:66 113 0.875
muscular dystrophy DOID:9884 51 0.313
central nervous system disease DOID:331 186 0.257
neurodegenerative disease DOID:1289 102 0.257
nervous system disease DOID:863 431 0.257
sensory system disease DOID:0050155 203 0.081
eye and adnexa disease DOID:1492 150 0.081
motor neuron disease DOID:231 27 0.002
amyotrophic lateral sclerosis DOID:332 20 0.002