Mus musculus

17 known processes

Pold4

polymerase (DNA-directed), delta 4

(Aliases: Polds,AI463381,p12,AW060307,2410012M21Rik)

Pold4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sphingolipid metabolic process GO:0006665 45 0.231
actin cytoskeleton organization GO:0030036 220 0.165
lamellipodium organization GO:0097581 29 0.088
macromolecule catabolic process GO:0009057 281 0.086
t cell activation GO:0042110 289 0.085
vesicle fusion GO:0006906 16 0.072
lytic vacuole organization GO:0080171 21 0.071
regulation of protein localization GO:0032880 231 0.066
carbohydrate derivative catabolic process GO:1901136 231 0.063
cation transport GO:0006812 399 0.059
regulation of hydrolase activity GO:0051336 246 0.059
divalent metal ion transport GO:0070838 172 0.057
maintenance of location GO:0051235 89 0.056
divalent inorganic cation transport GO:0072511 178 0.055
heterocycle catabolic process GO:0046700 280 0.055
striated muscle tissue development GO:0014706 293 0.053
regulation of neuron apoptotic process GO:0043523 122 0.053
calcium ion transport GO:0006816 159 0.052
muscle cell differentiation GO:0042692 261 0.052
t cell mediated immunity GO:0002456 50 0.051
positive regulation of protein modification process GO:0031401 299 0.050
endomembrane system organization GO:0010256 147 0.048
muscle tissue development GO:0060537 308 0.048
cation homeostasis GO:0055080 212 0.047
cellular metal ion homeostasis GO:0006875 151 0.047
metal ion homeostasis GO:0055065 189 0.047
regulation of t cell activation GO:0050863 170 0.045
membrane lipid metabolic process GO:0006643 53 0.045
myosin filament organization GO:0031033 3 0.044
calcium ion homeostasis GO:0055074 127 0.044
cytosolic calcium ion transport GO:0060401 48 0.044
apoptotic signaling pathway GO:0097190 306 0.043
regulation of proteolysis GO:0030162 164 0.043
protein processing GO:0016485 163 0.040
organelle fusion GO:0048284 28 0.040
actin filament organization GO:0007015 113 0.039
regulation of cytoplasmic transport GO:1903649 112 0.038
organelle localization GO:0051640 179 0.038
regulation of cellular component biogenesis GO:0044087 181 0.038
positive regulation of lamellipodium organization GO:1902745 3 0.037
neuron apoptotic process GO:0051402 142 0.037
positive regulation of proteolysis GO:0045862 85 0.037
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.036
cellular amino acid metabolic process GO:0006520 103 0.036
regulation of vesicle mediated transport GO:0060627 139 0.036
cellular nitrogen compound catabolic process GO:0044270 280 0.034
regulation of actin filament based process GO:0032970 99 0.034
organelle assembly GO:0070925 177 0.034
positive regulation of cell death GO:0010942 224 0.033
sequestering of metal ion GO:0051238 19 0.033
glycolipid metabolic process GO:0006664 25 0.033
sequestering of calcium ion GO:0051208 18 0.032
cellular protein complex assembly GO:0043623 116 0.032
regulation of ion transport GO:0043269 215 0.032
lymphocyte proliferation GO:0046651 164 0.032
membrane organization GO:0061024 245 0.031
negative regulation of neuron death GO:1901215 98 0.030
regulation of cellular amino acid metabolic process GO:0006521 5 0.030
oxidation reduction process GO:0055114 342 0.030
ion transmembrane transport GO:0034220 361 0.030
regulation of peptidase activity GO:0052547 96 0.030
regulation of cell adhesion GO:0030155 154 0.030
regulation of calcium ion transport GO:0051924 69 0.030
protein catabolic process GO:0030163 221 0.030
peptidyl amino acid modification GO:0018193 336 0.029
regulation of cell cycle GO:0051726 281 0.029
nucleoside phosphate catabolic process GO:1901292 222 0.029
regulation of cell projection organization GO:0031344 206 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
regulation of actin cytoskeleton organization GO:0032956 84 0.028
arp2 3 complex mediated actin nucleation GO:0034314 3 0.028
activation of cysteine type endopeptidase activity GO:0097202 27 0.028
sphingolipid catabolic process GO:0030149 7 0.028
regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling GO:0003027 1 0.028
cellular ketone metabolic process GO:0042180 84 0.028
actin filament polymerization GO:0030041 44 0.027
leukocyte apoptotic process GO:0071887 71 0.027
regulation of intracellular transport GO:0032386 159 0.027
regulation of lamellipodium morphogenesis GO:2000392 1 0.026
purine ribonucleotide metabolic process GO:0009150 290 0.026
response to extracellular stimulus GO:0009991 127 0.026
cellular homeostasis GO:0019725 240 0.026
positive regulation of programmed cell death GO:0043068 218 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.025
amide transport GO:0042886 138 0.025
zymogen activation GO:0031638 41 0.025
cognition GO:0050890 149 0.025
cellular response to hormone stimulus GO:0032870 150 0.025
response to inorganic substance GO:0010035 96 0.025
vesicle organization GO:0016050 60 0.025
protein polymerization GO:0051258 57 0.024
regulation of homeostatic process GO:0032844 182 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
nucleotide catabolic process GO:0009166 217 0.024
leukocyte homeostasis GO:0001776 79 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
cellular amine metabolic process GO:0044106 44 0.024
protein localization to cell leading edge GO:1902463 1 0.024
cell adhesion GO:0007155 329 0.024
cell substrate adhesion GO:0031589 130 0.023
cellular component assembly involved in morphogenesis GO:0010927 139 0.023
regulation of neuron death GO:1901214 134 0.023
nucleotide metabolic process GO:0009117 332 0.023
regulation of metal ion transport GO:0010959 106 0.023
cellular macromolecule catabolic process GO:0044265 206 0.023
microtubule based process GO:0007017 236 0.023
regulation of lymphocyte activation GO:0051249 240 0.023
regulation of cellular amine metabolic process GO:0033238 20 0.023
reactive oxygen species biosynthetic process GO:1903409 8 0.023
positive regulation of apoptotic process GO:0043065 217 0.022
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.022
neuron death GO:0070997 154 0.022
purine ribonucleoside metabolic process GO:0046128 241 0.022
negative regulation of homeostatic process GO:0032845 71 0.022
negative regulation of vesicle fusion GO:0031339 1 0.022
establishment of vesicle localization GO:0051650 81 0.022
protein maturation GO:0051604 176 0.022
organophosphate catabolic process GO:0046434 232 0.022
positive regulation of homeostatic process GO:0032846 64 0.022
aromatic compound catabolic process GO:0019439 286 0.022
cytosolic calcium ion homeostasis GO:0051480 70 0.022
organonitrogen compound catabolic process GO:1901565 264 0.021
neurotransmitter secretion GO:0007269 62 0.021
cell type specific apoptotic process GO:0097285 268 0.021
mitochondrion organization GO:0007005 134 0.021
regulation of cellular ketone metabolic process GO:0010565 66 0.021
nitrogen compound transport GO:0071705 271 0.020
male gamete generation GO:0048232 285 0.020
plasma membrane organization GO:0007009 90 0.020
positive regulation of macroautophagy GO:0016239 3 0.020
learning or memory GO:0007611 148 0.020
striated muscle cell development GO:0055002 125 0.020
adaptive immune response GO:0002250 155 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
glycosphingolipid catabolic process GO:0046479 5 0.020
response to organonitrogen compound GO:0010243 246 0.020
cellular ion homeostasis GO:0006873 165 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
leukocyte proliferation GO:0070661 172 0.020
calcium ion transport into cytosol GO:0060402 48 0.019
negative regulation of molecular function GO:0044092 258 0.019
learning GO:0007612 98 0.019
t cell homeostasis GO:0043029 35 0.019
carbohydrate homeostasis GO:0033500 128 0.019
cellular protein catabolic process GO:0044257 155 0.019
regulation of cytoskeleton organization GO:0051493 122 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.019
dephosphorylation GO:0016311 129 0.019
cytoplasmic transport GO:0016482 234 0.019
ribonucleotide metabolic process GO:0009259 291 0.019
amine metabolic process GO:0009308 45 0.019
nucleoside phosphate metabolic process GO:0006753 338 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.018
glycosylceramide metabolic process GO:0006677 4 0.018
regulation of transferase activity GO:0051338 263 0.018
glycosyl compound metabolic process GO:1901657 246 0.018
cellular response to extracellular stimulus GO:0031668 81 0.018
spermatogenesis GO:0007283 284 0.018
regulation of apoptotic signaling pathway GO:2001233 197 0.018
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.018
cardiac muscle tissue development GO:0048738 130 0.018
synaptic transmission GO:0007268 329 0.018
multi multicellular organism process GO:0044706 109 0.018
cellular chemical homeostasis GO:0055082 215 0.018
anatomical structure homeostasis GO:0060249 145 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.017
lymphocyte homeostasis GO:0002260 64 0.017
regulation of kinase activity GO:0043549 249 0.017
actin filament bundle assembly GO:0051017 40 0.017
multicellular organismal metabolic process GO:0044236 28 0.017
hematopoietic progenitor cell differentiation GO:0002244 143 0.017
glycosyl compound catabolic process GO:1901658 206 0.017
epidermis development GO:0008544 187 0.017
ceramide metabolic process GO:0006672 31 0.017
hormone secretion GO:0046879 128 0.017
cell chemotaxis GO:0060326 81 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
actin polymerization or depolymerization GO:0008154 54 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
nucleobase containing small molecule metabolic process GO:0055086 352 0.016
protein localization to membrane GO:0072657 108 0.016
positive regulation of cell projection organization GO:0031346 95 0.016
regulation of organelle organization GO:0033043 289 0.016
uropod organization GO:0032796 2 0.016
engulfment of apoptotic cell GO:0043652 3 0.016
organic cyclic compound catabolic process GO:1901361 295 0.016
positive regulation of actin filament polymerization GO:0030838 26 0.016
sensory organ morphogenesis GO:0090596 242 0.016
tissue homeostasis GO:0001894 115 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.016
positive regulation of cell motility GO:2000147 116 0.015
nucleoside catabolic process GO:0009164 206 0.015
lateral inhibition GO:0046331 1 0.015
response to peptide GO:1901652 136 0.015
cellular response to oxidative stress GO:0034599 76 0.015
cellular divalent inorganic cation homeostasis GO:0072503 127 0.015
phagocytosis GO:0006909 66 0.015
phagosome maturation GO:0090382 4 0.015
muscle cell development GO:0055001 133 0.015
regulation of mapk cascade GO:0043408 248 0.015
membrane protein proteolysis GO:0033619 10 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
rac protein signal transduction GO:0016601 13 0.015
positive regulation of cell activation GO:0050867 158 0.015
positive regulation of mapk cascade GO:0043410 170 0.015
guanosine containing compound metabolic process GO:1901068 144 0.015
purine nucleotide catabolic process GO:0006195 211 0.015
regulation of neuron projection development GO:0010975 169 0.015
ras protein signal transduction GO:0007265 77 0.015
regulation of calcium ion transport into cytosol GO:0010522 31 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
regulation of cell migration GO:0030334 219 0.015
i kappab kinase nf kappab signaling GO:0007249 85 0.015
endocytosis GO:0006897 168 0.015
regulation of protein kinase activity GO:0045859 232 0.015
divalent inorganic cation homeostasis GO:0072507 138 0.015
striated muscle myosin thick filament assembly GO:0071688 1 0.015
carbohydrate metabolic process GO:0005975 230 0.015
cell killing GO:0001906 67 0.015
lipid catabolic process GO:0016042 69 0.014
regulation of endopeptidase activity GO:0052548 89 0.014
nuclear import GO:0051170 95 0.014
peptide secretion GO:0002790 114 0.014
purine nucleotide metabolic process GO:0006163 302 0.014
regulation of intracellular protein transport GO:0033157 82 0.014
cellular calcium ion homeostasis GO:0006874 119 0.014
inflammatory response GO:0006954 244 0.014
response to organic cyclic compound GO:0014070 198 0.014
negative regulation of protein metabolic process GO:0051248 282 0.014
cellular response to glucose stimulus GO:0071333 45 0.014
cellular response to dna damage stimulus GO:0006974 207 0.014
regulation of binding GO:0051098 111 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
organelle fission GO:0048285 170 0.014
urogenital system development GO:0001655 261 0.014
cell matrix adhesion GO:0007160 68 0.014
golgi to endosome transport GO:0006895 3 0.014
positive regulation of secretion GO:0051047 130 0.014
positive regulation of cellular component biogenesis GO:0044089 94 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
carbohydrate catabolic process GO:0016052 32 0.014
response to nutrient levels GO:0031667 109 0.014
ameboidal type cell migration GO:0001667 128 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
myeloid cell homeostasis GO:0002262 114 0.014
regulation of cellular catabolic process GO:0031329 242 0.014
intracellular protein transport GO:0006886 204 0.014
regulation of protein catabolic process GO:0042176 108 0.014
single organism cell adhesion GO:0098602 156 0.014
t cell proliferation GO:0042098 120 0.013
regulation of actin nucleation GO:0051125 4 0.013
positive regulation of t cell activation GO:0050870 101 0.013
positive regulation of cell cycle GO:0045787 92 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.013
regulation of cell activation GO:0050865 289 0.013
establishment of protein localization to membrane GO:0090150 54 0.013
homeostasis of number of cells GO:0048872 210 0.013
regulation of protein maturation GO:1903317 96 0.013
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.013
peptide transport GO:0015833 133 0.013
leukocyte mediated cytotoxicity GO:0001909 62 0.013
establishment of organelle localization GO:0051656 122 0.013
synaptic vesicle localization GO:0097479 59 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
molting cycle GO:0042303 90 0.013
nucleoside triphosphate catabolic process GO:0009143 205 0.013
ribonucleoside metabolic process GO:0009119 245 0.012
cellular glucose homeostasis GO:0001678 52 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
single organismal cell cell adhesion GO:0016337 131 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
positive regulation of peptidase activity GO:0010952 49 0.012
purine ribonucleotide catabolic process GO:0009154 208 0.012
actomyosin structure organization GO:0031032 56 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
hair cycle GO:0042633 90 0.012
leukocyte mediated immunity GO:0002443 174 0.012
regulation of secretion GO:0051046 274 0.012
lung morphogenesis GO:0060425 50 0.012
negative regulation of protein modification process GO:0031400 163 0.012
respiratory tube development GO:0030323 167 0.012
leukocyte chemotaxis GO:0030595 69 0.012
positive regulation of lymphocyte activation GO:0051251 140 0.012
skeletal system development GO:0001501 356 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
negative regulation of intracellular transport GO:0032387 38 0.012
ceramide catabolic process GO:0046514 7 0.012
regulation of protein complex assembly GO:0043254 83 0.012
axonogenesis GO:0007409 274 0.012
release of sequestered calcium ion into cytosol GO:0051209 42 0.012
phospholipid transfer to membrane GO:0006649 2 0.012
protein localization to organelle GO:0033365 185 0.012
regulation of voltage gated calcium channel activity GO:1901385 4 0.012
lysosome organization GO:0007040 21 0.012
response to monosaccharide GO:0034284 67 0.012
filopodium assembly GO:0046847 19 0.011
negative regulation of organelle organization GO:0010639 90 0.011
neuromuscular process GO:0050905 99 0.011
antigen processing and presentation GO:0019882 47 0.011
protein targeting GO:0006605 143 0.011
regulation of hormone levels GO:0010817 211 0.011
transmembrane transport GO:0055085 412 0.011
skin development GO:0043588 220 0.011
negative regulation of proteolysis GO:0045861 74 0.011
regulation of membrane potential GO:0042391 192 0.011
regulation of nucleocytoplasmic transport GO:0046822 73 0.011
positive regulation of cellular catabolic process GO:0031331 148 0.011
establishment of protein localization to plasma membrane GO:0090002 34 0.011
membrane fusion GO:0061025 38 0.011
epithelium migration GO:0090132 63 0.011
lipid localization GO:0010876 126 0.011
skeletal muscle organ development GO:0060538 163 0.011
regulation of anatomical structure size GO:0090066 178 0.011
lipid transport GO:0006869 98 0.011
interleukin 1 alpha secretion GO:0050703 3 0.011
regulation of protein transport GO:0051223 163 0.011
protein import GO:0017038 101 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
positive regulation of protein complex assembly GO:0031334 45 0.011
positive regulation of endopeptidase activity GO:0010950 43 0.011
regulation of lamellipodium assembly GO:0010591 3 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
purine containing compound metabolic process GO:0072521 311 0.011
purine ribonucleoside catabolic process GO:0046130 205 0.010
purine nucleoside catabolic process GO:0006152 205 0.010
cell fate commitment GO:0045165 210 0.010
nuclear transport GO:0051169 139 0.010
innate immune response GO:0045087 157 0.010
synapse assembly GO:0007416 56 0.010
regulation of cell cycle process GO:0010564 160 0.010
renal system development GO:0072001 225 0.010
extracellular structure organization GO:0043062 148 0.010
glucose homeostasis GO:0042593 128 0.010
positive regulation of kinase activity GO:0033674 155 0.010
insulin secretion GO:0030073 89 0.010
regulation of cysteine type endopeptidase activity GO:2000116 65 0.010
response to osmotic stress GO:0006970 21 0.010
liposaccharide metabolic process GO:1903509 27 0.010
defense response to bacterium GO:0042742 119 0.010

Pold4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.145
lipid storage disease DOID:9455 0 0.145
lysosomal storage disease DOID:3211 0 0.145
sphingolipidosis DOID:1927 0 0.145
inherited metabolic disorder DOID:655 0 0.145
immune system disease DOID:2914 0 0.085
disease of anatomical entity DOID:7 0 0.085
central nervous system disease DOID:331 0 0.085
nervous system disease DOID:863 0 0.085
cerebral degeneration DOID:1443 0 0.028
brain disease DOID:936 0 0.028
primary immunodeficiency disease DOID:612 0 0.012
neurodegenerative disease DOID:1289 0 0.011
hematopoietic system disease DOID:74 0 0.010
musculoskeletal system disease DOID:17 0 0.010
connective tissue disease DOID:65 0 0.010