Mus musculus

225 known processes

Itch

itchy, E3 ubiquitin protein ligase

(Aliases: C230047C07Rik,mKIAA4011,8030492O04Rik,6720481N21Rik,KIAA4011,A130065M08,AIP4)

Itch biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.981
necroptotic process GO:0070266 21 0.901
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.740
programmed necrotic cell death GO:0097300 28 0.726
extrinsic apoptotic signaling pathway GO:0097191 126 0.694
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.672
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.634
necrotic cell death GO:0070265 30 0.579
regulation of necroptotic process GO:0060544 10 0.565
negative regulation of necroptotic process GO:0060546 9 0.388
regulation of apoptotic signaling pathway GO:2001233 197 0.386
negative regulation of molecular function GO:0044092 258 0.381
negative regulation of necrotic cell death GO:0060547 11 0.360
stress activated protein kinase signaling cascade GO:0031098 81 0.317
i kappab kinase nf kappab signaling GO:0007249 85 0.282
macromolecule catabolic process GO:0009057 281 0.263
positive regulation of cytokine production GO:0001819 174 0.223
small gtpase mediated signal transduction GO:0007264 97 0.217
protein modification by small protein removal GO:0070646 21 0.206
ripoptosome assembly GO:0097343 6 0.193
muscle cell proliferation GO:0033002 52 0.188
response to interleukin 12 GO:0070671 2 0.184
protein catabolic process GO:0030163 221 0.178
apoptotic signaling pathway GO:0097190 306 0.173
cellular protein catabolic process GO:0044257 155 0.172
modification dependent macromolecule catabolic process GO:0043632 133 0.170
t cell activation GO:0042110 289 0.168
activation of immune response GO:0002253 138 0.163
positive regulation of protein phosphorylation GO:0001934 242 0.163
protein modification by small protein conjugation or removal GO:0070647 207 0.160
ras protein signal transduction GO:0007265 77 0.158
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.153
rho protein signal transduction GO:0007266 32 0.151
t cell receptor signaling pathway GO:0050852 46 0.141
regulation of t cell proliferation GO:0042129 92 0.137
regulation of lymphocyte differentiation GO:0045619 107 0.136
activation of nf kappab inducing kinase activity GO:0007250 4 0.134
lymphocyte differentiation GO:0030098 242 0.133
negative regulation of lymphocyte activation GO:0051250 91 0.128
positive regulation of protein modification process GO:0031401 299 0.127
canonical wnt signaling pathway GO:0060070 130 0.125
alpha beta t cell activation GO:0046631 91 0.121
negative regulation of cell proliferation GO:0008285 296 0.120
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.116
t cell proliferation GO:0042098 120 0.115
pattern recognition receptor signaling pathway GO:0002221 47 0.113
regulation of transferase activity GO:0051338 263 0.112
myeloid leukocyte differentiation GO:0002573 119 0.111
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.110
regulation of lymphocyte activation GO:0051249 240 0.108
regulation of interferon gamma production GO:0032649 57 0.107
lymphocyte proliferation GO:0046651 164 0.106
nik nf kappab signaling GO:0038061 14 0.104
striated muscle atrophy GO:0014891 2 0.104
cell type specific apoptotic process GO:0097285 268 0.103
regulation of cd8 positive alpha beta cytotoxic t cell extravasation GO:2000452 2 0.100
negative regulation of intracellular signal transduction GO:1902532 167 0.099
immune response regulating signaling pathway GO:0002764 125 0.099
regulation of protein localization GO:0032880 231 0.099
Yeast Fly
epithelial tube morphogenesis GO:0060562 303 0.098
interleukin 8 production GO:0032637 4 0.096
actin cytoskeleton organization GO:0030036 220 0.094
Yeast
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.093
lymphocyte mediated immunity GO:0002449 139 0.093
t cell differentiation GO:0030217 174 0.093
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.092
response to organic cyclic compound GO:0014070 198 0.091
protein modification by small protein conjugation GO:0032446 187 0.090
regulation of interleukin 2 production GO:0032663 28 0.090
leukocyte mediated immunity GO:0002443 174 0.088
protein import into nucleus GO:0006606 95 0.085
negative regulation of apoptotic signaling pathway GO:2001234 104 0.085
positive regulation of hydrolase activity GO:0051345 148 0.084
regulation of cell migration GO:0030334 219 0.084
regulation of cell activation GO:0050865 289 0.084
jnk cascade GO:0007254 72 0.083
regulation of interleukin 8 production GO:0032677 3 0.083
cdc42 protein signal transduction GO:0032488 0 0.083
microtubule cytoskeleton organization GO:0000226 157 0.083
protein deacetylation GO:0006476 32 0.082
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.081
organonitrogen compound biosynthetic process GO:1901566 192 0.080
muscle atrophy GO:0014889 3 0.080
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.080
regulation of protein serine threonine kinase activity GO:0071900 157 0.077
immune effector process GO:0002252 321 0.077
leukocyte differentiation GO:0002521 342 0.076
gtp metabolic process GO:0046039 144 0.076
cellular response to lipid GO:0071396 145 0.075
nucleocytoplasmic transport GO:0006913 139 0.074
Yeast
cellular macromolecule catabolic process GO:0044265 206 0.073
positive regulation of mapk cascade GO:0043410 170 0.072
macromolecule deacylation GO:0098732 37 0.072
immune response activating signal transduction GO:0002757 116 0.072
tube formation GO:0035148 140 0.070
regulation of endopeptidase activity GO:0052548 89 0.069
regulation of protein transport GO:0051223 163 0.068
ubiquitin dependent protein catabolic process GO:0006511 129 0.067
homeostasis of number of cells GO:0048872 210 0.067
respiratory tube development GO:0030323 167 0.066
positive regulation of programmed cell death GO:0043068 218 0.066
digestive system development GO:0055123 200 0.065
response to oxidative stress GO:0006979 123 0.065
regulation of adaptive immune response GO:0002819 90 0.065
protein localization to organelle GO:0033365 185 0.064
regulation of lymphocyte mediated immunity GO:0002706 84 0.064
negative regulation of immune system process GO:0002683 209 0.064
positive regulation of cellular amine metabolic process GO:0033240 5 0.063
regulation of protein maturation GO:1903317 96 0.062
acylglycerol homeostasis GO:0055090 16 0.062
heart morphogenesis GO:0003007 178 0.062
Mouse
regulation of rho protein signal transduction GO:0035023 71 0.062
positive regulation of protein kinase activity GO:0045860 144 0.061
positive regulation of rac gtpase activity GO:0032855 14 0.061
morphogenesis of embryonic epithelium GO:0016331 159 0.061
regulation of t cell differentiation GO:0045580 83 0.061
intracellular protein transport GO:0006886 204 0.061
antigen receptor mediated signaling pathway GO:0050851 64 0.061
leukocyte activation involved in immune response GO:0002366 126 0.061
regulation of hydrolase activity GO:0051336 246 0.060
cellular homeostasis GO:0019725 240 0.060
digestive tract morphogenesis GO:0048546 147 0.059
myeloid cell differentiation GO:0030099 233 0.058
regulation of reactive oxygen species metabolic process GO:2000377 40 0.058
regulation of leukocyte proliferation GO:0070663 121 0.057
muscle tissue development GO:0060537 308 0.057
positive regulation of apoptotic signaling pathway GO:2001235 95 0.057
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.056
regulation of transmembrane transport GO:0034762 128 0.055
Mouse
regulation of cellular response to stress GO:0080135 159 0.055
positive regulation of gtpase activity GO:0043547 85 0.055
amine metabolic process GO:0009308 45 0.054
cytokine production GO:0001816 319 0.054
organelle localization GO:0051640 179 0.054
Yeast
cellular response to peptidoglycan GO:0071224 4 0.054
positive regulation of immature t cell proliferation GO:0033091 4 0.053
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.052
positive regulation of macroautophagy GO:0016239 3 0.052
activation of innate immune response GO:0002218 56 0.052
mitotic cell cycle GO:0000278 195 0.051
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.050
anion transport GO:0006820 177 0.050
negative regulation of protein processing GO:0010955 79 0.050
oxidation reduction process GO:0055114 342 0.049
purine ribonucleoside catabolic process GO:0046130 205 0.049
mitotic cell cycle process GO:1903047 159 0.049
leukocyte proliferation GO:0070661 172 0.049
positive regulation of kinase activity GO:0033674 155 0.048
response to reactive oxygen species GO:0000302 56 0.048
regulation of mapk cascade GO:0043408 248 0.048
regulation of myotube differentiation GO:0010830 62 0.047
regulation of necrotic cell death GO:0010939 13 0.047
regulation of production of molecular mediator of immune response GO:0002700 65 0.047
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.047
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.047
muscle cell differentiation GO:0042692 261 0.046
organelle assembly GO:0070925 177 0.046
mapk cascade GO:0000165 281 0.046
ear development GO:0043583 200 0.046
positive regulation of interleukin 8 production GO:0032757 2 0.045
positive regulation of map kinase activity GO:0043406 84 0.045
protein localization to nucleus GO:0034504 121 0.044
cellular response to nitric oxide GO:0071732 4 0.044
nuclear import GO:0051170 95 0.044
negative regulation of cell activation GO:0050866 111 0.044
skeletal muscle adaptation GO:0043501 16 0.043
regulation of cell cycle GO:0051726 281 0.043
cellular response to oxidative stress GO:0034599 76 0.043
striated muscle tissue development GO:0014706 293 0.042
heterocycle catabolic process GO:0046700 280 0.042
cellular amino acid metabolic process GO:0006520 103 0.042
negative regulation of endopeptidase activity GO:0010951 44 0.041
cytokine metabolic process GO:0042107 71 0.041
negative regulation of wnt signaling pathway GO:0030178 73 0.040
negative regulation of cellular component organization GO:0051129 194 0.040
nitrogen compound transport GO:0071705 271 0.040
Yeast
lipid homeostasis GO:0055088 63 0.040
t helper cell differentiation GO:0042093 28 0.040
regulation of alpha beta t cell activation GO:0046634 53 0.040
regulation of microtubule based process GO:0032886 52 0.040
myotube differentiation GO:0014902 105 0.039
regulation of mitotic cell cycle GO:0007346 126 0.039
regulation of organelle organization GO:0033043 289 0.039
Yeast
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.038
syncytium formation by plasma membrane fusion GO:0000768 42 0.038
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.038
positive regulation of stress activated mapk cascade GO:0032874 48 0.038
muscle system process GO:0003012 141 0.038
embryonic organ morphogenesis GO:0048562 276 0.038
response to lipopolysaccharide GO:0032496 128 0.038
muscle cell development GO:0055001 133 0.037
regulation of t cell extravasation GO:2000407 3 0.037
striated muscle adaptation GO:0014888 26 0.037
positive regulation of lymphocyte activation GO:0051251 140 0.037
skeletal myofibril assembly GO:0014866 4 0.036
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.036
neural tube development GO:0021915 160 0.035
response to molecule of bacterial origin GO:0002237 143 0.035
histone modification GO:0016570 159 0.035
positive regulation of innate immune response GO:0045089 80 0.035
skeletal muscle organ development GO:0060538 163 0.034
regulation of cytoskeleton organization GO:0051493 122 0.034
Yeast
cellular nitrogen compound catabolic process GO:0044270 280 0.034
embryonic epithelial tube formation GO:0001838 130 0.034
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.034
positive regulation of adaptive immune response GO:0002821 61 0.034
positive regulation of apoptotic process GO:0043065 217 0.034
cellular chemical homeostasis GO:0055082 215 0.034
cellular ion homeostasis GO:0006873 165 0.033
regulation of cellular ketone metabolic process GO:0010565 66 0.033
Yeast
regulation of establishment of protein localization GO:0070201 181 0.033
cytoplasmic transport GO:0016482 234 0.033
Yeast
cell activation involved in immune response GO:0002263 126 0.032
dna repair GO:0006281 107 0.032
regulation of cell motility GO:2000145 236 0.032
microtubule based process GO:0007017 236 0.032
negative regulation of lymphocyte differentiation GO:0045620 32 0.032
epithelial tube formation GO:0072175 130 0.032
epithelial cell proliferation GO:0050673 174 0.032
syncytium formation GO:0006949 43 0.031
establishment of protein localization to organelle GO:0072594 118 0.031
inorganic cation transmembrane transport GO:0098662 207 0.031
Mouse
retrograde transport endosome to golgi GO:0042147 2 0.031
regulation of nucleotide catabolic process GO:0030811 122 0.031
positive regulation of t cell activation GO:0050870 101 0.031
digestive tract development GO:0048565 190 0.031
positive regulation of ras gtpase activity GO:0032320 65 0.031
nuclear transport GO:0051169 139 0.031
Yeast
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.031
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.031
protein deacylation GO:0035601 36 0.031
sensory organ morphogenesis GO:0090596 242 0.031
interleukin 2 production GO:0032623 33 0.030
organelle fission GO:0048285 170 0.030
regulation of protein import into nucleus GO:0042306 52 0.030
transmembrane transport GO:0055085 412 0.030
Mouse
positive regulation of cell death GO:0010942 224 0.030
erk1 and erk2 cascade GO:0070371 77 0.030
regulation of protein processing GO:0070613 96 0.030
amide transport GO:0042886 138 0.030
regulation of microtubule cytoskeleton organization GO:0070507 37 0.030
response to organonitrogen compound GO:0010243 246 0.030
protein maturation GO:0051604 176 0.030
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.030
gland development GO:0048732 330 0.029
cellular component assembly involved in morphogenesis GO:0010927 139 0.029
Yeast
cellular protein complex assembly GO:0043623 116 0.029
limb development GO:0060173 166 0.029
ribonucleoside triphosphate catabolic process GO:0009203 199 0.029
tissue homeostasis GO:0001894 115 0.029
lymphocyte activation involved in immune response GO:0002285 93 0.029
regulation of erk1 and erk2 cascade GO:0070372 71 0.029
leukocyte migration GO:0050900 124 0.029
protein processing GO:0016485 163 0.029
cd4 positive alpha beta t cell activation GO:0035710 45 0.029
synaptic transmission GO:0007268 329 0.029
Mouse
defense response to other organism GO:0098542 197 0.029
regulation of ion transport GO:0043269 215 0.028
Mouse
regulation of peptide transport GO:0090087 91 0.028
regulation of cytokine production GO:0001817 266 0.028
negative regulation of leukocyte differentiation GO:1902106 51 0.028
regulation of gtp catabolic process GO:0033124 113 0.028
regulation of stress activated mapk cascade GO:0032872 69 0.028
purine ribonucleotide catabolic process GO:0009154 208 0.028
regulation of striated muscle cell differentiation GO:0051153 81 0.028
extracellular matrix organization GO:0030198 147 0.028
regulation of map kinase activity GO:0043405 120 0.028
guanosine containing compound metabolic process GO:1901068 144 0.028
cytokine production involved in immune response GO:0002367 34 0.028
negative regulation of endothelial cell migration GO:0010596 4 0.028
regulation of purine nucleotide catabolic process GO:0033121 122 0.027
regulation of cellular amino acid metabolic process GO:0006521 5 0.027
wnt signaling pathway GO:0016055 188 0.027
negative regulation of muscle cell differentiation GO:0051148 33 0.027
muscle adaptation GO:0043500 39 0.027
protein polyubiquitination GO:0000209 33 0.027
cellular metal ion homeostasis GO:0006875 151 0.027
cellular divalent inorganic cation homeostasis GO:0072503 127 0.027
regulation of defense response GO:0031347 233 0.027
negative regulation of peptidase activity GO:0010466 46 0.027
positive regulation of endocytosis GO:0045807 42 0.027
Yeast
interleukin 1 mediated signaling pathway GO:0070498 4 0.027
forebrain development GO:0030900 302 0.027
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.027
camera type eye development GO:0043010 266 0.026
cation transmembrane transport GO:0098655 266 0.026
Mouse
regulation of ras protein signal transduction GO:0046578 114 0.026
cellular response to organonitrogen compound GO:0071417 145 0.026
negative regulation of protein transport GO:0051224 46 0.026
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.026
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.026
interferon gamma production GO:0032609 67 0.026
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.026
t cell mediated immunity GO:0002456 50 0.026
purine containing compound catabolic process GO:0072523 213 0.026
t cell extravasation GO:0072683 4 0.026
blood circulation GO:0008015 195 0.025
Mouse
lymphocyte homeostasis GO:0002260 64 0.025
regulation of lymphocyte proliferation GO:0050670 117 0.025
regulation of interleukin 6 production GO:0032675 55 0.025
aromatic compound catabolic process GO:0019439 286 0.025
cellular response to lipopolysaccharide GO:0071222 77 0.025
regulation of myeloid leukocyte differentiation GO:0002761 58 0.025
purine ribonucleoside metabolic process GO:0046128 241 0.025
ameboidal type cell migration GO:0001667 128 0.025
ear morphogenesis GO:0042471 118 0.025
male gamete generation GO:0048232 285 0.025
regulation of myeloid cell differentiation GO:0045637 96 0.025
lymph node development GO:0048535 18 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.025
Mouse
cellular ketone metabolic process GO:0042180 84 0.025
Yeast
purine ribonucleotide metabolic process GO:0009150 290 0.025
stress activated mapk cascade GO:0051403 80 0.025
regulation of b cell activation GO:0050864 81 0.024
cation homeostasis GO:0055080 212 0.024
regulation of t cell mediated immunity GO:0002709 34 0.024
regulation of nucleocytoplasmic transport GO:0046822 73 0.024
Yeast
myeloid dendritic cell activation GO:0001773 25 0.024
alpha beta t cell differentiation GO:0046632 69 0.024
positive regulation of interleukin 6 production GO:0032755 37 0.024
primary neural tube formation GO:0014020 95 0.024
purine nucleotide metabolic process GO:0006163 302 0.024
regulation of rho gtpase activity GO:0032319 58 0.024
purine nucleoside triphosphate metabolic process GO:0009144 226 0.024
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.024
negative regulation of hydrolase activity GO:0051346 71 0.024
lateral inhibition GO:0046331 1 0.024
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.024
Yeast Mouse
negative regulation of proteolysis GO:0045861 74 0.023
cell adhesion GO:0007155 329 0.023
regulation of cellular catabolic process GO:0031329 242 0.023
Yeast
extracellular structure organization GO:0043062 148 0.023
divalent inorganic cation homeostasis GO:0072507 138 0.023
negative regulation of cellular protein metabolic process GO:0032269 247 0.023
regulation of leukocyte differentiation GO:1902105 159 0.023
memory GO:0007613 58 0.023
intrinsic apoptotic signaling pathway GO:0097193 132 0.023
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.022
type i interferon production GO:0032606 29 0.022
single organism nuclear import GO:1902593 95 0.022
regulation of canonical wnt signaling pathway GO:0060828 82 0.022
organic hydroxy compound transport GO:0015850 93 0.022
inner ear morphogenesis GO:0042472 101 0.022
organic hydroxy compound biosynthetic process GO:1901617 77 0.022
Yeast
membrane organization GO:0061024 245 0.022
positive regulation of interferon gamma production GO:0032729 39 0.022
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.022
response to inorganic substance GO:0010035 96 0.022
positive regulation of jnk cascade GO:0046330 46 0.022
locomotory behavior GO:0007626 195 0.022
modification dependent protein catabolic process GO:0019941 133 0.022
tube closure GO:0060606 91 0.022
nucleoside triphosphate metabolic process GO:0009141 230 0.022
regulation of intracellular transport GO:0032386 159 0.022
Yeast
protein k63 linked deubiquitination GO:0070536 1 0.021
cellular response to biotic stimulus GO:0071216 92 0.021
placenta development GO:0001890 140 0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.021
endocytosis GO:0006897 168 0.021
Yeast Fly
osteoclast differentiation GO:0030316 62 0.021
positive regulation of leukocyte mediated immunity GO:0002705 70 0.021
interleukin 6 production GO:0032635 58 0.021
bone resorption GO:0045453 38 0.021
lung development GO:0030324 164 0.021
positive regulation of proteolysis GO:0045862 85 0.021
Yeast
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.021
telencephalon development GO:0021537 186 0.021
purine nucleoside metabolic process GO:0042278 241 0.021
positive regulation of cellular catabolic process GO:0031331 148 0.021
Yeast
appendage development GO:0048736 166 0.021
Fly
positive regulation of transferase activity GO:0051347 167 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
defense response to bacterium GO:0042742 119 0.021
regeneration GO:0031099 38 0.021
positive regulation of rho gtpase activity GO:0032321 41 0.020
reactive oxygen species metabolic process GO:0072593 84 0.020
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.020
multicellular organismal homeostasis GO:0048871 164 0.020
ribose phosphate metabolic process GO:0019693 291 0.020
negative regulation of endothelial cell differentiation GO:0045602 2 0.020
regulation of protein kinase activity GO:0045859 232 0.020
cell division GO:0051301 120 0.020
regulation of system process GO:0044057 200 0.020
neural tube closure GO:0001843 90 0.020
kidney development GO:0001822 213 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
wound healing GO:0042060 157 0.020
purine nucleoside triphosphate catabolic process GO:0009146 203 0.020
positive regulation of leukocyte proliferation GO:0070665 73 0.020
regulation of tumor necrosis factor production GO:0032680 49 0.020
nuclear division GO:0000280 158 0.020
ribonucleoside triphosphate metabolic process GO:0009199 220 0.020
embryonic appendage morphogenesis GO:0035113 126 0.020
regulation of cysteine type endopeptidase activity GO:2000116 65 0.020
respiratory system development GO:0060541 190 0.020
regulation of nucleoside metabolic process GO:0009118 130 0.020
cellular response to external stimulus GO:0071496 88 0.020
positive regulation of leukocyte differentiation GO:1902107 86 0.020
actin filament organization GO:0007015 113 0.019
innate immune response GO:0045087 157 0.019
bone remodeling GO:0046849 53 0.019
nucleobase containing small molecule metabolic process GO:0055086 352 0.019
tumor necrosis factor production GO:0032640 50 0.019
tissue remodeling GO:0048771 102 0.019
inorganic ion transmembrane transport GO:0098660 234 0.019
Mouse
regulation of jnk cascade GO:0046328 62 0.019
regulation of leukocyte mediated immunity GO:0002703 104 0.019
signal transduction in absence of ligand GO:0038034 55 0.019
sensory perception GO:0007600 245 0.019
regulation of organ morphogenesis GO:2000027 144 0.018
organic cyclic compound catabolic process GO:1901361 295 0.018
regulation of t cell activation GO:0050863 170 0.018
protein ubiquitination GO:0016567 171 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
Yeast
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.018
calcium ion homeostasis GO:0055074 127 0.018
protein oligomerization GO:0051259 67 0.018
neural tube formation GO:0001841 108 0.018
negative regulation of t cell differentiation GO:0045581 23 0.018
positive regulation of necrotic cell death GO:0010940 1 0.018
appendage morphogenesis GO:0035107 149 0.018
Fly
protein targeting GO:0006605 143 0.018
regulation of secretion by cell GO:1903530 249 0.018
response to unfolded protein GO:0006986 21 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
nucleoside monophosphate metabolic process GO:0009123 85 0.017
circulatory system process GO:0003013 197 0.017
Mouse
negative regulation of cytokine production GO:0001818 84 0.017
nucleoside metabolic process GO:0009116 246 0.017
negative regulation of protein maturation GO:1903318 79 0.017
negative regulation of t cell proliferation GO:0042130 38 0.017
anatomical structure homeostasis GO:0060249 145 0.017
transmission of nerve impulse GO:0019226 76 0.017
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.017
renal system development GO:0072001 225 0.017
cell junction organization GO:0034330 77 0.017
Mouse
respiratory gaseous exchange GO:0007585 43 0.017
actomyosin structure organization GO:0031032 56 0.017
ribonucleoside metabolic process GO:0009119 245 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
covalent chromatin modification GO:0016569 163 0.016
embryonic placenta development GO:0001892 98 0.016
response to uv GO:0009411 44 0.016
Yeast
regulation of peptidase activity GO:0052547 96 0.016
response to starvation GO:0042594 65 0.016
hematopoietic progenitor cell differentiation GO:0002244 143 0.016
ion transmembrane transport GO:0034220 361 0.016
Mouse
regulation of nik nf kappab signaling GO:1901222 10 0.016
synaptic vesicle localization GO:0097479 59 0.016
palate development GO:0060021 76 0.016
regulation of cytoplasmic transport GO:1903649 112 0.016
Yeast
regulation of ras gtpase activity GO:0032318 88 0.016
positive regulation of defense response GO:0031349 124 0.016
negative regulation of striated muscle cell differentiation GO:0051154 14 0.016
neural precursor cell proliferation GO:0061351 121 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.016
humoral immune response GO:0006959 57 0.016
divalent metal ion transport GO:0070838 172 0.016
protein alkylation GO:0008213 81 0.016
regulation of homeostatic process GO:0032844 182 0.016
pharynx development GO:0060465 1 0.016
cognition GO:0050890 149 0.016
lipid localization GO:0010876 126 0.016
Worm Fly
peptide transport GO:0015833 133 0.016
leukocyte homeostasis GO:0001776 79 0.015
neuron death GO:0070997 154 0.015
glycoprotein metabolic process GO:0009100 116 0.015
maintenance of location GO:0051235 89 0.015
Worm Fly
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.015
skeletal system development GO:0001501 356 0.015
establishment of vesicle localization GO:0051650 81 0.015
protein deubiquitination GO:0016579 19 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 23 0.015
cellular response to topologically incorrect protein GO:0035967 25 0.015
regulation of alpha beta t cell proliferation GO:0046640 18 0.015
regulation of alpha beta t cell differentiation GO:0046637 35 0.015
organonitrogen compound catabolic process GO:1901565 264 0.015
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.015
regulation of endocytosis GO:0030100 69 0.015
Yeast
endoplasmic reticulum unfolded protein response GO:0030968 19 0.015
regulation of protein deacetylation GO:0090311 17 0.015

Itch disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.056
disease of cellular proliferation DOID:14566 0 0.056
organ system cancer DOID:0050686 0 0.056
disease of metabolism DOID:0014667 0 0.038
disease of anatomical entity DOID:7 0 0.024
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024
immune system cancer DOID:0060083 0 0.021
inherited metabolic disorder DOID:655 0 0.019
bone development disease DOID:0080006 0 0.019
bone disease DOID:0080001 0 0.019
immune system disease DOID:2914 0 0.016
hematopoietic system disease DOID:74 0 0.016