Mus musculus

44 known processes

Fen1

flap structure specific endonuclease 1

(Aliases: AW538437)

Fen1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.705
dna repair GO:0006281 107 0.514
meiotic cell cycle GO:0051321 122 0.377
mitotic cell cycle process GO:1903047 159 0.241
dna recombination GO:0006310 92 0.227
Yeast
nuclear division GO:0000280 158 0.201
gene silencing GO:0016458 38 0.200
dna replication GO:0006260 52 0.199
organelle fission GO:0048285 170 0.199
microtubule cytoskeleton organization GO:0000226 157 0.180
cellular protein catabolic process GO:0044257 155 0.175
regulation of mitotic cell cycle phase transition GO:1901990 73 0.156
mitotic cell cycle GO:0000278 195 0.150
negative regulation of cell cycle GO:0045786 123 0.141
regulation of cell cycle process GO:0010564 160 0.139
dna dependent dna replication GO:0006261 24 0.135
Human Yeast
chromatin organization GO:0006325 206 0.122
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.115
double strand break repair GO:0006302 48 0.115
Yeast
regulation of cellular catabolic process GO:0031329 242 0.108
macromolecule catabolic process GO:0009057 281 0.107
meiosis i GO:0007127 60 0.097
regulation of organelle organization GO:0033043 289 0.097
reciprocal dna recombination GO:0035825 16 0.094
development of primary sexual characteristics GO:0045137 143 0.092
Worm
endocytosis GO:0006897 168 0.092
Worm
negative regulation of molecular function GO:0044092 258 0.090
negative regulation of cell cycle process GO:0010948 69 0.089
regulation of hydrolase activity GO:0051336 246 0.087
meiotic cell cycle process GO:1903046 77 0.084
protein catabolic process GO:0030163 221 0.083
regulation of cell division GO:0051302 76 0.081
regulation of mitotic cell cycle GO:0007346 126 0.080
cellular response to dna damage stimulus GO:0006974 207 0.079
amine metabolic process GO:0009308 45 0.077
cell cycle checkpoint GO:0000075 47 0.072
regulation of cell cycle GO:0051726 281 0.072
nuclear dna replication GO:0033260 3 0.069
cellular amino acid metabolic process GO:0006520 103 0.067
cellular nitrogen compound catabolic process GO:0044270 280 0.067
mitotic sister chromatid segregation GO:0000070 14 0.067
recombinational repair GO:0000725 21 0.065
regulation of cellular amine metabolic process GO:0033238 20 0.064
response to organic cyclic compound GO:0014070 198 0.062
cellular amine metabolic process GO:0044106 44 0.061
homeostasis of number of cells GO:0048872 210 0.061
regulation of chromosome organization GO:0033044 83 0.060
nucleobase containing small molecule metabolic process GO:0055086 352 0.059
protein ubiquitination GO:0016567 171 0.059
nitrogen compound transport GO:0071705 271 0.058
oxidation reduction process GO:0055114 342 0.058
body morphogenesis GO:0010171 45 0.058
microtubule based process GO:0007017 236 0.058
regulation of cellular amino acid metabolic process GO:0006521 5 0.054
protein processing GO:0016485 163 0.053
negative regulation of cell cycle phase transition GO:1901988 48 0.052
histone modification GO:0016570 159 0.050
base excision repair GO:0006284 9 0.050
Yeast
cytoplasmic transport GO:0016482 234 0.049
posttranscriptional regulation of gene expression GO:0010608 155 0.048
negative regulation of cellular component organization GO:0051129 194 0.048
synapsis GO:0007129 34 0.046
dna modification GO:0006304 50 0.045
reciprocal meiotic recombination GO:0007131 16 0.045
double strand break repair via homologous recombination GO:0000724 21 0.045
protein modification by small protein conjugation GO:0032446 187 0.044
response to inorganic substance GO:0010035 96 0.043
mrna processing GO:0006397 63 0.043
nuclear transport GO:0051169 139 0.043
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.042
establishment of rna localization GO:0051236 18 0.042
meiotic nuclear division GO:0007126 115 0.042
regulation of nucleoside metabolic process GO:0009118 130 0.041
mitotic recombination GO:0006312 3 0.041
Yeast
gonad development GO:0008406 141 0.040
Worm
nucleobase containing compound transport GO:0015931 27 0.040
negative regulation of mitotic cell cycle GO:0045930 58 0.039
regulation of cellular ketone metabolic process GO:0010565 66 0.038
engulfment of apoptotic cell GO:0043652 3 0.038
nucleotide metabolic process GO:0009117 332 0.036
protein modification by small protein conjugation or removal GO:0070647 207 0.036
cellular ketone metabolic process GO:0042180 84 0.035
dna geometric change GO:0032392 7 0.035
chromatin modification GO:0016568 187 0.035
nucleoside triphosphate metabolic process GO:0009141 230 0.035
gland development GO:0048732 330 0.035
epithelial tube morphogenesis GO:0060562 303 0.034
spermatogenesis GO:0007283 284 0.034
chromosome organization involved in meiosis GO:0070192 39 0.034
cellular macromolecule catabolic process GO:0044265 206 0.034
forebrain development GO:0030900 302 0.034
regulation of cell cycle phase transition GO:1901987 77 0.034
cell type specific apoptotic process GO:0097285 268 0.033
chromosome segregation GO:0007059 48 0.033
nucleoside phosphate metabolic process GO:0006753 338 0.033
chemotaxis GO:0006935 247 0.033
response to organonitrogen compound GO:0010243 246 0.033
cell division GO:0051301 120 0.032
peptidyl amino acid modification GO:0018193 336 0.032
cellular homeostasis GO:0019725 240 0.032
organophosphate biosynthetic process GO:0090407 122 0.032
positive regulation of cellular amine metabolic process GO:0033240 5 0.031
mitotic nuclear division GO:0007067 48 0.031
nucleic acid transport GO:0050657 18 0.031
dna endoreduplication GO:0042023 4 0.031
mrna metabolic process GO:0016071 84 0.031
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.030
mitotic centrosome separation GO:0007100 4 0.030
purine ribonucleotide metabolic process GO:0009150 290 0.030
regulation of chromosome segregation GO:0051983 21 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
nucleocytoplasmic transport GO:0006913 139 0.029
histone acetylation GO:0016573 41 0.029
germ cell development GO:0007281 185 0.029
regulation of histone modification GO:0031056 56 0.029
glial cell differentiation GO:0010001 131 0.029
leukocyte differentiation GO:0002521 342 0.028
organic cyclic compound catabolic process GO:1901361 295 0.028
negative regulation of phosphate metabolic process GO:0045936 184 0.027
regulation of proteolysis GO:0030162 164 0.027
locomotory behavior GO:0007626 195 0.027
apoptotic signaling pathway GO:0097190 306 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.026
response to radiation GO:0009314 165 0.026
positive regulation of hydrolase activity GO:0051345 148 0.026
regulation of nucleotide catabolic process GO:0030811 122 0.026
dna unwinding involved in dna replication GO:0006268 5 0.026
ribonucleoside triphosphate catabolic process GO:0009203 199 0.026
mrna transport GO:0051028 13 0.026
leukocyte proliferation GO:0070661 172 0.025
blood circulation GO:0008015 195 0.025
purine containing compound metabolic process GO:0072521 311 0.025
nucleoside phosphate biosynthetic process GO:1901293 79 0.025
dna catabolic process GO:0006308 19 0.025
protein maturation GO:0051604 176 0.024
positive regulation of cell cycle GO:0045787 92 0.024
regulation of purine nucleotide metabolic process GO:1900542 169 0.024
cellular protein complex assembly GO:0043623 116 0.024
ribose phosphate metabolic process GO:0019693 291 0.024
heterocycle catabolic process GO:0046700 280 0.024
small gtpase mediated signal transduction GO:0007264 97 0.024
regulation of nucleotide metabolic process GO:0006140 169 0.024
intrinsic apoptotic signaling pathway GO:0097193 132 0.023
intracellular protein transport GO:0006886 204 0.023
negative regulation of atpase activity GO:0032780 2 0.023
regulation of kinase activity GO:0043549 249 0.023
cellular response to organonitrogen compound GO:0071417 145 0.023
chromatin silencing GO:0006342 15 0.023
dna conformation change GO:0071103 37 0.023
rna transport GO:0050658 18 0.022
anatomical structure homeostasis GO:0060249 145 0.022
digestive system development GO:0055123 200 0.022
covalent chromatin modification GO:0016569 163 0.022
ossification GO:0001503 216 0.022
translesion synthesis GO:0019985 1 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
ribonucleoside catabolic process GO:0042454 206 0.022
negative regulation of gene expression epigenetic GO:0045814 15 0.022
mrna 3 end processing GO:0031124 16 0.022
regulation of cellular response to stress GO:0080135 159 0.022
rna dependent dna replication GO:0006278 3 0.021
methylation GO:0032259 134 0.021
myeloid cell differentiation GO:0030099 233 0.021
nucleotide biosynthetic process GO:0009165 78 0.021
regulation of secretion GO:0051046 274 0.021
purine nucleoside triphosphate catabolic process GO:0009146 203 0.021
regulation of secretion by cell GO:1903530 249 0.021
regulation of purine nucleotide catabolic process GO:0033121 122 0.021
regulation of lymphocyte activation GO:0051249 240 0.021
positive regulation of protein modification process GO:0031401 299 0.021
cellular response to hormone stimulus GO:0032870 150 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.020
purine nucleoside triphosphate metabolic process GO:0009144 226 0.020
blood vessel morphogenesis GO:0048514 285 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.020
dna duplex unwinding GO:0032508 7 0.020
striated muscle myosin thick filament assembly GO:0071688 1 0.020
regulation of protein localization GO:0032880 231 0.020
negative regulation of atp metabolic process GO:1903579 4 0.020
regulation of protein maturation GO:1903317 96 0.020
nucleoside triphosphate catabolic process GO:0009143 205 0.020
negative regulation of proteolysis GO:0045861 74 0.020
negative regulation of protein metabolic process GO:0051248 282 0.019
purine ribonucleoside metabolic process GO:0046128 241 0.019
intra s dna damage checkpoint GO:0031573 4 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
aromatic compound catabolic process GO:0019439 286 0.019
positive regulation of dna templated transcription elongation GO:0032786 2 0.019
rna processing GO:0006396 105 0.019
negative regulation of nucleoside metabolic process GO:0045978 11 0.019
negative regulation of organelle organization GO:0010639 90 0.019
ribonucleotide catabolic process GO:0009261 208 0.019
nucleoside phosphate catabolic process GO:1901292 222 0.019
purine nucleotide metabolic process GO:0006163 302 0.019
deoxyribonucleotide metabolic process GO:0009262 14 0.019
response to acid chemical GO:0001101 111 0.018
nucleotide excision repair GO:0006289 13 0.018
regulation of protein kinase activity GO:0045859 232 0.018
embryonic placenta development GO:0001892 98 0.018
stem cell differentiation GO:0048863 268 0.018
metaphase plate congression GO:0051310 2 0.018
mitochondrion organization GO:0007005 134 0.018
regulation of transcription by chromatin organization GO:0034401 0 0.018
heart process GO:0003015 94 0.018
organonitrogen compound catabolic process GO:1901565 264 0.018
gtp catabolic process GO:0006184 143 0.017
cellular response to lipid GO:0071396 145 0.017
mitotic cytokinesis GO:0000281 4 0.017
stem cell development GO:0048864 219 0.017
negative regulation of cellular amine metabolic process GO:0033239 1 0.017
modification dependent protein catabolic process GO:0019941 133 0.017
cellular response to abiotic stimulus GO:0071214 56 0.017
respiratory system development GO:0060541 190 0.017
negative regulation of hydrolase activity GO:0051346 71 0.017
cellular chemical homeostasis GO:0055082 215 0.017
camera type eye development GO:0043010 266 0.016
Zebrafish
regulation of dna replication GO:0006275 17 0.016
ribonucleotide metabolic process GO:0009259 291 0.016
meiotic chromosome segregation GO:0045132 19 0.016
placenta development GO:0001890 140 0.016
negative regulation of protein processing GO:0010955 79 0.016
muscle cell differentiation GO:0042692 261 0.016
wnt signaling pathway GO:0016055 188 0.016
interspecies interaction between organisms GO:0044419 83 0.016
negative regulation of protein maturation GO:1903318 79 0.016
sister chromatid segregation GO:0000819 20 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
pyrimidine containing compound metabolic process GO:0072527 11 0.016
multicellular organismal homeostasis GO:0048871 164 0.016
proteasomal protein catabolic process GO:0010498 98 0.016
regulation of protein processing GO:0070613 96 0.016
positive regulation of gtpase activity GO:0043547 85 0.016
cellular response to acid chemical GO:0071229 68 0.016
circulatory system process GO:0003013 197 0.016
mitotic cell cycle checkpoint GO:0007093 31 0.015
glycosyl compound metabolic process GO:1901657 246 0.015
cell cycle g1 s phase transition GO:0044843 57 0.015
neural tube development GO:0021915 160 0.015
phagocytosis GO:0006909 66 0.015
rna splicing via transesterification reactions GO:0000375 43 0.015
receptor mediated endocytosis GO:0006898 51 0.015
Worm
multi multicellular organism process GO:0044706 109 0.015
establishment of organelle localization GO:0051656 122 0.015
rho protein signal transduction GO:0007266 32 0.015
cellular response to organic cyclic compound GO:0071407 87 0.015
purine ribonucleotide catabolic process GO:0009154 208 0.015
pharynx development GO:0060465 1 0.014
lymphocyte proliferation GO:0046651 164 0.014
negative regulation of cellular protein metabolic process GO:0032269 247 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
response to oxidative stress GO:0006979 123 0.014
membrane organization GO:0061024 245 0.014
gene silencing by rna GO:0031047 19 0.014
purine nucleoside metabolic process GO:0042278 241 0.014
regulation of gtp catabolic process GO:0033124 113 0.014
ras protein signal transduction GO:0007265 77 0.014
regulation of hormone levels GO:0010817 211 0.014
positive regulation of cellular catabolic process GO:0031331 148 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
myeloid leukocyte differentiation GO:0002573 119 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
multi organism behavior GO:0051705 62 0.014
leukocyte activation involved in immune response GO:0002366 126 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.014
digestive tract development GO:0048565 190 0.014
regulation of intracellular protein transport GO:0033157 82 0.013
response to steroid hormone GO:0048545 56 0.013
cofactor metabolic process GO:0051186 80 0.013
mapk cascade GO:0000165 281 0.013
organophosphate catabolic process GO:0046434 232 0.013
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.013
somatic diversification of immune receptors GO:0002200 53 0.013
amide transport GO:0042886 138 0.013
posttranscriptional gene silencing GO:0016441 10 0.013
hormone secretion GO:0046879 128 0.013
negative regulation of protein modification process GO:0031400 163 0.013
notch signaling pathway GO:0007219 71 0.013
rna splicing GO:0008380 54 0.013
regulation of cell migration GO:0030334 219 0.013
nuclear export GO:0051168 34 0.013
negative regulation of nucleotide catabolic process GO:0030812 9 0.013
transcription coupled nucleotide excision repair GO:0006283 2 0.013
nucleoside metabolic process GO:0009116 246 0.012
regulation of cell cycle checkpoint GO:1901976 9 0.012
positive regulation of cell death GO:0010942 224 0.012
cell adhesion GO:0007155 329 0.012
response to light stimulus GO:0009416 135 0.012
angiogenesis GO:0001525 201 0.012
carbohydrate homeostasis GO:0033500 128 0.012
protein localization to nucleus GO:0034504 121 0.012
positive regulation of histone modification GO:0031058 28 0.012
regulation of cell activation GO:0050865 289 0.012
b cell activation GO:0042113 161 0.012
protein secretion GO:0009306 111 0.012
female meiotic division GO:0007143 21 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
purine containing compound catabolic process GO:0072523 213 0.012
rna 3 end processing GO:0031123 20 0.012
cellular protein complex disassembly GO:0043624 36 0.012
humoral immune response GO:0006959 57 0.012
protein localization to organelle GO:0033365 185 0.012
dna dealkylation GO:0035510 11 0.012
female gamete generation GO:0007292 74 0.012
carbohydrate derivative catabolic process GO:1901136 231 0.012
regulation of peptidyl lysine acetylation GO:2000756 22 0.012
t cell activation GO:0042110 289 0.012
dna biosynthetic process GO:0071897 22 0.012
Yeast
ribonucleoside metabolic process GO:0009119 245 0.012
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.012
regulation of dna recombination GO:0000018 34 0.012
sensory perception GO:0007600 245 0.012
cation transport GO:0006812 399 0.012
nucleoside catabolic process GO:0009164 206 0.012
negative regulation of immune system process GO:0002683 209 0.012
dendrite development GO:0016358 115 0.012
glucose homeostasis GO:0042593 128 0.012
regulation of mitotic sister chromatid segregation GO:0033047 12 0.011
response to oxygen levels GO:0070482 62 0.011
peptide hormone secretion GO:0030072 109 0.011
nucleus organization GO:0006997 45 0.011
regulation of protein catabolic process GO:0042176 108 0.011
multicellular organism growth GO:0035264 161 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
regulation of ras gtpase activity GO:0032318 88 0.011
regulation of cellular protein catabolic process GO:1903362 61 0.011
heart morphogenesis GO:0003007 178 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
positive regulation of gtp catabolic process GO:0033126 85 0.011
positive regulation of secretion GO:0051047 130 0.011
peptide secretion GO:0002790 114 0.011
rna localization GO:0006403 23 0.011
response to extracellular stimulus GO:0009991 127 0.011
male gamete generation GO:0048232 285 0.011
regulation of binding GO:0051098 111 0.011
synaptonemal complex assembly GO:0007130 13 0.011
molting cycle GO:0042303 90 0.011
muscle cell development GO:0055001 133 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
cardiac muscle tissue development GO:0048738 130 0.011
developmental cell growth GO:0048588 84 0.011
telomere maintenance GO:0000723 19 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
regulation of cell motility GO:2000145 236 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
anion transport GO:0006820 177 0.011
response to purine containing compound GO:0014074 28 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.010
striated muscle tissue development GO:0014706 293 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.010
generation of precursor metabolites and energy GO:0006091 103 0.010
telencephalon development GO:0021537 186 0.010
immunoglobulin production GO:0002377 73 0.010
regulation of intracellular transport GO:0032386 159 0.010
peptide transport GO:0015833 133 0.010
response to lipopolysaccharide GO:0032496 128 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010

Fen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012