Mus musculus

7 known processes

Mmp1a

matrix metallopeptidase 1a (interstitial collagenase)

(Aliases: Mcol-A,Mcola)

Mmp1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transforming growth factor beta secretion GO:0038044 1 0.748
regulation of transforming growth factor beta secretion GO:2001201 1 0.617
regulation of microvillus organization GO:0032530 3 0.608
positive regulation of transforming growth factor beta secretion GO:2001203 1 0.592
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.563
negative regulation of endothelial cell migration GO:0010596 4 0.561
regulation of microvillus assembly GO:0032534 3 0.460
regulation of interleukin 10 secretion GO:2001179 4 0.176
striated muscle tissue development GO:0014706 293 0.145
neural precursor cell proliferation GO:0061351 121 0.123
positive regulation of nervous system development GO:0051962 221 0.108
muscle tissue development GO:0060537 308 0.107
positive regulation of cell development GO:0010720 237 0.084
cytokine production GO:0001816 319 0.081
transmembrane transport GO:0055085 412 0.078
interleukin 10 secretion GO:0072608 4 0.075
cellular response to organic cyclic compound GO:0071407 87 0.072
Rat
stem cell proliferation GO:0072089 117 0.068
regulation of skeletal muscle fiber development GO:0048742 36 0.065
blood vessel morphogenesis GO:0048514 285 0.064
negative regulation of angiogenesis GO:0016525 25 0.064
skeletal muscle fiber development GO:0048741 58 0.062
regulation of myoblast differentiation GO:0045661 29 0.062
negative regulation of vasculature development GO:1901343 26 0.061
protein catabolic process GO:0030163 221 0.061
Mouse
response to organic cyclic compound GO:0014070 198 0.059
Rat
protein processing GO:0016485 163 0.058
chemotaxis GO:0006935 247 0.056
regulation of myotube differentiation GO:0010830 62 0.056
myotube differentiation GO:0014902 105 0.055
regulation of cell projection organization GO:0031344 206 0.054
forebrain development GO:0030900 302 0.053
camera type eye development GO:0043010 266 0.053
skeletal muscle organ development GO:0060538 163 0.052
axonogenesis GO:0007409 274 0.052
cell fate commitment GO:0045165 210 0.051
regulation of cell motility GO:2000145 236 0.048
Rat
regulation of angiogenesis GO:0045765 81 0.048
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.047
negative regulation of cellular protein metabolic process GO:0032269 247 0.047
macromolecule catabolic process GO:0009057 281 0.047
Mouse
angiogenesis GO:0001525 201 0.044
positive regulation of angiogenesis GO:0045766 46 0.044
protein maturation GO:0051604 176 0.043
sensory perception GO:0007600 245 0.042
neuroblast proliferation GO:0007405 49 0.042
small molecule biosynthetic process GO:0044283 132 0.041
hematopoietic progenitor cell differentiation GO:0002244 143 0.041
Mouse
muscle cell differentiation GO:0042692 261 0.040
response to inorganic substance GO:0010035 96 0.040
Rat
regulation of proteolysis GO:0030162 164 0.039
regulation of striated muscle cell differentiation GO:0051153 81 0.039
cellular ketone metabolic process GO:0042180 84 0.039
ion transmembrane transport GO:0034220 361 0.038
multi multicellular organism process GO:0044706 109 0.037
myoblast differentiation GO:0045445 52 0.037
steroid metabolic process GO:0008202 119 0.037
positive regulation of cell projection organization GO:0031346 95 0.037
amine metabolic process GO:0009308 45 0.036
regulation of cellular ketone metabolic process GO:0010565 66 0.036
ameboidal type cell migration GO:0001667 128 0.035
Rat
negative regulation of protein maturation GO:1903318 79 0.035
regulation of muscle tissue development GO:1901861 97 0.035
oxidation reduction process GO:0055114 342 0.035
cellular chemical homeostasis GO:0055082 215 0.034
regulation of defense response GO:0031347 233 0.033
regulation of secretion by cell GO:1903530 249 0.032
extracellular matrix organization GO:0030198 147 0.032
Mouse
response to growth factor GO:0070848 198 0.032
gliogenesis GO:0042063 141 0.032
cellular amino acid metabolic process GO:0006520 103 0.032
regulation of innate immune response GO:0045088 91 0.032
negative regulation of cell motility GO:2000146 61 0.032
regulation of cell migration GO:0030334 219 0.032
Rat
multicellular organism growth GO:0035264 161 0.031
positive regulation of stem cell proliferation GO:2000648 59 0.031
lipid biosynthetic process GO:0008610 179 0.031
striated muscle cell development GO:0055002 125 0.031
regulation of blood vessel endothelial cell migration GO:0043535 12 0.030
cellular response to organonitrogen compound GO:0071417 145 0.030
Rat
regulation of vasculature development GO:1901342 88 0.030
regulation of stem cell proliferation GO:0072091 78 0.030
positive regulation of neural precursor cell proliferation GO:2000179 42 0.029
regulation of neural precursor cell proliferation GO:2000177 70 0.029
g protein coupled receptor signaling pathway GO:0007186 243 0.029
cellular response to hormone stimulus GO:0032870 150 0.029
Rat
epithelium migration GO:0090132 63 0.029
gland development GO:0048732 330 0.029
cellular homeostasis GO:0019725 240 0.029
response to organonitrogen compound GO:0010243 246 0.028
Rat
regulation of protein transport GO:0051223 163 0.028
cellular response to lipopolysaccharide GO:0071222 77 0.028
Rat
telencephalon development GO:0021537 186 0.028
cellular amine metabolic process GO:0044106 44 0.028
regulation of cellular component biogenesis GO:0044087 181 0.028
Human
negative regulation of myoblast differentiation GO:0045662 18 0.028
negative regulation of blood vessel morphogenesis GO:2000181 25 0.028
regulation of cell projection assembly GO:0060491 38 0.028
multi organism behavior GO:0051705 62 0.027
organic hydroxy compound metabolic process GO:1901615 203 0.027
cell adhesion GO:0007155 329 0.027
response to oxidative stress GO:0006979 123 0.027
positive regulation of cellular amine metabolic process GO:0033240 5 0.026
organic hydroxy compound biosynthetic process GO:1901617 77 0.026
response to acid chemical GO:0001101 111 0.026
negative regulation of cell migration GO:0030336 59 0.026
cellular response to lipid GO:0071396 145 0.026
Rat
regulation of neuroblast proliferation GO:1902692 27 0.026
negative regulation of cellular amine metabolic process GO:0033239 1 0.026
myotube cell development GO:0014904 60 0.026
gonad development GO:0008406 141 0.025
Rat
isoprenoid metabolic process GO:0006720 29 0.024
muscle cell development GO:0055001 133 0.024
regulation of peptidase activity GO:0052547 96 0.024
regulation of hydrolase activity GO:0051336 246 0.023
sprouting angiogenesis GO:0002040 26 0.023
antibacterial peptide biosynthetic process GO:0002780 2 0.023
response to steroid hormone GO:0048545 56 0.023
pallium development GO:0021543 120 0.023
regulation of cellular amine metabolic process GO:0033238 20 0.022
neuron death GO:0070997 154 0.022
regulation of endopeptidase activity GO:0052548 89 0.022
regulation of cytokine production GO:0001817 266 0.022
negative regulation of muscle cell differentiation GO:0051148 33 0.022
cellular lipid metabolic process GO:0044255 323 0.022
positive regulation of programmed cell death GO:0043068 218 0.022
exocytosis GO:0006887 121 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
carbohydrate metabolic process GO:0005975 230 0.021
tissue migration GO:0090130 68 0.021
cellular response to peptide GO:1901653 92 0.021
Rat
response to nutrient levels GO:0031667 109 0.021
Rat
microtubule based process GO:0007017 236 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
positive regulation of cell motility GO:2000147 116 0.021
Rat
activation of immune response GO:0002253 138 0.020
mitotic cell cycle GO:0000278 195 0.020
small gtpase mediated signal transduction GO:0007264 97 0.020
alcohol biosynthetic process GO:0046165 43 0.020
regulation of endothelial cell migration GO:0010594 22 0.020
coagulation GO:0050817 78 0.020
myeloid cell differentiation GO:0030099 233 0.020
bone development GO:0060348 120 0.020
blood vessel endothelial cell migration GO:0043534 23 0.020
regulation of membrane potential GO:0042391 192 0.020
positive regulation of growth GO:0045927 104 0.020
negative regulation of immune system process GO:0002683 209 0.020
regulation of epithelial cell migration GO:0010632 35 0.020
immune response regulating signaling pathway GO:0002764 125 0.019
developmental maturation GO:0021700 193 0.019
glycerolipid metabolic process GO:0046486 122 0.019
wound healing GO:0042060 157 0.019
endomembrane system organization GO:0010256 147 0.019
negative regulation of epithelial cell migration GO:0010633 9 0.019
response to peptide GO:1901652 136 0.018
Rat
cellular response to peptide hormone stimulus GO:0071375 92 0.018
Rat
leukocyte differentiation GO:0002521 342 0.018
sensory organ morphogenesis GO:0090596 242 0.018
renal system development GO:0072001 225 0.018
retina development in camera type eye GO:0060041 119 0.018
intracellular protein transport GO:0006886 204 0.018
diterpenoid metabolic process GO:0016101 24 0.018
cell type specific apoptotic process GO:0097285 268 0.018
synaptic transmission GO:0007268 329 0.018
regulation of cell cycle GO:0051726 281 0.018
innate immune response GO:0045087 157 0.018
locomotory behavior GO:0007626 195 0.017
positive regulation of neuroblast proliferation GO:0002052 19 0.017
oxidative demethylation GO:0070989 1 0.017
immune response activating signal transduction GO:0002757 116 0.017
regulation of cellular amino acid metabolic process GO:0006521 5 0.017
transmission of nerve impulse GO:0019226 76 0.017
spermatogenesis GO:0007283 284 0.017
regulation of secretion GO:0051046 274 0.017
male gamete generation GO:0048232 285 0.017
stem cell differentiation GO:0048863 268 0.017
endothelial cell migration GO:0043542 44 0.017
negative regulation of protein processing GO:0010955 79 0.017
neuron projection guidance GO:0097485 141 0.017
regulation of hormone levels GO:0010817 211 0.017
protein ubiquitination GO:0016567 171 0.017
defense response to bacterium GO:0042742 119 0.017
renal tubule development GO:0061326 87 0.016
cellular alcohol metabolic process GO:0044107 3 0.016
negative regulation of proteolysis GO:0045861 74 0.016
single organism cell adhesion GO:0098602 156 0.016
negative regulation of hydrolase activity GO:0051346 71 0.016
regulation of neuron differentiation GO:0045664 281 0.016
anion transport GO:0006820 177 0.016
stem cell maintenance GO:0019827 130 0.016
negative regulation of molecular function GO:0044092 258 0.016
chromatin organization GO:0006325 206 0.016
epithelial cell migration GO:0010631 63 0.016
regulation of protein localization GO:0032880 231 0.016
dephosphorylation GO:0016311 129 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
regulation of feeding behavior GO:0060259 3 0.016
cellular carbohydrate metabolic process GO:0044262 119 0.016
response to drug GO:0042493 75 0.016
Rat
regulation of organelle organization GO:0033043 289 0.016
cellular response to acid chemical GO:0071229 68 0.016
regulation of protein catabolic process GO:0042176 108 0.016
regulation of mitotic cell cycle GO:0007346 126 0.015
regulation of protein maturation GO:1903317 96 0.015
leukocyte mediated immunity GO:0002443 174 0.015
protein localization to nucleus GO:0034504 121 0.015
response to oxygen levels GO:0070482 62 0.015
regulation of lipid metabolic process GO:0019216 118 0.015
cellular response to steroid hormone stimulus GO:0071383 33 0.015
corpus callosum morphogenesis GO:0021540 3 0.015
negative regulation of cellular component organization GO:0051129 194 0.015
neuromuscular process GO:0050905 99 0.015
axon guidance GO:0007411 141 0.015
positive regulation of protein oligomerization GO:0032461 4 0.015
Human
carbohydrate derivative catabolic process GO:1901136 231 0.015
nuclear transport GO:0051169 139 0.015
inorganic ion transmembrane transport GO:0098660 234 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
feeding behavior GO:0007631 62 0.015
cation transmembrane transport GO:0098655 266 0.015
multicellular organismal signaling GO:0035637 91 0.015
terpenoid metabolic process GO:0006721 25 0.014
regulation of protein processing GO:0070613 96 0.014
regulation of transferase activity GO:0051338 263 0.014
positive regulation of transferase activity GO:0051347 167 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
aromatic compound catabolic process GO:0019439 286 0.014
positive regulation of cell death GO:0010942 224 0.014
reactive oxygen species biosynthetic process GO:1903409 8 0.014
chromatin modification GO:0016568 187 0.014
inorganic cation transmembrane transport GO:0098662 207 0.014
reflex GO:0060004 22 0.014
regulation of body fluid levels GO:0050878 162 0.014
rhythmic process GO:0048511 174 0.014
Rat
positive regulation of cell cycle GO:0045787 92 0.014
peptidyl amino acid modification GO:0018193 336 0.014
regulation of blood coagulation GO:0030193 28 0.014
carbohydrate biosynthetic process GO:0016051 74 0.014
dna metabolic process GO:0006259 303 0.014
neuron apoptotic process GO:0051402 142 0.014
immune effector process GO:0002252 321 0.014
negative regulation of response to wounding GO:1903035 77 0.014
mitotic cell cycle process GO:1903047 159 0.014
glucose homeostasis GO:0042593 128 0.014
negative regulation of peptidase activity GO:0010466 46 0.014
generation of precursor metabolites and energy GO:0006091 103 0.014
nucleocytoplasmic transport GO:0006913 139 0.014
humoral immune response GO:0006959 57 0.014
production of molecular mediator of immune response GO:0002440 103 0.014
cellular response to oxidative stress GO:0034599 76 0.014
negative regulation of protein modification process GO:0031400 163 0.014
developmental growth involved in morphogenesis GO:0060560 138 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
cytoplasmic transport GO:0016482 234 0.013
androgen biosynthetic process GO:0006702 4 0.013
bone morphogenesis GO:0060349 78 0.013
blood circulation GO:0008015 195 0.013
embryonic organ morphogenesis GO:0048562 276 0.013
ribose phosphate metabolic process GO:0019693 291 0.013
organelle fission GO:0048285 170 0.013
muscle fiber development GO:0048747 76 0.013
positive regulation of synaptic plasticity GO:0031915 4 0.013
response to lipopolysaccharide GO:0032496 128 0.013
Rat
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
apoptotic signaling pathway GO:0097190 306 0.013
myeloid cell homeostasis GO:0002262 114 0.013
eye photoreceptor cell development GO:0042462 31 0.013
nuclear division GO:0000280 158 0.013
photoreceptor cell development GO:0042461 40 0.013
negative regulation of endopeptidase activity GO:0010951 44 0.013
regulation of protein kinase activity GO:0045859 232 0.013
cellular response to molecule of bacterial origin GO:0071219 83 0.013
Rat
energy derivation by oxidation of organic compounds GO:0015980 77 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
digestive system development GO:0055123 200 0.013
fat cell differentiation GO:0045444 160 0.013
positive regulation of cell migration GO:0030335 109 0.013
Rat
posttranscriptional regulation of gene expression GO:0010608 155 0.013
testosterone biosynthetic process GO:0061370 2 0.013
cellular alcohol biosynthetic process GO:0044108 3 0.013
gastrulation GO:0007369 116 0.013
metanephric loop of henle development GO:0072236 4 0.013
circulatory system process GO:0003013 197 0.013
fat soluble vitamin biosynthetic process GO:0042362 4 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
auditory receptor cell fate specification GO:0042667 1 0.013
regulation of ossification GO:0030278 112 0.013
palate development GO:0060021 76 0.013
Mouse
regulation of cellular response to stress GO:0080135 159 0.013
histone modification GO:0016570 159 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
response to molecule of fungal origin GO:0002238 4 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
negative regulation of neuron death GO:1901215 98 0.012
regulation of cysteine type endopeptidase activity GO:2000116 65 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
reactive oxygen species metabolic process GO:0072593 84 0.012
positive regulation of cytokine production GO:0001819 174 0.012
regulation of cell cycle process GO:0010564 160 0.012
cellular ion homeostasis GO:0006873 165 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
Rat
purine ribonucleotide metabolic process GO:0009150 290 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
protein secretion GO:0009306 111 0.012
organic anion transport GO:0015711 137 0.012
negative regulation of defense response GO:0031348 77 0.012
response to transforming growth factor beta GO:0071559 88 0.012
maintenance of location GO:0051235 89 0.012
regulation of coagulation GO:0050818 31 0.012
positive regulation of protein modification process GO:0031401 299 0.012
response to insulin GO:0032868 100 0.012
organonitrogen compound catabolic process GO:1901565 264 0.012
regulation of wound healing GO:0061041 40 0.012
regulation of protein oligomerization GO:0032459 4 0.012
Human
response to peptide hormone GO:0043434 127 0.012
Rat
regulation of nuclear division GO:0051783 56 0.012
protein localization to organelle GO:0033365 185 0.012
nephron tubule development GO:0072080 84 0.012
negative regulation of nlrp3 inflammasome complex assembly GO:1900226 2 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
regulation of leukocyte mediated immunity GO:0002703 104 0.011
extracellular structure organization GO:0043062 148 0.011
Mouse
cellular glucose homeostasis GO:0001678 52 0.011
cellular response to monosaccharide stimulus GO:0071326 47 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
response to stilbenoid GO:0035634 22 0.011
response to metal ion GO:0010038 47 0.011
Rat
organelle localization GO:0051640 179 0.011
intestinal epithelial structure maintenance GO:0060729 4 0.011
single fertilization GO:0007338 82 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
response to amino acid GO:0043200 37 0.011
tube formation GO:0035148 140 0.011
cytokine metabolic process GO:0042107 71 0.011
epithelial cell proliferation GO:0050673 174 0.011
blastocyst development GO:0001824 80 0.011
skeletal system development GO:0001501 356 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
glial cell differentiation GO:0010001 131 0.011
regulation of neuron projection development GO:0010975 169 0.011
negative regulation of cell development GO:0010721 169 0.011
female gonad development GO:0008585 71 0.011
Rat
lymphocyte differentiation GO:0030098 242 0.011
branching morphogenesis of an epithelial tube GO:0048754 159 0.011
cell growth GO:0016049 130 0.011
antibacterial peptide production GO:0002778 2 0.011
positive regulation of proteolysis GO:0045862 85 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
positive regulation of epithelial cell migration GO:0010634 19 0.011
brown fat cell proliferation GO:0070342 1 0.011
morphogenesis of a branching structure GO:0001763 203 0.011
cellular response to inorganic substance GO:0071241 37 0.011
Rat
glycosylation GO:0070085 62 0.011
response to testosterone GO:0033574 3 0.011
cognition GO:0050890 149 0.011
negative regulation of growth GO:0045926 99 0.011
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.011
cation homeostasis GO:0055080 212 0.011
response to light stimulus GO:0009416 135 0.011
methylation GO:0032259 134 0.011
alcohol metabolic process GO:0006066 116 0.011
olfactory learning GO:0008355 2 0.011
regulation of binding GO:0051098 111 0.011
regulation of interleukin 10 production GO:0032653 21 0.011
macromolecule methylation GO:0043414 120 0.011
leukocyte migration GO:0050900 124 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
developmental cell growth GO:0048588 84 0.011
cell maturation GO:0048469 127 0.011
single organismal cell cell adhesion GO:0016337 131 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
nucleoside metabolic process GO:0009116 246 0.010
urogenital system development GO:0001655 261 0.010
nephron development GO:0072006 109 0.010
protein kinase b signaling GO:0043491 74 0.010
defense response to other organism GO:0098542 197 0.010
calcitriol biosynthetic process from calciol GO:0036378 3 0.010
dendrite development GO:0016358 115 0.010
placenta development GO:0001890 140 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.010
connective tissue development GO:0061448 179 0.010
anatomical structure homeostasis GO:0060249 145 0.010
positive regulation of immune effector process GO:0002699 107 0.010
somatotropin secreting cell differentiation GO:0060126 4 0.010
rna processing GO:0006396 105 0.010
covalent chromatin modification GO:0016569 163 0.010
cellular protein catabolic process GO:0044257 155 0.010
cellular divalent inorganic cation homeostasis GO:0072503 127 0.010
development of primary sexual characteristics GO:0045137 143 0.010
Rat
cell division GO:0051301 120 0.010
hemostasis GO:0007599 78 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
Rat
cartilage development GO:0051216 140 0.010
nucleoside triphosphate metabolic process GO:0009141 230 0.010
macromolecule glycosylation GO:0043413 55 0.010
cellular response to hexose stimulus GO:0071331 47 0.010
cellular response to insulin stimulus GO:0032869 78 0.010
inter male aggressive behavior GO:0002121 3 0.010
nitrogen compound transport GO:0071705 271 0.010
organ regeneration GO:0031100 2 0.010

Mmp1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
disease of metabolism DOID:0014667 0 0.021
sensory system disease DOID:0050155 0 0.015
musculoskeletal system disease DOID:17 0 0.012
inherited metabolic disorder DOID:655 0 0.011