Mus musculus

60 known processes

Smek2

SMEK homolog 2, suppressor of mek1 (Dictyostelium)

(Aliases: KIAA1387,AW557776,AW011752,mKIAA1387)

Smek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
purine ribonucleoside catabolic process GO:0046130 205 0.166
organic cyclic compound catabolic process GO:1901361 295 0.142
ribonucleoside triphosphate catabolic process GO:0009203 199 0.127
mitotic cell cycle GO:0000278 195 0.122
aromatic compound catabolic process GO:0019439 286 0.103
cellular response to dna damage stimulus GO:0006974 207 0.098
ribose phosphate metabolic process GO:0019693 291 0.091
nucleotide metabolic process GO:0009117 332 0.091
regulation of cell cycle process GO:0010564 160 0.090
ras protein signal transduction GO:0007265 77 0.086
dna metabolic process GO:0006259 303 0.085
chromatin organization GO:0006325 206 0.079
regulation of organelle organization GO:0033043 289 0.079
genetic imprinting GO:0071514 27 0.075
gene silencing by rna GO:0031047 19 0.067
cellular nitrogen compound catabolic process GO:0044270 280 0.063
positive regulation of protein modification process GO:0031401 299 0.061
carbohydrate derivative catabolic process GO:1901136 231 0.058
regulation of cellular ketone metabolic process GO:0010565 66 0.057
neural tube development GO:0021915 160 0.055
purine ribonucleotide catabolic process GO:0009154 208 0.055
posttranscriptional gene silencing GO:0016441 10 0.052
positive regulation of cell cycle process GO:0090068 61 0.048
organelle fission GO:0048285 170 0.047
nucleobase containing small molecule metabolic process GO:0055086 352 0.047
apical constriction GO:0003383 4 0.047
rna interference GO:0016246 2 0.047
cellular amino acid metabolic process GO:0006520 103 0.047
heterocycle catabolic process GO:0046700 280 0.046
regulation of chromosome organization GO:0033044 83 0.046
negative regulation of molecular function GO:0044092 258 0.046
chromatin modification GO:0016568 187 0.045
histone modification GO:0016570 159 0.045
nucleoside phosphate metabolic process GO:0006753 338 0.045
myeloid cell differentiation GO:0030099 233 0.043
histone lysine methylation GO:0034968 50 0.043
erythrocyte differentiation GO:0030218 88 0.043
purine containing compound metabolic process GO:0072521 311 0.043
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.042
rna processing GO:0006396 105 0.042
nuclear division GO:0000280 158 0.041
purine containing compound catabolic process GO:0072523 213 0.041
ribonucleotide catabolic process GO:0009261 208 0.040
organophosphate catabolic process GO:0046434 232 0.040
macromolecule methylation GO:0043414 120 0.039
cell division GO:0051301 120 0.038
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
cellular ketone metabolic process GO:0042180 84 0.036
protein polymerization GO:0051258 57 0.036
purine ribonucleoside metabolic process GO:0046128 241 0.036
cell type specific apoptotic process GO:0097285 268 0.036
methylation GO:0032259 134 0.036
positive regulation of cellular amine metabolic process GO:0033240 5 0.036
bone development GO:0060348 120 0.035
vacuole organization GO:0007033 38 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
regulation of chromatin modification GO:1903308 57 0.034
nucleoside phosphate catabolic process GO:1901292 222 0.034
mitotic nuclear division GO:0007067 48 0.034
ribonucleoside catabolic process GO:0042454 206 0.034
ribonucleoside triphosphate metabolic process GO:0009199 220 0.034
nucleoside triphosphate catabolic process GO:0009143 205 0.034
regulation of protein complex assembly GO:0043254 83 0.033
germ cell development GO:0007281 185 0.033
regulation of nucleotide metabolic process GO:0006140 169 0.033
cell cycle checkpoint GO:0000075 47 0.032
ossification GO:0001503 216 0.031
development of primary sexual characteristics GO:0045137 143 0.031
purine ribonucleotide metabolic process GO:0009150 290 0.030
purine nucleoside triphosphate catabolic process GO:0009146 203 0.030
blastocyst development GO:0001824 80 0.029
positive regulation of protein phosphorylation GO:0001934 242 0.029
cellular response to radiation GO:0071478 28 0.029
ribonucleoside metabolic process GO:0009119 245 0.029
mrna metabolic process GO:0016071 84 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
regulation of nucleoside metabolic process GO:0009118 130 0.027
epithelial cell development GO:0002064 159 0.027
nucleotide catabolic process GO:0009166 217 0.027
meiotic cell cycle process GO:1903046 77 0.027
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.027
regulation of cell cycle GO:0051726 281 0.026
uterus morphogenesis GO:0061038 2 0.026
mitotic cell cycle process GO:1903047 159 0.026
response to radiation GO:0009314 165 0.026
nucleoside metabolic process GO:0009116 246 0.026
small gtpase mediated signal transduction GO:0007264 97 0.025
positive regulation of cell cycle GO:0045787 92 0.025
rho protein signal transduction GO:0007266 32 0.025
ribonucleotide metabolic process GO:0009259 291 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
negative regulation of immune system process GO:0002683 209 0.024
regulation of cell motility GO:2000145 236 0.024
neural tube formation GO:0001841 108 0.024
regulation of cellular catabolic process GO:0031329 242 0.024
gene silencing GO:0016458 38 0.023
nucleoside catabolic process GO:0009164 206 0.023
purine nucleotide catabolic process GO:0006195 211 0.023
regulation of transcription by chromatin organization GO:0034401 0 0.023
microtubule cytoskeleton organization GO:0000226 157 0.023
nucleoside monophosphate metabolic process GO:0009123 85 0.023
posttranscriptional regulation of gene expression GO:0010608 155 0.022
negative regulation of cell cycle GO:0045786 123 0.022
microtubule based process GO:0007017 236 0.021
purine nucleoside metabolic process GO:0042278 241 0.021
purine nucleoside catabolic process GO:0006152 205 0.021
stem cell development GO:0048864 219 0.021
rna splicing GO:0008380 54 0.021
regulation of chromatin organization GO:1902275 57 0.021
positive regulation of protein kinase activity GO:0045860 144 0.020
retina development in camera type eye GO:0060041 119 0.020
chromosome segregation GO:0007059 48 0.020
regulation of mitotic cell cycle phase transition GO:1901990 73 0.020
regulation of feeding behavior GO:0060259 3 0.020
gland development GO:0048732 330 0.019
cell matrix adhesion GO:0007160 68 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
organelle assembly GO:0070925 177 0.019
skeletal system development GO:0001501 356 0.019
nucleoside triphosphate metabolic process GO:0009141 230 0.019
neuron apoptotic process GO:0051402 142 0.019
regulation of meiotic cell cycle GO:0051445 34 0.019
positive regulation of apoptotic process GO:0043065 217 0.018
locomotory behavior GO:0007626 195 0.018
regulation of mapk cascade GO:0043408 248 0.018
peptidyl amino acid modification GO:0018193 336 0.018
meiotic cell cycle GO:0051321 122 0.018
appendage development GO:0048736 166 0.018
regulation of neuron projection development GO:0010975 169 0.018
heart morphogenesis GO:0003007 178 0.018
cellular response to abiotic stimulus GO:0071214 56 0.018
ribonucleoside monophosphate catabolic process GO:0009158 57 0.017
amine metabolic process GO:0009308 45 0.017
angiogenesis GO:0001525 201 0.017
endocytosis GO:0006897 168 0.017
atp catabolic process GO:0006200 55 0.017
termination of rna polymerase i transcription GO:0006363 2 0.017
regulation of nucleotide catabolic process GO:0030811 122 0.017
circulatory system process GO:0003013 197 0.017
histone h3 k9 trimethylation GO:0036124 6 0.016
positive regulation of kinase activity GO:0033674 155 0.016
regulation of cell substrate adhesion GO:0010810 73 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.016
dna repair GO:0006281 107 0.016
oxidation reduction process GO:0055114 342 0.016
divalent inorganic cation homeostasis GO:0072507 138 0.016
chromatin silencing at rdna GO:0000183 3 0.016
homeostasis of number of cells GO:0048872 210 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
positive regulation of gtpase activity GO:0043547 85 0.016
histone h4 k20 trimethylation GO:0034773 2 0.016
positive regulation of transferase activity GO:0051347 167 0.016
blood circulation GO:0008015 195 0.016
regulation of cellular amino acid metabolic process GO:0006521 5 0.015
regulation of transferase activity GO:0051338 263 0.015
fat cell differentiation GO:0045444 160 0.015
cellular response to lipid GO:0071396 145 0.015
regulation of hydrolase activity GO:0051336 246 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
regulation of cell migration GO:0030334 219 0.015
establishment or maintenance of polarity of embryonic epithelium GO:0016332 1 0.015
spermatogenesis GO:0007283 284 0.015
protein autophosphorylation GO:0046777 61 0.015
necrotic cell death GO:0070265 30 0.015
regulation of cellular component biogenesis GO:0044087 181 0.015
bone morphogenesis GO:0060349 78 0.015
purine nucleotide metabolic process GO:0006163 302 0.015
response to growth factor GO:0070848 198 0.014
regulation of cell activation GO:0050865 289 0.014
sensory organ morphogenesis GO:0090596 242 0.014
regulation of cell projection organization GO:0031344 206 0.014
mapk cascade GO:0000165 281 0.014
positive regulation of response to wounding GO:1903036 66 0.014
regulation of cell cycle phase transition GO:1901987 77 0.014
membrane organization GO:0061024 245 0.014
positive regulation of mitotic cell cycle GO:0045931 41 0.014
meiotic nuclear division GO:0007126 115 0.013
dna replication GO:0006260 52 0.013
regulation of gtp catabolic process GO:0033124 113 0.013
regulation of neuron death GO:1901214 134 0.013
regulation of vasculature development GO:1901342 88 0.013
leukocyte differentiation GO:0002521 342 0.013
male gamete generation GO:0048232 285 0.013
transmission of nerve impulse GO:0019226 76 0.013
limb development GO:0060173 166 0.013
regulation of cellular amine metabolic process GO:0033238 20 0.013
ion transmembrane transport GO:0034220 361 0.013
action potential GO:0001508 78 0.013
regulation of ossification GO:0030278 112 0.013
apoptotic signaling pathway GO:0097190 306 0.013
protein methylation GO:0006479 81 0.013
negative regulation of dna replication GO:0008156 4 0.013
cellular amine metabolic process GO:0044106 44 0.013
cytokine production GO:0001816 319 0.013
protein alkylation GO:0008213 81 0.013
blood vessel morphogenesis GO:0048514 285 0.013
positive regulation of organelle organization GO:0010638 128 0.013
negative regulation of rho gtpase activity GO:0034259 1 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
retina morphogenesis in camera type eye GO:0060042 45 0.013
sensory perception GO:0007600 245 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
glycosyl compound catabolic process GO:1901658 206 0.012
adult behavior GO:0030534 135 0.012
regulation of embryonic development GO:0045995 71 0.012
regulation of purine nucleotide metabolic process GO:1900542 169 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
embryonic epithelial tube formation GO:0001838 130 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
regulation of cellular response to stress GO:0080135 159 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
mitotic sister chromatid segregation GO:0000070 14 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
mitotic cell cycle checkpoint GO:0007093 31 0.012
positive regulation of nucleotide metabolic process GO:0045981 114 0.012
negative regulation of protein processing GO:0010955 79 0.012
cellular homeostasis GO:0019725 240 0.012
positive regulation of nervous system development GO:0051962 221 0.012
rna phosphodiester bond hydrolysis exonucleolytic GO:0090503 4 0.011
cell adhesion GO:0007155 329 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
negative regulation of cell cycle process GO:0010948 69 0.011
hepaticobiliary system development GO:0061008 67 0.011
negative regulation of neuron death GO:1901215 98 0.011
inorganic cation transmembrane transport GO:0098662 207 0.011
positive regulation of translational initiation GO:0045948 4 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
actin mediated cell contraction GO:0070252 15 0.011
negative regulation of mitotic cell cycle GO:0045930 58 0.011
regulation of system process GO:0044057 200 0.011
neuron death GO:0070997 154 0.011
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 3 0.010
calcium ion homeostasis GO:0055074 127 0.010
histone h3 k9 methylation GO:0051567 17 0.010
regulation of protein maturation GO:1903317 96 0.010
developmental growth involved in morphogenesis GO:0060560 138 0.010
regulation of cell shape GO:0008360 39 0.010
cell substrate adhesion GO:0031589 130 0.010
modification dependent protein catabolic process GO:0019941 133 0.010
negative regulation of cell cycle phase transition GO:1901988 48 0.010
negative regulation of protein maturation GO:1903318 79 0.010

Smek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.037
disease of cellular proliferation DOID:14566 0 0.037
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
sensory system disease DOID:0050155 0 0.010