Mus musculus

21 known processes

Map2k2

mitogen-activated protein kinase kinase 2

(Aliases: MEK2,Prkmk2,AA589381,MK2)

Map2k2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of protein serine threonine kinase activity GO:0071900 157 0.386
Human Yeast Mouse Rat Worm
nucleoside metabolic process GO:0009116 246 0.338
regulation of kinase activity GO:0043549 249 0.331
Human Yeast Mouse Rat Worm
male gamete generation GO:0048232 285 0.321
positive regulation of protein modification process GO:0031401 299 0.270
Human Yeast Mouse Rat Worm
spermatogenesis GO:0007283 284 0.255
positive regulation of nucleotide catabolic process GO:0030813 88 0.253
glycosyl compound catabolic process GO:1901658 206 0.249
regulation of cellular response to stress GO:0080135 159 0.242
Yeast
negative regulation of molecular function GO:0044092 258 0.239
ribonucleoside triphosphate catabolic process GO:0009203 199 0.236
purine nucleoside metabolic process GO:0042278 241 0.218
ribose phosphate metabolic process GO:0019693 291 0.213
protein catabolic process GO:0030163 221 0.209
Worm
glycosyl compound metabolic process GO:1901657 246 0.209
oocyte construction GO:0007308 2 0.201
muscle tissue development GO:0060537 308 0.200
nucleoside phosphate metabolic process GO:0006753 338 0.199
actin cytoskeleton organization GO:0030036 220 0.185
Yeast
purine ribonucleoside metabolic process GO:0046128 241 0.180
purine nucleoside triphosphate metabolic process GO:0009144 226 0.179
organonitrogen compound catabolic process GO:1901565 264 0.169
purine containing compound catabolic process GO:0072523 213 0.169
nucleoside catabolic process GO:0009164 206 0.167
ribonucleotide metabolic process GO:0009259 291 0.167
organic cyclic compound catabolic process GO:1901361 295 0.164
cell fate commitment GO:0045165 210 0.153
g protein coupled receptor signaling pathway GO:0007186 243 0.149
Yeast
stem cell differentiation GO:0048863 268 0.145
oocyte axis specification GO:0007309 2 0.144
positive regulation of protein phosphorylation GO:0001934 242 0.144
Human Yeast Mouse Rat Worm
nucleoside phosphate catabolic process GO:1901292 222 0.143
mapk cascade GO:0000165 281 0.141
Human Yeast Mouse Rat Worm Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.140
positive regulation of nervous system development GO:0051962 221 0.135
nucleobase containing small molecule metabolic process GO:0055086 352 0.134
regulation of protein kinase activity GO:0045859 232 0.133
Human Yeast Mouse Rat Worm
purine ribonucleoside catabolic process GO:0046130 205 0.132
gtp metabolic process GO:0046039 144 0.127
purine nucleotide catabolic process GO:0006195 211 0.122
guanosine containing compound metabolic process GO:1901068 144 0.121
aromatic compound catabolic process GO:0019439 286 0.120
cellular nitrogen compound catabolic process GO:0044270 280 0.119
ribonucleoside metabolic process GO:0009119 245 0.118
regulation of mapk cascade GO:0043408 248 0.117
Human Yeast Mouse Rat Worm Fly
positive regulation of mapk cascade GO:0043410 170 0.116
Human Yeast Mouse Rat Worm Fly
apoptotic signaling pathway GO:0097190 306 0.114
peptidyl amino acid modification GO:0018193 336 0.112
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.112
macromolecule catabolic process GO:0009057 281 0.112
Worm
regulation of transferase activity GO:0051338 263 0.110
Human Yeast Mouse Rat Worm
cell fate specification GO:0001708 72 0.109
heterocycle catabolic process GO:0046700 280 0.109
development of primary sexual characteristics GO:0045137 143 0.107
Worm
digestive system development GO:0055123 200 0.104
muscle cell differentiation GO:0042692 261 0.102
positive regulation of cell projection organization GO:0031346 95 0.100
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.100
positive regulation of neuron differentiation GO:0045666 141 0.096
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.096
Human Yeast Mouse Rat Worm
compound eye development GO:0048749 1 0.094
germ cell development GO:0007281 185 0.093
Fly
nucleoside triphosphate metabolic process GO:0009141 230 0.093
ribonucleoside triphosphate metabolic process GO:0009199 220 0.093
protein modification by small protein conjugation or removal GO:0070647 207 0.091
carbohydrate derivative catabolic process GO:1901136 231 0.089
regulation of cell migration GO:0030334 219 0.088
nucleotide metabolic process GO:0009117 332 0.087
regulation of nucleoside metabolic process GO:0009118 130 0.087
spermatid differentiation GO:0048515 115 0.086
regulation of neuron apoptotic process GO:0043523 122 0.084
purine nucleoside catabolic process GO:0006152 205 0.084
gastrulation GO:0007369 116 0.084
regulation of exocytosis GO:0017157 61 0.082
cellular ketone metabolic process GO:0042180 84 0.080
response to oxidative stress GO:0006979 123 0.080
regulation of cell cycle process GO:0010564 160 0.077
organophosphate catabolic process GO:0046434 232 0.077
purine nucleoside triphosphate catabolic process GO:0009146 203 0.076
establishment or maintenance of bipolar cell polarity GO:0061245 21 0.076
digestive tract morphogenesis GO:0048546 147 0.075
cell type specific apoptotic process GO:0097285 268 0.075
purine ribonucleotide catabolic process GO:0009154 208 0.075
purine ribonucleotide metabolic process GO:0009150 290 0.075
regulation of epithelial cell proliferation GO:0050678 141 0.075
positive regulation of protein kinase activity GO:0045860 144 0.075
Human Yeast Mouse Rat Worm
regulation of cellular ketone metabolic process GO:0010565 66 0.074
positive regulation of nucleotide metabolic process GO:0045981 114 0.074
spermatid development GO:0007286 108 0.072
regionalization GO:0003002 337 0.072
Fly
negative regulation of synaptic vesicle transport GO:1902804 3 0.070
positive regulation of cell development GO:0010720 237 0.070
rhythmic process GO:0048511 174 0.069
cellular amino acid metabolic process GO:0006520 103 0.068
skeletal muscle organ development GO:0060538 163 0.067
multicellular organism growth GO:0035264 161 0.065
neuron apoptotic process GO:0051402 142 0.065
cytoplasmic transport GO:0016482 234 0.064
Yeast
negative regulation of protein metabolic process GO:0051248 282 0.064
digestive tract development GO:0048565 190 0.063
muscle system process GO:0003012 141 0.062
associative learning GO:0008306 61 0.062
actomyosin structure organization GO:0031032 56 0.062
ribonucleotide catabolic process GO:0009261 208 0.061
lung morphogenesis GO:0060425 50 0.060
positive regulation of kinase activity GO:0033674 155 0.060
Human Yeast Mouse Rat Worm
intrinsic apoptotic signaling pathway GO:0097193 132 0.060
establishment of organelle localization GO:0051656 122 0.059
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.059
Yeast
regulation of actin filament based process GO:0032970 99 0.059
respiratory system development GO:0060541 190 0.058
regulation of hydrolase activity GO:0051336 246 0.058
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.058
striated muscle cell development GO:0055002 125 0.057
regulation of neuron differentiation GO:0045664 281 0.056
neuron death GO:0070997 154 0.056
carbon catabolite activation of transcription GO:0045991 4 0.055
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.055
Fly
stem cell development GO:0048864 219 0.055
regulation of cell cycle GO:0051726 281 0.055
regulation of defense response GO:0031347 233 0.055
striated muscle tissue development GO:0014706 293 0.055
epithelial tube morphogenesis GO:0060562 303 0.054
negative regulation of neuron death GO:1901215 98 0.053
myosin filament organization GO:0031033 3 0.052
positive regulation of nucleoside metabolic process GO:0045979 91 0.051
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.051
Fly
regulation of organelle organization GO:0033043 289 0.051
social behavior GO:0035176 21 0.050
regulation of translation GO:0006417 71 0.049
negative regulation of cellular protein metabolic process GO:0032269 247 0.048
oocyte differentiation GO:0009994 35 0.048
response to radiation GO:0009314 165 0.048
regulation of vesicle mediated transport GO:0060627 139 0.047
response to light stimulus GO:0009416 135 0.047
cellular amine metabolic process GO:0044106 44 0.047
nucleotide catabolic process GO:0009166 217 0.046
carbohydrate derivative biosynthetic process GO:1901137 183 0.046
positive regulation of organelle organization GO:0010638 128 0.046
protein modification by small protein conjugation GO:0032446 187 0.045
membrane organization GO:0061024 245 0.045
cell maturation GO:0048469 127 0.045
placenta blood vessel development GO:0060674 31 0.044
Mouse
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.044
negative regulation of neuron apoptotic process GO:0043524 92 0.044
amine metabolic process GO:0009308 45 0.044
regulation of synaptic plasticity GO:0048167 87 0.044
muscle cell development GO:0055001 133 0.044
cellular response to extracellular stimulus GO:0031668 81 0.043
regulation of cell motility GO:2000145 236 0.043
neurotransmitter secretion GO:0007269 62 0.042
ribonucleoside catabolic process GO:0042454 206 0.042
proteasomal protein catabolic process GO:0010498 98 0.041
regulation of jnk cascade GO:0046328 62 0.040
response to heat GO:0009408 27 0.040
Yeast
epidermis development GO:0008544 187 0.040
Mouse
adherens junction organization GO:0034332 28 0.040
regulation of purine nucleotide metabolic process GO:1900542 169 0.039
negative regulation of ras gtpase activity GO:0034261 3 0.039
adiponectin activated signaling pathway GO:0033211 4 0.039
negative regulation of macroautophagy GO:0016242 5 0.039
cellular lipid metabolic process GO:0044255 323 0.039
epidermal growth factor receptor signaling pathway GO:0007173 28 0.038
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.038
purine nucleotide metabolic process GO:0006163 302 0.038
positive regulation of cell migration GO:0030335 109 0.038
embryonic placenta development GO:0001892 98 0.038
Mouse
skin development GO:0043588 220 0.038
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.038
regulation of purine nucleotide catabolic process GO:0033121 122 0.038
protein import into nucleus GO:0006606 95 0.038
Yeast
exocytosis GO:0006887 121 0.038
protein ubiquitination GO:0016567 171 0.037
negative regulation of protein phosphorylation GO:0001933 126 0.037
macroautophagy GO:0016236 21 0.037
wnt signaling pathway GO:0016055 188 0.036
regulation of secretion by cell GO:1903530 249 0.036
protein oligomerization GO:0051259 67 0.036
positive regulation of cellular catabolic process GO:0031331 148 0.035
positive regulation of cellular amine metabolic process GO:0033240 5 0.035
negative regulation of fibroblast migration GO:0010764 2 0.035
response to molecule of bacterial origin GO:0002237 143 0.035
positive regulation of gtp catabolic process GO:0033126 85 0.035
cellular protein catabolic process GO:0044257 155 0.034
establishment of vesicle localization GO:0051650 81 0.034
negative regulation of cell cycle process GO:0010948 69 0.034
negative regulation of cell proliferation GO:0008285 296 0.034
cell adhesion GO:0007155 329 0.034
circadian rhythm GO:0007623 114 0.034
cell growth GO:0016049 130 0.034
Yeast
erbb signaling pathway GO:0038127 32 0.034
endocytosis GO:0006897 168 0.034
leukocyte proliferation GO:0070661 172 0.034
positive regulation of jnk cascade GO:0046330 46 0.034
modification dependent protein catabolic process GO:0019941 133 0.034
response to temperature stimulus GO:0009266 55 0.033
Yeast
organonitrogen compound biosynthetic process GO:1901566 192 0.033
regulation of actin cytoskeleton organization GO:0032956 84 0.033
purine containing compound metabolic process GO:0072521 311 0.033
immune response regulating signaling pathway GO:0002764 125 0.033
cellular response to starvation GO:0009267 57 0.033
regulation of cellular catabolic process GO:0031329 242 0.033
ameboidal type cell migration GO:0001667 128 0.032
Fly
cellular response to cytokine stimulus GO:0071345 189 0.032
response to starvation GO:0042594 65 0.032
regulation of muscle tissue development GO:1901861 97 0.032
gonad development GO:0008406 141 0.031
Worm
mitotic cell cycle process GO:1903047 159 0.031
neurotransmitter transport GO:0006836 76 0.030
epithelial cell proliferation GO:0050673 174 0.030
gtp catabolic process GO:0006184 143 0.030
developmental maturation GO:0021700 193 0.030
posttranscriptional regulation of gene expression GO:0010608 155 0.030
negative regulation of intracellular signal transduction GO:1902532 167 0.030
cellular response to lipopolysaccharide GO:0071222 77 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
cellular macromolecule catabolic process GO:0044265 206 0.029
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.029
segmentation GO:0035282 93 0.029
Fly
regulation of erk1 and erk2 cascade GO:0070372 71 0.029
Fly
learning GO:0007612 98 0.029
positive regulation of rac gtpase activity GO:0032855 14 0.029
protein localization to organelle GO:0033365 185 0.029
Yeast
female gamete generation GO:0007292 74 0.028
Fly
camera type eye development GO:0043010 266 0.028
positive regulation of ruffle assembly GO:1900029 1 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
muscle contraction GO:0006936 101 0.028
cardiac muscle cell differentiation GO:0055007 69 0.028
regulation of leukocyte proliferation GO:0070663 121 0.028
nucleoside triphosphate catabolic process GO:0009143 205 0.027
regulation of macroautophagy GO:0016241 12 0.027
cellular response to growth factor stimulus GO:0071363 197 0.027
regulation of nucleotide catabolic process GO:0030811 122 0.027
regulation of stress activated mapk cascade GO:0032872 69 0.027
multi organism behavior GO:0051705 62 0.027
cell substrate adhesion GO:0031589 130 0.027
regulation of wnt signaling pathway GO:0030111 123 0.027
cell cycle arrest GO:0007050 37 0.027
positive regulation of transferase activity GO:0051347 167 0.027
Human Yeast Mouse Rat Worm
regulation of neuronal synaptic plasticity GO:0048168 30 0.027
response to inorganic substance GO:0010035 96 0.026
positive regulation of ras protein signal transduction GO:0046579 13 0.026
Fly
second messenger mediated signaling GO:0019932 73 0.026
actin filament organization GO:0007015 113 0.026
Yeast
jnk cascade GO:0007254 72 0.026
negative regulation of hydrolase activity GO:0051346 71 0.026
respiratory tube development GO:0030323 167 0.026
morphogenesis of a branching epithelium GO:0061138 193 0.026
vesicle localization GO:0051648 86 0.026
mitotic cell cycle GO:0000278 195 0.026
multi multicellular organism process GO:0044706 109 0.026
notch signaling pathway GO:0007219 71 0.025
negative regulation of phosphorylation GO:0042326 166 0.025
brain segmentation GO:0035284 3 0.025
olfactory learning GO:0008355 2 0.025
positive regulation of cellular component biogenesis GO:0044089 94 0.025
cellular response to peptide hormone stimulus GO:0071375 92 0.025
response to lipopolysaccharide GO:0032496 128 0.025
telencephalon development GO:0021537 186 0.025
cognition GO:0050890 149 0.024
fertilization GO:0009566 127 0.024
regulation of lymphocyte proliferation GO:0050670 117 0.024
protein autophosphorylation GO:0046777 61 0.024
Human
positive regulation of map kinase activity GO:0043406 84 0.024
Human Yeast Mouse Rat Worm
oogenesis GO:0048477 56 0.023
Fly
positive regulation of hydrolase activity GO:0051345 148 0.023
myotube differentiation GO:0014902 105 0.023
regulation of neuron death GO:1901214 134 0.023
response to ischemia GO:0002931 14 0.023
retina development in camera type eye GO:0060041 119 0.023
negative regulation of cell migration GO:0030336 59 0.023
response to peptide hormone GO:0043434 127 0.023
negative regulation of apoptotic signaling pathway GO:2001234 104 0.023
response to nutrient levels GO:0031667 109 0.023
leukocyte differentiation GO:0002521 342 0.023
epidermis morphogenesis GO:0048730 33 0.023
oocyte development GO:0048599 33 0.023
cytokine production GO:0001816 319 0.023
regulation of neuron projection development GO:0010975 169 0.023
regulation of gtp catabolic process GO:0033124 113 0.023
regulation of neurotransmitter transport GO:0051588 35 0.022
nucleocytoplasmic transport GO:0006913 139 0.022
Yeast
placenta development GO:0001890 140 0.022
Mouse
peptidyl tyrosine dephosphorylation GO:0035335 23 0.022
Mouse
negative regulation of g protein coupled receptor protein signaling pathway GO:0045744 12 0.022
negative regulation of nucleotide catabolic process GO:0030812 9 0.022
cellular response to dna damage stimulus GO:0006974 207 0.022
smooth muscle contraction GO:0006939 44 0.022
response to hypoxia GO:0001666 58 0.022
regulation of secretion GO:0051046 274 0.021
negative regulation of phosphorus metabolic process GO:0010563 184 0.021
nuclear division GO:0000280 158 0.021
regulation of protein maturation GO:1903317 96 0.021
regulation of protein processing GO:0070613 96 0.021
regulation of cytoskeleton organization GO:0051493 122 0.021
t cell activation GO:0042110 289 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.021
cellular senescence GO:0090398 11 0.021
nucleoside monophosphate metabolic process GO:0009123 85 0.021
gland development GO:0048732 330 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
rap protein signal transduction GO:0032486 3 0.021
cellular response to external stimulus GO:0071496 88 0.020
response to reactive oxygen species GO:0000302 56 0.020
regulation of anatomical structure size GO:0090066 178 0.020
microtubule based movement GO:0007018 84 0.020
regulation of mitotic cell cycle GO:0007346 126 0.020
response to growth factor GO:0070848 198 0.020
protein localization to membrane GO:0072657 108 0.020
positive t cell selection GO:0043368 23 0.020
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.020
negative regulation of transferase activity GO:0051348 85 0.020
establishment of protein localization to organelle GO:0072594 118 0.020
Yeast
regulation of t cell proliferation GO:0042129 92 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.019
organelle localization GO:0051640 179 0.019
central nervous system segmentation GO:0035283 3 0.019
negative regulation of cell cycle GO:0045786 123 0.019
positive regulation of cell death GO:0010942 224 0.019
regulation of synaptic vesicle exocytosis GO:2000300 11 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.019
peptidyl serine phosphorylation GO:0018105 74 0.018
Human
rna interference GO:0016246 2 0.018
regulation of myotube differentiation GO:0010830 62 0.018
vesicle organization GO:0016050 60 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
glycoprotein metabolic process GO:0009100 116 0.018
regulation of multi organism process GO:0043900 111 0.018
Yeast
regulation of reproductive process GO:2000241 66 0.018
Yeast
localization within membrane GO:0051668 4 0.018
response to extracellular stimulus GO:0009991 127 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.018
carbon catabolite regulation of transcription GO:0045990 4 0.018
t cell proliferation GO:0042098 120 0.018
single organism cell adhesion GO:0098602 156 0.018
myofibril assembly GO:0030239 34 0.018
establishment of mitochondrion localization GO:0051654 4 0.018
ubiquitin dependent protein catabolic process GO:0006511 129 0.018
neuromuscular process GO:0050905 99 0.018
morphogenesis of a branching structure GO:0001763 203 0.017
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.017
stress activated protein kinase signaling cascade GO:0031098 81 0.017
positive regulation of stress activated mapk cascade GO:0032874 48 0.017
peptidyl lysine modification GO:0018205 77 0.017
learning or memory GO:0007611 148 0.017
cd4 positive alpha beta t cell activation GO:0035710 45 0.017
guanosine containing compound catabolic process GO:1901069 144 0.017
organelle assembly GO:0070925 177 0.017
cellular response to lipid GO:0071396 145 0.017
response to organonitrogen compound GO:0010243 246 0.017
regulation of neurotransmitter levels GO:0001505 87 0.017
embryonic organ morphogenesis GO:0048562 276 0.017
extrinsic apoptotic signaling pathway GO:0097191 126 0.016
labyrinthine layer development GO:0060711 49 0.016
Mouse
regulation of cell activation GO:0050865 289 0.016
formation of primary germ layer GO:0001704 77 0.016
regulation of protein localization GO:0032880 231 0.016
regulation of intracellular transport GO:0032386 159 0.016
negative regulation of cell motility GO:2000146 61 0.016
peptidyl serine modification GO:0018209 83 0.016
Human
blood vessel morphogenesis GO:0048514 285 0.016
regulation of cell adhesion GO:0030155 154 0.016
cellular response to ethanol GO:0071361 3 0.016
regulation of system process GO:0044057 200 0.016
regulation of cellular component biogenesis GO:0044087 181 0.015
positive regulation of cell substrate adhesion GO:0010811 47 0.015
regulation of translational initiation GO:0006446 15 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
visual learning GO:0008542 44 0.015
cytokine mediated signaling pathway GO:0019221 115 0.015
cellular protein complex assembly GO:0043623 116 0.015
regulation of cell projection organization GO:0031344 206 0.015
positive regulation of cytoskeleton organization GO:0051495 49 0.015
nuclear import GO:0051170 95 0.015
Yeast
cerebral cortex development GO:0021987 86 0.015
activation of adenylate cyclase activity GO:0007190 4 0.015
negative regulation of protein maturation GO:1903318 79 0.015
gene silencing by rna GO:0031047 19 0.015
negative regulation of protein processing GO:0010955 79 0.015
microtubule based transport GO:0010970 50 0.015
meiotic cell cycle GO:0051321 122 0.015
molting cycle GO:0042303 90 0.015
erk1 and erk2 cascade GO:0070371 77 0.015
Fly
sensory organ morphogenesis GO:0090596 242 0.015
modification dependent macromolecule catabolic process GO:0043632 133 0.015
regulation of synaptic vesicle transport GO:1902803 13 0.014
nucleotide biosynthetic process GO:0009165 78 0.014
cellular response to nutrient levels GO:0031669 64 0.014
translation GO:0006412 93 0.014
regulation of map kinase activity GO:0043405 120 0.014
Human Yeast Mouse Rat Worm
regulation of membrane potential GO:0042391 192 0.014
b cell activation GO:0042113 161 0.014
positive regulation of actin filament bundle assembly GO:0032233 11 0.014
protein processing GO:0016485 163 0.014
calcineurin nfat signaling cascade GO:0033173 8 0.014
epithelial cell development GO:0002064 159 0.014
Fly
stress activated mapk cascade GO:0051403 80 0.014
regulation of striated muscle cell differentiation GO:0051153 81 0.014
protein acylation GO:0043543 64 0.014
fatty acid metabolic process GO:0006631 121 0.014
regulation of notch signaling pathway GO:0008593 35 0.014
autophagy GO:0006914 45 0.013
Yeast
intraspecies interaction between organisms GO:0051703 21 0.013
protein localization to cell junction GO:1902414 3 0.013
negative regulation of cellular catabolic process GO:0031330 47 0.013
gene silencing GO:0016458 38 0.013
immune response activating signal transduction GO:0002757 116 0.013
lymphocyte proliferation GO:0046651 164 0.013
negative regulation of protein modification process GO:0031400 163 0.013
positive regulation of transcription by galactose GO:0000411 1 0.013
organ growth GO:0035265 117 0.013
endomembrane system organization GO:0010256 147 0.013
homeostasis of number of cells GO:0048872 210 0.013
lung development GO:0030324 164 0.013
protein maturation GO:0051604 176 0.013
regulation of lipid metabolic process GO:0019216 118 0.013
single organism nuclear import GO:1902593 95 0.013
Yeast
regulation of protein catabolic process GO:0042176 108 0.013
purine nucleoside monophosphate metabolic process GO:0009126 81 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.013
positive regulation of programmed cell death GO:0043068 218 0.013
synaptic transmission gabaergic GO:0051932 19 0.013
regulation of inflammatory response GO:0050727 147 0.013
activation of immune response GO:0002253 138 0.013
regulation of lymphocyte activation GO:0051249 240 0.012
heart trabecula formation GO:0060347 14 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
Fly
mesoderm development GO:0007498 100 0.012
ribonucleoside monophosphate metabolic process GO:0009161 80 0.012
nucleoside monophosphate catabolic process GO:0009125 59 0.012
chromatin organization GO:0006325 206 0.012
forebrain development GO:0030900 302 0.012
regulation of response to wounding GO:1903034 189 0.012
skin morphogenesis GO:0043589 38 0.012
cytoskeleton dependent intracellular transport GO:0030705 50 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
extracellular matrix organization GO:0030198 147 0.012
adaptive immune response GO:0002250 155 0.012
response to uv GO:0009411 44 0.012
organelle fission GO:0048285 170 0.012
lymphocyte mediated immunity GO:0002449 139 0.012
locomotor rhythm GO:0045475 8 0.012
ovarian follicle development GO:0001541 40 0.012
positive regulation of rap gtpase activity GO:0032854 3 0.012
rna processing GO:0006396 105 0.012
renal system development GO:0072001 225 0.012
cellular homeostasis GO:0019725 240 0.012
regulation of mitotic cell cycle phase transition GO:1901990 73 0.012
response to oxygen levels GO:0070482 62 0.011
negative regulation of proteolysis GO:0045861 74 0.011
regulation of erbb signaling pathway GO:1901184 16 0.011
regulation of peptidase activity GO:0052547 96 0.011
negative regulation of peptidase activity GO:0010466 46 0.011
intracellular protein transport GO:0006886 204 0.011
Yeast
cardiac muscle tissue development GO:0048738 130 0.011
inflammatory response GO:0006954 244 0.011
immune effector process GO:0002252 321 0.011
positive regulation of activin receptor signaling pathway GO:0032927 3 0.011
glucose homeostasis GO:0042593 128 0.011
regulation of myeloid leukocyte differentiation GO:0002761 58 0.011
protein targeting GO:0006605 143 0.011
Yeast
striated muscle myosin thick filament assembly GO:0071688 1 0.011
blood circulation GO:0008015 195 0.011
negative regulation of epithelial cell proliferation GO:0050680 64 0.011
response to peptide GO:1901652 136 0.011
response to insulin GO:0032868 100 0.011
positive regulation of immune effector process GO:0002699 107 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
receptor mediated endocytosis GO:0006898 51 0.011
stem cell maintenance GO:0019827 130 0.011
internal protein amino acid acetylation GO:0006475 42 0.011
embryonic axis specification GO:0000578 30 0.011
Fly
synaptic transmission GO:0007268 329 0.011
dephosphorylation GO:0016311 129 0.011
Mouse
intermediate filament cytoskeleton organization GO:0045104 26 0.011
regulation of nucleotide metabolic process GO:0006140 169 0.011
pallium development GO:0021543 120 0.011
t cell differentiation GO:0030217 174 0.011
positive regulation of defense response GO:0031349 124 0.011
myosin filament assembly GO:0031034 2 0.011

Map2k2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.027
nervous system disease DOID:863 0 0.026
disease of anatomical entity DOID:7 0 0.026
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.019
muscle tissue disease DOID:66 0 0.016
musculoskeletal system disease DOID:17 0 0.016
muscular disease DOID:0080000 0 0.016
myopathy DOID:423 0 0.014
central nervous system disease DOID:331 0 0.014
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012