Mus musculus

360 known processes

Cdkn2a

cyclin-dependent kinase inhibitor 2A

(Aliases: p16INK4a,MTS1,p16,Pctr1,INK4a-ARF,Ink4a/Arf,p16(INK4a),ARF-INK4a,Arf,p19ARF,p19<ARF>)

Cdkn2a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cell cycle GO:0045786 123 0.981
regulation of cell cycle GO:0051726 281 0.978
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.967
negative regulation of cell proliferation GO:0008285 296 0.965
skeletal system development GO:0001501 356 0.949
regulation of protein kinase activity GO:0045859 232 0.920
cell cycle arrest GO:0007050 37 0.882
axon guidance GO:0007411 141 0.842
signal transduction by p53 class mediator GO:0072331 51 0.841
intrinsic apoptotic signaling pathway GO:0097193 132 0.836
gland development GO:0048732 330 0.825
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.799
cellular response to dna damage stimulus GO:0006974 207 0.792
regulation of kinase activity GO:0043549 249 0.785
regulation of cell cycle process GO:0010564 160 0.749
Human Mouse
segmentation GO:0035282 93 0.743
regulation of synaptic plasticity GO:0048167 87 0.671
male gamete generation GO:0048232 285 0.666
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.661
Human
positive regulation of cell development GO:0010720 237 0.656
appendage morphogenesis GO:0035107 149 0.632
cellular ketone metabolic process GO:0042180 84 0.631
cell growth GO:0016049 130 0.628
cellular amino acid metabolic process GO:0006520 103 0.608
apoptotic signaling pathway GO:0097190 306 0.606
regionalization GO:0003002 337 0.601
cellular amine metabolic process GO:0044106 44 0.598
regulation of reactive oxygen species metabolic process GO:2000377 40 0.596
cellular response to growth factor stimulus GO:0071363 197 0.591
Human
positive regulation of nervous system development GO:0051962 221 0.591
negative regulation of growth GO:0045926 99 0.579
neuron projection guidance GO:0097485 141 0.563
mitotic cell cycle GO:0000278 195 0.558
Human Mouse
axonogenesis GO:0007409 274 0.550
germ cell development GO:0007281 185 0.536
positive regulation of cellular amine metabolic process GO:0033240 5 0.522
negative regulation of immune system process GO:0002683 209 0.506
myeloid cell differentiation GO:0030099 233 0.502
Human
embryonic organ morphogenesis GO:0048562 276 0.502
developmental maturation GO:0021700 193 0.498
regulation of cellular amine metabolic process GO:0033238 20 0.495
spermatogenesis GO:0007283 284 0.494
regulation of organ morphogenesis GO:2000027 144 0.491
regulation of transferase activity GO:0051338 263 0.491
positive regulation of cell cycle GO:0045787 92 0.486
dna recombination GO:0006310 92 0.484
regulation of mitotic cell cycle GO:0007346 126 0.481
Human Mouse
positive regulation of apoptotic process GO:0043065 217 0.468
carbon catabolite activation of transcription GO:0045991 4 0.467
collagen fibril organization GO:0030199 32 0.464
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.452
Human
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.446
nuclear division GO:0000280 158 0.440
odontogenesis of dentin containing tooth GO:0042475 66 0.436
jnk cascade GO:0007254 72 0.429
telencephalon development GO:0021537 186 0.428
oocyte differentiation GO:0009994 35 0.427
negative regulation of epithelial cell proliferation GO:0050680 64 0.427
mitotic g1 dna damage checkpoint GO:0031571 4 0.424
stem cell proliferation GO:0072089 117 0.419
oocyte axis specification GO:0007309 2 0.418
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.415
response to growth factor GO:0070848 198 0.411
Human
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.410
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.406
regulation of stress activated mapk cascade GO:0032872 69 0.403
meiotic cell cycle GO:0051321 122 0.402
glycosyl compound catabolic process GO:1901658 206 0.401
negative regulation of kinase activity GO:0033673 81 0.397
mesenchyme development GO:0060485 152 0.396
ras protein signal transduction GO:0007265 77 0.392
embryonic appendage morphogenesis GO:0035113 126 0.388
positive regulation of keratinocyte proliferation GO:0010838 4 0.386
hippocampus development GO:0021766 52 0.383
positive regulation of cell death GO:0010942 224 0.378
positive regulation of mitotic cell cycle GO:0045931 41 0.362
negative regulation of phosphorus metabolic process GO:0010563 184 0.362
regulation of cellular catabolic process GO:0031329 242 0.358
pole plasm assembly GO:0007315 2 0.355
regulation of cell division GO:0051302 76 0.354
g1 s transition of mitotic cell cycle GO:0000082 57 0.340
Mouse
embryonic skeletal system development GO:0048706 120 0.340
negative regulation of molecular function GO:0044092 258 0.340
stem cell development GO:0048864 219 0.334
cell fate commitment GO:0045165 210 0.333
myeloid leukocyte differentiation GO:0002573 119 0.331
regulation of cell growth GO:0001558 91 0.325
pyramidal neuron migration GO:0021852 1 0.316
response to x ray GO:0010165 11 0.315
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.314
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.311
peptidyl tyrosine modification GO:0018212 145 0.309
regulation of neuron projection development GO:0010975 169 0.309
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.309
b cell differentiation GO:0030183 78 0.306
regulation of cellular amino acid metabolic process GO:0006521 5 0.305
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.303
organelle fission GO:0048285 170 0.303
dna metabolic process GO:0006259 303 0.302
leukocyte differentiation GO:0002521 342 0.300
signal transduction involved in dna damage checkpoint GO:0072422 3 0.299
regulation of cell cycle arrest GO:0071156 12 0.294
ameboidal type cell migration GO:0001667 128 0.293
negative regulation of leukocyte differentiation GO:1902106 51 0.293
negative regulation of cell cycle phase transition GO:1901988 48 0.292
Human Mouse
lymphocyte differentiation GO:0030098 242 0.289
positive regulation of growth GO:0045927 104 0.286
negative regulation of lymphocyte activation GO:0051250 91 0.286
cell division GO:0051301 120 0.280
appendage development GO:0048736 166 0.279
developmental programmed cell death GO:0010623 41 0.277
response to nutrient levels GO:0031667 109 0.275
Human
positive regulation of apoptotic signaling pathway GO:2001235 95 0.275
camera type eye development GO:0043010 266 0.275
female sex differentiation GO:0046660 84 0.273
retinal ganglion cell axon guidance GO:0031290 18 0.270
dendrite development GO:0016358 115 0.269
endochondral bone morphogenesis GO:0060350 50 0.269
regulation of erythrocyte differentiation GO:0045646 23 0.269
regulation of mapk cascade GO:0043408 248 0.268
reactive oxygen species metabolic process GO:0072593 84 0.266
nephron morphogenesis GO:0072028 69 0.265
morphogenesis of a branching structure GO:0001763 203 0.262
chromatin organization GO:0006325 206 0.259
regulation of angiogenesis GO:0045765 81 0.255
ossification GO:0001503 216 0.255
regulation of t cell differentiation GO:0045580 83 0.254
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.253
cellular senescence GO:0090398 11 0.251
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.250
actin filament organization GO:0007015 113 0.250
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.249
Human
peptidyl amino acid modification GO:0018193 336 0.249
cellular response to external stimulus GO:0071496 88 0.247
Human
central nervous system neuron differentiation GO:0021953 162 0.247
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.246
regulation of neuron differentiation GO:0045664 281 0.244
gtp catabolic process GO:0006184 143 0.244
lung induction GO:0060492 3 0.243
meiotic nuclear division GO:0007126 115 0.238
posttranscriptional regulation of gene expression GO:0010608 155 0.237
ureteric bud morphogenesis GO:0060675 62 0.236
developmental growth involved in morphogenesis GO:0060560 138 0.234
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.231
meiosis i GO:0007127 60 0.231
regulation of intracellular transport GO:0032386 159 0.231
cell adhesion GO:0007155 329 0.228
angiogenesis GO:0001525 201 0.226
regulation of leukocyte differentiation GO:1902105 159 0.225
auditory receptor cell fate specification GO:0042667 1 0.223
regulation of mitosis GO:0007088 29 0.222
negative regulation of cellular catabolic process GO:0031330 47 0.221
response to oxygen levels GO:0070482 62 0.221
stem cell differentiation GO:0048863 268 0.220
regulation of epithelial cell proliferation GO:0050678 141 0.218
regulation of cell projection organization GO:0031344 206 0.216
regulation of apoptotic signaling pathway GO:2001233 197 0.214
regulation of vasculature development GO:1901342 88 0.211
regulation of cell motility GO:2000145 236 0.211
epithelium migration GO:0090132 63 0.210
regulation of cell substrate adhesion GO:0010810 73 0.210
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 2 0.208
male sex differentiation GO:0046661 109 0.206
negative regulation of cellular protein metabolic process GO:0032269 247 0.206
cell type specific apoptotic process GO:0097285 268 0.205
mesenchymal cell development GO:0014031 93 0.204
oviduct development GO:0060066 3 0.204
epithelial cell development GO:0002064 159 0.202
organ growth GO:0035265 117 0.202
mesonephric tubule development GO:0072164 94 0.202
negative regulation of intracellular signal transduction GO:1902532 167 0.199
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.199
Human Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.198
response to extracellular stimulus GO:0009991 127 0.197
Human
regulation of cytoskeleton organization GO:0051493 122 0.196
response to organic cyclic compound GO:0014070 198 0.196
regulation of neuron apoptotic process GO:0043523 122 0.196
ribonucleoside catabolic process GO:0042454 206 0.196
regulation of ras protein signal transduction GO:0046578 114 0.195
regulation of peptide secretion GO:0002791 77 0.192
negative regulation of fibroblast proliferation GO:0048147 14 0.192
mitral valve development GO:0003174 4 0.191
regulation of ras gtpase activity GO:0032318 88 0.189
regulation of cell size GO:0008361 72 0.188
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.187
schwann cell proliferation GO:0014010 2 0.187
positive regulation of protein phosphorylation GO:0001934 242 0.186
neuroblast differentiation GO:0014016 2 0.186
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.186
neuron death GO:0070997 154 0.185
endothelial cell migration GO:0043542 44 0.185
nephron tubule morphogenesis GO:0072078 68 0.184
wound healing GO:0042060 157 0.184
stem cell maintenance GO:0019827 130 0.182
positive regulation of cell cycle process GO:0090068 61 0.181
heterocycle catabolic process GO:0046700 280 0.181
response to decreased oxygen levels GO:0036293 59 0.180
negative regulation of t cell proliferation GO:0042130 38 0.179
limb morphogenesis GO:0035108 149 0.179
pallium development GO:0021543 120 0.179
homeostasis of number of cells GO:0048872 210 0.178
regulation of map kinase activity GO:0043405 120 0.177
protein modification by small protein conjugation or removal GO:0070647 207 0.177
regulation of protein stability GO:0031647 52 0.177
somite development GO:0061053 81 0.176
regulation of nucleocytoplasmic transport GO:0046822 73 0.176
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.175
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.175
forebrain neuron development GO:0021884 30 0.175
mesenchymal cell differentiation GO:0048762 107 0.175
positive regulation of stem cell differentiation GO:2000738 23 0.174
odontogenesis GO:0042476 78 0.173
regulation of cellular response to stress GO:0080135 159 0.173
male gonad development GO:0008584 88 0.172
positive regulation of neuron projection development GO:0010976 79 0.172
response to radiation GO:0009314 165 0.172
positive regulation of neuron differentiation GO:0045666 141 0.172
limb development GO:0060173 166 0.172
regulation of cell cycle phase transition GO:1901987 77 0.171
Human Mouse
limbic system development GO:0021761 72 0.170
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.169
auditory receptor cell fate determination GO:0042668 3 0.169
regulation of protein serine threonine kinase activity GO:0071900 157 0.167
cellular nitrogen compound catabolic process GO:0044270 280 0.166
somitogenesis GO:0001756 69 0.166
activation of adenylate cyclase activity GO:0007190 4 0.166
chemotaxis GO:0006935 247 0.165
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.165
regulation of cellular ketone metabolic process GO:0010565 66 0.163
sprouting angiogenesis GO:0002040 26 0.163
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.162
embryonic limb morphogenesis GO:0030326 126 0.161
carbohydrate derivative catabolic process GO:1901136 231 0.160
regulation of mast cell differentiation GO:0060375 3 0.159
purine nucleotide metabolic process GO:0006163 302 0.159
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.157
multicellular organism growth GO:0035264 161 0.157
blood vessel morphogenesis GO:0048514 285 0.157
nephron tubule development GO:0072080 84 0.156
response to transforming growth factor beta GO:0071559 88 0.155
Human
oogenesis GO:0048477 56 0.155
paraxial mesodermal cell differentiation GO:0048342 2 0.155
negative regulation of stem cell proliferation GO:2000647 12 0.155
aortic valve morphogenesis GO:0003180 4 0.153
meiotic cell cycle process GO:1903046 77 0.152
stem cell division GO:0017145 30 0.151
spermatid differentiation GO:0048515 115 0.151
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.151
tube closure GO:0060606 91 0.151
notch signaling pathway GO:0007219 71 0.150
lens development in camera type eye GO:0002088 62 0.150
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.149
positive regulation of organelle organization GO:0010638 128 0.149
peptidyl tyrosine phosphorylation GO:0018108 143 0.149
t cell differentiation in thymus GO:0033077 77 0.148
negative regulation of nuclear division GO:0051784 19 0.147
mesenchyme morphogenesis GO:0072132 32 0.147
nuclear transport GO:0051169 139 0.147
negative regulation of cell growth GO:0030308 44 0.146
ribonucleotide metabolic process GO:0009259 291 0.146
regulation of kidney development GO:0090183 40 0.146
embryonic skeletal system morphogenesis GO:0048704 91 0.144
protein localization to organelle GO:0033365 185 0.144
nucleoside phosphate metabolic process GO:0006753 338 0.143
blastocyst development GO:0001824 80 0.143
phenol containing compound metabolic process GO:0018958 60 0.143
regulation of actin filament bundle assembly GO:0032231 18 0.142
regulation of stem cell differentiation GO:2000736 50 0.141
regulation of hydrolase activity GO:0051336 246 0.141
morphogenesis of a branching epithelium GO:0061138 193 0.141
negative regulation of phosphorylation GO:0042326 166 0.140
sensory organ morphogenesis GO:0090596 242 0.139
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.139
oocyte construction GO:0007308 2 0.138
skeletal system morphogenesis GO:0048705 203 0.138
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.137
Human
regulation of cellular response to growth factor stimulus GO:0090287 82 0.136
Human
cardiac muscle tissue development GO:0048738 130 0.136
organic cyclic compound catabolic process GO:1901361 295 0.135
ear morphogenesis GO:0042471 118 0.134
rhythmic process GO:0048511 174 0.134
regulation of cell cycle g1 s phase transition GO:1902806 35 0.132
Mouse
morphogenesis of a polarized epithelium GO:0001738 37 0.130
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.129
nucleocytoplasmic transport GO:0006913 139 0.129
chondrocyte differentiation GO:0002062 72 0.128
cytokine production GO:0001816 319 0.128
positive regulation of transferase activity GO:0051347 167 0.128
nucleotide catabolic process GO:0009166 217 0.127
positive regulation of protein modification process GO:0031401 299 0.127
t cell selection GO:0045058 34 0.127
neuron apoptotic process GO:0051402 142 0.127
extracellular structure organization GO:0043062 148 0.126
regulation of cellular component biogenesis GO:0044087 181 0.126
regulation of rho gtpase activity GO:0032319 58 0.126
cation transport GO:0006812 399 0.126
development of primary female sexual characteristics GO:0046545 73 0.125
negative regulation of phosphate metabolic process GO:0045936 184 0.124
erythrocyte differentiation GO:0030218 88 0.122
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.122
extrinsic apoptotic signaling pathway GO:0097191 126 0.121
regulation of organelle organization GO:0033043 289 0.121
regulation of lymphocyte differentiation GO:0045619 107 0.121
protein maturation GO:0051604 176 0.120
neural tube development GO:0021915 160 0.120
ovulation cycle GO:0042698 59 0.120
actin filament bundle assembly GO:0051017 40 0.120
kidney morphogenesis GO:0060993 83 0.120
negative regulation of transferase activity GO:0051348 85 0.119
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.118
positive regulation of map kinase activity GO:0043406 84 0.118
tissue migration GO:0090130 68 0.118
embryonic axis specification GO:0000578 30 0.118
cardiac right ventricle formation GO:0003219 3 0.117
positive regulation of chromosome organization GO:2001252 33 0.117
nucleobase containing small molecule metabolic process GO:0055086 352 0.116
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.116
maternal determination of anterior posterior axis embryo GO:0008358 2 0.115
glycosyl compound metabolic process GO:1901657 246 0.114
protein targeting GO:0006605 143 0.114
positive regulation of exit from mitosis GO:0031536 1 0.113
hormone secretion GO:0046879 128 0.113
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.112
muscle cell differentiation GO:0042692 261 0.112
forebrain development GO:0030900 302 0.112
mitotic cell cycle process GO:1903047 159 0.112
Human Mouse
negative regulation of cell motility GO:2000146 61 0.112
b cell activation GO:0042113 161 0.112
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.111
heart formation GO:0060914 16 0.111
positive regulation of kinase activity GO:0033674 155 0.110
cell maturation GO:0048469 127 0.110
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.110
protein localization to nucleus GO:0034504 121 0.110
negative regulation of cell cycle process GO:0010948 69 0.109
Human Mouse
digestive system development GO:0055123 200 0.109
mammary gland morphogenesis GO:0060443 54 0.109
nucleoside phosphate catabolic process GO:1901292 222 0.109
female gamete generation GO:0007292 74 0.108
positive regulation of camp biosynthetic process GO:0030819 19 0.108
negative regulation of neuron apoptotic process GO:0043524 92 0.107
embryonic digit morphogenesis GO:0042733 56 0.107
primary neural tube formation GO:0014020 95 0.107
female genitalia morphogenesis GO:0048807 3 0.106
blood vessel endothelial cell migration GO:0043534 23 0.106
oocyte development GO:0048599 33 0.106
development of primary male sexual characteristics GO:0046546 88 0.106
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.105
digestive tract development GO:0048565 190 0.105
kidney epithelium development GO:0072073 121 0.105
t cell proliferation GO:0042098 120 0.105
cerebellum development GO:0021549 77 0.104
positive regulation of epithelial cell proliferation GO:0050679 68 0.104
organonitrogen compound catabolic process GO:1901565 264 0.104
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.104
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.103
fibroblast proliferation GO:0048144 35 0.102
anatomical structure homeostasis GO:0060249 145 0.102
regulation of neuron death GO:1901214 134 0.102
positive regulation of cellular catabolic process GO:0031331 148 0.101
neural tube closure GO:0001843 90 0.101
regulation of cell migration GO:0030334 219 0.101
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.101
hemangioblast cell differentiation GO:0060217 1 0.101
megakaryocyte differentiation GO:0030219 26 0.100
Human
pancreatic pp cell fate commitment GO:0003329 2 0.100
astrocyte fate commitment GO:0060018 4 0.100
positive regulation of cytokine production GO:0001819 174 0.100
gastrulation GO:0007369 116 0.100
regulation of mitotic cell cycle phase transition GO:1901990 73 0.099
Human Mouse
central nervous system neuron development GO:0021954 67 0.099
phenol containing compound biosynthetic process GO:0046189 21 0.099
actin cytoskeleton organization GO:0030036 220 0.099
covalent chromatin modification GO:0016569 163 0.099
cloacal septation GO:0060197 2 0.098
response to endoplasmic reticulum stress GO:0034976 53 0.098
negative regulation of odontogenesis GO:0042483 3 0.097
regulation of anatomical structure size GO:0090066 178 0.097
neuroblast proliferation GO:0007405 49 0.097
nephric duct formation GO:0072179 4 0.097
regulation of histone modification GO:0031056 56 0.096
negative regulation of protein metabolic process GO:0051248 282 0.096
urogenital system development GO:0001655 261 0.096
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.096
pituitary gland development GO:0021983 38 0.096
mitral valve morphogenesis GO:0003183 4 0.096
regulation of chromatin organization GO:1902275 57 0.095
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.095
gonad development GO:0008406 141 0.095
regulation of rho protein signal transduction GO:0035023 71 0.094
guanosine containing compound metabolic process GO:1901068 144 0.094
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.094
heart morphogenesis GO:0003007 178 0.094
negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 7 0.093
germ line stem cell division GO:0042078 2 0.093
purine ribonucleoside catabolic process GO:0046130 205 0.093
regulation of fibroblast proliferation GO:0048145 34 0.092
skeletal muscle cell differentiation GO:0035914 66 0.092
female genitalia development GO:0030540 14 0.091
development of primary sexual characteristics GO:0045137 143 0.091
cellular macromolecule catabolic process GO:0044265 206 0.091
visceral serous pericardium development GO:0061032 2 0.091
negative regulation of neuron death GO:1901215 98 0.091
positive regulation of mechanoreceptor differentiation GO:0045633 1 0.091
epithelial cell proliferation GO:0050673 174 0.090
apoptotic process involved in mammary gland involution GO:0060057 4 0.090
protein kinase b signaling GO:0043491 74 0.090
renal inner medulla development GO:0072053 3 0.090
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.089
regulation of glial cell differentiation GO:0045685 41 0.089
regulation of actin cytoskeleton organization GO:0032956 84 0.089
regulation of somitogenesis GO:0014807 6 0.089
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.089
nucleoside triphosphate metabolic process GO:0009141 230 0.088
neural crest cell development GO:0014032 48 0.088
purine ribonucleotide metabolic process GO:0009150 290 0.088
formation of primary germ layer GO:0001704 77 0.088
neural crest cell migration GO:0001755 32 0.087
neuron projection extension GO:1990138 64 0.087
negative regulation of t cell activation GO:0050868 65 0.087
aromatic compound catabolic process GO:0019439 286 0.087
regulation of cytokine production GO:0001817 266 0.087
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 3 0.086
neuron migration GO:0001764 122 0.086
chromatin modification GO:0016568 187 0.086
regulation of chromatin modification GO:1903308 57 0.085
forebrain generation of neurons GO:0021872 63 0.085
regulation of nucleotide metabolic process GO:0006140 169 0.085
regulation of morphogenesis of a branching structure GO:0060688 53 0.085
regulation of cell activation GO:0050865 289 0.085
protein ubiquitination GO:0016567 171 0.084
regulation of muscle cell apoptotic process GO:0010660 17 0.083
methylation GO:0032259 134 0.083
protein processing GO:0016485 163 0.083
tendon formation GO:0035992 4 0.083
organic hydroxy compound biosynthetic process GO:1901617 77 0.082
mesenchymal to epithelial transition GO:0060231 12 0.082
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.082
response to hypoxia GO:0001666 58 0.082
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.082
organic hydroxy compound metabolic process GO:1901615 203 0.082
hindbrain development GO:0030902 128 0.081
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.081
bmp signaling pathway GO:0030509 93 0.081
peptide transport GO:0015833 133 0.080
ribonucleoside metabolic process GO:0009119 245 0.080
positive regulation of hydrolase activity GO:0051345 148 0.079
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.079
negative regulation of nervous system development GO:0051961 156 0.079
purine nucleoside catabolic process GO:0006152 205 0.079
nephron epithelium morphogenesis GO:0072088 68 0.079
regulation of odontogenesis GO:0042481 18 0.078
mesangial cell differentiation GO:0072007 4 0.078
negative regulation of cell substrate adhesion GO:0010812 16 0.078
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.078
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.077
regulation of gliogenesis GO:0014013 50 0.077
positive regulation of angiogenesis GO:0045766 46 0.077
protein catabolic process GO:0030163 221 0.077
mesodermal cell differentiation GO:0048333 22 0.077
carbon catabolite regulation of transcription GO:0045990 4 0.076
negative regulation of dna replication GO:0008156 4 0.076
negative regulation of mitotic cell cycle GO:0045930 58 0.076
Human Mouse
negative regulation of cytokine production GO:0001818 84 0.076
protein autophosphorylation GO:0046777 61 0.076
positive regulation of histone modification GO:0031058 28 0.076
hematopoietic progenitor cell differentiation GO:0002244 143 0.075
Human
negative regulation of map kinase activity GO:0043407 34 0.075
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.075
regulation of nucleotide catabolic process GO:0030811 122 0.075
nephron development GO:0072006 109 0.075
cellular response to lipid GO:0071396 145 0.075
regulation of translation GO:0006417 71 0.075
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.075
carboxylic acid biosynthetic process GO:0046394 86 0.075
negative regulation of cell development GO:0010721 169 0.075
extracellular matrix organization GO:0030198 147 0.075
apoptotic process involved in development GO:1902742 28 0.075
regulation of actin filament based process GO:0032970 99 0.074
transdifferentiation GO:0060290 1 0.074
cell aging GO:0007569 35 0.074
peptide secretion GO:0002790 114 0.074
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.074
intracellular protein transport GO:0006886 204 0.074
artery development GO:0060840 53 0.073
response to oxidative stress GO:0006979 123 0.073
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.073

Cdkn2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.947
cancer DOID:162 0 0.865
organ system cancer DOID:0050686 0 0.865
disease of anatomical entity DOID:7 0 0.144
musculoskeletal system disease DOID:17 0 0.144
connective tissue disease DOID:65 0 0.144
urinary system cancer DOID:3996 0 0.086
endocrine gland cancer DOID:170 0 0.079