IMP
Process View
canonical wnt signaling pathway involved in negative regulation of apoptotic process
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "canonical wnt signaling pathway involved in negative regulation of apoptotic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 1.000 | Human | |
| Trp53 | transformation related protein 53 | 1.000 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.970 | Mouse | |
| Kit | kit oncogene | 0.873 | ||
| Pten | phosphatase and tensin homolog | 0.800 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.705 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.503 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.465 | ||
| Gsk3b | glycogen synthase kinase 3 beta | 0.421 | ||
| Tcf7 | transcription factor 7, T-cell specific | 0.416 | ||
| Pax3 | paired box gene 3 | 0.383 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.371 | ||
| Ccnd1 | cyclin D1 | 0.334 | ||
| Lepr | leptin receptor | 0.330 | ||
| Braf | Braf transforming gene | 0.328 | ||
| Kitl | kit ligand | 0.271 | ||
| Ptch1 | patched homolog 1 | 0.267 | ||
| Pax6 | paired box gene 6 | 0.255 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.250 | ||
| Lyst | lysosomal trafficking regulator | 0.239 | ||
| Max | Max protein | 0.237 | ||
| Nf2 | neurofibromatosis 2 | 0.219 | ||
| Nf1 | neurofibromatosis 1 | 0.216 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.204 | ||
| Axin1 | axin 1 | 0.195 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.187 | ||
| Numb | numb gene homolog (Drosophila) | 0.187 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.184 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.175 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.143 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.143 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.136 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.129 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.124 | ||
| Axin2 | axin2 | 0.120 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.111 | ||
| Trp73 | transformation related protein 73 | 0.108 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.106 | ||
| Cdkn2a | cyclin-dependent kinase inhibitor 2A | 0.104 | ||
| Htt | huntingtin | 0.103 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.092 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.091 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.091 | ||
| Cd44 | CD44 antigen | 0.087 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.085 | ||
| Meox2 | mesenchyme homeobox 2 | 0.084 | ||
| Ar | androgen receptor | 0.081 | ||
| Rb1 | retinoblastoma 1 | 0.080 | ||
| Trp63 | transformation related protein 63 | 0.078 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.077 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.064 | ||
| Psen1 | presenilin 1 | 0.063 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.060 | ||
| Runx1 | runt related transcription factor 1 | 0.059 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.058 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.058 | ||
| Ahr | aryl-hydrocarbon receptor | 0.056 | ||
| Ctnna1 | catenin (cadherin associated protein), alpha 1 | 0.054 | ||
| Tead3 | TEA domain family member 3 | 0.052 | ||
| Pla2g2a | phospholipase A2, group IIA (platelets, synovial fluid) | 0.052 | ||
| Stk11 | serine/threonine kinase 11 | 0.051 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.048 | ||
| Smad2 | MAD homolog 2 (Drosophila) | 0.046 | ||
| Tsc1 | tuberous sclerosis 1 | 0.043 | ||
| Ret | ret proto-oncogene | 0.042 | ||
| Il6st | interleukin 6 signal transducer | 0.042 | ||
| Tbx3 | T-box 3 | 0.041 | ||
| Brca1 | breast cancer 1 | 0.040 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.039 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.038 | ||
| Rara | retinoic acid receptor, alpha | 0.035 | ||
| Tyr | tyrosinase | 0.035 | ||
| Prkar1a | protein kinase, cAMP dependent regulatory, type I, alpha | 0.034 | ||
| Sgpl1 | sphingosine phosphate lyase 1 | 0.033 | ||
| E2f1 | E2F transcription factor 1 | 0.032 | ||
| Sox11 | SRY-box containing gene 11 | 0.032 | ||
| Zic2 | zinc finger protein of the cerebellum 2 | 0.032 | ||
| Lyz2 | lysozyme 2 | 0.031 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.031 | ||
| Esr2 | estrogen receptor 2 (beta) | 0.030 | ||
| Tax1bp3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.030 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.030 | ||
| Egr1 | early growth response 1 | 0.029 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.029 | ||
| S1pr2 | sphingosine-1-phosphate receptor 2 | 0.028 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.028 | ||
| Thbs1 | thrombospondin 1 | 0.028 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.026 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.026 | ||
| Vdr | vitamin D receptor | 0.025 | ||
| Sox9 | SRY-box containing gene 9 | 0.024 | ||
| Foxp3 | forkhead box P3 | 0.024 | ||
| Sox10 | SRY-box containing gene 10 | 0.024 | ||
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.023 | ||
| Tlr4 | toll-like receptor 4 | 0.022 | ||
| Ctnnd1 | catenin (cadherin associated protein), delta 1 | 0.022 | ||
| Sept1 | septin 1 | 0.022 | ||
| Tyrp1 | tyrosinase-related protein 1 | 0.021 | ||
| Foxa2 | forkhead box A2 | 0.021 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.021 | ||
| Oca2 | oculocutaneous albinism II | 0.021 | ||
| Lrp5 | low density lipoprotein receptor-related protein 5 | 0.021 | ||
| Hhat | hedgehog acyltransferase | 0.020 | ||
| Hoxb1 | homeobox B1 | 0.020 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.020 | ||
| Itga3 | integrin alpha 3 | 0.020 | ||
| Mecom | MDS1 and EVI1 complex locus | 0.020 | ||
| Tgif1 | TGFB-induced factor homeobox 1 | 0.020 | ||
| Cdh1 | cadherin 1 | 0.019 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.019 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.019 | ||
| Hps1 | Hermansky-Pudlak syndrome 1 homolog (human) | 0.018 | ||
| Twsg1 | twisted gastrulation homolog 1 (Drosophila) | 0.018 | ||
| Tcf7l2 | transcription factor 7-like 2, T-cell specific, HMG-box | 0.018 | Mouse | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.018 | ||
| Apc | adenomatosis polyposis coli | 0.018 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.018 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.017 | ||
| Brca2 | breast cancer 2 | 0.017 | ||
| Msx2 | homeobox, msh-like 2 | 0.017 | ||
| Pgr | progesterone receptor | 0.017 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.017 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.017 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.017 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.016 | ||
| Fam83h | family with sequence similarity 83, member H | 0.016 | ||
| En2 | engrailed 2 | 0.016 | ||
| Syt9 | synaptotagmin IX | 0.016 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.016 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.016 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.015 | Mouse | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.015 | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.015 | ||
| Arid3b | AT rich interactive domain 3B (BRIGHT-like) | 0.015 | ||
| Ctnnbip1 | catenin beta interacting protein 1 | 0.015 | ||
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.014 | ||
| Gja1 | gap junction protein, alpha 1 | 0.014 | ||
| Epn1 | epsin 1 | 0.014 | ||
| Smad1 | MAD homolog 1 (Drosophila) | 0.014 | ||
| Pprc1 | peroxisome proliferative activated receptor, gamma, coactivator-related 1 | 0.014 | ||
| Tgif2 | TGFB-induced factor homeobox 2 | 0.014 | ||
| Ets2 | E26 avian leukemia oncogene 2, 3' domain | 0.013 | ||
| Zfp865 | zinc finger protein 865 | 0.013 | ||
| Lep | leptin | 0.013 | ||
| Psap | prosaposin | 0.013 | ||
| Tlr2 | toll-like receptor 2 | 0.013 | ||
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.013 | ||
| Ap3b1 | adaptor-related protein complex 3, beta 1 subunit | 0.013 | ||
| Arl10 | ADP-ribosylation factor-like 10 | 0.013 | ||
| Slc24a5 | solute carrier family 24, member 5 | 0.013 | ||
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.013 | ||
| Hps6 | Hermansky-Pudlak syndrome 6 | 0.013 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.013 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.013 | ||
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.013 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.013 | ||
| Socs1 | suppressor of cytokine signaling 1 | 0.013 | ||
| Csf1r | colony stimulating factor 1 receptor | 0.012 | ||
| Tnf | tumor necrosis factor | 0.012 | ||
| Lilrb3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.012 | ||
| Shh | sonic hedgehog | 0.012 | ||
| Sfpi1 | SFFV proviral integration 1 | 0.012 | ||
| Fbrs | fibrosin | 0.012 | ||
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.012 | ||
| Cd27 | CD27 antigen | 0.012 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.012 | ||
| Cacng8 | calcium channel, voltage-dependent, gamma subunit 8 | 0.012 | ||
| Usf1 | upstream transcription factor 1 | 0.012 | ||
| Cdk6 | cyclin-dependent kinase 6 | 0.012 | ||
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.012 | ||
| Cd8b1 | CD8 antigen, beta chain 1 | 0.012 | ||
| Amhr2 | anti-Mullerian hormone type 2 receptor | 0.012 | ||
| Yap1 | yes-associated protein 1 | 0.012 | ||
| Eomes | eomesodermin homolog (Xenopus laevis) | 0.012 | ||
| Il10 | interleukin 10 | 0.012 | ||
| Cbx2 | chromobox homolog 2 (Drosophila Pc class) | 0.012 | ||
| Sox2 | SRY-box containing gene 2 | 0.012 | ||
| Ggt1 | gamma-glutamyltransferase 1 | 0.011 | ||
| Npc1 | Niemann Pick type C1 | 0.011 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.011 | ||
| Sh3rf1 | SH3 domain containing ring finger 1 | 0.011 | ||
| Klf5 | Kruppel-like factor 5 | 0.011 | ||
| Itgb2 | integrin beta 2 | 0.011 | ||
| 0610031J06Rik | RIKEN cDNA 0610031J06 gene | 0.011 | ||
| Sall4 | sal-like 4 (Drosophila) | 0.011 | ||
| Wls | wntless homolog (Drosophila) | 0.011 | ||
| Myb | myeloblastosis oncogene | 0.011 | ||
| Rfx2 | regulatory factor X, 2 (influences HLA class II expression) | 0.011 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.011 | ||
| Rxra | retinoid X receptor alpha | 0.011 | ||
| Gata3 | GATA binding protein 3 | 0.011 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.011 | ||
| Skil | SKI-like | 0.011 | ||
| Zic3 | zinc finger protein of the cerebellum 3 | 0.011 | ||
| Apoe | apolipoprotein E | 0.011 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.011 | ||
| Gpc3 | glypican 3 | 0.011 | ||
| Ednrb | endothelin receptor type B | 0.010 | ||
| Cirh1a | cirrhosis, autosomal recessive 1A (human) | 0.010 | ||
| 1110035H17Rik | RIKEN cDNA 1110035H17 gene | 0.010 | ||
| Arvcf | armadillo repeat gene deleted in velo-cardio-facial syndrome | 0.010 | ||
| Foxo3 | forkhead box O3 | 0.010 | ||
| Sox4 | SRY-box containing gene 4 | 0.010 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.010 | ||
| Clec4n | C-type lectin domain family 4, member n | 0.010 | ||
| Sall3 | sal-like 3 (Drosophila) | 0.010 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.010 |