Mus musculus

221 known processes

Ins2

insulin II

(Aliases: Mody,InsII,Ins-2,AA986540,Mody4,proinsulin)

Ins2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
exocrine pancreas development GO:0031017 7 0.983
Mouse
regulation of feeding behavior GO:0060259 3 0.937
Zebrafish
glucose metabolic process GO:0006006 92 0.891
cellular amino acid metabolic process GO:0006520 103 0.858
cellular response to peptide GO:1901653 92 0.766
positive regulation of lipid kinase activity GO:0090218 11 0.755
inflammatory response GO:0006954 244 0.731
regulation of cellular amine metabolic process GO:0033238 20 0.724
cellular amine metabolic process GO:0044106 44 0.666
cellular glucan metabolic process GO:0006073 32 0.655
Mouse
oxidation reduction process GO:0055114 342 0.627
Mouse
water homeostasis GO:0030104 27 0.619
Mouse
peptidyl amino acid modification GO:0018193 336 0.595
positive regulation of mapk cascade GO:0043410 170 0.594
gland development GO:0048732 330 0.591
Mouse
positive regulation of kinase activity GO:0033674 155 0.561
urogenital system development GO:0001655 261 0.552
Mouse
response to peptide GO:1901652 136 0.551
regulation of kinase activity GO:0043549 249 0.518
circadian rhythm GO:0007623 114 0.495
Mouse
negative regulation of cell proliferation GO:0008285 296 0.495
Mouse
regulation of glycogen metabolic process GO:0070873 13 0.476
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.474
exocrine system development GO:0035272 45 0.471
Mouse
amine metabolic process GO:0009308 45 0.456
regulation of polysaccharide metabolic process GO:0032881 13 0.452
Mouse
carbohydrate metabolic process GO:0005975 230 0.452
regulation of cellular ketone metabolic process GO:0010565 66 0.451
regulation of response to wounding GO:1903034 189 0.450
feeding behavior GO:0007631 62 0.449
Zebrafish
fat cell differentiation GO:0045444 160 0.442
hexose metabolic process GO:0019318 98 0.428
phospholipid metabolic process GO:0006644 87 0.413
lipid catabolic process GO:0016042 69 0.412
cellular lipid metabolic process GO:0044255 323 0.409
response to insulin GO:0032868 100 0.390
regulation of inflammatory response GO:0050727 147 0.381
circulatory system process GO:0003013 197 0.372
positive regulation of lipid metabolic process GO:0045834 40 0.371
forebrain development GO:0030900 302 0.366
regulation of glucose metabolic process GO:0010906 60 0.365
Mouse
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.364
regulation of lipid metabolic process GO:0019216 118 0.356
hindbrain development GO:0030902 128 0.354
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.349
carbohydrate derivative biosynthetic process GO:1901137 183 0.347
Mouse
regulation of cell migration GO:0030334 219 0.345
response to peptide hormone GO:0043434 127 0.344
positive regulation of transferase activity GO:0051347 167 0.334
positive regulation of map kinase activity GO:0043406 84 0.333
regulation of carbohydrate metabolic process GO:0006109 75 0.328
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.323
glycogen biosynthetic process GO:0005978 14 0.322
Mouse
rhythmic process GO:0048511 174 0.319
Mouse
response to monosaccharide GO:0034284 67 0.316
Zebrafish
regulation of transferase activity GO:0051338 263 0.313
blood circulation GO:0008015 195 0.309
positive regulation of protein modification process GO:0031401 299 0.306
regulation of cell motility GO:2000145 236 0.304
regulation of fatty acid metabolic process GO:0019217 28 0.302
cellular response to insulin stimulus GO:0032869 78 0.299
response to organic cyclic compound GO:0014070 198 0.299
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.297
Mouse
response to growth factor GO:0070848 198 0.296
polysaccharide biosynthetic process GO:0000271 20 0.294
Mouse
regulation of circadian sleep wake cycle GO:0042749 3 0.290
negative regulation of phosphorylation GO:0042326 166 0.289
Mouse
negative regulation of cellular component organization GO:0051129 194 0.289
Mouse
activation of mapk activity GO:0000187 59 0.287
glycoprotein biosynthetic process GO:0009101 89 0.287
Mouse
regulation of protein kinase activity GO:0045859 232 0.278
generation of precursor metabolites and energy GO:0006091 103 0.278
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.278
Mouse
anatomical structure homeostasis GO:0060249 145 0.276
cellular response to growth factor stimulus GO:0071363 197 0.275
cellular ketone metabolic process GO:0042180 84 0.271
locomotory behavior GO:0007626 195 0.270
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.269
Mouse
polysaccharide metabolic process GO:0005976 39 0.263
Mouse
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.243
positive regulation of insulin secretion GO:0032024 26 0.240
extracellular structure organization GO:0043062 148 0.238
erk1 and erk2 cascade GO:0070371 77 0.233
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.230
organelle localization GO:0051640 179 0.229
response to nutrient levels GO:0031667 109 0.226
Zebrafish
insulin receptor signaling pathway GO:0008286 49 0.226
proteoglycan biosynthetic process GO:0030166 20 0.226
Mouse
response to endoplasmic reticulum stress GO:0034976 53 0.223
telencephalon development GO:0021537 186 0.223
prostate gland morphogenesis GO:0060512 32 0.214
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.213
positive regulation of peptide hormone secretion GO:0090277 31 0.213
cerebellar granule cell precursor proliferation GO:0021930 10 0.212
Mouse
fertilization GO:0009566 127 0.210
epithelial tube morphogenesis GO:0060562 303 0.210
Mouse
digestive system development GO:0055123 200 0.207
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.201
Mouse
adult behavior GO:0030534 135 0.198
establishment of organelle localization GO:0051656 122 0.197
asymmetric stem cell division GO:0098722 3 0.195
cellular response to organonitrogen compound GO:0071417 145 0.192
response to organonitrogen compound GO:0010243 246 0.191
regulation of generation of precursor metabolites and energy GO:0043467 38 0.189
Mouse
ear development GO:0043583 200 0.189
Mouse
negative regulation of intracellular signal transduction GO:1902532 167 0.187
Mouse
negative regulation of response to wounding GO:1903035 77 0.187
muscle cell differentiation GO:0042692 261 0.186
connective tissue development GO:0061448 179 0.184
Mouse
striated muscle tissue development GO:0014706 293 0.184
monocarboxylic acid catabolic process GO:0072329 27 0.181
positive regulation of leukocyte proliferation GO:0070665 73 0.181
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.178
negative regulation of feeding behavior GO:2000252 1 0.173
Zebrafish
insulin like growth factor receptor signaling pathway GO:0048009 21 0.171
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.171
regulation of androgen receptor signaling pathway GO:0060765 3 0.169
Mouse
cell fate commitment GO:0045165 210 0.168
organic hydroxy compound metabolic process GO:1901615 203 0.167
neuron death GO:0070997 154 0.165
negative regulation of phosphate metabolic process GO:0045936 184 0.164
Mouse
camera type eye development GO:0043010 266 0.164
negative regulation of phosphorus metabolic process GO:0010563 184 0.163
Mouse
cellular response to hormone stimulus GO:0032870 150 0.162
extracellular matrix organization GO:0030198 147 0.162
renal system process GO:0003014 48 0.160
negative regulation of protein metabolic process GO:0051248 282 0.159
glucan metabolic process GO:0044042 32 0.159
Mouse
embryonic placenta development GO:0001892 98 0.156
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.155
blood vessel remodeling GO:0001974 33 0.150
Mouse
release of cytochrome c from mitochondria GO:0001836 23 0.150
Mouse
regulation of circadian rhythm GO:0042752 58 0.147
positive regulation of neuron differentiation GO:0045666 141 0.146
glucose import GO:0046323 32 0.146
heart contraction GO:0060047 93 0.144
glycogen metabolic process GO:0005977 32 0.143
Mouse
apoptotic signaling pathway GO:0097190 306 0.142
second messenger mediated signaling GO:0019932 73 0.141
regulation of lipid kinase activity GO:0043550 14 0.141
positive regulation of keratinocyte proliferation GO:0010838 4 0.140
positive regulation of secretion by cell GO:1903532 114 0.138
defense response to bacterium GO:0042742 119 0.132
negative regulation of cell development GO:0010721 169 0.131
cell adhesion GO:0007155 329 0.128
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 0.127
Mouse
pancreas development GO:0031016 57 0.125
Mouse
peptide secretion GO:0002790 114 0.123
circadian sleep wake cycle GO:0042745 5 0.122
organic hydroxy compound transport GO:0015850 93 0.121
neuromuscular process GO:0050905 99 0.120
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 11 0.117
positive regulation of hormone secretion GO:0046887 38 0.117
regulation of cell activation GO:0050865 289 0.116
response to starvation GO:0042594 65 0.116
regulation of anatomical structure size GO:0090066 178 0.116
cytokine mediated signaling pathway GO:0019221 115 0.112
response to extracellular stimulus GO:0009991 127 0.111
Zebrafish
cellular polysaccharide metabolic process GO:0044264 38 0.111
Mouse
intrinsic apoptotic signaling pathway GO:0097193 132 0.110
lung epithelium development GO:0060428 37 0.109
Mouse
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.109
Mouse
positive regulation of carbohydrate metabolic process GO:0045913 30 0.109
Mouse
response to alkaloid GO:0043279 34 0.108
fatty acid metabolic process GO:0006631 121 0.108
developmental cell growth GO:0048588 84 0.108
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.107
carbohydrate biosynthetic process GO:0016051 74 0.106
Mouse
regulation of secretion GO:0051046 274 0.106
t cell activation GO:0042110 289 0.105
regulation of leukocyte differentiation GO:1902105 159 0.105
lipid transport GO:0006869 98 0.104
positive regulation of glycogen metabolic process GO:0070875 8 0.104
Mouse
glucose homeostasis GO:0042593 128 0.103
cell growth GO:0016049 130 0.102
regulation of system process GO:0044057 200 0.101
protein kinase b signaling GO:0043491 74 0.100
Mouse
long term synaptic potentiation GO:0060291 25 0.099
regulation of body fluid levels GO:0050878 162 0.099
cellular chemical homeostasis GO:0055082 215 0.099
lipid biosynthetic process GO:0008610 179 0.099
response to purine containing compound GO:0014074 28 0.097
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.097
peptidyl tyrosine phosphorylation GO:0018108 143 0.097
defense response to other organism GO:0098542 197 0.097
positive regulation of glycogen starch synthase activity GO:2000467 4 0.097
Mouse
positive regulation of cell activation GO:0050867 158 0.097
gliogenesis GO:0042063 141 0.097
Mouse
cerebral cortex development GO:0021987 86 0.094
positive regulation of calcium ion transport GO:0051928 27 0.094
response to oxygen levels GO:0070482 62 0.094
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.093
peptidyl tyrosine modification GO:0018212 145 0.091
prostate gland epithelium morphogenesis GO:0060740 31 0.090
Mouse
regulation of neuron differentiation GO:0045664 281 0.090
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.089
Mouse
cell type specific apoptotic process GO:0097285 268 0.088
multi multicellular organism process GO:0044706 109 0.086
positive regulation of nervous system development GO:0051962 221 0.086
Mouse
response to cocaine GO:0042220 14 0.086
epithelial cell proliferation GO:0050673 174 0.083
peptide transport GO:0015833 133 0.083
germ cell development GO:0007281 185 0.082
prostate gland stromal morphogenesis GO:0060741 2 0.082
Mouse
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.082
regulation of hormone secretion GO:0046883 88 0.082
positive regulation of t cell activation GO:0050870 101 0.081
intracellular receptor signaling pathway GO:0030522 74 0.081
Mouse
positive regulation of peptide secretion GO:0002793 33 0.081
germline stem cell asymmetric division GO:0098728 2 0.080
placenta development GO:0001890 140 0.080
calcium mediated signaling GO:0019722 46 0.079
organic anion transport GO:0015711 137 0.079
eating behavior GO:0042755 15 0.079
lipid localization GO:0010876 126 0.079
positive regulation of cell development GO:0010720 237 0.078
negative regulation of cellular protein metabolic process GO:0032269 247 0.078
apoptotic mitochondrial changes GO:0008637 48 0.078
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.078
insulin secretion GO:0030073 89 0.077
positive regulation of glucose metabolic process GO:0010907 21 0.077
Mouse
regulation of mapk cascade GO:0043408 248 0.077
positive regulation of glucose transport GO:0010828 16 0.077
regulation of lymphocyte activation GO:0051249 240 0.077
extrinsic apoptotic signaling pathway GO:0097191 126 0.076
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.075
regulation of lymphocyte differentiation GO:0045619 107 0.075
epithelial cell migration GO:0010631 63 0.074
energy derivation by oxidation of organic compounds GO:0015980 77 0.074
Mouse
posttranscriptional regulation of gene expression GO:0010608 155 0.073
spinal cord development GO:0021510 81 0.073
mitochondrion organization GO:0007005 134 0.073
Mouse
heart process GO:0003015 94 0.073
cellular polysaccharide biosynthetic process GO:0033692 19 0.073
Mouse
regulation of systemic arterial blood pressure GO:0003073 61 0.073
response to ethanol GO:0045471 18 0.072
somatotropin secreting cell differentiation GO:0060126 4 0.072
ribonucleotide metabolic process GO:0009259 291 0.072
cellular response to starvation GO:0009267 57 0.071
monosaccharide metabolic process GO:0005996 106 0.071
ventral spinal cord development GO:0021517 48 0.069
regulation of multi organism process GO:0043900 111 0.068
action potential GO:0001508 78 0.068
male germ line stem cell asymmetric division GO:0048133 2 0.068
regulation of secretion by cell GO:1903530 249 0.068
regulation of wound healing GO:0061041 40 0.067
regulation of hormone levels GO:0010817 211 0.066
leukocyte migration GO:0050900 124 0.066
transmission of nerve impulse GO:0019226 76 0.066
digestion GO:0007586 40 0.066
catecholamine metabolic process GO:0006584 30 0.065
positive regulation of ion transmembrane transport GO:0034767 24 0.065
axonogenesis GO:0007409 274 0.065
exploration behavior GO:0035640 21 0.065
regulation of vesicle mediated transport GO:0060627 139 0.064
tissue homeostasis GO:0001894 115 0.064
adult locomotory behavior GO:0008344 91 0.064
regulation of glucan biosynthetic process GO:0010962 7 0.063
Mouse
regulation of blood circulation GO:1903522 93 0.061
multicellular organism growth GO:0035264 161 0.060
Mouse
nitrogen compound transport GO:0071705 271 0.060
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.060
monosaccharide transport GO:0015749 58 0.060
type ii pneumocyte differentiation GO:0060510 7 0.059
Mouse
response to alkaline ph GO:0010446 1 0.059
regulation of defense response GO:0031347 233 0.059
myeloid cell differentiation GO:0030099 233 0.059
regulation of polysaccharide biosynthetic process GO:0032885 7 0.059
Mouse
carbohydrate homeostasis GO:0033500 128 0.059
regulation of cellular response to stress GO:0080135 159 0.058
regulation of carbohydrate biosynthetic process GO:0043255 40 0.058
Mouse
prostate gland growth GO:0060736 13 0.058
Mouse
negative regulation of cytokine production GO:0001818 84 0.057
organic acid catabolic process GO:0016054 51 0.057
divalent metal ion transport GO:0070838 172 0.057
positive regulation of lymphocyte proliferation GO:0050671 70 0.057
lactation GO:0007595 25 0.057
cellular response to abiotic stimulus GO:0071214 56 0.057
response to radiation GO:0009314 165 0.056
amide transport GO:0042886 138 0.056
negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 11 0.056
Mouse
negative regulation of neuron apoptotic process GO:0043524 92 0.055
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.055
Mouse
organ growth GO:0035265 117 0.054
Mouse
striated muscle contraction GO:0006941 45 0.054
type i pneumocyte differentiation GO:0060509 7 0.054
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.054
diencephalon development GO:0021536 63 0.054
hippocampus development GO:0021766 52 0.054
response to drug GO:0042493 75 0.054
ameboidal type cell migration GO:0001667 128 0.054
cell chemotaxis GO:0060326 81 0.054
pigment granule localization GO:0051875 13 0.054
learning or memory GO:0007611 148 0.053
inner ear morphogenesis GO:0042472 101 0.053
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.053
carboxylic acid catabolic process GO:0046395 51 0.053
regulation of metal ion transport GO:0010959 106 0.053
establishment of melanosome localization GO:0032401 11 0.052
cation transport GO:0006812 399 0.052
regulation of keratinocyte differentiation GO:0045616 11 0.052
sulfur compound metabolic process GO:0006790 100 0.051
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.051
regulation of glycogen starch synthase activity GO:2000465 5 0.051
Mouse
neuron migration GO:0001764 122 0.051
positive regulation of cell migration GO:0030335 109 0.051
cellular response to peptide hormone stimulus GO:0071375 92 0.050
inositol lipid mediated signaling GO:0048017 41 0.050
Mouse
glycerolipid metabolic process GO:0046486 122 0.050
protein oligomerization GO:0051259 67 0.049
response to inorganic substance GO:0010035 96 0.049
epithelial cell development GO:0002064 159 0.049
cell differentiation in spinal cord GO:0021515 53 0.049
cation transmembrane transport GO:0098655 266 0.049
response to testosterone GO:0033574 3 0.049
positive regulation of cellular catabolic process GO:0031331 148 0.049
neuron projection guidance GO:0097485 141 0.048
purine nucleotide metabolic process GO:0006163 302 0.048
cardiac ventricle development GO:0003231 83 0.048
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.048
multicellular organismal homeostasis GO:0048871 164 0.048
multicellular organismal response to stress GO:0033555 62 0.047
phenol containing compound biosynthetic process GO:0046189 21 0.047
negative regulation of epithelial cell proliferation GO:0050680 64 0.047
tissue migration GO:0090130 68 0.047
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.047
negative regulation of defense response GO:0031348 77 0.047
ribonucleotide biosynthetic process GO:0009260 59 0.047
sensory organ morphogenesis GO:0090596 242 0.047
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.046
regulation of transmembrane transport GO:0034762 128 0.046
sodium ion transport GO:0006814 73 0.046
nucleoside phosphate metabolic process GO:0006753 338 0.046
myotube differentiation GO:0014902 105 0.046
blood vessel morphogenesis GO:0048514 285 0.045
regulation of organ growth GO:0046620 61 0.045
regulation of cellular component biogenesis GO:0044087 181 0.045
positive regulation of secretion GO:0051047 130 0.045
regulation of myoblast proliferation GO:2000291 8 0.045
Mouse
divalent inorganic cation transport GO:0072511 178 0.045
negative regulation of transferase activity GO:0051348 85 0.045
neuron apoptotic process GO:0051402 142 0.045
glycerolipid biosynthetic process GO:0045017 50 0.045
maintenance of location GO:0051235 89 0.044
nucleoside monophosphate metabolic process GO:0009123 85 0.044
spermatogenesis GO:0007283 284 0.044
regulation of peptide transport GO:0090087 91 0.044
glucan biosynthetic process GO:0009250 14 0.044
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.044
Mouse
positive regulation of homeostatic process GO:0032846 64 0.044
regulation of t cell activation GO:0050863 170 0.044
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.044
regulation of cell cycle GO:0051726 281 0.044
chondroitin sulfate proteoglycan metabolic process GO:0050654 20 0.043
Mouse
cartilage development GO:0051216 140 0.043
positive regulation of protein kinase activity GO:0045860 144 0.043
pancreatic a cell fate commitment GO:0003326 2 0.043
response to transforming growth factor beta GO:0071559 88 0.042
establishment of protein localization to organelle GO:0072594 118 0.042
response to decreased oxygen levels GO:0036293 59 0.042
cellular nitrogen compound catabolic process GO:0044270 280 0.042
transmembrane transport GO:0055085 412 0.042
fatty acid oxidation GO:0019395 28 0.042
catecholamine transport GO:0051937 21 0.042
cellular protein complex assembly GO:0043623 116 0.041
covalent chromatin modification GO:0016569 163 0.041
single fertilization GO:0007338 82 0.040
purine nucleoside metabolic process GO:0042278 241 0.040
jak stat cascade GO:0007259 42 0.040
cellular lipid catabolic process GO:0044242 52 0.040
auditory receptor cell fate specification GO:0042667 1 0.040
atp metabolic process GO:0046034 75 0.039
single organism cell adhesion GO:0098602 156 0.039
regulation of auditory receptor cell differentiation GO:0045607 4 0.039
peptide hormone secretion GO:0030072 109 0.039
positive regulation of blood circulation GO:1903524 22 0.039
chromatin organization GO:0006325 206 0.039
mating GO:0007618 27 0.039
regulation of ion transport GO:0043269 215 0.039
vasodilation GO:0042311 28 0.039
negative regulation of cellular amine metabolic process GO:0033239 1 0.039
organophosphate biosynthetic process GO:0090407 122 0.038
positive regulation of programmed cell death GO:0043068 218 0.038
nitric oxide mediated signal transduction GO:0007263 4 0.038
adrenergic receptor signaling pathway GO:0071875 13 0.038
glycosaminoglycan biosynthetic process GO:0006024 15 0.038
Mouse
syncytium formation by plasma membrane fusion GO:0000768 42 0.038
monoamine transport GO:0015844 33 0.038
single organismal cell cell adhesion GO:0016337 131 0.038
b cell proliferation GO:0042100 53 0.037
hormone secretion GO:0046879 128 0.037
prostate gland development GO:0030850 48 0.037
Mouse
regulation of glycogen biosynthetic process GO:0005979 7 0.037
Mouse
cellular glucose homeostasis GO:0001678 52 0.037
calcium ion transmembrane transport GO:0070588 85 0.037
visual learning GO:0008542 44 0.037
carbohydrate transport GO:0008643 62 0.036
multicellular organismal water homeostasis GO:0050891 23 0.036
cardiocyte differentiation GO:0035051 87 0.036
negative regulation of inflammatory response GO:0050728 61 0.036
positive regulation of glycolytic process GO:0045821 4 0.036
purine containing compound metabolic process GO:0072521 311 0.036
negative regulation of cell migration GO:0030336 59 0.036
purine nucleoside monophosphate metabolic process GO:0009126 81 0.036
regulation of blood pressure GO:0008217 93 0.036
positive regulation of cerebellar granule cell precursor proliferation GO:0021940 10 0.036
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.035
Mouse
lateral line system development GO:0048925 1 0.035
negative regulation of rho protein signal transduction GO:0035024 7 0.035
hexose transport GO:0008645 56 0.035
negative regulation of mapk cascade GO:0043409 65 0.035
Mouse
negative regulation of nervous system development GO:0051961 156 0.035
signal transduction in absence of ligand GO:0038034 55 0.035
Mouse
regulation of peptide hormone secretion GO:0090276 75 0.035
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.035
response to nicotine GO:0035094 6 0.034
response to corticosterone GO:0051412 1 0.034
cellular response to external stimulus GO:0071496 88 0.034
regulation of transcription involved in cell fate commitment GO:0060850 15 0.034
insulin receptor signaling pathway via phosphatidylinositol 3 kinase GO:0038028 3 0.034
Mouse
regulation of blood vessel size GO:0050880 56 0.034
cellular metal ion homeostasis GO:0006875 151 0.034
regulation of water loss via skin GO:0033561 16 0.034
nucleoside metabolic process GO:0009116 246 0.034
negative regulation of epidermal cell differentiation GO:0045605 7 0.034
regulation of neuron projection development GO:0010975 169 0.034
macromolecule catabolic process GO:0009057 281 0.034
cerebral cortex neuron differentiation GO:0021895 19 0.034
regulation of ion transmembrane transport GO:0034765 119 0.033
intestinal absorption GO:0050892 13 0.033
forebrain neuron differentiation GO:0021879 52 0.033
corticosterone secretion GO:0035934 3 0.033
astrocyte fate commitment GO:0060018 4 0.033
pallium development GO:0021543 120 0.033
germ line stem cell division GO:0042078 2 0.033
negative regulation of molecular function GO:0044092 258 0.033
myeloid leukocyte activation GO:0002274 83 0.033
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.033
regulation of neuron death GO:1901214 134 0.033
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.033
regulation of circadian sleep wake cycle rem sleep GO:0042320 1 0.033
reactive nitrogen species metabolic process GO:2001057 0 0.033
cyclic purine nucleotide metabolic process GO:0052652 43 0.033
synaptic transmission GO:0007268 329 0.032
skin development GO:0043588 220 0.032
limbic system development GO:0021761 72 0.032
cognition GO:0050890 149 0.032
vascular process in circulatory system GO:0003018 62 0.032
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.032
adult feeding behavior GO:0008343 9 0.032
negative regulation of mitochondrion organization GO:0010823 9 0.032
Mouse
muscle contraction GO:0006936 101 0.032
kidney development GO:0001822 213 0.032
regulation of embryonic development GO:0045995 71 0.032
regulation of protein serine threonine kinase activity GO:0071900 157 0.032
pituitary gland development GO:0021983 38 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.032
regulation of b cell proliferation GO:0030888 39 0.032
negative regulation of protein phosphorylation GO:0001933 126 0.032
respiratory system development GO:0060541 190 0.031
Mouse
positive regulation of sodium ion transmembrane transport GO:1902307 4 0.031
regulation of purine nucleotide metabolic process GO:1900542 169 0.031
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 7 0.031
Mouse
response to acid chemical GO:0001101 111 0.031
defense response to virus GO:0051607 68 0.031
cell substrate adhesion GO:0031589 130 0.031
cytokine production GO:0001816 319 0.031
skeletal muscle organ development GO:0060538 163 0.031
intestinal cholesterol absorption GO:0030299 5 0.031
glycoprotein metabolic process GO:0009100 116 0.031
Mouse
regulation of acetylcholine secretion neurotransmission GO:0014056 2 0.031
heterocycle catabolic process GO:0046700 280 0.031
ribonucleoside metabolic process GO:0009119 245 0.031
endomembrane system organization GO:0010256 147 0.031
ribonucleoside monophosphate metabolic process GO:0009161 80 0.031
pancreatic pp cell fate commitment GO:0003329 2 0.031
wnt signaling pathway GO:0016055 188 0.031
regulation of homeostatic process GO:0032844 182 0.030
multicellular organismal signaling GO:0035637 91 0.030
metal ion homeostasis GO:0055065 189 0.030
reactive oxygen species metabolic process GO:0072593 84 0.030
regulation of membrane potential GO:0042391 192 0.030
negative regulation of apoptotic signaling pathway GO:2001234 104 0.030
Mouse
regulation of glucose import GO:0046324 26 0.030
regulation of intestinal cholesterol absorption GO:0030300 4 0.030
regulation of cell adhesion GO:0030155 154 0.030
cell maturation GO:0048469 127 0.030
forebrain generation of neurons GO:0021872 63 0.030
regulation of norepinephrine secretion GO:0014061 2 0.030

Ins2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.647
diabetes mellitus DOID:9351 0 0.360
type 2 diabetes mellitus DOID:9352 0 0.360
carbohydrate metabolism disease DOID:0050013 0 0.360
glucose metabolism disease DOID:4194 0 0.360
acquired metabolic disease DOID:0060158 0 0.360
inherited metabolic disorder DOID:655 0 0.045