Mus musculus

0 known processes

Map3k8

mitogen-activated protein kinase kinase kinase 8

(Aliases: Estf,Est,Cot,Tpl-2,Tpl2,Cot/Tpl2,c-COT)

Map3k8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
activation of innate immune response GO:0002218 56 0.998
toll like receptor signaling pathway GO:0002224 38 0.997
positive regulation of innate immune response GO:0045089 80 0.994
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.988
response to interleukin 12 GO:0070671 2 0.987
activation of immune response GO:0002253 138 0.985
immune response activating signal transduction GO:0002757 116 0.984
cellular response to molecule of bacterial origin GO:0071219 83 0.980
cellular response to biotic stimulus GO:0071216 92 0.979
regulation of innate immune response GO:0045088 91 0.976
pattern recognition receptor signaling pathway GO:0002221 47 0.971
cellular response to lipopolysaccharide GO:0071222 77 0.959
cytokine production GO:0001816 319 0.958
cytokine mediated signaling pathway GO:0019221 115 0.956
regulation of defense response GO:0031347 233 0.954
cellular response to cytokine stimulus GO:0071345 189 0.953
i kappab kinase nf kappab signaling GO:0007249 85 0.946
innate immune response activating signal transduction GO:0002758 50 0.942
immune response regulating signaling pathway GO:0002764 125 0.924
innate immune response GO:0045087 157 0.917
positive regulation of defense response GO:0031349 124 0.903
tumor necrosis factor production GO:0032640 50 0.899
regulation of chemokine production GO:0032642 30 0.887
regulation of tumor necrosis factor production GO:0032680 49 0.886
positive regulation of cytokine production GO:0001819 174 0.883
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.878
response to lipopolysaccharide GO:0032496 128 0.857
regulation of cd8 positive alpha beta cytotoxic t cell extravasation GO:2000452 2 0.850
regulation of cytokine production GO:0001817 266 0.836
response to molecule of bacterial origin GO:0002237 143 0.831
regulation of lymphocyte activation GO:0051249 240 0.815
regulation of interleukin 6 production GO:0032675 55 0.789
regulation of interleukin 8 production GO:0032677 3 0.788
regulation of cell activation GO:0050865 289 0.784
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.784
defense response to other organism GO:0098542 197 0.778
defense response to virus GO:0051607 68 0.762
ripoptosome assembly involved in necroptotic process GO:1901026 6 0.737
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.704
positive regulation of cell activation GO:0050867 158 0.702
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.689
response to interleukin 1 GO:0070555 11 0.680
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.674
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.663
cellular response to lipid GO:0071396 145 0.657
positive regulation of interleukin 8 production GO:0032757 2 0.654
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.648
positive regulation of chemokine production GO:0032722 22 0.639
positive regulation of lymphocyte activation GO:0051251 140 0.634
regulation of reactive oxygen species metabolic process GO:2000377 40 0.631
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.630
interleukin 8 production GO:0032637 4 0.596
t helper cell differentiation GO:0042093 28 0.588
immune effector process GO:0002252 321 0.588
positive regulation of tumor necrosis factor production GO:0032760 30 0.585
alpha beta t cell activation involved in immune response GO:0002287 31 0.580
t cell activation involved in immune response GO:0002286 43 0.575
regulation of necroptotic process GO:0060544 10 0.572
chemokine production GO:0032602 34 0.569
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.564
inflammatory response GO:0006954 244 0.564
cytokine metabolic process GO:0042107 71 0.548
cell activation involved in immune response GO:0002263 126 0.547
negative regulation of immune system process GO:0002683 209 0.542
cellular response to peptidoglycan GO:0071224 4 0.532
lymphocyte differentiation GO:0030098 242 0.529
negative regulation of cytokine production GO:0001818 84 0.525
positive regulation of response to cytokine stimulus GO:0060760 11 0.521
peptidyl amino acid modification GO:0018193 336 0.499
t cell activation GO:0042110 289 0.494
positive regulation of t cell differentiation GO:0045582 52 0.485
positive regulation of immature t cell proliferation GO:0033091 4 0.461
cd4 positive alpha beta t cell activation GO:0035710 45 0.450
regulation of leukocyte differentiation GO:1902105 159 0.448
positive regulation of lymphocyte differentiation GO:0045621 61 0.447
adaptive immune response GO:0002250 155 0.444
cellular response to organonitrogen compound GO:0071417 145 0.441
intracellular receptor signaling pathway GO:0030522 74 0.436
t cell apoptotic process GO:0070231 39 0.432
positive regulation of cytokine biosynthetic process GO:0042108 40 0.427
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.425
leukocyte activation involved in immune response GO:0002366 126 0.420
t cell differentiation involved in immune response GO:0002292 30 0.414
positive regulation of apoptotic process GO:0043065 217 0.410
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.409
regulation of transferase activity GO:0051338 263 0.404
positive regulation of interferon alpha production GO:0032727 4 0.402
jnk cascade GO:0007254 72 0.396
regulation of cellular amino acid metabolic process GO:0006521 5 0.395
regulation of leukocyte proliferation GO:0070663 121 0.394
regulation of defense response to fungus GO:1900150 1 0.386
defense response to gram positive bacterium GO:0050830 50 0.386
mapk cascade GO:0000165 281 0.382
alpha beta t cell differentiation GO:0046632 69 0.381
myeloid leukocyte activation GO:0002274 83 0.379
type i interferon production GO:0032606 29 0.377
response to organic cyclic compound GO:0014070 198 0.376
homeostasis of number of cells GO:0048872 210 0.368
toll like receptor 4 signaling pathway GO:0034142 9 0.367
cell type specific apoptotic process GO:0097285 268 0.366
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.351
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.349
t helper 1 cell differentiation GO:0045063 13 0.348
nik nf kappab signaling GO:0038061 14 0.348
regulation of interferon gamma production GO:0032649 57 0.344
positive regulation of type i interferon production GO:0032481 14 0.340
t helper 1 type immune response GO:0042088 25 0.335
positive regulation of antimicrobial peptide production GO:0002225 1 0.333
regulation of lymphocyte apoptotic process GO:0070228 41 0.330
defense response to bacterium GO:0042742 119 0.329
positive regulation of protein modification process GO:0031401 299 0.321
positive regulation of programmed cell death GO:0043068 218 0.316
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.316
positive regulation of immune effector process GO:0002699 107 0.312
antigen receptor mediated signaling pathway GO:0050851 64 0.310
interleukin 6 production GO:0032635 58 0.308
apoptotic signaling pathway GO:0097190 306 0.300
positive regulation of stress activated mapk cascade GO:0032874 48 0.298
toll like receptor 3 signaling pathway GO:0034138 4 0.296
lymphocyte proliferation GO:0046651 164 0.293
leukocyte migration GO:0050900 124 0.288
regulation of toll like receptor signaling pathway GO:0034121 20 0.278
reactive oxygen species metabolic process GO:0072593 84 0.275
positive regulation of mapk cascade GO:0043410 170 0.271
cellular ketone metabolic process GO:0042180 84 0.269
positive regulation of cell death GO:0010942 224 0.268
cellular amino acid metabolic process GO:0006520 103 0.267
t cell proliferation GO:0042098 120 0.266
regulation of interleukin 2 production GO:0032663 28 0.265
antimicrobial peptide production GO:0002775 2 0.260
necroptotic process GO:0070266 21 0.259
carbohydrate metabolic process GO:0005975 230 0.258
lymphocyte apoptotic process GO:0070227 54 0.257
interferon gamma production GO:0032609 67 0.256
regulation of t cell activation GO:0050863 170 0.253
leukocyte proliferation GO:0070661 172 0.247
positive regulation of interleukin 6 production GO:0032755 37 0.241
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.239
regulation of response to cytokine stimulus GO:0060759 23 0.237
b cell activation GO:0042113 161 0.234
leukocyte differentiation GO:0002521 342 0.232
reactive nitrogen species metabolic process GO:2001057 0 0.231
regulation of t helper 1 cell differentiation GO:0045625 7 0.231
positive regulation of lymphocyte proliferation GO:0050671 70 0.228
regulation of leukocyte apoptotic process GO:2000106 56 0.228
regulation of stress activated mapk cascade GO:0032872 69 0.223
regulation of t cell differentiation GO:0045580 83 0.222
negative regulation of phosphate metabolic process GO:0045936 184 0.220
response to dsrna GO:0043331 30 0.218
regulation of response to wounding GO:1903034 189 0.218
regulation of defense response to bacterium GO:1900424 3 0.213
stress activated protein kinase signaling cascade GO:0031098 81 0.212
regulation of protein kinase activity GO:0045859 232 0.211
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.211
regulation of necrotic cell death GO:0010939 13 0.209
positive regulation of leukocyte differentiation GO:1902107 86 0.208
myeloid cell differentiation GO:0030099 233 0.208
regulation of interferon beta biosynthetic process GO:0045357 4 0.206
negative regulation of lymphocyte activation GO:0051250 91 0.205
interleukin 2 production GO:0032623 33 0.205
alpha beta t cell activation GO:0046631 91 0.205
leukocyte homeostasis GO:0001776 79 0.204
regulation of cellular catabolic process GO:0031329 242 0.203
interferon beta production GO:0032608 16 0.202
lymphocyte activation involved in immune response GO:0002285 93 0.202
regulation of multi organism process GO:0043900 111 0.199
t cell differentiation GO:0030217 174 0.199
regulation of adaptive immune response GO:0002819 90 0.198
regulation of protein transport GO:0051223 163 0.198
cellular amine metabolic process GO:0044106 44 0.197
extrinsic apoptotic signaling pathway GO:0097191 126 0.195
response to organonitrogen compound GO:0010243 246 0.194
wound healing GO:0042060 157 0.191
positive regulation of jnk cascade GO:0046330 46 0.190
lymphocyte mediated immunity GO:0002449 139 0.188
regulation of lymphocyte proliferation GO:0050670 117 0.185
negative regulation of cell proliferation GO:0008285 296 0.185
peptidyl tyrosine phosphorylation GO:0018108 143 0.185
regulation of cellular response to stress GO:0080135 159 0.184
interleukin 1 mediated signaling pathway GO:0070498 4 0.182
t cell extravasation GO:0072683 4 0.181
negative regulation of cellular protein metabolic process GO:0032269 247 0.181
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.181
regulation of antimicrobial humoral response GO:0002759 3 0.180
negative regulation of intracellular signal transduction GO:1902532 167 0.180
positive regulation of interferon gamma production GO:0032729 39 0.179
positive regulation of t cell activation GO:0050870 101 0.178
positive regulation of antimicrobial humoral response GO:0002760 2 0.176
regulation of cytokine production involved in immune response GO:0002718 26 0.172
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.171
regulation of cell killing GO:0031341 40 0.169
regulation of alpha beta t cell activation GO:0046634 53 0.167
regulation of protein deacetylation GO:0090311 17 0.166
interleukin 18 mediated signaling pathway GO:0035655 2 0.166
positive regulation of apoptotic signaling pathway GO:2001235 95 0.165
regulation of cellular amine metabolic process GO:0033238 20 0.164
leukocyte apoptotic process GO:0071887 71 0.162
toll like receptor 7 signaling pathway GO:0034154 4 0.160
regulation of cell migration GO:0030334 219 0.160
regulation of secretion by cell GO:1903530 249 0.160
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.159
cd8 positive alpha beta cytotoxic t cell extravasation GO:0035698 2 0.159
regulation of cell motility GO:2000145 236 0.157
positive regulation of protein phosphorylation GO:0001934 242 0.155
regulation of lymphocyte differentiation GO:0045619 107 0.155
cytokine biosynthetic process GO:0042089 68 0.154
myeloid leukocyte differentiation GO:0002573 119 0.152
regulation of leukocyte mediated immunity GO:0002703 104 0.152
positive regulation of cellular amine metabolic process GO:0033240 5 0.151
negative regulation of protein metabolic process GO:0051248 282 0.149
regulation of ion transport GO:0043269 215 0.148
negative regulation of defense response GO:0031348 77 0.147
protein ubiquitination GO:0016567 171 0.147
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.144
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.142
regulation of cellular ketone metabolic process GO:0010565 66 0.142
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.141
regulation of response to biotic stimulus GO:0002831 38 0.141
heterocycle catabolic process GO:0046700 280 0.140
positive regulation of necrotic cell death GO:0010940 1 0.136
negative regulation of inflammatory response GO:0050728 61 0.136
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.135
interspecies interaction between organisms GO:0044419 83 0.134
production of molecular mediator of immune response GO:0002440 103 0.132
regulation of jnk cascade GO:0046328 62 0.131
positive regulation of transferase activity GO:0051347 167 0.131
protein deacetylation GO:0006476 32 0.130
positive regulation of alpha beta t cell activation GO:0046635 39 0.128
protein oligomerization GO:0051259 67 0.128
wound healing involved in inflammatory response GO:0002246 4 0.128
stress activated mapk cascade GO:0051403 80 0.127
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.126
macromolecule deacylation GO:0098732 37 0.124
t cell receptor signaling pathway GO:0050852 46 0.124
macromolecule catabolic process GO:0009057 281 0.123
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.123
protein modification by small protein conjugation or removal GO:0070647 207 0.122
regulation of cytokine biosynthetic process GO:0042035 59 0.121
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.121
cytoplasmic transport GO:0016482 234 0.121
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.121
peptidyl serine modification GO:0018209 83 0.121
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.121
response to peptidoglycan GO:0032494 9 0.120
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.120
negative regulation of apoptotic signaling pathway GO:2001234 104 0.119
negative regulation of nf kappab transcription factor activity GO:0032088 15 0.119
organophosphate catabolic process GO:0046434 232 0.119
granulocyte chemotaxis GO:0071621 39 0.118
regulation of apoptotic signaling pathway GO:2001233 197 0.118
response to interleukin 18 GO:0070673 4 0.116
interferon beta biosynthetic process GO:0045350 4 0.116
purine containing compound metabolic process GO:0072521 311 0.115
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.115
skin development GO:0043588 220 0.115
regulation of t cell mediated immunity GO:0002709 34 0.114
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.112
positive regulation of adaptive immune response GO:0002821 61 0.112
regulation of alpha beta t cell differentiation GO:0046637 35 0.110
carbohydrate derivative biosynthetic process GO:1901137 183 0.110
regulation of t cell proliferation GO:0042129 92 0.110
organic cyclic compound catabolic process GO:1901361 295 0.109
macrophage activation GO:0042116 27 0.109
regulation of activated t cell proliferation GO:0046006 16 0.109
alpha beta t cell proliferation GO:0046633 21 0.107
t cell differentiation in thymus GO:0033077 77 0.107
regulation of protein complex assembly GO:0043254 83 0.104
regulation of protein localization GO:0032880 231 0.104
regulation of inflammatory response GO:0050727 147 0.104
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.104
regulation of b cell activation GO:0050864 81 0.104
protein modification by small protein conjugation GO:0032446 187 0.103
regulation of secretion GO:0051046 274 0.102
response to exogenous dsrna GO:0043330 22 0.102
regulation of nucleotide metabolic process GO:0006140 169 0.101
anion transport GO:0006820 177 0.101
positive regulation of hydrolase activity GO:0051345 148 0.100
t cell mediated immunity GO:0002456 50 0.100
programmed necrotic cell death GO:0097300 28 0.099
regulation of erk1 and erk2 cascade GO:0070372 71 0.099
negative regulation of cell activation GO:0050866 111 0.099
regulation of establishment of protein localization GO:0070201 181 0.098
ribonucleotide metabolic process GO:0009259 291 0.097
leukocyte mediated immunity GO:0002443 174 0.097
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 6 0.097
nucleobase containing small molecule metabolic process GO:0055086 352 0.097
myeloid dendritic cell activation GO:0001773 25 0.096
negative regulation of tumor necrosis factor production GO:0032720 17 0.095
regulation of body fluid levels GO:0050878 162 0.095
regulation of t helper 1 type immune response GO:0002825 17 0.095
nucleoside phosphate metabolic process GO:0006753 338 0.094
lymphocyte homeostasis GO:0002260 64 0.094
regulation of endothelial cell apoptotic process GO:2000351 9 0.094
peptidyl serine autophosphorylation GO:0036289 1 0.093
positive regulation of t cell proliferation GO:0042102 52 0.091
negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 17 0.091
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.090
regulation of mapk cascade GO:0043408 248 0.088
phagocytosis GO:0006909 66 0.088
regulation of type i interferon production GO:0032479 22 0.088
nitrogen compound transport GO:0071705 271 0.088
reactive oxygen species biosynthetic process GO:1903409 8 0.087
negative regulation of endothelial cell apoptotic process GO:2000352 7 0.087
small gtpase mediated signal transduction GO:0007264 97 0.087
negative regulation of multi organism process GO:0043901 68 0.087
t cell homeostasis GO:0043029 35 0.087
regulation of t cell apoptotic process GO:0070232 28 0.087
positive regulation of chemokine biosynthetic process GO:0045080 6 0.086
cellular response to growth factor stimulus GO:0071363 197 0.086
type i interferon signaling pathway GO:0060337 10 0.086
b 1 b cell homeostasis GO:0001922 4 0.086
negative regulation of t cell activation GO:0050868 65 0.086
purine containing compound catabolic process GO:0072523 213 0.086
cellular response to organic cyclic compound GO:0071407 87 0.086
response to molecule of fungal origin GO:0002238 4 0.085
ras protein signal transduction GO:0007265 77 0.085
leukocyte mediated cytotoxicity GO:0001909 62 0.085
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.084
ribose phosphate metabolic process GO:0019693 291 0.084
establishment of protein localization to organelle GO:0072594 118 0.084
protein localization to organelle GO:0033365 185 0.083
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.083
protein secretion GO:0009306 111 0.083
purine nucleotide metabolic process GO:0006163 302 0.083
nuclear transport GO:0051169 139 0.083
purine ribonucleoside metabolic process GO:0046128 241 0.083
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.083
positive regulation of protein kinase activity GO:0045860 144 0.082
regulation of production of molecular mediator of immune response GO:0002700 65 0.082
antibacterial peptide production GO:0002778 2 0.081
intrinsic apoptotic signaling pathway GO:0097193 132 0.081
necrotic cell death GO:0070265 30 0.081
amine metabolic process GO:0009308 45 0.081
positive regulation of cellular catabolic process GO:0031331 148 0.080
t cell mediated cytotoxicity GO:0001913 26 0.080
angiogenesis GO:0001525 201 0.080
positive regulation of t helper 1 type immune response GO:0002827 12 0.080
nucleocytoplasmic transport GO:0006913 139 0.079
antimicrobial peptide biosynthetic process GO:0002777 2 0.078
toll like receptor 9 signaling pathway GO:0034162 6 0.078
positive regulation of proteolysis GO:0045862 85 0.078
regulation of defense response to virus GO:0050688 18 0.078
gland development GO:0048732 330 0.077
regulation of ion transmembrane transport GO:0034765 119 0.076
cellular nitrogen compound catabolic process GO:0044270 280 0.076
regulation of defense response to virus by host GO:0050691 8 0.076
negative regulation of protein phosphorylation GO:0001933 126 0.075
transmembrane transport GO:0055085 412 0.074
antibacterial peptide biosynthetic process GO:0002780 2 0.074
negative regulation of interleukin 2 production GO:0032703 8 0.073
response to radiation GO:0009314 165 0.073
single organism nuclear import GO:1902593 95 0.073
nucleotide metabolic process GO:0009117 332 0.073
regulation of kinase activity GO:0043549 249 0.073
response to lipoteichoic acid GO:0070391 6 0.073
viral process GO:0016032 41 0.072
inflammatory response to wounding GO:0090594 4 0.071
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 9 0.070
osteoclast differentiation GO:0030316 62 0.069
protein autophosphorylation GO:0046777 61 0.069
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.069
purine nucleotide catabolic process GO:0006195 211 0.069
compound eye development GO:0048749 1 0.068
regulation of antimicrobial peptide production GO:0002784 1 0.068
g protein coupled receptor signaling pathway GO:0007186 243 0.068
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.068
cell killing GO:0001906 67 0.068
b cell mediated immunity GO:0019724 71 0.068
protein localization to nucleus GO:0034504 121 0.067
negative regulation of molecular function GO:0044092 258 0.067
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.067
negative regulation of protein modification process GO:0031400 163 0.067
spleen development GO:0048536 39 0.066
carbohydrate derivative catabolic process GO:1901136 231 0.066
positive regulation of nucleotide catabolic process GO:0030813 88 0.066
regulation of lymphocyte mediated immunity GO:0002706 84 0.065
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.065
antigen processing and presentation GO:0019882 47 0.065
regulation of hydrolase activity GO:0051336 246 0.065
positive regulation of secretion by cell GO:1903532 114 0.065
positive regulation of nucleotide metabolic process GO:0045981 114 0.065
antibacterial humoral response GO:0019731 8 0.065
posttranscriptional regulation of gene expression GO:0010608 155 0.064
regulation of organelle organization GO:0033043 289 0.064
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.064
response to type i interferon GO:0034340 12 0.063
protein catabolic process GO:0030163 221 0.063
purine nucleoside triphosphate metabolic process GO:0009144 226 0.063
lipid biosynthetic process GO:0008610 179 0.062
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.062
negative regulation of interleukin 6 production GO:0032715 17 0.062
immunoglobulin mediated immune response GO:0016064 69 0.061
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.061
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 16 0.061
engulfment of apoptotic cell GO:0043652 3 0.061
regulation of vitamin d biosynthetic process GO:0060556 1 0.060
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.060
aromatic compound catabolic process GO:0019439 286 0.060
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.060
purine ribonucleotide metabolic process GO:0009150 290 0.059
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.059
regulation of nucleocytoplasmic transport GO:0046822 73 0.059
regulation of t cell extravasation GO:2000407 3 0.058
regulation of intracellular protein transport GO:0033157 82 0.058
intracellular protein transport GO:0006886 204 0.058
glycosyl compound catabolic process GO:1901658 206 0.058
toll like receptor 2 signaling pathway GO:0034134 6 0.058
regulation of anion transport GO:0044070 27 0.058
regulation of t cell mediated cytotoxicity GO:0001914 18 0.058
regionalization GO:0003002 337 0.057
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.057
glycosyl compound metabolic process GO:1901657 246 0.057
regulation of cytoplasmic transport GO:1903649 112 0.057
nucleoside triphosphate metabolic process GO:0009141 230 0.056
purine nucleoside catabolic process GO:0006152 205 0.056
positive regulation of interferon beta production GO:0032728 8 0.056
response to light stimulus GO:0009416 135 0.056
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.056
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.056
nitric oxide metabolic process GO:0046209 25 0.055
cellular response to dna damage stimulus GO:0006974 207 0.055
muscle tissue development GO:0060537 308 0.055
macrophage differentiation GO:0030225 20 0.054
protein maturation GO:0051604 176 0.054
erk1 and erk2 cascade GO:0070371 77 0.053
positive regulation of leukocyte proliferation GO:0070665 73 0.053
nucleotide catabolic process GO:0009166 217 0.052
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.052
positive regulation of macrophage activation GO:0043032 10 0.052
immunoglobulin production GO:0002377 73 0.052
response to peptide GO:1901652 136 0.052
regulation of neuron differentiation GO:0045664 281 0.051
protein import into nucleus GO:0006606 95 0.051
ribonucleotide catabolic process GO:0009261 208 0.051
granulocyte migration GO:0097530 43 0.051
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.050
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.050
positive regulation of nervous system development GO:0051962 221 0.050
cellular response to peptide GO:1901653 92 0.050
negative regulation of phosphorus metabolic process GO:0010563 184 0.050
mucopolysaccharide metabolic process GO:1903510 25 0.050
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.050
regulation of protein ubiquitination GO:0031396 52 0.049
regulation of purine nucleotide metabolic process GO:1900542 169 0.049
purine nucleoside metabolic process GO:0042278 241 0.048
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.048
protein deacylation GO:0035601 36 0.048
positive regulation of inflammatory response GO:0050729 47 0.047
natural killer cell activation GO:0030101 44 0.047
interleukin 1 production GO:0032612 31 0.047
membrane organization GO:0061024 245 0.047
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.047
blood circulation GO:0008015 195 0.047
response to growth factor GO:0070848 198 0.047
regulation of protein serine threonine kinase activity GO:0071900 157 0.047
regulation of macrophage activation GO:0043030 17 0.046
cation homeostasis GO:0055080 212 0.046
toxin transport GO:1901998 38 0.046
positive regulation of protein transport GO:0051222 93 0.046
negative regulation of t cell proliferation GO:0042130 38 0.046
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.046
blood vessel morphogenesis GO:0048514 285 0.045
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.045
activation induced cell death of t cells GO:0006924 10 0.045
3 utr mediated mrna stabilization GO:0070935 2 0.045
organonitrogen compound catabolic process GO:1901565 264 0.045
regulation of interleukin 23 production GO:0032667 2 0.045
peptidyl tyrosine modification GO:0018212 145 0.044
positive regulation of necroptotic process GO:0060545 1 0.044
regulation of alpha beta t cell proliferation GO:0046640 18 0.044
rho protein signal transduction GO:0007266 32 0.044
cellular carbohydrate metabolic process GO:0044262 119 0.043
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.043
positive regulation of secretion GO:0051047 130 0.043
response to peptide hormone GO:0043434 127 0.043
positive regulation of protein deacetylation GO:0090312 9 0.042
regulation of oxidoreductase activity GO:0051341 15 0.042
cellular macromolecule catabolic process GO:0044265 206 0.042
ribonucleoside triphosphate metabolic process GO:0009199 220 0.042
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.042
regulation of type i interferon mediated signaling pathway GO:0060338 7 0.041
regulation of nitric oxide biosynthetic process GO:0045428 18 0.041
ribonucleoside catabolic process GO:0042454 206 0.041
regulation of cellular component biogenesis GO:0044087 181 0.041
amide transport GO:0042886 138 0.040
regulation of interferon beta production GO:0032648 13 0.040
organonitrogen compound biosynthetic process GO:1901566 192 0.040
peptidyl serine phosphorylation GO:0018105 74 0.040
rhythmic process GO:0048511 174 0.040
protein targeting GO:0006605 143 0.040
regulation of endopeptidase activity GO:0052548 89 0.039
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
blood coagulation GO:0007596 76 0.039
negative regulation of necroptotic process GO:0060546 9 0.038
polysaccharide metabolic process GO:0005976 39 0.038
regulation of antibacterial peptide production GO:0002786 1 0.038

Map3k8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.277
Human
disease of cellular proliferation DOID:14566 0 0.277
Human
organ system cancer DOID:0050686 0 0.148
Human