IMP

Process View

Mus musculus

12 genes annotated in mouse

response to type i interferon

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to type i interferon"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to type i interferon" (in gray)

Name	Description	Probability	Func Analog Organism
Irf9	interferon regulatory factor 9	0.997	Mouse
Stat2	signal transducer and activator of transcription 2	0.969	Mouse
Stat1	signal transducer and activator of transcription 1	0.925
Usp18	ubiquitin specific peptidase 18	0.806
Ifi35	interferon-induced protein 35	0.756
Stat3	signal transducer and activator of transcription 3	0.727	Mouse
Irf1	interferon regulatory factor 1	0.697	Mouse
Stat5b	signal transducer and activator of transcription 5B	0.668	Mouse
Uba7	ubiquitin-like modifier activating enzyme 7	0.603
Myd88	myeloid differentiation primary response gene 88	0.513
Trim21	tripartite motif-containing 21	0.476
Irf7	interferon regulatory factor 7	0.423
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.397
Il1r1	interleukin 1 receptor, type I	0.385
Isg15	ISG15 ubiquitin-like modifier	0.345	Human
Rsad2	radical S-adenosyl methionine domain containing 2	0.342
Stat5a	signal transducer and activator of transcription 5A	0.340	Mouse
Irgm2	immunity-related GTPase family M member 2	0.331
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.329
Irgm1	immunity-related GTPase family M member 1	0.321
Igtp	interferon gamma induced GTPase	0.320
Parp14	poly (ADP-ribose) polymerase family, member 14	0.319
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.298
H2-K1	histocompatibility 2, K1, K region	0.244
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.211	Human
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.211
Bcl3	B-cell leukemia/lymphoma 3	0.186
Unc93b1	unc-93 homolog B1 (C. elegans)	0.179
Mx1	myxovirus (influenza virus) resistance 1	0.168
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.168
Pparg	peroxisome proliferator activated receptor gamma	0.150
H2-D1	histocompatibility 2, D region locus 1	0.135
Trim30a	tripartite motif-containing 30A	0.131
Tapbp	TAP binding protein	0.124
Tgtp2	T-cell specific GTPase 2	0.118
Tor3a	torsin family 3, member A	0.111
Parp10	poly (ADP-ribose) polymerase family, member 10	0.101
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.089
Ifi47	interferon gamma inducible protein 47	0.081
Rtp4	receptor transporter protein 4	0.078
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.077
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.077
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.074
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.072
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.063
Gbp7	guanylate binding protein 7	0.062
Stat6	signal transducer and activator of transcription 6	0.061	Mouse
Traf3	TNF receptor-associated factor 3	0.060
Ncoa3	nuclear receptor coactivator 3	0.059
Znfx1	zinc finger, NFX1-type containing 1	0.058
Ifnar2	interferon (alpha and beta) receptor 2	0.058
Nmi	N-myc (and STAT) interactor	0.057
Mx2	myxovirus (influenza virus) resistance 2	0.055
Il4ra	interleukin 4 receptor, alpha	0.055
Oas1a	2'-5' oligoadenylate synthetase 1A	0.052
Ifnar1	interferon (alpha and beta) receptor 1	0.052
Ifi44	interferon-induced protein 44	0.051
Socs3	suppressor of cytokine signaling 3	0.050
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.050
BC006779	cDNA sequence BC006779	0.050
Lepr	leptin receptor	0.043
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.042
Lgals9	lectin, galactose binding, soluble 9	0.041
Sfpi1	SFFV proviral integration 1	0.041
Csf1	colony stimulating factor 1 (macrophage)	0.040
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.039
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.038
Icam1	intercellular adhesion molecule 1	0.038
Fas	Fas (TNF receptor superfamily member 6)	0.037
Irf8	interferon regulatory factor 8	0.037	Mouse
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.036
Gbp3	guanylate binding protein 3	0.035
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.035
Trim30d	tripartite motif-containing 30D	0.035
Pml	promyelocytic leukemia	0.035
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.033
Lyz2	lysozyme 2	0.033
Junb	Jun-B oncogene	0.032
Irf4	interferon regulatory factor 4	0.032	Mouse
Ticam1	toll-like receptor adaptor molecule 1	0.032
Gbp2	guanylate binding protein 2	0.030
Ifitm2	interferon induced transmembrane protein 2	0.030
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.029
Pyhin1	pyrin and HIN domain family, member 1	0.029
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.028
Cxcl10	chemokine (C-X-C motif) ligand 10	0.028
Parp12	poly (ADP-ribose) polymerase family, member 12	0.028
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.027
Zbp1	Z-DNA binding protein 1	0.026
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.026
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.025
Adar	adenosine deaminase, RNA-specific	0.025
Tmem176a	transmembrane protein 176A	0.024
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.024
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.023
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.023
Batf	basic leucine zipper transcription factor, ATF-like	0.023
Slfn2	schlafen 2	0.021
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.021
Prlr	prolactin receptor	0.021
Parp9	poly (ADP-ribose) polymerase family, member 9	0.020
Samd9l	sterile alpha motif domain containing 9-like	0.019
Ifih1	interferon induced with helicase C domain 1	0.019
D14Ertd668e	DNA segment, Chr 14, ERATO Doi 668, expressed	0.018
Trim25	tripartite motif-containing 25	0.018
Ifi203	interferon activated gene 203	0.017
Daxx	Fas death domain-associated protein	0.017
Ccl2	chemokine (C-C motif) ligand 2	0.017
Cd274	CD274 antigen	0.017
Oas2	2'-5' oligoadenylate synthetase 2	0.017
BC013712	cDNA sequence BC013712	0.016
Il17ra	interleukin 17 receptor A	0.016
Epsti1	epithelial stromal interaction 1 (breast)	0.016
Dtx3l	deltex 3-like (Drosophila)	0.016
Rnf31	ring finger protein 31	0.016
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.016
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.016
Jak3	Janus kinase 3	0.016
Dock2	dedicator of cyto-kinesis 2	0.016
Bst2	bone marrow stromal cell antigen 2	0.016
Samhd1	SAM domain and HD domain, 1	0.016
Jak2	Janus kinase 2	0.016
Il6st	interleukin 6 signal transducer	0.015
Irf5	interferon regulatory factor 5	0.015	Mouse
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.015
Cd72	CD72 antigen	0.014
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.014
Ifitm3	interferon induced transmembrane protein 3	0.014
Iigp1	interferon inducible GTPase 1	0.014
Ccl5	chemokine (C-C motif) ligand 5	0.014
Herc6	hect domain and RLD 6	0.013
Traf2	TNF receptor-associated factor 2	0.013
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.013
Ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.013
Tapbpl	TAP binding protein-like	0.013
Oas1b	2'-5' oligoadenylate synthetase 1B	0.012
Tmem173	transmembrane protein 173	0.012
Sfn	stratifin	0.012
Hck	hemopoietic cell kinase	0.012
Flii	flightless I homolog (Drosophila)	0.011
Slfn8	schlafen 8	0.011
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.011
H2-T24	histocompatibility 2, T region locus 24	0.011
Jak1	Janus kinase 1	0.011
H2-Q8	histocompatibility 2, Q region locus 8	0.011
Nckap1l	NCK associated protein 1 like	0.011
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.011
Birc3	baculoviral IAP repeat-containing 3	0.011
Rhog	ras homolog gene family, member G	0.011
Arid1b	AT rich interactive domain 1B (SWI-like)	0.011
Cxcl9	chemokine (C-X-C motif) ligand 9	0.010
Shisa5	shisa homolog 5 (Xenopus laevis)	0.010
Ikbkb	inhibitor of kappaB kinase beta	0.010