Mus musculus

116 known processes

Numb

numb gene homolog (Drosophila)

(Aliases: m-numb,mnb,m-Nb)

Numb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of hydrolase activity GO:0051336 246 0.739
myeloid cell differentiation GO:0030099 233 0.612
Zebrafish
wnt signaling pathway GO:0016055 188 0.558
cell adhesion GO:0007155 329 0.542
formation of radial glial scaffolds GO:0021943 4 0.532
forebrain development GO:0030900 302 0.489
apoptotic signaling pathway GO:0097190 306 0.483
positive regulation of apoptotic process GO:0043065 217 0.463
positive regulation of apoptotic signaling pathway GO:2001235 95 0.446
amine metabolic process GO:0009308 45 0.435
protein processing GO:0016485 163 0.433
protein localization to membrane GO:0072657 108 0.408
Human Worm
positive regulation of hydrolase activity GO:0051345 148 0.399
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.390
Worm
hindbrain radial glia guided cell migration GO:0021932 12 0.380
regulation of apoptotic signaling pathway GO:2001233 197 0.357
axonogenesis GO:0007409 274 0.355
negative regulation of molecular function GO:0044092 258 0.349
positive regulation of rho gtpase activity GO:0032321 41 0.330
endomembrane system organization GO:0010256 147 0.322
Human
digestive tract development GO:0048565 190 0.307
positive regulation of cell death GO:0010942 224 0.296
regulation of peptidase activity GO:0052547 96 0.292
extrinsic apoptotic signaling pathway GO:0097191 126 0.291
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.290
negative regulation of cell proliferation GO:0008285 296 0.284
regulation of cellular ketone metabolic process GO:0010565 66 0.282
rna 3 end processing GO:0031123 20 0.281
g protein coupled receptor signaling pathway GO:0007186 243 0.279
developmental cell growth GO:0048588 84 0.275
morphogenesis of a branching epithelium GO:0061138 193 0.272
sensory organ morphogenesis GO:0090596 242 0.259
skeletal system development GO:0001501 356 0.255
positive regulation of programmed cell death GO:0043068 218 0.254
membrane organization GO:0061024 245 0.253
Human Worm
cellular ketone metabolic process GO:0042180 84 0.244
rho protein signal transduction GO:0007266 32 0.242
telencephalon development GO:0021537 186 0.242
response to organonitrogen compound GO:0010243 246 0.241
peptidyl amino acid modification GO:0018193 336 0.239
regulation of cell migration GO:0030334 219 0.236
Human
myeloid leukocyte differentiation GO:0002573 119 0.234
neuron projection extension GO:1990138 64 0.233
neuroblast division in subventricular zone GO:0021849 2 0.232
regulation of endopeptidase activity GO:0052548 89 0.230
kidney development GO:0001822 213 0.229
cell cell junction organization GO:0045216 72 0.228
negative regulation of apoptotic signaling pathway GO:2001234 104 0.226
cell junction maintenance GO:0034331 4 0.223
synaptic transmission GO:0007268 329 0.222
developmental growth involved in morphogenesis GO:0060560 138 0.217
protein maturation GO:0051604 176 0.207
dendrite development GO:0016358 115 0.204
positive regulation of gtpase activity GO:0043547 85 0.200
regulation of myeloid cell differentiation GO:0045637 96 0.199
small gtpase mediated signal transduction GO:0007264 97 0.197
maintenance of location GO:0051235 89 0.197
gliogenesis GO:0042063 141 0.196
Fly
regulation of cellular amino acid metabolic process GO:0006521 5 0.196
regulation of cell motility GO:2000145 236 0.195
Human
anion transport GO:0006820 177 0.195
Worm
transmembrane transport GO:0055085 412 0.190
copper ion homeostasis GO:0055070 9 0.187
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.187
digestive tract morphogenesis GO:0048546 147 0.187
ras protein signal transduction GO:0007265 77 0.183
morphogenesis of a branching structure GO:0001763 203 0.181
establishment or maintenance of cell polarity GO:0007163 86 0.181
single organism cell adhesion GO:0098602 156 0.181
neuron apoptotic process GO:0051402 142 0.181
single organismal cell cell adhesion GO:0016337 131 0.181
regulation of cellular amine metabolic process GO:0033238 20 0.178
response to organic cyclic compound GO:0014070 198 0.178
cellular amine metabolic process GO:0044106 44 0.177
response to radiation GO:0009314 165 0.176
urogenital system development GO:0001655 261 0.176
Fly
regulation of ras gtpase activity GO:0032318 88 0.175
regulation of cellular catabolic process GO:0031329 242 0.169
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.166
peptidyl tyrosine phosphorylation GO:0018108 143 0.165
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.163
negative regulation of cell development GO:0010721 169 0.162
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.160
muscle cell differentiation GO:0042692 261 0.159
Fly
negative regulation of protein metabolic process GO:0051248 282 0.158
regulation of synapse structural plasticity GO:0051823 4 0.157
ribose phosphate metabolic process GO:0019693 291 0.156
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.156
digestive system development GO:0055123 200 0.155
cell junction organization GO:0034330 77 0.155
cellular lipid metabolic process GO:0044255 323 0.154
renal tubule development GO:0061326 87 0.153
Fly
kidney morphogenesis GO:0060993 83 0.153
gastrulation GO:0007369 116 0.152
hindbrain development GO:0030902 128 0.152
regulation of purine nucleotide metabolic process GO:1900542 169 0.151
cell migration involved in gastrulation GO:0042074 13 0.150
insulin metabolic process GO:1901142 3 0.149
stem cell differentiation GO:0048863 268 0.149
cell growth GO:0016049 130 0.148
regulation of nucleoside metabolic process GO:0009118 130 0.148
nephron epithelium morphogenesis GO:0072088 68 0.148
ureteric bud morphogenesis GO:0060675 62 0.146
synapse organization GO:0050808 125 0.143
chemotaxis GO:0006935 247 0.143
appendage development GO:0048736 166 0.142
regulation of protein kinase activity GO:0045859 232 0.141
lung development GO:0030324 164 0.140
stem cell proliferation GO:0072089 117 0.140
oxidation reduction process GO:0055114 342 0.140
positive regulation of protein kinase activity GO:0045860 144 0.140
regulation of chemotaxis GO:0050920 53 0.136
leukocyte migration GO:0050900 124 0.135
regulation of binding GO:0051098 111 0.134
ion transmembrane transport GO:0034220 361 0.134
mesoderm development GO:0007498 100 0.133
epithelial tube morphogenesis GO:0060562 303 0.133
leukocyte proliferation GO:0070661 172 0.133
regulation of neuron differentiation GO:0045664 281 0.130
embryonic skeletal system development GO:0048706 120 0.130
regulation of wnt signaling pathway GO:0030111 123 0.129
skeletal system morphogenesis GO:0048705 203 0.128
endocytosis GO:0006897 168 0.126
Fly
renal system development GO:0072001 225 0.125
Fly
pole plasm assembly GO:0007315 2 0.124
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.124
cellular response to cytokine stimulus GO:0071345 189 0.123
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.122
polarity specification of proximal distal axis GO:0010085 2 0.121
branching morphogenesis of an epithelial tube GO:0048754 159 0.119
vesicle localization GO:0051648 86 0.118
cytoskeleton dependent intracellular transport GO:0030705 50 0.117
regulation of ion transport GO:0043269 215 0.116
embryonic epithelial tube formation GO:0001838 130 0.115
cell fate specification GO:0001708 72 0.112
Fly
rhodopsin mediated signaling pathway GO:0016056 4 0.111
cytokine mediated signaling pathway GO:0019221 115 0.111
epithelial cell proliferation GO:0050673 174 0.110
negative regulation of protein phosphorylation GO:0001933 126 0.110
regulation of nucleotide catabolic process GO:0030811 122 0.108
ubiquitin dependent protein catabolic process GO:0006511 129 0.107
morphogenesis of embryonic epithelium GO:0016331 159 0.107
regulation of gtp catabolic process GO:0033124 113 0.107
cellular copper ion homeostasis GO:0006878 8 0.107
alcohol metabolic process GO:0006066 116 0.106
regulation of asymmetric cell division GO:0009786 4 0.105
Fly
protein targeting GO:0006605 143 0.105
Worm
nucleobase containing small molecule metabolic process GO:0055086 352 0.105
endocrine system development GO:0035270 98 0.105
locomotory behavior GO:0007626 195 0.104
modification dependent macromolecule catabolic process GO:0043632 133 0.104
asymmetric stem cell division GO:0098722 3 0.104
Fly
positive regulation of growth GO:0045927 104 0.104
neuron maturation GO:0042551 29 0.103
purine nucleotide metabolic process GO:0006163 302 0.102
positive regulation of nucleotide catabolic process GO:0030813 88 0.102
establishment of protein localization to membrane GO:0090150 54 0.102
Worm
positive regulation of cell development GO:0010720 237 0.101
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.101
neural tube development GO:0021915 160 0.100
asymmetric neuroblast division GO:0055059 1 0.100
Fly
regulation of membrane potential GO:0042391 192 0.099
negative regulation of nervous system development GO:0051961 156 0.098
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.098
camera type eye development GO:0043010 266 0.098
body morphogenesis GO:0010171 45 0.098
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.098
regulation of canonical wnt signaling pathway GO:0060828 82 0.097
somatic stem cell maintenance GO:0035019 47 0.097
negative regulation of cellular protein metabolic process GO:0032269 247 0.097
regulation of t cell activation GO:0050863 170 0.097
positive regulation of protein modification process GO:0031401 299 0.095
protein modification by small protein conjugation or removal GO:0070647 207 0.095
cellular homeostasis GO:0019725 240 0.095
regulation of stem cell proliferation GO:0072091 78 0.094
positive regulation of gtp catabolic process GO:0033126 85 0.094
cation transport GO:0006812 399 0.094
response to light stimulus GO:0009416 135 0.094
leukocyte differentiation GO:0002521 342 0.093
guanosine containing compound metabolic process GO:1901068 144 0.093
regulation of leukocyte differentiation GO:1902105 159 0.093
cell type specific apoptotic process GO:0097285 268 0.093
signal transduction in absence of ligand GO:0038034 55 0.093
regulation of cysteine type endopeptidase activity GO:2000116 65 0.092
myeloid cell homeostasis GO:0002262 114 0.091
Zebrafish
smoothened signaling pathway GO:0007224 105 0.091
positive regulation of nucleotide metabolic process GO:0045981 114 0.090
purine containing compound metabolic process GO:0072521 311 0.089
regulation of receptor activity GO:0010469 41 0.089
cell chemotaxis GO:0060326 81 0.088
gtp metabolic process GO:0046039 144 0.088
positive regulation of protein phosphorylation GO:0001934 242 0.088
purine ribonucleotide metabolic process GO:0009150 290 0.088
regulation of protein tyrosine kinase activity GO:0061097 17 0.088
ribonucleoside catabolic process GO:0042454 206 0.087
stem cell development GO:0048864 219 0.087
negative regulation of hydrolase activity GO:0051346 71 0.087
adult behavior GO:0030534 135 0.086
regulation of proteolysis GO:0030162 164 0.085
organelle localization GO:0051640 179 0.085
Fly
negative regulation of phosphorylation GO:0042326 166 0.085
regulation of axon extension GO:0030516 43 0.085
glycoprotein biosynthetic process GO:0009101 89 0.085
microtubule based process GO:0007017 236 0.085
regulation of cell adhesion GO:0030155 154 0.084
regulation of lymphocyte proliferation GO:0050670 117 0.084
neural precursor cell proliferation GO:0061351 121 0.084
purine nucleoside metabolic process GO:0042278 241 0.084
negative regulation of cellular amine metabolic process GO:0033239 1 0.083
nephron development GO:0072006 109 0.083
peptidyl tyrosine modification GO:0018212 145 0.083
glial cell differentiation GO:0010001 131 0.083
negative regulation of wnt signaling pathway GO:0030178 73 0.083
nitrogen compound transport GO:0071705 271 0.083
t cell proliferation GO:0042098 120 0.083
regulation of rho protein signal transduction GO:0035023 71 0.082
dna metabolic process GO:0006259 303 0.082
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.082
morphogenesis of a polarized epithelium GO:0001738 37 0.081
bmp signaling pathway GO:0030509 93 0.081
neuromuscular process GO:0050905 99 0.081
purine nucleotide catabolic process GO:0006195 211 0.081
neuron projection guidance GO:0097485 141 0.081
hormone metabolic process GO:0042445 86 0.080
cellular nitrogen compound catabolic process GO:0044270 280 0.080
proteoglycan biosynthetic process GO:0030166 20 0.080
negative regulation of cellular component organization GO:0051129 194 0.080
Human
protein localization to plasma membrane GO:0072659 57 0.079
Human
glycosyl compound metabolic process GO:1901657 246 0.078
canonical wnt signaling pathway GO:0060070 130 0.078
male gamete generation GO:0048232 285 0.078
regulation of mapk cascade GO:0043408 248 0.078
cellular macromolecule catabolic process GO:0044265 206 0.077
ameboidal type cell migration GO:0001667 128 0.077
microtubule based transport GO:0010970 50 0.077
ribonucleotide metabolic process GO:0009259 291 0.076
microtubule cytoskeleton organization GO:0000226 157 0.076
protein ubiquitination GO:0016567 171 0.076
cellular response to organic cyclic compound GO:0071407 87 0.076
cellular divalent inorganic cation homeostasis GO:0072503 127 0.076
circulatory system process GO:0003013 197 0.076
blood vessel morphogenesis GO:0048514 285 0.075
regulation of purine nucleotide catabolic process GO:0033121 122 0.075
positive regulation of endocytosis GO:0045807 42 0.075
Fly
regulation of nucleotide metabolic process GO:0006140 169 0.075
angiogenesis GO:0001525 201 0.074
negative regulation of protein processing GO:0010955 79 0.074
regionalization GO:0003002 337 0.074
positive regulation of cell motility GO:2000147 116 0.074
Human
purine containing compound catabolic process GO:0072523 213 0.073
mrna 3 end processing GO:0031124 16 0.073
sensory perception GO:0007600 245 0.072
regulation of protein localization GO:0032880 231 0.072
Human
tube formation GO:0035148 140 0.072
macromolecule catabolic process GO:0009057 281 0.072
nephron morphogenesis GO:0072028 69 0.072
regulation of protein processing GO:0070613 96 0.072
regulation of cytokine production GO:0001817 266 0.071
cellular amino acid metabolic process GO:0006520 103 0.071
negative regulation of epithelial cell proliferation GO:0050680 64 0.071
gtp catabolic process GO:0006184 143 0.071
positive regulation of ras gtpase activity GO:0032320 65 0.070
regulation of leukocyte proliferation GO:0070663 121 0.070
modification dependent protein catabolic process GO:0019941 133 0.070
l amino acid transport GO:0015807 32 0.070
regulation of intracellular protein transport GO:0033157 82 0.070
regulation of protein binding GO:0043393 60 0.069
regulation of actin cytoskeleton organization GO:0032956 84 0.069
ossification GO:0001503 216 0.069
positive regulation of proteolysis GO:0045862 85 0.069
leukocyte activation involved in immune response GO:0002366 126 0.069
positive regulation of dna biosynthetic process GO:2000573 4 0.069
positive regulation of nucleoside metabolic process GO:0045979 91 0.068
nephron tubule morphogenesis GO:0072078 68 0.068
striated muscle tissue development GO:0014706 293 0.068
mesonephric epithelium development GO:0072163 94 0.068
embryonic organ morphogenesis GO:0048562 276 0.067
positive regulation of leukocyte differentiation GO:1902107 86 0.067
cell fate commitment GO:0045165 210 0.067
Fly
organic cyclic compound catabolic process GO:1901361 295 0.067
cellular chemical homeostasis GO:0055082 215 0.067
embryonic skeletal system morphogenesis GO:0048704 91 0.067
cellular protein catabolic process GO:0044257 155 0.066
positive regulation of cell adhesion GO:0045785 80 0.066
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.066
negative regulation of protein maturation GO:1903318 79 0.066
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.066
glycoprotein metabolic process GO:0009100 116 0.066
embryonic appendage morphogenesis GO:0035113 126 0.066
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.066
cytoskeletal anchoring at plasma membrane GO:0007016 2 0.065
regulation of neural precursor cell proliferation GO:2000177 70 0.065
defecation GO:0030421 1 0.065
retinoid metabolic process GO:0001523 24 0.065
response to lipopolysaccharide GO:0032496 128 0.064
steroid metabolic process GO:0008202 119 0.064
directional locomotion GO:0033058 3 0.064
multicellular organismal homeostasis GO:0048871 164 0.064
protein oligomerization GO:0051259 67 0.063
regulation of transferase activity GO:0051338 263 0.063
guanosine containing compound catabolic process GO:1901069 144 0.063
respiratory system development GO:0060541 190 0.063
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.062
nuclear transport GO:0051169 139 0.062
regulation of erbb signaling pathway GO:1901184 16 0.062
intracellular protein transport GO:0006886 204 0.062
Worm
regulation of protein serine threonine kinase activity GO:0071900 157 0.062
regulation of ras protein signal transduction GO:0046578 114 0.062
nephron epithelium development GO:0072009 92 0.062
purine ribonucleoside metabolic process GO:0046128 241 0.062
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.061
neuroblast proliferation GO:0007405 49 0.061
axon guidance GO:0007411 141 0.061
osteoclast differentiation GO:0030316 62 0.061
regulation of map kinase activity GO:0043405 120 0.061
regulation of t cell proliferation GO:0042129 92 0.061
endodermal cell fate specification GO:0001714 4 0.061
regulation of resting membrane potential GO:0060075 3 0.060
regulation of gliogenesis GO:0014013 50 0.060
establishment of vesicle localization GO:0051650 81 0.060
positive regulation of cell projection organization GO:0031346 95 0.060
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.060
axis elongation involved in somitogenesis GO:0090245 4 0.060
cognition GO:0050890 149 0.059
homeostasis of number of cells GO:0048872 210 0.059
Zebrafish
negative regulation of peptidase activity GO:0010466 46 0.059
regulation of lymphocyte activation GO:0051249 240 0.059
negative regulation of immune system process GO:0002683 209 0.058
positive regulation of cellular amine metabolic process GO:0033240 5 0.058
nephron tubule development GO:0072080 84 0.058
cellular transition metal ion homeostasis GO:0046916 32 0.058
regulation of hormone levels GO:0010817 211 0.057
organic hydroxy compound metabolic process GO:1901615 203 0.057
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.057
regulation of establishment of protein localization GO:0070201 181 0.057
regulation of epithelial cell proliferation GO:0050678 141 0.057
negative regulation of cell adhesion GO:0007162 45 0.056
negative regulation of phosphate metabolic process GO:0045936 184 0.056
ensheathment of neurons GO:0007272 76 0.056
positive regulation of transferase activity GO:0051347 167 0.056
innate immune response GO:0045087 157 0.056
negative regulation of neuron differentiation GO:0045665 101 0.056
mesonephric tubule morphogenesis GO:0072171 63 0.056
positive regulation of kinase activity GO:0033674 155 0.056
negative regulation of phosphorus metabolic process GO:0010563 184 0.055
cell cell junction assembly GO:0007043 27 0.055
regulation of kinase activity GO:0043549 249 0.055
muscle tissue development GO:0060537 308 0.055
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.055
cell matrix adhesion GO:0007160 68 0.055
nucleoside phosphate metabolic process GO:0006753 338 0.055
mapk cascade GO:0000165 281 0.055
transition metal ion transport GO:0000041 38 0.054
regulation of interleukin 8 production GO:0032677 3 0.054
ribonucleoside metabolic process GO:0009119 245 0.053
schwann cell proliferation GO:0014010 2 0.053
regulation of synaptic plasticity GO:0048167 87 0.053
regulation of protein maturation GO:1903317 96 0.053
apical junction assembly GO:0043297 15 0.053
bone remodeling GO:0046849 53 0.053
gland development GO:0048732 330 0.053
protein modification by small protein conjugation GO:0032446 187 0.053
activation of cdc42 gtpase activity GO:0032864 2 0.053
lymphocyte proliferation GO:0046651 164 0.053
cellular response to growth factor stimulus GO:0071363 197 0.052
regulation of anatomical structure size GO:0090066 178 0.052
cellular response to organonitrogen compound GO:0071417 145 0.052
nucleoside triphosphate catabolic process GO:0009143 205 0.052
response to metal ion GO:0010038 47 0.052
oocyte anterior posterior axis specification GO:0007314 2 0.052
immune effector process GO:0002252 321 0.052
central nervous system neuron differentiation GO:0021953 162 0.052
embryonic hemopoiesis GO:0035162 23 0.051
Zebrafish
negative regulation of cell motility GO:2000146 61 0.051
establishment of endothelial blood brain barrier GO:0014045 3 0.051
positive regulation of lymphocyte activation GO:0051251 140 0.051
lipid homeostasis GO:0055088 63 0.051
Mouse
extracellular matrix organization GO:0030198 147 0.051
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.051
spermatogenesis GO:0007283 284 0.051
regulation of secretion GO:0051046 274 0.051
purine ribonucleotide catabolic process GO:0009154 208 0.051
pharynx development GO:0060465 1 0.050
spermatid differentiation GO:0048515 115 0.050
protein localization to nucleus GO:0034504 121 0.050
negative regulation of protein modification process GO:0031400 163 0.050
organonitrogen compound biosynthetic process GO:1901566 192 0.050
cellular response to radiation GO:0071478 28 0.050
generation of precursor metabolites and energy GO:0006091 103 0.050
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.049
tissue remodeling GO:0048771 102 0.049
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.049
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.049
learning or memory GO:0007611 148 0.049
regulation of endocytosis GO:0030100 69 0.049
Fly
anterior posterior axis specification embryo GO:0008595 9 0.049
interleukin 8 production GO:0032637 4 0.049
ureteric bud development GO:0001657 94 0.048
ventricular system development GO:0021591 27 0.048
alpha amino acid metabolic process GO:1901605 59 0.048
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.048
ribonucleoside triphosphate catabolic process GO:0009203 199 0.048
carbohydrate derivative biosynthetic process GO:1901137 183 0.048
developmental maturation GO:0021700 193 0.048
formation of primary germ layer GO:0001704 77 0.048
nucleotide metabolic process GO:0009117 332 0.048
monocarboxylic acid metabolic process GO:0032787 191 0.047
long term memory GO:0007616 15 0.047
cell activation involved in immune response GO:0002263 126 0.047
positive regulation of cellular catabolic process GO:0031331 148 0.047
mesenchyme development GO:0060485 152 0.047
nucleoside metabolic process GO:0009116 246 0.047
cytokine production GO:0001816 319 0.047
divalent inorganic cation transport GO:0072511 178 0.047
glucose homeostasis GO:0042593 128 0.047
leukocyte chemotaxis GO:0030595 69 0.046
regulation of transmembrane transport GO:0034762 128 0.046
immune response activating signal transduction GO:0002757 116 0.046
rna polyadenylation GO:0043631 6 0.046
negative regulation of cytokine production GO:0001818 84 0.046
activation of immune response GO:0002253 138 0.046
receptor mediated endocytosis GO:0006898 51 0.046
organic anion transport GO:0015711 137 0.046
Worm
regulation of smoothened signaling pathway GO:0008589 58 0.046
blood circulation GO:0008015 195 0.046
regulation of neuron projection development GO:0010975 169 0.046
visual learning GO:0008542 44 0.046
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.046
small molecule biosynthetic process GO:0044283 132 0.046
neural tube formation GO:0001841 108 0.045
response to molecule of bacterial origin GO:0002237 143 0.045
neuron death GO:0070997 154 0.045
regulation of myeloid leukocyte differentiation GO:0002761 58 0.045
positive regulation of protein transport GO:0051222 93 0.045
organophosphate catabolic process GO:0046434 232 0.045
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.045
regulation of organ morphogenesis GO:2000027 144 0.045
negative regulation of kinase activity GO:0033673 81 0.045
salivary gland development GO:0007431 37 0.045
regulation of cardiac cell fate specification GO:2000043 1 0.045
anatomical structure homeostasis GO:0060249 145 0.044
regulation of striated muscle cell differentiation GO:0051153 81 0.044
regulation of system process GO:0044057 200 0.044
regulation of protein transport GO:0051223 163 0.043
embryonic limb morphogenesis GO:0030326 126 0.043
response to inorganic substance GO:0010035 96 0.043
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.043
carboxylic acid transport GO:0046942 100 0.043
establishment of protein localization to organelle GO:0072594 118 0.043
adult locomotory behavior GO:0008344 91 0.043
myelination GO:0042552 74 0.043
fat cell differentiation GO:0045444 160 0.043
extracellular structure organization GO:0043062 148 0.042
regulation of cell projection organization GO:0031344 206 0.042
cellular response to light stimulus GO:0071482 19 0.042
notch signaling pathway GO:0007219 71 0.042
mitotic cell cycle process GO:1903047 159 0.042
lipid localization GO:0010876 126 0.042
Worm
telencephalon cell migration GO:0022029 55 0.042
metal ion homeostasis GO:0055065 189 0.042
regulation of cytoskeleton organization GO:0051493 122 0.041
organonitrogen compound catabolic process GO:1901565 264 0.041
transition metal ion homeostasis GO:0055076 54 0.041
mitotic cell cycle GO:0000278 195 0.041
microtubule based movement GO:0007018 84 0.041
cellular response to hormone stimulus GO:0032870 150 0.041
stem cell division GO:0017145 30 0.041
response to drug GO:0042493 75 0.041
positive regulation of secretion GO:0051047 130 0.041
axon cargo transport GO:0008088 33 0.041
positive regulation of secretion by cell GO:1903532 114 0.041
germ line stem cell division GO:0042078 2 0.041
positive regulation of myeloid cell differentiation GO:0045639 43 0.040
response to growth factor GO:0070848 198 0.040
cellularization GO:0007349 1 0.040
heterocycle catabolic process GO:0046700 280 0.040
muscle fiber development GO:0048747 76 0.040
adherens junction assembly GO:0034333 22 0.040
radial glia guided migration of purkinje cell GO:0021942 6 0.040
regulation of cell cycle GO:0051726 281 0.040
lateral inhibition GO:0046331 1 0.040
axon ensheathment GO:0008366 76 0.040
hormone secretion GO:0046879 128 0.039
purine nucleoside catabolic process GO:0006152 205 0.039
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.039
negative regulation of endopeptidase activity GO:0010951 44 0.039

Numb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.154
disease of anatomical entity DOID:7 0 0.154
nervous system disease DOID:863 0 0.154
neurodegenerative disease DOID:1289 0 0.092
disease of metabolism DOID:0014667 0 0.083
acquired metabolic disease DOID:0060158 0 0.083
cancer DOID:162 0 0.081
disease of cellular proliferation DOID:14566 0 0.081
dementia DOID:1307 0 0.058
alzheimer s disease DOID:10652 0 0.058
disease of mental health DOID:150 0 0.058
tauopathy DOID:680 0 0.058
cognitive disorder DOID:1561 0 0.058