IMP
Process View
Mus musculus
0 genes annotated in mouse
alzheimer s disease
DOID:10652
A dementia and a tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.
In addition to gene-name show these genes:
Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Psen1 | presenilin 1 | 0.958 | Human | |
| Prnp | prion protein | 0.629 | ||
| Ncstn | nicastrin | 0.550 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.499 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.248 | ||
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.202 | ||
| App | amyloid beta (A4) precursor protein | 0.190 | Human | |
| Aplp2 | amyloid beta (A4) precursor-like protein 2 | 0.140 | ||
| Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1 | 0.077 | ||
| Psen2 | presenilin 2 | 0.075 | Human | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.060 | ||
| Numb | numb gene homolog (Drosophila) | 0.058 | ||
| Erlin2 | ER lipid raft associated 2 | 0.055 | ||
| Psap | prosaposin | 0.049 | ||
| Itm2b | integral membrane protein 2B | 0.043 | ||
| Clstn1 | calsyntenin 1 | 0.043 | ||
| Npc1 | Niemann Pick type C1 | 0.029 | ||
| Ctsd | cathepsin D | 0.027 | ||
| Calr | calreticulin | 0.025 | ||
| Cp | ceruloplasmin | 0.023 | ||
| Nucb1 | nucleobindin 1 | 0.022 | ||
| Dlg1 | discs, large homolog 1 (Drosophila) | 0.019 | ||
| Psenen | presenilin enhancer 2 homolog (C. elegans) | 0.018 | ||
| 0610031J06Rik | RIKEN cDNA 0610031J06 gene | 0.018 | ||
| Plat | plasminogen activator, tissue | 0.016 | ||
| Itm2c | integral membrane protein 2C | 0.015 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.015 | ||
| Wls | wntless homolog (Drosophila) | 0.015 | ||
| Ldlr | low density lipoprotein receptor | 0.015 | ||
| Gnb2 | guanine nucleotide binding protein (G protein), beta 2 | 0.013 | ||
| Sparcl1 | SPARC-like 1 | 0.013 | ||
| Cpd | carboxypeptidase D | 0.013 | ||
| Atp6v0d1 | ATPase, H+ transporting, lysosomal V0 subunit D1 | 0.012 | ||
| Mecp2 | methyl CpG binding protein 2 | 0.012 | ||
| Mapk3 | mitogen-activated protein kinase 3 | 0.011 | ||
| Atp6v1a | ATPase, H+ transporting, lysosomal V1 subunit A | 0.011 | ||
| Mt1 | metallothionein 1 | 0.011 | ||
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.010 | ||
| Atp6v0b | ATPase, H+ transporting, lysosomal V0 subunit B | 0.010 | ||
| Abhd12 | abhydrolase domain containing 12 | 0.010 |