Mus musculus

27 known processes

Ctsb

cathepsin B

(Aliases: CB)

Ctsb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of angiotensin levels in blood GO:0002002 4 0.843
renin angiotensin regulation of aldosterone production GO:0002018 3 0.740
natural killer cell degranulation GO:0043320 3 0.712
natural killer cell activation involved in immune response GO:0002323 10 0.698
ceramide metabolic process GO:0006672 31 0.693
regulation of angiotensin metabolic process GO:0060177 4 0.638
peptide metabolic process GO:0006518 46 0.636
vacuole organization GO:0007033 38 0.606
immune effector process GO:0002252 321 0.558
cell killing GO:0001906 67 0.447
male sex differentiation GO:0046661 109 0.441
leukocyte mediated cytotoxicity GO:0001909 62 0.431
membrane protein proteolysis GO:0033619 10 0.428
leukocyte mediated immunity GO:0002443 174 0.379
lymphocyte mediated immunity GO:0002449 139 0.364
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.359
renal system process GO:0003014 48 0.350
organelle assembly GO:0070925 177 0.333
extracellular matrix organization GO:0030198 147 0.333
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.321
necrotic cell death GO:0070265 30 0.295
antigen processing and presentation GO:0019882 47 0.282
apoptotic signaling pathway GO:0097190 306 0.266
male gonad development GO:0008584 88 0.266
kidney development GO:0001822 213 0.256
antigen processing and presentation of peptide antigen GO:0048002 29 0.250
developmental maturation GO:0021700 193 0.234
cellular response to hormone stimulus GO:0032870 150 0.212
Human
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 15 0.204
protein processing GO:0016485 163 0.202
regulation of cell killing GO:0031341 40 0.198
development of primary sexual characteristics GO:0045137 143 0.194
renal system development GO:0072001 225 0.182
antigen processing and presentation of exogenous peptide antigen GO:0002478 21 0.177
gonad development GO:0008406 141 0.171
regulation of systemic arterial blood pressure GO:0003073 61 0.166
hormone metabolic process GO:0042445 86 0.165
cellular amide metabolic process GO:0043603 58 0.163
positive regulation of lymphocyte activation GO:0051251 140 0.163
antigen processing and presentation of exogenous antigen GO:0019884 26 0.159
positive regulation of apoptotic signaling pathway GO:2001235 95 0.152
regulation of epithelial cell proliferation GO:0050678 141 0.148
glycosphingolipid catabolic process GO:0046479 5 0.137
development of primary male sexual characteristics GO:0046546 88 0.134
protein autoprocessing GO:0016540 2 0.132
epidermis development GO:0008544 187 0.131
sphingolipid metabolic process GO:0006665 45 0.131
microtubule based transport GO:0010970 50 0.130
regulation of leukocyte mediated immunity GO:0002703 104 0.130
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.130
cellular component assembly involved in morphogenesis GO:0010927 139 0.125
peptide hormone processing GO:0016486 9 0.122
carbohydrate derivative catabolic process GO:1901136 231 0.121
lymphocyte activation involved in immune response GO:0002285 93 0.121
regulation of lymphocyte activation GO:0051249 240 0.108
positive regulation of exocytosis GO:0045921 20 0.108
oligosaccharide catabolic process GO:0009313 2 0.107
glycolipid metabolic process GO:0006664 25 0.107
regulation of protein stability GO:0031647 52 0.105
hormone mediated signaling pathway GO:0009755 23 0.102
cytoskeleton dependent intracellular transport GO:0030705 50 0.101
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.101
autophagic vacuole assembly GO:0000045 13 0.099
positive regulation of response to wounding GO:1903036 66 0.097
adaptive immune response GO:0002250 155 0.097
angiogenesis GO:0001525 201 0.095
regulation of response to wounding GO:1903034 189 0.093
maintenance of location GO:0051235 89 0.090
response to organic cyclic compound GO:0014070 198 0.090
Rat
response to extracellular stimulus GO:0009991 127 0.088
regulation of hormone levels GO:0010817 211 0.082
mesonephros development GO:0001823 97 0.078
negative regulation of response to oxidative stress GO:1902883 10 0.078
cation homeostasis GO:0055080 212 0.076
regulation of blood pressure GO:0008217 93 0.074
protein maturation GO:0051604 176 0.072
regulation of neuron apoptotic process GO:0043523 122 0.072
regulation of apoptotic signaling pathway GO:2001233 197 0.071
positive regulation of inflammatory response GO:0050729 47 0.070
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.068
sphingolipid catabolic process GO:0030149 7 0.068
regulation of response to oxidative stress GO:1902882 19 0.068
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.068
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.067
regulation of cellular response to stress GO:0080135 159 0.066
cellular homeostasis GO:0019725 240 0.065
ceramide catabolic process GO:0046514 7 0.064
natural killer cell mediated immunity GO:0002228 29 0.063
positive regulation of necrotic cell death GO:0010940 1 0.062
inflammatory response GO:0006954 244 0.062
posttranscriptional regulation of gene expression GO:0010608 155 0.062
cell activation involved in immune response GO:0002263 126 0.062
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 17 0.061
regulation of lymphocyte mediated immunity GO:0002706 84 0.061
regulation of peptidase activity GO:0052547 96 0.060
endocrine process GO:0050886 39 0.058
microtubule based process GO:0007017 236 0.058
cellular chemical homeostasis GO:0055082 215 0.057
positive regulation of innate immune response GO:0045089 80 0.057
glycolipid catabolic process GO:0019377 5 0.057
cell recognition GO:0008037 83 0.057
positive regulation of cell death GO:0010942 224 0.056
regulation of defense response GO:0031347 233 0.056
calcium ion transport GO:0006816 159 0.055
regulation of proteolysis GO:0030162 164 0.055
negative regulation of neuron death GO:1901215 98 0.054
cellular response to extracellular stimulus GO:0031668 81 0.054
positive regulation of defense response GO:0031349 124 0.054
circulatory system process GO:0003013 197 0.053
response to nutrient levels GO:0031667 109 0.052
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 14 0.052
feeding behavior GO:0007631 62 0.051
i kappab kinase nf kappab signaling GO:0007249 85 0.050
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.050
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.050
macroautophagy GO:0016236 21 0.050
leukocyte degranulation GO:0043299 27 0.050
response to oxidative stress GO:0006979 123 0.049
small molecule catabolic process GO:0044282 71 0.049
cellular response to nutrient levels GO:0031669 64 0.049
molting cycle GO:0042303 90 0.047
cellular macromolecule catabolic process GO:0044265 206 0.046
Human
extracellular structure organization GO:0043062 148 0.046
multicellular organismal aging GO:0010259 24 0.046
Worm
male gamete generation GO:0048232 285 0.045
Rat
regulation of blood volume by renin angiotensin GO:0002016 7 0.045
germ cell development GO:0007281 185 0.045
membrane lipid catabolic process GO:0046466 8 0.045
lipid catabolic process GO:0016042 69 0.045
ion transmembrane transport GO:0034220 361 0.044
natural killer cell mediated cytotoxicity GO:0042267 29 0.044
reactive oxygen species metabolic process GO:0072593 84 0.043
phospholipid metabolic process GO:0006644 87 0.042
divalent inorganic cation transport GO:0072511 178 0.041
decidualization GO:0046697 10 0.041
cellular lipid catabolic process GO:0044242 52 0.041
defense response to gram positive bacterium GO:0050830 50 0.041
regulation of secretion GO:0051046 274 0.041
skeletal system development GO:0001501 356 0.040
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.040
lipid storage GO:0019915 36 0.039
positive regulation of programmed cell death GO:0043068 218 0.039
metal ion homeostasis GO:0055065 189 0.039
regulation of natural killer cell activation GO:0032814 22 0.039
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.038
keratinocyte proliferation GO:0043616 21 0.037
regulation of phosphatidylcholine catabolic process GO:0010899 2 0.036
cation transport GO:0006812 399 0.036
autophagy GO:0006914 45 0.035
Rat
neuron apoptotic process GO:0051402 142 0.035
sphingosine metabolic process GO:0006670 4 0.035
regulation of natural killer cell mediated immunity GO:0002715 19 0.035
respiratory tube development GO:0030323 167 0.035
sterol metabolic process GO:0016125 58 0.034
leukocyte activation involved in immune response GO:0002366 126 0.033
transmission of nerve impulse GO:0019226 76 0.032
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 17 0.032
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.032
glycosylceramide metabolic process GO:0006677 4 0.031
lung morphogenesis GO:0060425 50 0.031
t cell mediated cytotoxicity GO:0001913 26 0.030
regulated secretory pathway GO:0045055 32 0.030
regulation of vesicle mediated transport GO:0060627 139 0.030
sequestering of metal ion GO:0051238 19 0.029
positive regulation of cell activation GO:0050867 158 0.029
developmental growth involved in morphogenesis GO:0060560 138 0.029
response to starvation GO:0042594 65 0.029
muscle contraction GO:0006936 101 0.029
cellular ion homeostasis GO:0006873 165 0.028
spermatogenesis GO:0007283 284 0.028
Rat
positive regulation of macroautophagy GO:0016239 3 0.028
protein stabilization GO:0050821 25 0.028
positive regulation of apoptotic process GO:0043065 217 0.028
cytokine production GO:0001816 319 0.028
engulfment of apoptotic cell GO:0043652 3 0.028
positive regulation of immune effector process GO:0002699 107 0.027
multi multicellular organism process GO:0044706 109 0.027
t cell activation GO:0042110 289 0.027
gland development GO:0048732 330 0.027
protein catabolic process GO:0030163 221 0.027
Human
morphogenesis of a branching structure GO:0001763 203 0.026
neuronal action potential GO:0019228 54 0.026
blood circulation GO:0008015 195 0.026
muscle cell differentiation GO:0042692 261 0.026
macromolecule catabolic process GO:0009057 281 0.025
Human
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.025
positive regulation of cell killing GO:0031343 33 0.025
endocytosis GO:0006897 168 0.025
Worm
regulation of cytokine production GO:0001817 266 0.025
leukocyte differentiation GO:0002521 342 0.025
alcohol metabolic process GO:0006066 116 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.025
regulation of membrane potential GO:0042391 192 0.024
regulation of microtubule based process GO:0032886 52 0.024
glycoprotein metabolic process GO:0009100 116 0.024
epithelial tube branching involved in lung morphogenesis GO:0060441 28 0.024
cellular metal ion homeostasis GO:0006875 151 0.024
regulation of system process GO:0044057 200 0.024
organic hydroxy compound biosynthetic process GO:1901617 77 0.024
l ascorbic acid metabolic process GO:0019852 4 0.024
lipid localization GO:0010876 126 0.024
anatomical structure maturation GO:0071695 49 0.023
triglyceride metabolic process GO:0006641 51 0.023
cell maturation GO:0048469 127 0.023
response to molecule of bacterial origin GO:0002237 143 0.023
organic acid catabolic process GO:0016054 51 0.023
regulation of leukocyte apoptotic process GO:2000106 56 0.023
regulation of angiogenesis GO:0045765 81 0.023
iron ion homeostasis GO:0055072 36 0.023
regulation of cell activation GO:0050865 289 0.022
cation transmembrane transport GO:0098655 266 0.022
divalent metal ion transport GO:0070838 172 0.022
cell adhesion GO:0007155 329 0.022
negative regulation of keratinocyte proliferation GO:0010839 7 0.022
cell type specific apoptotic process GO:0097285 268 0.022
organic acid transport GO:0015849 101 0.022
protein lipid complex subunit organization GO:0071825 12 0.022
regulation of neuron death GO:1901214 134 0.022
cellular response to starvation GO:0009267 57 0.022
t cell mediated immunity GO:0002456 50 0.021
carbohydrate catabolic process GO:0016052 32 0.021
production of molecular mediator of immune response GO:0002440 103 0.021
regulation of binding GO:0051098 111 0.021
multicellular organismal catabolic process GO:0044243 7 0.021
Human
vacuolar transport GO:0007034 11 0.021
regulation of hemostasis GO:1900046 28 0.021
respiratory system development GO:0060541 190 0.021
glycerolipid metabolic process GO:0046486 122 0.020
regulation of cell motility GO:2000145 236 0.020
oxidation reduction process GO:0055114 342 0.020
transmembrane transport GO:0055085 412 0.020
negative regulation of neuron apoptotic process GO:0043524 92 0.020
hair cycle GO:0042633 90 0.020
regulation of removal of superoxide radicals GO:2000121 4 0.020
lysosomal transport GO:0007041 10 0.020
regulation of erbb signaling pathway GO:1901184 16 0.019
sulfur compound metabolic process GO:0006790 100 0.019
acetylcholine transport GO:0015870 2 0.019
response to monosaccharide GO:0034284 67 0.019
Rat
nerve development GO:0021675 67 0.019
regulation of cellular response to oxidative stress GO:1900407 19 0.019
response to reactive oxygen species GO:0000302 56 0.019
positive regulation of secretion by cell GO:1903532 114 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
homeostasis of number of cells GO:0048872 210 0.019
circadian sleep wake cycle rem sleep GO:0042747 1 0.019
regulation of endocytosis GO:0030100 69 0.019
cholesterol metabolic process GO:0008203 56 0.018
negative regulation of erbb signaling pathway GO:1901185 7 0.018
response to steroid hormone GO:0048545 56 0.018
nucleotide metabolic process GO:0009117 332 0.018
nucleoside phosphate metabolic process GO:0006753 338 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
lipid modification GO:0030258 65 0.018
determination of left right symmetry GO:0007368 80 0.018
regulation of regulated secretory pathway GO:1903305 20 0.018
prostate gland development GO:0030850 48 0.018
regulation of immunological synapse formation GO:2000520 2 0.017
actin cytoskeleton organization GO:0030036 220 0.017
monocarboxylic acid transport GO:0015718 44 0.017
establishment of planar polarity GO:0001736 28 0.017
wound healing GO:0042060 157 0.017
Zebrafish
liposaccharide metabolic process GO:1903509 27 0.017
sterol transport GO:0015918 38 0.017
positive regulation of mapk cascade GO:0043410 170 0.017
multicellular organismal signaling GO:0035637 91 0.017
regulation of actin cytoskeleton organization GO:0032956 84 0.017
organic anion transport GO:0015711 137 0.016
rho protein signal transduction GO:0007266 32 0.016
fibrinolysis GO:0042730 3 0.016
multicellular organismal homeostasis GO:0048871 164 0.016
morphogenesis of a branching epithelium GO:0061138 193 0.016
regulation of myeloid cell apoptotic process GO:0033032 19 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
negative regulation of cellular response to oxidative stress GO:1900408 10 0.016
cellular amino acid metabolic process GO:0006520 103 0.016
positive regulation of chemotaxis GO:0050921 38 0.016
lysosome organization GO:0007040 21 0.015
negative regulation of immune effector process GO:0002698 55 0.015
cell cell recognition GO:0009988 44 0.015
amyloid precursor protein biosynthetic process GO:0042983 3 0.015
positive regulation of neutrophil apoptotic process GO:0033031 1 0.015
cellular protein catabolic process GO:0044257 155 0.015
Human
neuromuscular process controlling balance GO:0050885 59 0.015
protein localization to vacuole GO:0072665 4 0.015
lung development GO:0030324 164 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.015
regulation of inflammatory response GO:0050727 147 0.015
muscle system process GO:0003012 141 0.015
phospholipid transfer to membrane GO:0006649 2 0.015
water soluble vitamin biosynthetic process GO:0042364 3 0.015
camera type eye development GO:0043010 266 0.015
superoxide metabolic process GO:0006801 27 0.015
small molecule biosynthetic process GO:0044283 132 0.014
female gamete generation GO:0007292 74 0.014
small gtpase mediated signal transduction GO:0007264 97 0.014
negative regulation of proteolysis GO:0045861 74 0.014
muscle cell development GO:0055001 133 0.014
alpha beta t cell activation GO:0046631 91 0.014
cytoplasmic transport GO:0016482 234 0.014
microtubule based movement GO:0007018 84 0.014
cell chemotaxis GO:0060326 81 0.014
regulation of keratinocyte proliferation GO:0010837 15 0.014
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.014
catagen GO:0042637 5 0.014
regulation of protein catabolic process GO:0042176 108 0.014
negative regulation of platelet derived growth factor receptor alpha signaling pathway GO:2000584 2 0.014
positive regulation of endocytosis GO:0045807 42 0.014
striated muscle cell development GO:0055002 125 0.014
glycerolipid catabolic process GO:0046503 16 0.013
eosinophil migration GO:0072677 3 0.013
forebrain radial glial cell differentiation GO:0021861 4 0.013
sertoli cell differentiation GO:0060008 18 0.013
heterocycle catabolic process GO:0046700 280 0.013
sensory system development GO:0048880 3 0.013
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.013
negative regulation of epithelial cell proliferation GO:0050680 64 0.013
defense response to bacterium GO:0042742 119 0.013
maternal process involved in female pregnancy GO:0060135 32 0.013
response to lipopolysaccharide GO:0032496 128 0.013
aromatic compound catabolic process GO:0019439 286 0.013
hair cycle phase GO:0044851 16 0.013
ceramide biosynthetic process GO:0046513 20 0.013
blood vessel morphogenesis GO:0048514 285 0.013
positive regulation of homeostatic process GO:0032846 64 0.013
cellular lipid metabolic process GO:0044255 323 0.013
cellular response to acid chemical GO:0071229 68 0.013
cellular response to oxidative stress GO:0034599 76 0.013
lipid transport GO:0006869 98 0.013
regulation of body fluid levels GO:0050878 162 0.013
organ growth GO:0035265 117 0.013
regulation of transferase activity GO:0051338 263 0.013
myelination GO:0042552 74 0.013
lateral line system development GO:0048925 1 0.013
regulation of adaptive immune response GO:0002819 90 0.013
notochord cell differentiation GO:0060034 1 0.012
intracellular sterol transport GO:0032366 3 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
positive regulation of nervous system development GO:0051962 221 0.012
positive regulation of leukocyte mediated immunity GO:0002705 70 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
regulation of protein transport GO:0051223 163 0.012
response to acid chemical GO:0001101 111 0.012
regulation of leukocyte degranulation GO:0043300 20 0.012
lymphocyte costimulation GO:0031294 15 0.012
single fertilization GO:0007338 82 0.012
nucleobase containing small molecule metabolic process GO:0055086 352 0.012
skin development GO:0043588 220 0.012
blood coagulation GO:0007596 76 0.012
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.012
positive regulation of eosinophil migration GO:2000418 2 0.012
fertilization GO:0009566 127 0.012
action potential GO:0001508 78 0.012
natural killer cell activation GO:0030101 44 0.012
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
defense response to other organism GO:0098542 197 0.011
carbohydrate derivative biosynthetic process GO:1901137 183 0.011
carboxylic acid transport GO:0046942 100 0.011
protein oligomerization GO:0051259 67 0.011
neuron projection regeneration GO:0031102 14 0.011
cellular response to hydroperoxide GO:0071447 4 0.011
glycosaminoglycan metabolic process GO:0030203 34 0.011
tissue homeostasis GO:0001894 115 0.011
adult locomotory behavior GO:0008344 91 0.011
urogenital system development GO:0001655 261 0.011
myosin filament organization GO:0031033 3 0.011
cellular ketone metabolic process GO:0042180 84 0.011
positive regulation of regulated secretory pathway GO:1903307 10 0.011
skin morphogenesis GO:0043589 38 0.011
organonitrogen compound catabolic process GO:1901565 264 0.011
carbohydrate homeostasis GO:0033500 128 0.011
regulation of intracellular transport GO:0032386 159 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
meiotic nuclear division GO:0007126 115 0.011
leukocyte chemotaxis GO:0030595 69 0.010
negative regulation of apoptotic signaling pathway GO:2001234 104 0.010
regulation of cellular amine metabolic process GO:0033238 20 0.010
fat soluble vitamin biosynthetic process GO:0042362 4 0.010
myosin filament assembly GO:0031034 2 0.010
learning or memory GO:0007611 148 0.010
thymocyte migration GO:0072679 2 0.010
lateral inhibition GO:0046331 1 0.010
positive regulation of leukocyte degranulation GO:0043302 10 0.010
myeloid leukocyte migration GO:0097529 57 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
bone development GO:0060348 120 0.010
negative regulation of vesicle fusion GO:0031339 1 0.010
epithelial cell proliferation GO:0050673 174 0.010
blastocyst development GO:0001824 80 0.010
t cell activation involved in immune response GO:0002286 43 0.010
establishment of vesicle localization GO:0051650 81 0.010
striated muscle tissue development GO:0014706 293 0.010
Rat
plasma cell differentiation GO:0002317 3 0.010
anatomical structure homeostasis GO:0060249 145 0.010
regulation of exocytosis GO:0017157 61 0.010

Ctsb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.993
lysosomal storage disease DOID:3211 0 0.993
inherited metabolic disorder DOID:655 0 0.993
lipid storage disease DOID:9455 0 0.972
central nervous system disease DOID:331 0 0.702
disease of anatomical entity DOID:7 0 0.702
nervous system disease DOID:863 0 0.702
sphingolipidosis DOID:1927 0 0.576
brain disease DOID:936 0 0.335
neuronal ceroid lipofuscinosis DOID:14503 0 0.231
cerebral degeneration DOID:1443 0 0.172
neuromuscular disease DOID:440 0 0.047
charcot marie tooth disease DOID:10595 0 0.047
neuropathy DOID:870 0 0.047
immune system disease DOID:2914 0 0.033
lymphatic system disease DOID:75 0 0.031
epilepsy syndrome DOID:1826 0 0.027
electroclinical syndrome DOID:0050701 0 0.027
retinal disease DOID:5679 0 0.027
retinal degeneration DOID:8466 0 0.027
sensory system disease DOID:0050155 0 0.027
eye and adnexa disease DOID:1492 0 0.027
eye disease DOID:5614 0 0.027
disease of mental health DOID:150 0 0.020
cognitive disorder DOID:1561 0 0.020
variable age at onset electroclinical syndrome DOID:0050706 0 0.018
acquired metabolic disease DOID:0060158 0 0.018
progressive myoclonus epilepsy DOID:891 0 0.016
musculoskeletal system disease DOID:17 0 0.012
connective tissue disease DOID:65 0 0.012