Mus musculus

160 known processes

Apoe

apolipoprotein E

(Aliases: AI255918)

Apoe biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cholesterol metabolic process GO:0008203 56 1.000
sterol metabolic process GO:0016125 58 1.000
cholesterol homeostasis GO:0042632 44 1.000
protein lipid complex subunit organization GO:0071825 12 1.000
sterol transport GO:0015918 38 1.000
neutral lipid metabolic process GO:0006638 57 1.000
Human Mouse
positive regulation of sterol transport GO:0032373 9 1.000
Human
lipid homeostasis GO:0055088 63 1.000
regulation of plasma lipoprotein particle levels GO:0097006 23 1.000
regulation of phosphatidylcholine catabolic process GO:0010899 2 1.000
triglyceride metabolic process GO:0006641 51 1.000
Human Mouse
sterol homeostasis GO:0055092 45 1.000
sterol transmembrane transport GO:0035382 2 1.000
cholesterol transport GO:0030301 38 1.000
reverse cholesterol transport GO:0043691 6 1.000
Human
acylglycerol homeostasis GO:0055090 16 0.999
Mouse
response to low density lipoprotein particle GO:0055098 2 0.999
cholesterol esterification GO:0034435 3 0.999
positive regulation of lipid metabolic process GO:0045834 40 0.999
acylglycerol metabolic process GO:0006639 55 0.999
Human Mouse
positive regulation of lipid transport GO:0032370 22 0.999
Human
positive regulation of triglyceride metabolic process GO:0090208 9 0.999
sterol esterification GO:0034434 3 0.999
lipid catabolic process GO:0016042 69 0.999
positive regulation of cholesterol transport GO:0032376 9 0.999
Human
triglyceride homeostasis GO:0070328 15 0.999
regulation of beta amyloid clearance GO:1900221 1 0.999
Human
plasma lipoprotein particle organization GO:0071827 11 0.998
acylglycerol biosynthetic process GO:0046463 18 0.998
regulation of triglyceride metabolic process GO:0090207 17 0.998
glycerolipid metabolic process GO:0046486 122 0.998
Human Mouse
regulation of cholesterol metabolic process GO:0090181 14 0.998
Human
cellular ketone metabolic process GO:0042180 84 0.997
intracellular cholesterol transport GO:0032367 3 0.997
cholesterol storage GO:0010878 4 0.997
cholesterol efflux GO:0033344 24 0.997
cholesterol import GO:0070508 2 0.996
organic hydroxy compound transport GO:0015850 93 0.996
macromolecular complex remodeling GO:0034367 6 0.996
small molecule catabolic process GO:0044282 71 0.996
high density lipoprotein particle assembly GO:0034380 3 0.995
Human
intestinal absorption GO:0050892 13 0.995
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.995
peptidyl tyrosine modification GO:0018212 145 0.995
organic anion transport GO:0015711 137 0.995
Human
phospholipid transfer to membrane GO:0006649 2 0.995
regulation of removal of superoxide radicals GO:2000121 4 0.994
amine metabolic process GO:0009308 45 0.994
glycerolipid catabolic process GO:0046503 16 0.994
steroid metabolic process GO:0008202 119 0.994
positive regulation of cholesterol efflux GO:0010875 9 0.994
Human
phospholipid transport GO:0015914 21 0.994
Human
regulation of defense response GO:0031347 233 0.994
regulation of fatty acid metabolic process GO:0019217 28 0.994
regulation of cellular amino acid metabolic process GO:0006521 5 0.994
cellular amide metabolic process GO:0043603 58 0.993
Human
positive regulation of phagocytosis GO:0050766 26 0.991
formation of radial glial scaffolds GO:0021943 4 0.991
alcohol metabolic process GO:0006066 116 0.990
steroid esterification GO:0034433 3 0.990
phospholipid catabolic process GO:0009395 5 0.990
positive regulation of cellular amine metabolic process GO:0033240 5 0.989
activation of membrane attack complex GO:0001905 4 0.988
regulation of cellular amine metabolic process GO:0033238 20 0.988
immune response activating signal transduction GO:0002757 116 0.987
phospholipid efflux GO:0033700 3 0.987
Human
plasma lipoprotein particle remodeling GO:0034369 6 0.985
regulation of kinase activity GO:0043549 249 0.985
Human
regulation of cytokine production GO:0001817 266 0.984
glycerolipid biosynthetic process GO:0045017 50 0.984
plasma lipoprotein particle clearance GO:0034381 13 0.984
Human
regulation of triglyceride biosynthetic process GO:0010866 10 0.984
regulation of lipoprotein lipase activity GO:0051004 4 0.983
regulation of transferase activity GO:0051338 263 0.982
Human Mouse
lipid storage GO:0019915 36 0.982
Mouse
positive regulation of lipid storage GO:0010884 10 0.981
coagulation GO:0050817 78 0.981
Human
organophosphate ester transport GO:0015748 28 0.980
Human
positive regulation of defense response GO:0031349 124 0.979
lipid transport GO:0006869 98 0.979
regulation of phagocytosis engulfment GO:0060099 5 0.975
phospholipid metabolic process GO:0006644 87 0.975
Mouse
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.971
cellular response to cytokine stimulus GO:0071345 189 0.971
cytokine production GO:0001816 319 0.969
peptidyl amino acid modification GO:0018193 336 0.969
organic hydroxy compound catabolic process GO:1901616 25 0.969
response to lipoprotein particle GO:0055094 5 0.967
superoxide metabolic process GO:0006801 27 0.965
regulation of response to wounding GO:1903034 189 0.963
cellular amine metabolic process GO:0044106 44 0.962
organic hydroxy compound metabolic process GO:1901615 203 0.958
positive regulation of kinase activity GO:0033674 155 0.956
positive regulation of phagocytosis engulfment GO:0060100 3 0.955
neutral lipid biosynthetic process GO:0046460 18 0.955
regulation of phospholipid catabolic process GO:0060696 2 0.954
defense response to gram positive bacterium GO:0050830 50 0.953
triglyceride biosynthetic process GO:0019432 17 0.951
maintenance of location GO:0051235 89 0.949
lipid localization GO:0010876 126 0.948
reactive oxygen species metabolic process GO:0072593 84 0.947
positive regulation of mapk cascade GO:0043410 170 0.946
stress response to metal ion GO:0097501 3 0.945
phospholipid homeostasis GO:0055091 6 0.945
positive regulation of reverse cholesterol transport GO:1903064 1 0.945
intracellular lipid transport GO:0032365 3 0.943
neuron apoptotic process GO:0051402 142 0.942
sterol import GO:0035376 2 0.937
cellular lipid catabolic process GO:0044242 52 0.937
positive regulation of glial cell proliferation GO:0060252 4 0.935
negative regulation of inflammatory response GO:0050728 61 0.935
response to organic cyclic compound GO:0014070 198 0.932
Mouse
regulation of lipid biosynthetic process GO:0046890 54 0.932
Human
negative regulation of fat cell differentiation GO:0045599 36 0.928
regulation of inflammatory response GO:0050727 147 0.927
cellular response to oxygen radical GO:0071450 14 0.923
carbohydrate metabolic process GO:0005975 230 0.922
response to hyperoxia GO:0055093 2 0.920
response to oxygen levels GO:0070482 62 0.919
cellular amino acid metabolic process GO:0006520 103 0.916
intestinal cholesterol absorption GO:0030299 5 0.914
Mouse
positive regulation of protein modification process GO:0031401 299 0.912
liver development GO:0001889 66 0.911
positive regulation of cytokine production GO:0001819 174 0.911
low density lipoprotein particle clearance GO:0034383 8 0.908
regulation of growth of symbiont in host GO:0044126 19 0.906
metanephric glomerular mesangium development GO:0072223 3 0.905
defense response to bacterium GO:0042742 119 0.904
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.903
acute inflammatory response GO:0002526 41 0.897
activation of immune response GO:0002253 138 0.896
cdc42 protein signal transduction GO:0032488 0 0.895
Human
defense response to other organism GO:0098542 197 0.894
regulation of protein processing GO:0070613 96 0.893
mapk cascade GO:0000165 281 0.890
Human
drug catabolic process GO:0042737 2 0.890
vitamin metabolic process GO:0006766 23 0.890
regulation of cell migration GO:0030334 219 0.890
Human
blood vessel morphogenesis GO:0048514 285 0.887
transmission of nerve impulse GO:0019226 76 0.886
beta amyloid clearance GO:0097242 2 0.885
Human
positive regulation of lipid biosynthetic process GO:0046889 18 0.883
Human
respiratory system development GO:0060541 190 0.883
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.882
regulation of acute inflammatory response GO:0002673 27 0.881
regulation of lipase activity GO:0060191 15 0.879
humoral immune response GO:0006959 57 0.877
regulation of reactive oxygen species metabolic process GO:2000377 40 0.876
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.876
response to inorganic substance GO:0010035 96 0.876
cellular response to peptide GO:1901653 92 0.874
regulation of cholesterol esterification GO:0010872 2 0.873
cellular response to tumor necrosis factor GO:0071356 21 0.872
cellular response to amino acid stimulus GO:0071230 29 0.871
cytokine mediated signaling pathway GO:0019221 115 0.870
peptidyl tyrosine phosphorylation GO:0018108 143 0.868
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.868
cation homeostasis GO:0055080 212 0.863
positive regulation of endocytosis GO:0045807 42 0.860
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.859
regulation of phospholipase a2 activity GO:0032429 3 0.856
positive regulation of apoptotic cell clearance GO:2000427 3 0.856
response to metal ion GO:0010038 47 0.855
negative regulation of growth of symbiont in host GO:0044130 19 0.855
cellular response to molecule of bacterial origin GO:0071219 83 0.853
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.852
positive regulation of beta amyloid clearance GO:1900223 1 0.846
response to lipopolysaccharide GO:0032496 128 0.843
glycerophospholipid metabolic process GO:0006650 71 0.839
respiratory tube development GO:0030323 167 0.838
response to oxygen radical GO:0000305 16 0.838
response to insulin GO:0032868 100 0.837
positive regulation of protein phosphorylation GO:0001934 242 0.836
intracellular sterol transport GO:0032366 3 0.834
regulation of sterol transport GO:0032371 17 0.827
Human Mouse
response to lithium ion GO:0010226 10 0.826
chemotaxis GO:0006935 247 0.822
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.821
striated muscle tissue development GO:0014706 293 0.818
response to corticosterone GO:0051412 1 0.816
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.813
positive regulation of lipoprotein lipase activity GO:0051006 3 0.811
protein kinase b signaling GO:0043491 74 0.807
positive regulation of transferase activity GO:0051347 167 0.802
Mouse
cellular lipid metabolic process GO:0044255 323 0.801
regulation of mapk cascade GO:0043408 248 0.801
Human
regulation of glutamine family amino acid metabolic process GO:0000820 1 0.798
anion homeostasis GO:0055081 16 0.796
Human
complement activation GO:0006956 16 0.794
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.791
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.790
fatty acid biosynthetic process GO:0006633 41 0.788
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.784
cellular biogenic amine metabolic process GO:0006576 28 0.784
myeloid leukocyte activation GO:0002274 83 0.783
regulation of nitrogen cycle metabolic process GO:1903314 1 0.783
reactive nitrogen species metabolic process GO:2001057 0 0.783
regulation of cell projection organization GO:0031344 206 0.781
Human
negative regulation of protein processing GO:0010955 79 0.778
regulation of response to oxidative stress GO:1902882 19 0.776
removal of superoxide radicals GO:0019430 12 0.776
response to steroid hormone GO:0048545 56 0.776
neuron death GO:0070997 154 0.764
Human
lipoprotein metabolic process GO:0042157 43 0.759
regulation of protein maturation GO:1903317 96 0.759
divalent inorganic cation homeostasis GO:0072507 138 0.758
lipid modification GO:0030258 65 0.757
regulation of cytokine production involved in immune response GO:0002718 26 0.752
plasma lipoprotein particle assembly GO:0034377 6 0.751
Human
dna metabolic process GO:0006259 303 0.749
epithelial cell migration GO:0010631 63 0.747
Human Mouse
regulation of neuron death GO:1901214 134 0.745
Human
leukocyte mediated immunity GO:0002443 174 0.744
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.743
blood vessel endothelial cell migration GO:0043534 23 0.741
Human Mouse
cell chemotaxis GO:0060326 81 0.739
negative regulation of response to wounding GO:1903035 77 0.738
negative regulation of protein metabolic process GO:0051248 282 0.736
Human
response to extracellular stimulus GO:0009991 127 0.736
positive regulation of secretion by cell GO:1903532 114 0.735
response to amino acid GO:0043200 37 0.727
protein activation cascade GO:0072376 19 0.727
regulation of protein serine threonine kinase activity GO:0071900 157 0.726
Human
glycerophospholipid catabolic process GO:0046475 5 0.725
regulation of angiogenesis GO:0045765 81 0.724
positive regulation of protein kinase activity GO:0045860 144 0.723
response to increased oxygen levels GO:0036296 2 0.722
negative regulation of cytokine production GO:0001818 84 0.722
cellular response to growth factor stimulus GO:0071363 197 0.719
receptor biosynthetic process GO:0032800 3 0.719
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.718
positive regulation of inflammatory response GO:0050729 47 0.716
positive regulation of cell migration GO:0030335 109 0.713
regulation of cholesterol transport GO:0032374 17 0.712
Human Mouse
regulation of membrane potential GO:0042391 192 0.711
response to molecule of bacterial origin GO:0002237 143 0.711
positive regulation of innate immune response GO:0045089 80 0.710
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.710
regulation of endocytosis GO:0030100 69 0.706
response to superoxide GO:0000303 16 0.705
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.703
membrane invagination GO:0010324 17 0.702
positive regulation of response to wounding GO:1903036 66 0.694
cell adhesion GO:0007155 329 0.689
response to reactive oxygen species GO:0000302 56 0.688
regulation of lipid catabolic process GO:0050994 15 0.688
ethanolamine containing compound metabolic process GO:0042439 18 0.687
regulation of fat cell differentiation GO:0045598 81 0.686
protein lipid complex remodeling GO:0034368 6 0.684
negative regulation of apoptotic signaling pathway GO:2001234 104 0.683
multicellular organismal signaling GO:0035637 91 0.681
fatty acid metabolic process GO:0006631 121 0.680
endothelial cell migration GO:0043542 44 0.679
Human Mouse
positive regulation of programmed cell death GO:0043068 218 0.676
regulation of presynaptic membrane organization GO:1901629 3 0.674
Human
leukocyte chemotaxis GO:0030595 69 0.666
protein localization to nucleus GO:0034504 121 0.663
regulation of phospholipid efflux GO:1902994 2 0.663
Human
regulation of innate immune response GO:0045088 91 0.659
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.656
membrane organization GO:0061024 245 0.656
Human
regulation of lipid storage GO:0010883 20 0.654
steroid catabolic process GO:0006706 7 0.654
macrophage derived foam cell differentiation GO:0010742 6 0.650
regulation of secretion GO:0051046 274 0.650
receptor mediated endocytosis GO:0006898 51 0.645
Human
metanephric glomerular epithelium development GO:0072244 3 0.643
regulation of lipid transport GO:0032368 36 0.640
Human Mouse
muscle tissue development GO:0060537 308 0.639
regulation of response to reactive oxygen species GO:1901031 9 0.637
immune effector process GO:0002252 321 0.637
fat soluble vitamin biosynthetic process GO:0042362 4 0.636
ammonia assimilation cycle GO:0019676 2 0.636
cellular response to oxidative stress GO:0034599 76 0.636
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.627
monocarboxylic acid metabolic process GO:0032787 191 0.623
endocytosis GO:0006897 168 0.622
Human
negative regulation of beta amyloid formation GO:1902430 4 0.620
Human
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.619
regulation of lipid metabolic process GO:0019216 118 0.618
macromolecule catabolic process GO:0009057 281 0.617
regulation of map kinase activity GO:0043405 120 0.616
Human
neuronal action potential GO:0019228 54 0.616
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.616
inflammatory response GO:0006954 244 0.613
response to estrogen GO:0043627 24 0.605
regulation of protein tyrosine kinase activity GO:0061097 17 0.604
lipoprotein transport GO:0042953 7 0.603
granulocyte migration GO:0097530 43 0.602
phagocytosis GO:0006909 66 0.602
high density lipoprotein particle remodeling GO:0034375 4 0.601
Human
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.601
lytic vacuole organization GO:0080171 21 0.600
regulation of hypersensitivity GO:0002883 10 0.600
oligodendrocyte differentiation GO:0048709 53 0.599
extrinsic apoptotic signaling pathway GO:0097191 126 0.599
lipid biosynthetic process GO:0008610 179 0.596
Human Mouse
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.595
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.594
response to tumor necrosis factor GO:0034612 26 0.592
positive regulation of cholesterol esterification GO:0010873 1 0.583
innate immune response GO:0045087 157 0.579
Mouse
regulation of stem cell proliferation GO:0072091 78 0.577
negative regulation of phagocytosis GO:0050765 4 0.573
regulation of engulfment of apoptotic cell GO:1901074 2 0.573
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.572
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.570
canonical wnt signaling pathway involved in neural crest cell differentiation GO:0044335 1 0.568
cellular response to increased oxygen levels GO:0036295 1 0.566
response to corticosteroid GO:0031960 20 0.562
cellular response to superoxide GO:0071451 14 0.561
response to iron ion GO:0010039 4 0.556
granulocyte chemotaxis GO:0071621 39 0.553
positive regulation of cytokine secretion GO:0050715 41 0.552
ensheathment of neurons GO:0007272 76 0.547
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.546
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.545
positive regulation of map kinase activity GO:0043406 84 0.545
low density lipoprotein particle remodeling GO:0034374 2 0.543
response to vitamin GO:0033273 6 0.543
cardiocyte differentiation GO:0035051 87 0.542
regulation of cholesterol efflux GO:0010874 13 0.541
Human
drug metabolic process GO:0017144 4 0.540
digestive tract development GO:0048565 190 0.540
hypersensitivity GO:0002524 10 0.539
negative regulation of cholesterol transport GO:0032375 4 0.539
Human
cellular response to lipid GO:0071396 145 0.537
negative regulation of defense response GO:0031348 77 0.535
triglyceride catabolic process GO:0019433 9 0.533
positive regulation of type ii hypersensitivity GO:0002894 4 0.532
immune complex clearance GO:0002434 2 0.529
activation of mapk activity GO:0000187 59 0.528
regulation of wound healing GO:0061041 40 0.527
Human
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.525
response to acid chemical GO:0001101 111 0.521
regulation of vesicle mediated transport GO:0060627 139 0.514
response to vitamin a GO:0033189 1 0.511
tissue remodeling GO:0048771 102 0.510
protein localization to organelle GO:0033365 185 0.504
lung development GO:0030324 164 0.501
apoptotic cell clearance GO:0043277 17 0.501
hepaticobiliary system development GO:0061008 67 0.499
regulation of type iia hypersensitivity GO:0001796 4 0.498
cell type specific apoptotic process GO:0097285 268 0.492
hindbrain radial glia guided cell migration GO:0021932 12 0.490
regulation of proteolysis GO:0030162 164 0.489
Human
positive regulation of acute inflammatory response GO:0002675 16 0.489
ras protein signal transduction GO:0007265 77 0.488
Human
carboxylic acid biosynthetic process GO:0046394 86 0.487
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.487
brown fat cell differentiation GO:0050873 36 0.486
positive regulation of triglyceride biosynthetic process GO:0010867 6 0.484
regulation of insulin receptor signaling pathway GO:0046626 21 0.484
response to chromate GO:0046687 1 0.483
insulin receptor signaling pathway GO:0008286 49 0.483
regulation of cholesterol storage GO:0010885 4 0.480
regulation of protein kinase b signaling GO:0051896 56 0.480
regulation of leukocyte mediated immunity GO:0002703 104 0.479
negative regulation of angiogenesis GO:0016525 25 0.478
regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000165 1 0.477
response to interleukin 1 GO:0070555 11 0.473
negative regulation of cellular protein metabolic process GO:0032269 247 0.473
Human
positive regulation of keratinocyte differentiation GO:0045618 3 0.472
cellular macromolecule catabolic process GO:0044265 206 0.467
Human
cardiac muscle cell differentiation GO:0055007 69 0.467
epithelial cell proliferation GO:0050673 174 0.466
Human Mouse
negative regulation of cellular amide metabolic process GO:0034249 4 0.461
Human
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.460
lipoprotein biosynthetic process GO:0042158 33 0.453
positive regulation of growth GO:0045927 104 0.452
spinal cord development GO:0021510 81 0.448
cytokine production involved in immune response GO:0002367 34 0.448
camera type eye development GO:0043010 266 0.446
urea metabolic process GO:0019627 3 0.445
production of molecular mediator of immune response GO:0002440 103 0.443
production of molecular mediator involved in inflammatory response GO:0002532 21 0.442
exogenous drug catabolic process GO:0042738 1 0.441
oxidation reduction process GO:0055114 342 0.440
Human
regulation of protein catabolic process GO:0042176 108 0.439
Human
negative regulation of multi organism process GO:0043901 68 0.436
negative regulation of molecular function GO:0044092 258 0.434
Human Mouse
positive regulation of protein transport GO:0051222 93 0.432
negative regulation of endocytosis GO:0045806 12 0.432
response to retinoic acid GO:0032526 56 0.428
regulation of cellular response to stress GO:0080135 159 0.428
leukocyte migration GO:0050900 124 0.426
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.426
small molecule biosynthetic process GO:0044283 132 0.426
Human Mouse
negative regulation of platelet derived growth factor receptor beta signaling pathway GO:2000587 2 0.423
nitrogen cycle metabolic process GO:0071941 3 0.422
lymphocyte migration GO:0072676 26 0.420
negative regulation of neuron death GO:1901215 98 0.418
Human
skeletal system development GO:0001501 356 0.416
regulation of glutamate metabolic process GO:2000211 1 0.415
response to oxidative stress GO:0006979 123 0.414
t cell migration GO:0072678 19 0.411
developmental cell growth GO:0048588 84 0.410
regulation of urea metabolic process GO:0034255 1 0.410
cellular zinc ion homeostasis GO:0006882 9 0.409
growth of symbiont in host GO:0044117 23 0.408
negative regulation of neuron apoptotic process GO:0043524 92 0.408
response to hypoxia GO:0001666 58 0.408
metal ion homeostasis GO:0055065 189 0.406
activation of mapk activity involved in innate immune response GO:0035419 2 0.405
peptide metabolic process GO:0006518 46 0.403
Human
growth of symbiont involved in interaction with host GO:0044116 23 0.401
cognition GO:0050890 149 0.401
protein catabolic process GO:0030163 221 0.400
regulation of neuron apoptotic process GO:0043523 122 0.399
positive regulation of triglyceride lipase activity GO:0061365 3 0.399
steroid biosynthetic process GO:0006694 47 0.398
Human Mouse
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000151 1 0.398
regulation of ammonia assimilation cycle GO:2001248 1 0.397
digestive system development GO:0055123 200 0.394
negative regulation of cellular component organization GO:0051129 194 0.393
Human
regulation of tube size GO:0035150 57 0.393
regulation of body fluid levels GO:0050878 162 0.390
Human
regulation of phagocytosis GO:0050764 33 0.385
negative regulation of hydrolase activity GO:0051346 71 0.382
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.379
negative regulation of lipoprotein lipase activity GO:0051005 1 0.378
regulation of b cell mediated immunity GO:0002712 37 0.377
regulation of complement activation GO:0030449 7 0.375
regulation of blood coagulation GO:0030193 28 0.374
Human
protein secretion GO:0009306 111 0.374
positive regulation of activation of membrane attack complex GO:0001970 2 0.372
positive regulation of nervous system development GO:0051962 221 0.372
Human
metanephric mesenchymal cell migration GO:0035789 2 0.372
positive regulation of b cell mediated immunity GO:0002714 26 0.372
transmembrane transport GO:0055085 412 0.369
response to bile acid GO:1903412 1 0.368
release of cytochrome c from mitochondria GO:0001836 23 0.368
molting cycle GO:0042303 90 0.365
positive regulation of cholesterol storage GO:0010886 3 0.363
urea cycle GO:0000050 2 0.362
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.362
positive regulation of adaptive immune response GO:0002821 61 0.361
erythrocyte differentiation GO:0030218 88 0.360
cellular response to retinoic acid GO:0071300 25 0.360
response to fluid shear stress GO:0034405 7 0.360
positive regulation of nitric oxide synthase activity GO:0051000 2 0.358
Human
positive regulation of dendrite development GO:1900006 21 0.358
Human
myelination GO:0042552 74 0.357
anion transport GO:0006820 177 0.357
Human
regulation of type ii hypersensitivity GO:0002892 4 0.356
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.354
engulfment of apoptotic cell GO:0043652 3 0.353
positive regulation of hypersensitivity GO:0002885 7 0.352
regulation of blood pressure GO:0008217 93 0.352
regulation of reverse cholesterol transport GO:1903062 1 0.351
muscle contraction GO:0006936 101 0.351
glucocorticoid metabolic process GO:0008211 9 0.347
Mouse
peptide secretion GO:0002790 114 0.346
response to transition metal nanoparticle GO:1990267 11 0.346
myeloid leukocyte migration GO:0097529 57 0.342
positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 7 0.341
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.340
positive regulation of fat cell differentiation GO:0045600 32 0.337
interspecies interaction between organisms GO:0044419 83 0.336
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.336
sphingolipid metabolic process GO:0006665 45 0.335
negative regulation of endothelial cell apoptotic process GO:2000352 7 0.334
blood coagulation GO:0007596 76 0.334
Human
cellular response to fluid shear stress GO:0071498 4 0.333
positive regulation of creb transcription factor activity GO:0032793 4 0.331
regulation of cholesterol homeostasis GO:2000188 9 0.330
regulation of rho protein signal transduction GO:0035023 71 0.328
Human
glutamate metabolic process GO:0006536 9 0.327
kidney development GO:0001822 213 0.325
epidermis development GO:0008544 187 0.325
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.320
negative regulation of protein maturation GO:1903318 79 0.319
cellular response to biotic stimulus GO:0071216 92 0.313
cardiac muscle tissue development GO:0048738 130 0.313
negative regulation of proteolysis GO:0045861 74 0.313

Apoe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.999
Human
disease of anatomical entity DOID:7 0 0.998
Human
nervous system disease DOID:863 0 0.998
Human
retinal disease DOID:5679 0 0.996
sensory system disease DOID:0050155 0 0.996
eye and adnexa disease DOID:1492 0 0.996
eye disease DOID:5614 0 0.996
inherited metabolic disorder DOID:655 0 0.996
Human
retinal degeneration DOID:8466 0 0.991
lipid metabolism disorder DOID:3146 0 0.980
immune system disease DOID:2914 0 0.923
Human
hemolytic anemia DOID:583 0 0.684
hemolytic uremic syndrome DOID:12554 0 0.684
normocytic anemia DOID:720 0 0.684
anemia DOID:2355 0 0.684
hematopoietic system disease DOID:74 0 0.684
degeneration of macula and posterior pole DOID:2007 0 0.579
macular degeneration DOID:4448 0 0.579
age related macular degeneration DOID:10871 0 0.579
disease of cellular proliferation DOID:14566 0 0.318