Mus musculus

50 known processes

Mdm2

transformed mouse 3T3 cell double minute 2

(Aliases: AA415488,1700007J15Rik,Mdm-2)

Mdm2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 1.000
Human
signal transduction by p53 class mediator GO:0072331 51 1.000
Human
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 1.000
Human
negative regulation of nik nf kappab signaling GO:1901223 2 1.000
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 1.000
negative regulation of cell cycle GO:0045786 123 0.999
Human Zebrafish
regulation of protein stability GO:0031647 52 0.999
Human
apoptotic signaling pathway GO:0097190 306 0.999
cell cycle arrest GO:0007050 37 0.999
Human Zebrafish
modification dependent macromolecule catabolic process GO:0043632 133 0.999
Human
epidermal growth factor receptor signaling pathway via i kappab kinase nf kappab cascade GO:0038168 1 0.998
extrinsic apoptotic signaling pathway GO:0097191 126 0.998
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.998
cellular response to gamma radiation GO:0071480 4 0.997
protein modification by small protein conjugation GO:0032446 187 0.997
protein modification by small protein conjugation or removal GO:0070647 207 0.996
modification dependent protein catabolic process GO:0019941 133 0.996
Human
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.996
Human
dna metabolic process GO:0006259 303 0.995
regulation of cell cycle GO:0051726 281 0.993
covalent chromatin modification GO:0016569 163 0.992
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.989
Human
intrinsic apoptotic signaling pathway GO:0097193 132 0.989
ubiquitin dependent protein catabolic process GO:0006511 129 0.989
Human
regulation of mitotic cell cycle phase transition GO:1901990 73 0.989
peptidyl threonine phosphorylation GO:0018107 31 0.987
protein ubiquitination GO:0016567 171 0.987
protein autophosphorylation GO:0046777 61 0.984
negative regulation of phosphorylation GO:0042326 166 0.984
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.982
Human
positive regulation of protein modification process GO:0031401 299 0.980
negative regulation of cell proliferation GO:0008285 296 0.976
endothelial cell apoptotic process GO:0072577 9 0.976
regulation of cell cycle process GO:0010564 160 0.973
positive regulation of programmed cell death GO:0043068 218 0.972
regulation of cellular catabolic process GO:0031329 242 0.970
Human
negative regulation of map kinase activity GO:0043407 34 0.969
proteasomal protein catabolic process GO:0010498 98 0.963
Human
regulation of transferase activity GO:0051338 263 0.963
protein localization to organelle GO:0033365 185 0.957
Human
voluntary musculoskeletal movement GO:0050882 3 0.951
regulation of protein kinase activity GO:0045859 232 0.951
cell cycle g1 s phase transition GO:0044843 57 0.945
chromatin organization GO:0006325 206 0.941
positive regulation of apoptotic process GO:0043065 217 0.940
mitotic cell cycle arrest GO:0071850 4 0.938
histone modification GO:0016570 159 0.936
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.929
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.929
Human
regulation of response to dna damage stimulus GO:2001020 34 0.928
Human
regulation of leukocyte differentiation GO:1902105 159 0.926
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.924
organelle fission GO:0048285 170 0.924
regulation of mitotic cell cycle GO:0007346 126 0.923
negative regulation of kinase activity GO:0033673 81 0.920
glial cell apoptotic process GO:0034349 3 0.914
negative regulation of intracellular signal transduction GO:1902532 167 0.912
Human
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.910
Human
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.907
epidermal growth factor receptor signaling pathway via positive regulation of nf kappab transcription factor activity GO:0038167 1 0.905
positive regulation of apoptotic signaling pathway GO:2001235 95 0.903
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.899
Human
traversing start control point of mitotic cell cycle GO:0007089 2 0.898
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.897
regulation of cell cycle g1 s phase transition GO:1902806 35 0.893
negative regulation of cellular protein metabolic process GO:0032269 247 0.893
regionalization GO:0003002 337 0.892
positive regulation of protein phosphorylation GO:0001934 242 0.886
g1 s transition of mitotic cell cycle GO:0000082 57 0.882
negative regulation of phosphate metabolic process GO:0045936 184 0.882
macroautophagy GO:0016236 21 0.882
cellular protein catabolic process GO:0044257 155 0.881
Human
regulation of apoptotic signaling pathway GO:2001233 197 0.880
peptidyl serine modification GO:0018209 83 0.880
cell cycle checkpoint GO:0000075 47 0.879
Human
posttranscriptional regulation of gene expression GO:0010608 155 0.879
Human
protein processing GO:0016485 163 0.878
protein catabolic process GO:0030163 221 0.877
positive regulation of transferase activity GO:0051347 167 0.877
mitotic g1 dna damage checkpoint GO:0031571 4 0.874
Human
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.867
mitotic cell cycle GO:0000278 195 0.865
ras protein signal transduction GO:0007265 77 0.865
signal transduction in response to dna damage GO:0042770 21 0.863
Human
regulation of protein maturation GO:1903317 96 0.863
regulation of cellular response to stress GO:0080135 159 0.863
Human
negative regulation of cell cycle process GO:0010948 69 0.860
Human Zebrafish
cellular response to growth factor stimulus GO:0071363 197 0.859
regulation of cell cycle phase transition GO:1901987 77 0.857
response to growth factor GO:0070848 198 0.852
positive regulation of mitotic cell cycle GO:0045931 41 0.847
negative regulation of transferase activity GO:0051348 85 0.844
meiotic nuclear division GO:0007126 115 0.844
homeostasis of number of cells GO:0048872 210 0.841
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.834
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.829
Human
regulation of osteoblast differentiation GO:0045667 67 0.828
peptidyl amino acid modification GO:0018193 336 0.826
Human
meiotic cell cycle GO:0051321 122 0.824
mitochondrial dna repair GO:0043504 3 0.822
negative regulation of epithelial cell proliferation GO:0050680 64 0.820
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.820
regulation of protein ubiquitination GO:0031396 52 0.818
regulation of kinase activity GO:0043549 249 0.808
regulation of macroautophagy GO:0016241 12 0.807
myeloid leukocyte differentiation GO:0002573 119 0.806
negative regulation of mapk cascade GO:0043409 65 0.804
dna replication GO:0006260 52 0.803
negative regulation of cell cycle arrest GO:0071157 1 0.799
Human Zebrafish
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.797
Human
protein stabilization GO:0050821 25 0.793
cellular senescence GO:0090398 11 0.789
regulation of myeloid leukocyte differentiation GO:0002761 58 0.787
positive regulation of cellular catabolic process GO:0031331 148 0.785
Human
meiotic cell cycle process GO:1903046 77 0.780
regulation of chromosome organization GO:0033044 83 0.780
regulation of reactive oxygen species metabolic process GO:2000377 40 0.770
positive regulation of cell cycle phase transition GO:1901989 17 0.765
regulation of protein catabolic process GO:0042176 108 0.762
Human
cell aging GO:0007569 35 0.761
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.760
jnk cascade GO:0007254 72 0.752
g0 to g1 transition GO:0045023 3 0.751
telomere maintenance GO:0000723 19 0.749
regulation of chromatin modification GO:1903308 57 0.743
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.739
negative regulation of dna replication GO:0008156 4 0.738
regulation of hippo signaling GO:0035330 1 0.737
response to light stimulus GO:0009416 135 0.728
regulation of autophagy GO:0010506 30 0.726
negative regulation of phosphorus metabolic process GO:0010563 184 0.726
cellular response to decreased oxygen levels GO:0036294 18 0.723
Human
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.721
negative regulation of neuron death GO:1901215 98 0.718
response to endoplasmic reticulum stress GO:0034976 53 0.711
skeletal system development GO:0001501 356 0.710
blastocyst growth GO:0001832 23 0.707
negative regulation of jnk cascade GO:0046329 12 0.707
positive regulation of leukocyte apoptotic process GO:2000108 21 0.704
negative regulation of jun kinase activity GO:0043508 9 0.701
positive regulation of kinase activity GO:0033674 155 0.692
camera type eye development GO:0043010 266 0.690
stress activated protein kinase signaling cascade GO:0031098 81 0.688
fibroblast migration GO:0010761 21 0.687
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.687
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.682
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.675
Human
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.671
cellular response to hypoxia GO:0071456 17 0.671
Human
b cell activation GO:0042113 161 0.666
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.661
cellular response to nitric oxide GO:0071732 4 0.654
negative regulation of protein catabolic process GO:0042177 36 0.651
regulation of erythrocyte differentiation GO:0045646 23 0.646
dna endoreduplication GO:0042023 4 0.646
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.633
osteoclast differentiation GO:0030316 62 0.626
peptidyl threonine modification GO:0018210 31 0.625
peptidyl serine phosphorylation GO:0018105 74 0.623
dna integrity checkpoint GO:0031570 28 0.622
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.619
oocyte differentiation GO:0009994 35 0.618
negative regulation of fibroblast migration GO:0010764 2 0.618
positive regulation of macroautophagy GO:0016239 3 0.617
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.611
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.610
Human
negative regulation of cellular amine metabolic process GO:0033239 1 0.610
negative regulation of lipid kinase activity GO:0090219 1 0.609
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.608
positive regulation of protein ubiquitination GO:0031398 27 0.606
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.603
regulation of cellular protein catabolic process GO:1903362 61 0.603
Human
mitochondrion degradation GO:0000422 3 0.599
negative regulation of protein metabolic process GO:0051248 282 0.588
germ cell development GO:0007281 185 0.587
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.587
mitotic cell cycle checkpoint GO:0007093 31 0.587
Human
regulation of b cell proliferation GO:0030888 39 0.579
cellular macromolecule catabolic process GO:0044265 206 0.576
Human
epidermal cell division GO:0010481 3 0.566
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.566
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.565
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.562
chromosome segregation GO:0007059 48 0.561
muscle cell apoptotic process GO:0010657 18 0.558
leukocyte differentiation GO:0002521 342 0.556
hippo signaling GO:0035329 11 0.553
erythrocyte differentiation GO:0030218 88 0.552
nuclear division GO:0000280 158 0.550
negative regulation of proteolysis GO:0045861 74 0.550
response to hypoxia GO:0001666 58 0.549
Human
dendrite development GO:0016358 115 0.548
dna damage checkpoint GO:0000077 26 0.547
Human
cellular response to drug GO:0035690 15 0.546
myeloid cell differentiation GO:0030099 233 0.544
regulation of cell cycle arrest GO:0071156 12 0.544
Human Zebrafish
locomotory behavior GO:0007626 195 0.536
neuron death GO:0070997 154 0.534
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.530
embryonic appendage morphogenesis GO:0035113 126 0.528
nucleotide excision repair GO:0006289 13 0.527
negative regulation of stress activated mapk cascade GO:0032873 14 0.525
cellular amine metabolic process GO:0044106 44 0.525
epithelial cell proliferation GO:0050673 174 0.522
cellular response to oxygen levels GO:0071453 20 0.520
Human
negative regulation of cell growth GO:0030308 44 0.519
regulation of neuron death GO:1901214 134 0.516
regulation of stress activated mapk cascade GO:0032872 69 0.515
cellular response to tumor necrosis factor GO:0071356 21 0.514
negative regulation of lymphocyte activation GO:0051250 91 0.512
activation of adenylate cyclase activity GO:0007190 4 0.503
positive regulation of keratinocyte proliferation GO:0010838 4 0.493
regulation of neuron apoptotic process GO:0043523 122 0.490
response to x ray GO:0010165 11 0.489
Zebrafish
autophagy GO:0006914 45 0.481
cell division GO:0051301 120 0.480
microtubule polymerization or depolymerization GO:0031109 26 0.476
response to tumor necrosis factor GO:0034612 26 0.476
regulation of hydrolase activity GO:0051336 246 0.476
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.476
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.472
negative regulation of cellular catabolic process GO:0031330 47 0.471
mitotic cell cycle process GO:1903047 159 0.470
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.468
retina morphogenesis in camera type eye GO:0060042 45 0.466
regulation of protein localization to nucleus GO:1900180 60 0.462
regulation of cellular amine metabolic process GO:0033238 20 0.459
response to transforming growth factor beta GO:0071559 88 0.456
histone phosphorylation GO:0016572 9 0.453
leukocyte proliferation GO:0070661 172 0.452
regulation of muscle cell apoptotic process GO:0010660 17 0.446
embryonic organ morphogenesis GO:0048562 276 0.441
response to antibiotic GO:0046677 11 0.437
Human
stress activated mapk cascade GO:0051403 80 0.437
negative regulation of protein maturation GO:1903318 79 0.436
central nervous system neuron differentiation GO:0021953 162 0.436
regulation of osteoclast differentiation GO:0045670 36 0.430
cellular response to cytokine stimulus GO:0071345 189 0.429
positive regulation of g1 s transition of mitotic cell cycle GO:1900087 9 0.427
reactive oxygen species metabolic process GO:0072593 84 0.427
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.418
positive regulation of proteolysis GO:0045862 85 0.414
Human
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.414
regulation of organelle organization GO:0033043 289 0.411
methylation GO:0032259 134 0.409
positive regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902231 6 0.399
reciprocal dna recombination GO:0035825 16 0.396
negative regulation of fibroblast proliferation GO:0048147 14 0.394
macromolecule catabolic process GO:0009057 281 0.391
negative regulation of protein phosphorylation GO:0001933 126 0.389
regulation of map kinase activity GO:0043405 120 0.389
signal transduction involved in dna damage checkpoint GO:0072422 3 0.385
Human
t cell differentiation in thymus GO:0033077 77 0.384
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.383
cellular response to toxic substance GO:0097237 7 0.381
cohesin localization to chromatin GO:0071921 1 0.380
pole plasm assembly GO:0007315 2 0.376
cellular response to extracellular stimulus GO:0031668 81 0.374
fatty acid transmembrane transport GO:1902001 1 0.370
response to drug GO:0042493 75 0.368
amine metabolic process GO:0009308 45 0.362
limb development GO:0060173 166 0.359
cellular response to radiation GO:0071478 28 0.356
negative regulation of neuron apoptotic process GO:0043524 92 0.354
purine ribonucleotide metabolic process GO:0009150 290 0.354
positive regulation of cell death GO:0010942 224 0.353
regulation of protein serine threonine kinase activity GO:0071900 157 0.350
regulation of sister chromatid segregation GO:0033045 13 0.348
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.347
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.344
cell fate commitment GO:0045165 210 0.343
multicellular organismal aging GO:0010259 24 0.339
mitotic sister chromatid separation GO:0051306 9 0.339
cellular response to external stimulus GO:0071496 88 0.338
negative regulation of fatty acid transport GO:2000192 1 0.337
t cell proliferation involved in immune response GO:0002309 4 0.335
cellular amino acid metabolic process GO:0006520 103 0.335
genetic imprinting GO:0071514 27 0.334
male meiosis i GO:0007141 16 0.333
cerebrospinal fluid secretion GO:0033326 4 0.330
negative regulation of leukocyte differentiation GO:1902106 51 0.329
photoreceptor cell morphogenesis GO:0008594 3 0.328
dna recombination GO:0006310 92 0.327
cellular response to x ray GO:0071481 2 0.326
regulation of epithelial cell proliferation GO:0050678 141 0.325
positive regulation of cellular amine metabolic process GO:0033240 5 0.323
cellular response to inorganic substance GO:0071241 37 0.320
intra s dna damage checkpoint GO:0031573 4 0.319
positive regulation of protein kinase activity GO:0045860 144 0.319
negative regulation of macroautophagy GO:0016242 5 0.319
regulation of synaptic plasticity GO:0048167 87 0.318
oocyte development GO:0048599 33 0.317
regulation of proteolysis GO:0030162 164 0.314
Human
negative regulation of fatty acid metabolic process GO:0045922 10 0.313
negative regulation of response to dna damage stimulus GO:2001021 10 0.307
Human
telomere capping GO:0016233 4 0.307
fibroblast proliferation GO:0048144 35 0.302
negative regulation of molecular function GO:0044092 258 0.301
protein modification by small protein removal GO:0070646 21 0.298
protein maturation GO:0051604 176 0.297
developmental maturation GO:0021700 193 0.295
regulation of intracellular protein transport GO:0033157 82 0.293
cell type specific apoptotic process GO:0097285 268 0.292
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.287
cellular response to starvation GO:0009267 57 0.280
negative regulation of leukocyte proliferation GO:0070664 46 0.279
female gamete generation GO:0007292 74 0.277
notch signaling pathway GO:0007219 71 0.277
negative regulation of reactive oxygen species metabolic process GO:2000378 10 0.276
mammary gland epithelium development GO:0061180 65 0.272
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.271
response to reactive oxygen species GO:0000302 56 0.270
neuron apoptotic process GO:0051402 142 0.268
tissue remodeling GO:0048771 102 0.266
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 2 0.265
regulation of dna binding GO:0051101 39 0.264
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.263
regulation of cytoplasmic transport GO:1903649 112 0.262
adult behavior GO:0030534 135 0.260
positive regulation of smooth muscle cell migration GO:0014911 4 0.259
striated muscle cell apoptotic process GO:0010658 12 0.259
positive regulation of protein autophosphorylation GO:0031954 4 0.258
peptidyl tyrosine modification GO:0018212 145 0.255
erbb signaling pathway GO:0038127 32 0.255
apoptotic process involved in mammary gland involution GO:0060057 4 0.255
negative regulation of lymphocyte proliferation GO:0050672 45 0.254
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.254
regulation of dna templated transcription in response to stress GO:0043620 9 0.251
negative regulation of neural precursor cell proliferation GO:2000178 18 0.248
histone h4 k16 acetylation GO:0043984 3 0.245
small gtpase mediated signal transduction GO:0007264 97 0.245
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.239
b cell proliferation GO:0042100 53 0.238
oocyte maturation GO:0001556 18 0.236
skeletal muscle organ development GO:0060538 163 0.236
negative regulation of dna damage response signal transduction by p53 class mediator GO:0043518 5 0.235
Human
cation transport GO:0006812 399 0.235
positive regulation of cell cycle process GO:0090068 61 0.234
positive regulation of cell cycle GO:0045787 92 0.233
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.230
regulation of cellular ketone metabolic process GO:0010565 66 0.227
mitochondrial membrane organization GO:0007006 26 0.225
positive regulation of nucleotide metabolic process GO:0045981 114 0.223
positive regulation of binding GO:0051099 49 0.222
activation of mapk activity GO:0000187 59 0.219
appendage development GO:0048736 166 0.219
mitochondrion distribution GO:0048311 4 0.217
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.216
response to inorganic substance GO:0010035 96 0.214
cellular response to light stimulus GO:0071482 19 0.213
negative regulation of endothelial cell migration GO:0010596 4 0.212
cellular response to antibiotic GO:0071236 4 0.211
positive regulation of mitochondrion organization GO:0010822 17 0.210
regulation of mitosis GO:0007088 29 0.210
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.210
Human
regulation of ion transmembrane transport GO:0034765 119 0.210
t cell activation GO:0042110 289 0.208
retina development in camera type eye GO:0060041 119 0.208
positive regulation of autophagy GO:0010508 9 0.207
ribonucleoside catabolic process GO:0042454 206 0.207
negative regulation of organ growth GO:0046621 17 0.207
response to nitric oxide GO:0071731 4 0.206
chromatin modification GO:0016568 187 0.205
oocyte axis specification GO:0007309 2 0.204
dna damage response signal transduction resulting in transcription GO:0042772 2 0.204
dendritic spine morphogenesis GO:0060997 22 0.203
negative regulation of apoptotic signaling pathway GO:2001234 104 0.202
regulation of protein localization GO:0032880 231 0.200
positive regulation of macrophage apoptotic process GO:2000111 3 0.199
positive regulation of peptidase activity GO:0010952 49 0.199
negative regulation of growth GO:0045926 99 0.199
regulation of mesoderm development GO:2000380 12 0.198
neuron projection guidance GO:0097485 141 0.197
release of cytochrome c from mitochondria GO:0001836 23 0.197
response to oxygen levels GO:0070482 62 0.194
Human
regulation of histone modification GO:0031056 56 0.194
cellular response to nutrient levels GO:0031669 64 0.194
positive regulation of growth GO:0045927 104 0.194
b cell lineage commitment GO:0002326 4 0.194
purine containing compound metabolic process GO:0072521 311 0.193
cellular response to oxidative stress GO:0034599 76 0.191
negative regulation of cellular protein catabolic process GO:1903363 22 0.191
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.189
regulation of jun kinase activity GO:0043506 40 0.189
regulation of purine nucleotide metabolic process GO:1900542 169 0.189
regulation of jnk cascade GO:0046328 62 0.187
aromatic compound catabolic process GO:0019439 286 0.186
cell growth GO:0016049 130 0.186
regulation of peptidase activity GO:0052547 96 0.185
lymphocyte proliferation GO:0046651 164 0.185
regulation of microtubule polymerization GO:0031113 7 0.184
regulation of binding GO:0051098 111 0.184
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.183
phosphatidylinositol biosynthetic process GO:0006661 15 0.183
compound eye development GO:0048749 1 0.182
regulation of nucleotide metabolic process GO:0006140 169 0.181
dendritic spine development GO:0060996 30 0.180
regulation of mapk cascade GO:0043408 248 0.179
attachment of spindle microtubules to kinetochore GO:0008608 4 0.179
translation GO:0006412 93 0.178
mitotic sister chromatid segregation GO:0000070 14 0.177
regulation of intracellular transport GO:0032386 159 0.177
negative regulation of mitotic cell cycle GO:0045930 58 0.176
Human
cognition GO:0050890 149 0.176
regulation of cell size GO:0008361 72 0.174
positive regulation of response to dna damage stimulus GO:2001022 14 0.174
positive regulation of histone modification GO:0031058 28 0.173
tor signaling GO:0031929 21 0.171
response to nutrient levels GO:0031667 109 0.171
response to radiation GO:0009314 165 0.170
Zebrafish
anatomical structure homeostasis GO:0060249 145 0.169
embryonic skeletal system development GO:0048706 120 0.168
regulation of leukocyte proliferation GO:0070663 121 0.168
apoptotic mitochondrial changes GO:0008637 48 0.166
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.165
positive regulation of hydrolase activity GO:0051345 148 0.165
bone development GO:0060348 120 0.164
regulation of fibrinolysis GO:0051917 1 0.163
second messenger mediated signaling GO:0019932 73 0.163
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.162
hematopoietic progenitor cell differentiation GO:0002244 143 0.162
membrane organization GO:0061024 245 0.162
myeloid cell homeostasis GO:0002262 114 0.161
regulation of fibroblast proliferation GO:0048145 34 0.161
monocarboxylic acid metabolic process GO:0032787 191 0.160
positive regulation of neuron apoptotic process GO:0043525 25 0.158
cyclic nucleotide metabolic process GO:0009187 59 0.158
engulfment of apoptotic cell GO:0043652 3 0.157
regulation of cellular amino acid metabolic process GO:0006521 5 0.157
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.156
negative regulation of protein modification process GO:0031400 163 0.153
chromatin assembly GO:0031497 13 0.153
regulation of epidermal cell division GO:0010482 3 0.152
negative regulation of b cell activation GO:0050869 27 0.152
negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 7 0.151
immunoglobulin production GO:0002377 73 0.151
protein kinase b signaling GO:0043491 74 0.151
mapk cascade GO:0000165 281 0.150
blastocyst development GO:0001824 80 0.150
cytokine mediated signaling pathway GO:0019221 115 0.149
oocyte construction GO:0007308 2 0.147
regulation of lymphocyte proliferation GO:0050670 117 0.147
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.146
stem cell differentiation GO:0048863 268 0.146
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.144
mitotic g2 dna damage checkpoint GO:0007095 8 0.144
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.144
negative regulation of immune system process GO:0002683 209 0.144
regulation of ion transport GO:0043269 215 0.143
positive regulation of cell motility GO:2000147 116 0.143
purine nucleotide metabolic process GO:0006163 302 0.141
immature b cell differentiation GO:0002327 10 0.141
g2 dna damage checkpoint GO:0031572 8 0.140
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.140
negative regulation of cell division GO:0051782 24 0.139
central nervous system projection neuron axonogenesis GO:0021952 21 0.139
axon guidance GO:0007411 141 0.138
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.137
regulation of mitochondrion degradation GO:1903146 2 0.136
regulation of cell activation GO:0050865 289 0.136
cytokinesis GO:0000910 17 0.136
dna alkylation GO:0006305 43 0.135
double strand break repair GO:0006302 48 0.135
neuron maturation GO:0042551 29 0.135
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.135
regulation of defense response GO:0031347 233 0.135
regulation of plasminogen activation GO:0010755 4 0.134
positive regulation of rac protein signal transduction GO:0035022 1 0.134
response to extracellular stimulus GO:0009991 127 0.133
ion transmembrane transport GO:0034220 361 0.132
negative regulation of angiogenesis GO:0016525 25 0.132

Mdm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.998
cancer DOID:162 0 0.990
organ system cancer DOID:0050686 0 0.990
thoracic cancer DOID:5093 0 0.898
endocrine gland cancer DOID:170 0 0.885
immune system disease DOID:2914 0 0.696
disease of anatomical entity DOID:7 0 0.696
bone marrow disease DOID:4961 0 0.696
hematopoietic system disease DOID:74 0 0.696
large intestine cancer DOID:5672 0 0.644
colon cancer DOID:219 0 0.644
gastrointestinal system cancer DOID:3119 0 0.644
intestinal cancer DOID:10155 0 0.644
colorectal cancer DOID:9256 0 0.644
pancreatic cancer DOID:1793 0 0.502
immune system cancer DOID:0060083 0 0.423
breast cancer DOID:1612 0 0.374
male reproductive organ cancer DOID:3856 0 0.327
reproductive organ cancer DOID:193 0 0.327
hematologic cancer DOID:2531 0 0.309
respiratory system cancer DOID:0050615 0 0.192
lung cancer DOID:1324 0 0.192
urinary system cancer DOID:3996 0 0.192
colon carcinoma DOID:1520 0 0.156