Mus musculus

60 known processes

Atxn3

ataxin 3

(Aliases: ATX3,Mjd,2210008M02Rik,ataxin-3,MJD1,AI647473,Sca3,AI463012)

Atxn3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.253
cellular macromolecule catabolic process GO:0044265 206 0.217
protein catabolic process GO:0030163 221 0.204
protein modification by small protein conjugation GO:0032446 187 0.187
cellular protein catabolic process GO:0044257 155 0.186
macromolecule catabolic process GO:0009057 281 0.177
positive regulation of cellular catabolic process GO:0031331 148 0.155
protein polyubiquitination GO:0000209 33 0.155
protein ubiquitination GO:0016567 171 0.153
modification dependent macromolecule catabolic process GO:0043632 133 0.147
protein modification by small protein conjugation or removal GO:0070647 207 0.141
modification dependent protein catabolic process GO:0019941 133 0.108
amine metabolic process GO:0009308 45 0.092
peptidyl amino acid modification GO:0018193 336 0.083
covalent chromatin modification GO:0016569 163 0.082
Rat
chromatin modification GO:0016568 187 0.080
Rat
regulation of cellular ketone metabolic process GO:0010565 66 0.078
purine containing compound metabolic process GO:0072521 311 0.072
purine containing compound catabolic process GO:0072523 213 0.072
glycosyl compound metabolic process GO:1901657 246 0.070
positive regulation of protein modification process GO:0031401 299 0.070
purine ribonucleotide metabolic process GO:0009150 290 0.069
ribonucleoside metabolic process GO:0009119 245 0.066
aromatic compound catabolic process GO:0019439 286 0.066
cellular amino acid metabolic process GO:0006520 103 0.065
purine ribonucleoside metabolic process GO:0046128 241 0.063
purine nucleoside triphosphate catabolic process GO:0009146 203 0.061
purine nucleotide metabolic process GO:0006163 302 0.061
ribonucleotide metabolic process GO:0009259 291 0.058
nucleotide metabolic process GO:0009117 332 0.056
cellular amine metabolic process GO:0044106 44 0.056
regulation of cellular catabolic process GO:0031329 242 0.056
heterocycle catabolic process GO:0046700 280 0.055
positive regulation of cellular protein catabolic process GO:1903364 34 0.054
nucleoside phosphate metabolic process GO:0006753 338 0.054
regulation of cellular amine metabolic process GO:0033238 20 0.053
nucleobase containing small molecule metabolic process GO:0055086 352 0.053
ribose phosphate metabolic process GO:0019693 291 0.052
transmembrane transport GO:0055085 412 0.052
purine nucleoside triphosphate metabolic process GO:0009144 226 0.051
membrane organization GO:0061024 245 0.050
cellular nitrogen compound catabolic process GO:0044270 280 0.049
cellular response to dna damage stimulus GO:0006974 207 0.048
purine nucleoside catabolic process GO:0006152 205 0.046
regulation of cellular amino acid metabolic process GO:0006521 5 0.045
organophosphate catabolic process GO:0046434 232 0.045
purine nucleoside metabolic process GO:0042278 241 0.044
cellular ketone metabolic process GO:0042180 84 0.044
nucleoside monophosphate metabolic process GO:0009123 85 0.044
nucleoside catabolic process GO:0009164 206 0.044
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.043
carbohydrate derivative catabolic process GO:1901136 231 0.043
ribonucleoside triphosphate metabolic process GO:0009199 220 0.042
nucleoside metabolic process GO:0009116 246 0.042
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.041
carbohydrate metabolic process GO:0005975 230 0.041
ubiquitin dependent protein catabolic process GO:0006511 129 0.041
histone modification GO:0016570 159 0.041
Rat
regulation of proteolysis GO:0030162 164 0.041
chromatin organization GO:0006325 206 0.040
Rat
positive regulation of protein catabolic process GO:0045732 60 0.040
negative regulation of cellular protein metabolic process GO:0032269 247 0.039
ribonucleoside catabolic process GO:0042454 206 0.039
positive regulation of proteolysis GO:0045862 85 0.039
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.039
spermatogenesis GO:0007283 284 0.038
cellular lipid metabolic process GO:0044255 323 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
purine ribonucleotide catabolic process GO:0009154 208 0.037
organonitrogen compound catabolic process GO:1901565 264 0.037
nucleoside triphosphate catabolic process GO:0009143 205 0.037
carbohydrate derivative biosynthetic process GO:1901137 183 0.037
endocytosis GO:0006897 168 0.036
regulation of cellular component biogenesis GO:0044087 181 0.036
nucleoside phosphate catabolic process GO:1901292 222 0.036
ribonucleotide catabolic process GO:0009261 208 0.036
ribonucleoside triphosphate catabolic process GO:0009203 199 0.035
male gamete generation GO:0048232 285 0.035
glycosyl compound catabolic process GO:1901658 206 0.035
fertilization GO:0009566 127 0.034
urogenital system development GO:0001655 261 0.034
negative regulation of intracellular signal transduction GO:1902532 167 0.034
positive regulation of apoptotic process GO:0043065 217 0.034
positive regulation of cellular amine metabolic process GO:0033240 5 0.034
purine nucleotide catabolic process GO:0006195 211 0.033
regulation of cellular protein catabolic process GO:1903362 61 0.033
glycoprotein biosynthetic process GO:0009101 89 0.033
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.032
learning or memory GO:0007611 148 0.032
cognition GO:0050890 149 0.032
proteasomal protein catabolic process GO:0010498 98 0.031
regulation of organelle organization GO:0033043 289 0.031
nucleoside triphosphate metabolic process GO:0009141 230 0.030
protein processing GO:0016485 163 0.030
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.030
gland development GO:0048732 330 0.030
nucleotide catabolic process GO:0009166 217 0.030
organelle assembly GO:0070925 177 0.029
positive regulation of cell death GO:0010942 224 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.029
protein glycosylation GO:0006486 55 0.029
positive regulation of programmed cell death GO:0043068 218 0.029
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.029
purine ribonucleoside catabolic process GO:0046130 205 0.028
regulation of protein complex assembly GO:0043254 83 0.028
cellular response to external stimulus GO:0071496 88 0.027
regulation of hydrolase activity GO:0051336 246 0.027
positive regulation of organelle organization GO:0010638 128 0.027
immune effector process GO:0002252 321 0.027
mitochondrion organization GO:0007005 134 0.027
positive regulation of protein ubiquitination GO:0031398 27 0.027
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.027
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.027
dna metabolic process GO:0006259 303 0.026
ribonucleoside monophosphate metabolic process GO:0009161 80 0.026
cation transmembrane transport GO:0098655 266 0.026
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.026
protein oligomerization GO:0051259 67 0.026
cation transport GO:0006812 399 0.025
regulation of protein ubiquitination GO:0031396 52 0.025
multicellular organismal homeostasis GO:0048871 164 0.025
negative regulation of cellular component organization GO:0051129 194 0.025
regulation of cell cycle GO:0051726 281 0.025
macromolecule glycosylation GO:0043413 55 0.025
response to growth factor GO:0070848 198 0.025
positive regulation of hydrolase activity GO:0051345 148 0.025
leukocyte differentiation GO:0002521 342 0.024
cellular response to topologically incorrect protein GO:0035967 25 0.024
intracellular protein transport GO:0006886 204 0.023
cytoplasmic transport GO:0016482 234 0.023
regulation of transferase activity GO:0051338 263 0.023
regulation of cell activation GO:0050865 289 0.022
protein localization to organelle GO:0033365 185 0.022
dna repair GO:0006281 107 0.022
negative regulation of protein metabolic process GO:0051248 282 0.022
positive regulation of protein phosphorylation GO:0001934 242 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
cellular response to growth factor stimulus GO:0071363 197 0.022
sensory perception GO:0007600 245 0.021
ion transmembrane transport GO:0034220 361 0.021
cellular component assembly involved in morphogenesis GO:0010927 139 0.021
regulation of protein catabolic process GO:0042176 108 0.021
translation GO:0006412 93 0.021
response to extracellular stimulus GO:0009991 127 0.021
regulation of apoptotic signaling pathway GO:2001233 197 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.021
mapk cascade GO:0000165 281 0.020
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.020
skeletal system development GO:0001501 356 0.020
protein autophosphorylation GO:0046777 61 0.020
organonitrogen compound biosynthetic process GO:1901566 192 0.020
cellular protein complex assembly GO:0043623 116 0.020
negative regulation of molecular function GO:0044092 258 0.019
nitrogen compound transport GO:0071705 271 0.019
positive regulation of transferase activity GO:0051347 167 0.019
inorganic cation transmembrane transport GO:0098662 207 0.019
methylation GO:0032259 134 0.019
cellular homeostasis GO:0019725 240 0.019
myeloid cell differentiation GO:0030099 233 0.019
response to misfolded protein GO:0051788 5 0.019
single fertilization GO:0007338 82 0.019
macromolecule methylation GO:0043414 120 0.018
axonogenesis GO:0007409 274 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
regulation of protein kinase activity GO:0045859 232 0.018
fat cell differentiation GO:0045444 160 0.018
regulation of chromosome organization GO:0033044 83 0.018
protein maturation GO:0051604 176 0.018
wound healing GO:0042060 157 0.017
regulation of ion transport GO:0043269 215 0.017
ras protein signal transduction GO:0007265 77 0.017
atp metabolic process GO:0046034 75 0.017
positive regulation of protein kinase activity GO:0045860 144 0.017
rhythmic process GO:0048511 174 0.017
nucleoside monophosphate catabolic process GO:0009125 59 0.017
ovulation cycle GO:0042698 59 0.017
response to transforming growth factor beta GO:0071559 88 0.017
chemotaxis GO:0006935 247 0.017
actin cytoskeleton organization GO:0030036 220 0.017
Human
positive regulation of cellular component biogenesis GO:0044089 94 0.017
intracellular receptor signaling pathway GO:0030522 74 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
purine nucleoside monophosphate metabolic process GO:0009126 81 0.017
regulation of purine nucleotide metabolic process GO:1900542 169 0.017
glycosylation GO:0070085 62 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
multicellular organism growth GO:0035264 161 0.016
regulation of cell migration GO:0030334 219 0.016
lateral inhibition GO:0046331 1 0.016
regulation of chromatin organization GO:1902275 57 0.016
endomembrane system organization GO:0010256 147 0.016
protein localization to membrane GO:0072657 108 0.016
response to inorganic substance GO:0010035 96 0.016
regulation of membrane potential GO:0042391 192 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.015
oxidation reduction process GO:0055114 342 0.015
divalent metal ion transport GO:0070838 172 0.015
organelle disassembly GO:1903008 2 0.015
organelle localization GO:0051640 179 0.015
circadian rhythm GO:0007623 114 0.015
small gtpase mediated signal transduction GO:0007264 97 0.015
sensory perception of mechanical stimulus GO:0050954 107 0.015
regulation of protein transport GO:0051223 163 0.015
regulation of nucleotide metabolic process GO:0006140 169 0.015
glycoprotein metabolic process GO:0009100 116 0.015
tissue homeostasis GO:0001894 115 0.015
negative regulation of immune system process GO:0002683 209 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
neuron apoptotic process GO:0051402 142 0.015
stem cell differentiation GO:0048863 268 0.015
cellular response to cytokine stimulus GO:0071345 189 0.015
striated muscle tissue development GO:0014706 293 0.015
regulation of cell motility GO:2000145 236 0.015
anion transport GO:0006820 177 0.015
cellular response to starvation GO:0009267 57 0.015
positive regulation of cell activation GO:0050867 158 0.015
lipid biosynthetic process GO:0008610 179 0.015
meiotic cell cycle GO:0051321 122 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.014
positive regulation of protein complex assembly GO:0031334 45 0.014
cytokine production GO:0001816 319 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.014
regulation of map kinase activity GO:0043405 120 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
regulation of chromatin modification GO:1903308 57 0.014
development of primary sexual characteristics GO:0045137 143 0.014
muscle cell differentiation GO:0042692 261 0.014
regulation of stress activated mapk cascade GO:0032872 69 0.014
skeletal muscle organ development GO:0060538 163 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
stress activated mapk cascade GO:0051403 80 0.014
protein polymerization GO:0051258 57 0.014
metal ion homeostasis GO:0055065 189 0.014
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.014
muscle tissue development GO:0060537 308 0.014
mitotic cell cycle GO:0000278 195 0.014
cellular ion homeostasis GO:0006873 165 0.014
regulation of cytoskeleton organization GO:0051493 122 0.014
heart morphogenesis GO:0003007 178 0.014
atp catabolic process GO:0006200 55 0.014
cell growth GO:0016049 130 0.014
g protein coupled receptor signaling pathway GO:0007186 243 0.013
divalent inorganic cation transport GO:0072511 178 0.013
organic anion transport GO:0015711 137 0.013
action potential GO:0001508 78 0.013
rho protein signal transduction GO:0007266 32 0.013
actin filament organization GO:0007015 113 0.013
positive regulation of lymphocyte activation GO:0051251 140 0.013
organelle fission GO:0048285 170 0.013
cellular response to lipid GO:0071396 145 0.013
anatomical structure homeostasis GO:0060249 145 0.013
regulation of t cell activation GO:0050863 170 0.013
purine nucleoside monophosphate catabolic process GO:0009128 58 0.013
ribonucleoside monophosphate catabolic process GO:0009158 57 0.013
gonad development GO:0008406 141 0.013
ear development GO:0043583 200 0.013
reactive oxygen species metabolic process GO:0072593 84 0.013
response to radiation GO:0009314 165 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.013
negative regulation of organelle organization GO:0010639 90 0.013
cellular chemical homeostasis GO:0055082 215 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
regulation of cell projection organization GO:0031344 206 0.013
viral process GO:0016032 41 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
regulation of mapk cascade GO:0043408 248 0.013
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000058 14 0.013
microtubule based process GO:0007017 236 0.013
Human
locomotory behavior GO:0007626 195 0.013
interspecies interaction between organisms GO:0044419 83 0.013
regulation of nucleoside metabolic process GO:0009118 130 0.013
developmental maturation GO:0021700 193 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.012
nucleocytoplasmic transport GO:0006913 139 0.012
renal system development GO:0072001 225 0.012
phospholipid metabolic process GO:0006644 87 0.012
b cell activation GO:0042113 161 0.012
cell type specific apoptotic process GO:0097285 268 0.012
cation homeostasis GO:0055080 212 0.012
protein homooligomerization GO:0051260 43 0.012
er nucleus signaling pathway GO:0006984 27 0.012
regulation of cellular component size GO:0032535 121 0.012
dendrite development GO:0016358 115 0.012
ossification GO:0001503 216 0.012
apoptotic mitochondrial changes GO:0008637 48 0.012
maintenance of location GO:0051235 89 0.012
viral gene expression GO:0019080 3 0.012
cellular response to misfolded protein GO:0071218 5 0.012
positive regulation of nervous system development GO:0051962 221 0.012
camera type eye development GO:0043010 266 0.012
actin filament polymerization GO:0030041 44 0.012
regulation of cytokine production GO:0001817 266 0.012
negative regulation of protein modification process GO:0031400 163 0.012
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
homeostasis of number of cells GO:0048872 210 0.012
negative regulation of cell cycle GO:0045786 123 0.012
regulation of cell adhesion GO:0030155 154 0.012
response to nutrient levels GO:0031667 109 0.012
compound eye development GO:0048749 1 0.012
synaptic transmission GO:0007268 329 0.012
Worm
organ growth GO:0035265 117 0.012
regulation of cell growth GO:0001558 91 0.012
b cell differentiation GO:0030183 78 0.012
regulation of peptidase activity GO:0052547 96 0.012
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.012
embryonic organ morphogenesis GO:0048562 276 0.012
germ cell development GO:0007281 185 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
regulation of lipid metabolic process GO:0019216 118 0.011
negative regulation of cytoskeleton organization GO:0051494 36 0.011
nuclear division GO:0000280 158 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
carbohydrate homeostasis GO:0033500 128 0.011
mrna metabolic process GO:0016071 84 0.011
lymphocyte proliferation GO:0046651 164 0.011
epithelial cell development GO:0002064 159 0.011
digestive system development GO:0055123 200 0.011
cellular response to nutrient levels GO:0031669 64 0.011
negative regulation of cell proliferation GO:0008285 296 0.011
mitochondrial transport GO:0006839 36 0.011
regulation of nucleotide catabolic process GO:0030811 122 0.011
protein deubiquitination GO:0016579 19 0.011
response to acid chemical GO:0001101 111 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
regulation of proteasomal protein catabolic process GO:0061136 46 0.011
organelle membrane fusion GO:0090174 1 0.011
long term memory GO:0007616 15 0.011
dephosphorylation GO:0016311 129 0.011
regulation of protein localization GO:0032880 231 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
meiotic nuclear division GO:0007126 115 0.011
regulation of neuron death GO:1901214 134 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.011
extrinsic apoptotic signaling pathway GO:0097191 126 0.011
t cell activation GO:0042110 289 0.011
nuclear import GO:0051170 95 0.011
protein localization to nucleus GO:0034504 121 0.011
positive regulation of nucleotide metabolic process GO:0045981 114 0.011
respiratory system development GO:0060541 190 0.011
regulation of histone modification GO:0031056 56 0.011
detection of stimulus GO:0051606 84 0.011
embryonic epithelial tube formation GO:0001838 130 0.011
microtubule cytoskeleton organization GO:0000226 157 0.011
Human
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.011
positive regulation of chromatin modification GO:1903310 28 0.011
regulation of purine nucleotide catabolic process GO:0033121 122 0.011
calcium ion transport GO:0006816 159 0.011
transmission of nerve impulse GO:0019226 76 0.011
actin filament bundle assembly GO:0051017 40 0.011
calcium ion homeostasis GO:0055074 127 0.011
apoptotic signaling pathway GO:0097190 306 0.011
carbohydrate transport GO:0008643 62 0.011
negative regulation of neuron death GO:1901215 98 0.011
response to light stimulus GO:0009416 135 0.011
regulation of ion transmembrane transport GO:0034765 119 0.010
cellular calcium ion homeostasis GO:0006874 119 0.010
sperm motility GO:0030317 47 0.010
response to molecule of bacterial origin GO:0002237 143 0.010
regulation of transmembrane transport GO:0034762 128 0.010
regulation of leukocyte differentiation GO:1902105 159 0.010
mitotic cell cycle process GO:1903047 159 0.010
neural tube development GO:0021915 160 0.010
guanosine containing compound catabolic process GO:1901069 144 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
positive regulation of nucleoside metabolic process GO:0045979 91 0.010
canonical wnt signaling pathway GO:0060070 130 0.010
small molecule biosynthetic process GO:0044283 132 0.010
leukocyte activation involved in immune response GO:0002366 126 0.010
response to endoplasmic reticulum stress GO:0034976 53 0.010
lymphocyte differentiation GO:0030098 242 0.010
inflammatory response GO:0006954 244 0.010

Atxn3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.041
Human
nervous system disease DOID:863 0 0.041
Human
central nervous system disease DOID:331 0 0.030
Human
neurodegenerative disease DOID:1289 0 0.022
Human
disease of cellular proliferation DOID:14566 0 0.020
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.014