Mus musculus

269 known processes

Notch2

Notch gene homolog 2 (Drosophila)

(Aliases: N2,AI853703)

Notch2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of blood vessel endothelial cell migration GO:0043537 3 1.000
somite specification GO:0001757 4 1.000
venous blood vessel morphogenesis GO:0048845 7 0.999
Mouse
blood vessel endothelial cell differentiation GO:0060837 6 0.999
Mouse
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.998
Mouse
blood vessel lumenization GO:0072554 2 0.996
cardiac vascular smooth muscle cell development GO:0060948 3 0.996
Mouse
negative regulation of endothelial cell migration GO:0010596 4 0.995
epithelial tube morphogenesis GO:0060562 303 0.993
anagen GO:0042640 13 0.991
Mouse
cardiac right atrium morphogenesis GO:0003213 3 0.990
Mouse
gland development GO:0048732 330 0.990
Zebrafish Mouse Fly
positive regulation of transcription of notch receptor target GO:0007221 4 0.990
Mouse
lateral inhibition GO:0046331 1 0.989
Fly
myeloid cell differentiation GO:0030099 233 0.988
regulation of endothelial cell chemotaxis GO:2001026 1 0.983
cell migration involved in endocardial cushion formation GO:0003273 3 0.983
Mouse
embryonic placenta development GO:0001892 98 0.980
autophagic vacuole assembly GO:0000045 13 0.979
metanephric glomerular mesangium development GO:0072223 3 0.979
endothelial tube morphogenesis GO:0061154 2 0.979
negative regulation of cell migration GO:0030336 59 0.979
vascular smooth muscle cell differentiation GO:0035886 11 0.977
Mouse
cardiac right ventricle formation GO:0003219 3 0.977
Mouse
arterial endothelial cell differentiation GO:0060842 5 0.975
Mouse
placenta blood vessel development GO:0060674 31 0.974
cellular amino acid metabolic process GO:0006520 103 0.974
regulation of cellular ketone metabolic process GO:0010565 66 0.973
hair follicle development GO:0001942 85 0.973
Mouse
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.972
renal tubule development GO:0061326 87 0.971
embryonic heart tube morphogenesis GO:0003143 51 0.968
neural tube development GO:0021915 160 0.967
Mouse
regulation of neuron differentiation GO:0045664 281 0.965
Mouse Fly
morphogenesis of an endothelium GO:0003159 2 0.965
pulmonary valve morphogenesis GO:0003184 5 0.964
Human
appendage morphogenesis GO:0035107 149 0.959
epithelium migration GO:0090132 63 0.958
Fly
dorsal aorta morphogenesis GO:0035912 5 0.957
striated muscle tissue development GO:0014706 293 0.957
Mouse Fly
positive regulation of map kinase activity GO:0043406 84 0.957
ossification GO:0001503 216 0.955
Mouse
regulation of cell cycle GO:0051726 281 0.955
Human Worm Fly
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.954
growth involved in heart morphogenesis GO:0003241 4 0.954
Mouse
negative regulation of cell motility GO:2000146 61 0.953
interleukin 4 secretion GO:0072602 5 0.952
positive regulation of keratinocyte differentiation GO:0045618 3 0.949
Mouse
cation transport GO:0006812 399 0.948
muscle tissue development GO:0060537 308 0.945
Mouse Fly
regulation of somitogenesis GO:0014807 6 0.945
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.944
Mouse Fly
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.944
respiratory system development GO:0060541 190 0.944
Mouse Fly
regulation of blood vessel endothelial cell migration GO:0043535 12 0.941
artery development GO:0060840 53 0.941
Mouse
hair cycle GO:0042633 90 0.940
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.940
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.938
determination of heart left right asymmetry GO:0061371 48 0.936
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.930
positive regulation of cell cycle GO:0045787 92 0.929
Fly
cell adhesion GO:0007155 329 0.926
Fly
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.920
hematopoietic progenitor cell differentiation GO:0002244 143 0.912
Mouse
coronary vein morphogenesis GO:0003169 2 0.908
Mouse
axonogenesis GO:0007409 274 0.908
Mouse Fly
leukocyte differentiation GO:0002521 342 0.907
cardiocyte differentiation GO:0035051 87 0.903
Mouse Fly
response to peptide GO:1901652 136 0.901
Mouse
regulation of cardiac cell fate specification GO:2000043 1 0.901
Fly
placenta development GO:0001890 140 0.901
stem cell differentiation GO:0048863 268 0.900
Mouse Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.900
Mouse
pericardium morphogenesis GO:0003344 5 0.898
Mouse
organelle fission GO:0048285 170 0.895
Worm
gonad development GO:0008406 141 0.892
Worm
regulation of cell migration GO:0030334 219 0.887
Mouse
i kappab phosphorylation GO:0007252 6 0.887
Fly
macromolecule glycosylation GO:0043413 55 0.886
choline transport GO:0015871 3 0.886
mesenchyme development GO:0060485 152 0.886
Mouse
negative regulation of epithelial cell migration GO:0010633 9 0.886
formation of radial glial scaffolds GO:0021943 4 0.880
myeloid leukocyte differentiation GO:0002573 119 0.878
neuron migration GO:0001764 122 0.877
positive regulation of transferase activity GO:0051347 167 0.877
mesenchymal cell differentiation GO:0048762 107 0.876
Mouse
coronary vasculature morphogenesis GO:0060977 9 0.876
Mouse
cilium assembly GO:0042384 81 0.873
negative regulation of protein phosphorylation GO:0001933 126 0.873
regulation of organelle organization GO:0033043 289 0.872
Worm
regulation of dna templated transcription in response to stress GO:0043620 9 0.872
Mouse
response to x ray GO:0010165 11 0.872
epithelial cell proliferation GO:0050673 174 0.865
Mouse Fly
epithelial cell differentiation involved in kidney development GO:0035850 23 0.863
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.861
ameboidal type cell migration GO:0001667 128 0.860
Fly
immune effector process GO:0002252 321 0.860
negative regulation of glial cell proliferation GO:0060253 4 0.858
Mouse
cardiac muscle tissue development GO:0048738 130 0.856
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.856
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.856
Mouse
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.854
Mouse
biological phase GO:0044848 20 0.851
Mouse
embryonic skeletal system development GO:0048706 120 0.851
transmembrane transport GO:0055085 412 0.850
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.850
Fly
meiotic cell cycle GO:0051321 122 0.847
Worm
protein glycosylation GO:0006486 55 0.845
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.845
organelle assembly GO:0070925 177 0.843
regulation of kinase activity GO:0043549 249 0.841
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.841
sensory organ boundary specification GO:0008052 1 0.838
Fly
odontogenesis GO:0042476 78 0.838
divalent inorganic cation transport GO:0072511 178 0.831
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.830
Mouse
copper ion transport GO:0006825 10 0.828
regulation of cell motility GO:2000145 236 0.824
Mouse
photoreceptor cell differentiation GO:0046530 52 0.822
Mouse Fly
immune response regulating signaling pathway GO:0002764 125 0.822
cytokine production GO:0001816 319 0.822
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 1 0.822
Mouse
activation of mapkk activity GO:0000186 15 0.820
apoptotic process involved in morphogenesis GO:0060561 25 0.820
Mouse
ventricular septum morphogenesis GO:0060412 27 0.819
myeloid dendritic cell differentiation GO:0043011 16 0.816
negative regulation of cellular component organization GO:0051129 194 0.812
sprouting angiogenesis GO:0002040 26 0.811
Mouse
regulation of cytokine production GO:0001817 266 0.810
embryonic heart tube development GO:0035050 65 0.809
negative regulation of immune system process GO:0002683 209 0.809
Mouse
appendage development GO:0048736 166 0.807
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.801
Mouse
positive regulation of apoptotic process GO:0043065 217 0.801
glomerular visceral epithelial cell development GO:0072015 6 0.800
regulation of chemotaxis GO:0050920 53 0.799
morphogenesis of a branching epithelium GO:0061138 193 0.798
Mouse
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.796
Mouse
regulation of pro b cell differentiation GO:2000973 5 0.794
Mouse
axon guidance GO:0007411 141 0.793
Fly
kidney development GO:0001822 213 0.789
autophagy GO:0006914 45 0.788
nuclear division GO:0000280 158 0.786
Worm
erythrocyte differentiation GO:0030218 88 0.776
regulation of myeloid cell differentiation GO:0045637 96 0.775
renal system vasculature development GO:0061437 15 0.774
digestive tract morphogenesis GO:0048546 147 0.774
Mouse Fly
cardiac muscle cell differentiation GO:0055007 69 0.769
positive regulation of mitotic cell cycle GO:0045931 41 0.762
Fly
clara cell differentiation GO:0060486 4 0.761
glomerular capillary formation GO:0072104 6 0.760
ovulation cycle GO:0042698 59 0.759
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.758
melanocyte differentiation GO:0030318 25 0.756
kidney vasculature morphogenesis GO:0061439 7 0.755
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.751
segment specification GO:0007379 15 0.747
development of primary sexual characteristics GO:0045137 143 0.747
Worm
regulation of epithelial cell proliferation GO:0050678 141 0.744
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.740
positive regulation of creb transcription factor activity GO:0032793 4 0.735
skin development GO:0043588 220 0.734
Mouse
extracellular matrix organization GO:0030198 147 0.730
Mouse
salivary gland development GO:0007431 37 0.730
regulation of heart growth GO:0060420 31 0.729
Mouse
response to hypoxia GO:0001666 58 0.723
Mouse
gliogenesis GO:0042063 141 0.720
Mouse Fly
cation homeostasis GO:0055080 212 0.719
cell substrate adhesion GO:0031589 130 0.718
humoral immune response GO:0006959 57 0.718
cardiac muscle tissue morphogenesis GO:0055008 44 0.717
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.717
cellular amine metabolic process GO:0044106 44 0.716
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.715
membrane protein proteolysis GO:0033619 10 0.715
glomerular mesangial cell development GO:0072144 3 0.714
Mouse
neuron projection guidance GO:0097485 141 0.714
Fly
embryonic limb morphogenesis GO:0030326 126 0.714
regulation of proteolysis GO:0030162 164 0.713
negative regulation of anoikis GO:2000811 2 0.712
neuron apoptotic process GO:0051402 142 0.709
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.707
labyrinthine layer development GO:0060711 49 0.706
labyrinthine layer blood vessel development GO:0060716 21 0.705
tissue remodeling GO:0048771 102 0.701
Human
regulation of cardioblast differentiation GO:0051890 3 0.699
Fly
beta amyloid formation GO:0034205 9 0.697
protein modification by small protein conjugation or removal GO:0070647 207 0.697
homeostasis of number of cells GO:0048872 210 0.696
Fly
determination of left right symmetry GO:0007368 80 0.696
developmental growth involved in morphogenesis GO:0060560 138 0.693
Mouse
amine metabolic process GO:0009308 45 0.691
regulation of cellular amine metabolic process GO:0033238 20 0.691
proteasomal protein catabolic process GO:0010498 98 0.689
limb development GO:0060173 166 0.688
carbohydrate derivative biosynthetic process GO:1901137 183 0.687
cardiac neural crest cell differentiation involved in heart development GO:0061307 8 0.686
glial cell fate determination GO:0007403 3 0.685
Fly
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.685
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.685
positive regulation of osteoclast differentiation GO:0045672 15 0.684
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 6 0.683
myeloid leukocyte activation GO:0002274 83 0.682
stem cell development GO:0048864 219 0.681
Mouse Fly
response to oxygen levels GO:0070482 62 0.679
Mouse
spermatogenesis GO:0007283 284 0.678
embryonic organ morphogenesis GO:0048562 276 0.677
negative regulation of auditory receptor cell differentiation GO:0045608 2 0.673
heart morphogenesis GO:0003007 178 0.673
negative regulation of neuron differentiation GO:0045665 101 0.672
Mouse Fly
negative regulation of cell development GO:0010721 169 0.671
Mouse Fly
response to symbiont GO:0009608 2 0.671
Fly
embryonic hemopoiesis GO:0035162 23 0.667
Fly
cell type specific apoptotic process GO:0097285 268 0.663
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.663
cellular response to external stimulus GO:0071496 88 0.661
dorsal aorta development GO:0035907 6 0.661
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.657
regulation of neuron projection development GO:0010975 169 0.656
urogenital system development GO:0001655 261 0.655
lymph vessel morphogenesis GO:0036303 11 0.654
Zebrafish
response to molecule of bacterial origin GO:0002237 143 0.652
epithelial cell development GO:0002064 159 0.651
coronary vasculature development GO:0060976 12 0.649
Mouse
myeloid dendritic cell activation GO:0001773 25 0.648
interleukin 4 production GO:0032633 24 0.647
multi organism behavior GO:0051705 62 0.643
Worm
regulation of membrane potential GO:0042391 192 0.639
stem cell maintenance GO:0019827 130 0.639
Fly
memory GO:0007613 58 0.638
Fly
cellular response to radiation GO:0071478 28 0.636
release of cytochrome c from mitochondria GO:0001836 23 0.633
defense response to other organism GO:0098542 197 0.632
cellular amide metabolic process GO:0043603 58 0.631
regulation of reactive oxygen species metabolic process GO:2000377 40 0.629
actin filament organization GO:0007015 113 0.629
Fly
cellular ketone metabolic process GO:0042180 84 0.629
positive regulation of epithelial cell proliferation GO:0050679 68 0.628
Mouse
positive regulation of cell cycle process GO:0090068 61 0.627
Fly
positive regulation of bmp signaling pathway GO:0030513 23 0.624
organic hydroxy compound transport GO:0015850 93 0.618
regulation of bmp signaling pathway GO:0030510 60 0.617
negative regulation of neuron projection development GO:0010977 50 0.617
negative regulation of fat cell differentiation GO:0045599 36 0.615
regulation of cell cycle process GO:0010564 160 0.612
Worm Fly
pigment cell differentiation GO:0050931 27 0.609
atrioventricular node development GO:0003162 3 0.606
Mouse
synaptic transmission GO:0007268 329 0.605
tissue migration GO:0090130 68 0.603
Fly
notch signaling involved in heart development GO:0061314 5 0.603
Mouse
regulation of epidermal cell differentiation GO:0045604 21 0.597
Mouse
regulation of smooth muscle cell migration GO:0014910 6 0.596
ventricular septum development GO:0003281 42 0.595
outflow tract morphogenesis GO:0003151 53 0.594
regulation of resting membrane potential GO:0060075 3 0.591
inner ear receptor cell fate commitment GO:0060120 6 0.591
Mouse
myeloid cell homeostasis GO:0002262 114 0.590
regulation of vesicle mediated transport GO:0060627 139 0.590
Mouse
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 4 0.588
Mouse
protein ubiquitination GO:0016567 171 0.588
positive regulation of mitotic cell cycle embryonic GO:0045977 2 0.586
lung development GO:0030324 164 0.586
Mouse
cell division GO:0051301 120 0.585
Mouse Worm
somitogenesis GO:0001756 69 0.583
Mouse
activation of immune response GO:0002253 138 0.581
mesonephric epithelium development GO:0072163 94 0.580
mitotic cell cycle process GO:1903047 159 0.580
Fly
morphogenesis of an epithelial sheet GO:0002011 27 0.578
skeletal muscle organ development GO:0060538 163 0.576
Mouse Fly
protein modification by small protein conjugation GO:0032446 187 0.576
formation of organ boundary GO:0010160 1 0.575
Fly
ciliary body morphogenesis GO:0061073 3 0.575
glycosylation GO:0070085 62 0.575
neuroblast fate determination GO:0007400 1 0.572
Fly
molting cycle GO:0042303 90 0.571
Mouse
response to growth factor GO:0070848 198 0.568
embryonic appendage morphogenesis GO:0035113 126 0.568
negative regulation of cell proliferation GO:0008285 296 0.567
Human Mouse
digestive system development GO:0055123 200 0.565
Mouse Worm Fly
morphogenesis of embryonic epithelium GO:0016331 159 0.561
regulation of muscle tissue development GO:1901861 97 0.561
Mouse
mesangial cell differentiation GO:0072007 4 0.560
Mouse
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.555
Fly
mitotic cell cycle GO:0000278 195 0.554
Fly
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.554
positive regulation of cell fate commitment GO:0010455 8 0.551
development of primary female sexual characteristics GO:0046545 73 0.550
cell chemotaxis GO:0060326 81 0.549
ion transmembrane transport GO:0034220 361 0.549
somite development GO:0061053 81 0.547
Mouse
response to radiation GO:0009314 165 0.546
b cell activation GO:0042113 161 0.545
cell fate determination involved in pattern specification GO:0060582 1 0.543
Fly
regulation of cardiac muscle tissue growth GO:0055021 26 0.542
Mouse
cognition GO:0050890 149 0.542
Fly
tube formation GO:0035148 140 0.542
positive regulation of protein kinase activity GO:0045860 144 0.538
regulation of cell activation GO:0050865 289 0.538
regulation of protein processing GO:0070613 96 0.537
ovarian follicle development GO:0001541 40 0.535
l amino acid transport GO:0015807 32 0.533
regulation of protein kinase activity GO:0045859 232 0.532
glomerular mesangial cell differentiation GO:0072008 3 0.532
Mouse
cellular response to x ray GO:0071481 2 0.531
inner ear receptor cell differentiation GO:0060113 61 0.530
Mouse
developmental programmed cell death GO:0010623 41 0.528
Mouse
negative regulation of protein processing GO:0010955 79 0.528
regionalization GO:0003002 337 0.525
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.525
regulation of mitotic cell cycle GO:0007346 126 0.519
Fly
retinal blood vessel morphogenesis GO:0061304 3 0.518
developmental maturation GO:0021700 193 0.517
Mouse
odontogenesis of dentin containing tooth GO:0042475 66 0.516
regulation of map kinase activity GO:0043405 120 0.516
response to organic cyclic compound GO:0014070 198 0.516
regulation of cellular response to growth factor stimulus GO:0090287 82 0.515
extrinsic apoptotic signaling pathway GO:0097191 126 0.514
cardiac septum morphogenesis GO:0060411 46 0.513
Human Mouse
mesoderm development GO:0007498 100 0.513
Fly
dna biosynthetic process GO:0071897 22 0.512
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.512
neural tube formation GO:0001841 108 0.511
dendritic cell differentiation GO:0097028 26 0.510
response to organonitrogen compound GO:0010243 246 0.510
Mouse
metanephric glomerular endothelium development GO:0072264 1 0.508
blood vessel morphogenesis GO:0048514 285 0.508
peptidyl serine modification GO:0018209 83 0.508
morphogenesis of a branching structure GO:0001763 203 0.507
Mouse
cardiac chamber development GO:0003205 108 0.506
Human Mouse
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.504
Mouse
neural precursor cell proliferation GO:0061351 121 0.500
venous blood vessel development GO:0060841 13 0.498
Mouse
nephron morphogenesis GO:0072028 69 0.496
regulation of myeloid leukocyte differentiation GO:0002761 58 0.496
response to decreased oxygen levels GO:0036293 59 0.492
Mouse
striated muscle contraction GO:0006941 45 0.491
skeletal system development GO:0001501 356 0.490
Zebrafish
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.489
Mouse
positive regulation of kinase activity GO:0033674 155 0.488
left right axis specification GO:0070986 13 0.488
lymphocyte proliferation GO:0046651 164 0.486
glycerolipid metabolic process GO:0046486 122 0.485
cardiac left ventricle morphogenesis GO:0003214 9 0.484
Mouse
photoreceptor cell development GO:0042461 40 0.484
Fly
regulation of neuroblast proliferation GO:1902692 27 0.484
regulation of coagulation GO:0050818 31 0.482
regulation of neuron apoptotic process GO:0043523 122 0.481
regulation of protein targeting GO:1903533 61 0.479
inflammatory response GO:0006954 244 0.479
regulation of establishment of protein localization GO:0070201 181 0.478
carbohydrate metabolic process GO:0005975 230 0.474
membrane protein ectodomain proteolysis GO:0006509 7 0.472
mesenchymal cell development GO:0014031 93 0.472
Mouse
kidney vasculature development GO:0061440 15 0.471
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.470
peptidyl amino acid modification GO:0018193 336 0.470
multi multicellular organism process GO:0044706 109 0.466
Worm
divalent metal ion transport GO:0070838 172 0.466
nephron tubule development GO:0072080 84 0.465
reactive oxygen species metabolic process GO:0072593 84 0.464
lipid biosynthetic process GO:0008610 179 0.463
positive regulation of heart growth GO:0060421 18 0.463
Mouse
regulation of anoikis GO:2000209 2 0.463
respiratory tube development GO:0030323 167 0.462
Mouse
protein catabolic process GO:0030163 221 0.461
keratinocyte differentiation GO:0030216 48 0.460
Mouse
female sex differentiation GO:0046660 84 0.459
endocardial cushion formation GO:0003272 13 0.459
Mouse
regulation of cellular catabolic process GO:0031329 242 0.456
innate immune response GO:0045087 157 0.455
negative regulation of endothelial cell differentiation GO:0045602 2 0.453
Mouse
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.453
Mouse
germ cell development GO:0007281 185 0.452
Fly
positive regulation of smooth muscle cell migration GO:0014911 4 0.452
extracellular structure organization GO:0043062 148 0.450
Mouse
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.449
renal system development GO:0072001 225 0.448
secondary heart field specification GO:0003139 6 0.446
leukocyte proliferation GO:0070661 172 0.443
coagulation GO:0050817 78 0.438
cardiac muscle contraction GO:0060048 32 0.437
positive regulation of cell death GO:0010942 224 0.437
blood vessel endothelial cell migration GO:0043534 23 0.435
retina vasculature development in camera type eye GO:0061298 17 0.433
cellular protein catabolic process GO:0044257 155 0.432
nephron development GO:0072006 109 0.430
positive regulation of astrocyte differentiation GO:0048711 8 0.428
Mouse
lipid homeostasis GO:0055088 63 0.428
t cell activation GO:0042110 289 0.427
regulation of phospholipase c activity GO:1900274 3 0.425
kidney epithelium development GO:0072073 121 0.424
neural crest cell differentiation GO:0014033 54 0.424
photoreceptor cell morphogenesis GO:0008594 3 0.424
positive regulation of cell migration GO:0030335 109 0.424
Mouse
neuropilin signaling pathway GO:0038189 2 0.420
regulation of transferase activity GO:0051338 263 0.420
negative regulation of ligase activity GO:0051352 3 0.418
neural tube patterning GO:0021532 43 0.418
positive regulation of protein autophosphorylation GO:0031954 4 0.418
regulation of endopeptidase activity GO:0052548 89 0.417
apoptotic process involved in development GO:1902742 28 0.415
Mouse
retina vasculature morphogenesis in camera type eye GO:0061299 10 0.415
primary neural tube formation GO:0014020 95 0.415
negative regulation of epidermal cell differentiation GO:0045605 7 0.414
neural crest cell migration GO:0001755 32 0.414
regulation of protein serine threonine kinase activity GO:0071900 157 0.413
regulation of peptidase activity GO:0052547 96 0.413
glomerular epithelium development GO:0072010 11 0.411
cellular macromolecule catabolic process GO:0044265 206 0.410
aortic valve morphogenesis GO:0003180 4 0.409
regulation of protein complex assembly GO:0043254 83 0.409
gamma delta t cell differentiation GO:0042492 11 0.408
neuroblast differentiation GO:0014016 2 0.406
Fly
glomerulus vasculature morphogenesis GO:0072103 6 0.405
spinal cord development GO:0021510 81 0.405
regulation of calcium ion dependent exocytosis GO:0017158 16 0.404
Mouse
apoptotic process involved in mammary gland involution GO:0060057 4 0.403
cardiac neural crest cell development involved in heart development GO:0061308 7 0.398
regulation of endothelial cell migration GO:0010594 22 0.398
cellular response to ionizing radiation GO:0071479 11 0.396
negative regulation of protein maturation GO:1903318 79 0.395
positive regulation of protein modification process GO:0031401 299 0.393
mitral valve morphogenesis GO:0003183 4 0.392
wnt signaling pathway GO:0016055 188 0.391
Mouse
aorta development GO:0035904 23 0.387
cardiac muscle cell development GO:0055013 39 0.386
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.385
nephron epithelium development GO:0072009 92 0.385
organ regeneration GO:0031100 2 0.385
regulation of apoptotic signaling pathway GO:2001233 197 0.384
regulation of cardiac muscle tissue development GO:0055024 31 0.384
Mouse
endocytosis GO:0006897 168 0.383
Worm
heart field specification GO:0003128 6 0.381
cellular response to starvation GO:0009267 57 0.381
response to steroid hormone GO:0048545 56 0.379
embryonic epithelial tube formation GO:0001838 130 0.376
morphogenesis of a polarized epithelium GO:0001738 37 0.371
divalent inorganic cation homeostasis GO:0072507 138 0.371
cilium morphogenesis GO:0060271 102 0.369
neuron death GO:0070997 154 0.368
positive regulation of myeloid cell differentiation GO:0045639 43 0.368
embryonic digit morphogenesis GO:0042733 56 0.368
Mouse
glomerulus vasculature development GO:0072012 14 0.368
retina development in camera type eye GO:0060041 119 0.367
positive regulation of dna biosynthetic process GO:2000573 4 0.366
positive regulation of protein phosphorylation GO:0001934 242 0.366
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.366
positive regulation of cellular amine metabolic process GO:0033240 5 0.365
cardiac conduction system development GO:0003161 12 0.365
Mouse
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.364
Mouse
metanephric mesenchymal cell migration GO:0035789 2 0.364
positive regulation of cardiac muscle cell differentiation GO:2000727 6 0.364
ras protein signal transduction GO:0007265 77 0.363
Human
cellular response to lipid GO:0071396 145 0.363
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.361
heart growth GO:0060419 45 0.361
Mouse
regulation of cell adhesion GO:0030155 154 0.359
negative regulation of mechanoreceptor differentiation GO:0045632 3 0.359
branching involved in salivary gland morphogenesis GO:0060445 26 0.358
jak stat cascade GO:0007259 42 0.358
Mouse
cellular lipid metabolic process GO:0044255 323 0.357
cell migration involved in sprouting angiogenesis GO:0002042 9 0.355
calcium ion transport GO:0006816 159 0.355
b cell differentiation GO:0030183 78 0.354
positive regulation of neural precursor cell proliferation GO:2000179 42 0.354
lung vasculature development GO:0060426 7 0.353
regulation of embryonic development GO:0045995 71 0.353
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.353
primitive hemopoiesis GO:0060215 7 0.353
learning or memory GO:0007611 148 0.352
Fly
endothelial cell differentiation GO:0045446 41 0.352
Mouse
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.352
blood coagulation GO:0007596 76 0.351
exocrine system development GO:0035272 45 0.350
negative regulation of cell projection organization GO:0031345 56 0.350
regulation of nuclear division GO:0051783 56 0.350
Worm
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.349
male gamete generation GO:0048232 285 0.347
positive regulation of lymphocyte proliferation GO:0050671 70 0.347
regulation of protein maturation GO:1903317 96 0.347

Notch2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.932
disease of anatomical entity DOID:7 0 0.932
Human
cardiovascular system disease DOID:1287 0 0.932
disease of cellular proliferation DOID:14566 0 0.897
cancer DOID:162 0 0.782
muscular disease DOID:0080000 0 0.765
musculoskeletal system disease DOID:17 0 0.765
muscle tissue disease DOID:66 0 0.765
disease of mental health DOID:150 0 0.684
cognitive disorder DOID:1561 0 0.684
myopathy DOID:423 0 0.684
cardiomyopathy DOID:0050700 0 0.684
intrinsic cardiomyopathy DOID:0060036 0 0.684
dementia DOID:1307 0 0.444
central nervous system disease DOID:331 0 0.347
neurodegenerative disease DOID:1289 0 0.347
nervous system disease DOID:863 0 0.347