IMP

Process View

Mus musculus

11 genes annotated in mouse

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO:1902042

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
Psen1	presenilin 1	0.991	Mouse
Ptgs2	prostaglandin-endoperoxide synthase 2	0.982
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.917
Notch1	Notch gene homolog 1 (Drosophila)	0.849
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.841
Mmp9	matrix metallopeptidase 9	0.837
Ccl2	chemokine (C-C motif) ligand 2	0.723
Cd44	CD44 antigen	0.712
Sfrp2	secreted frizzled-related protein 2	0.677
Sfrp1	secreted frizzled-related protein 1	0.663	Mouse
Notch2	Notch gene homolog 2 (Drosophila)	0.663
Egfr	epidermal growth factor receptor	0.648
Apc	adenomatosis polyposis coli	0.603
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.542
Trp53	transformation related protein 53	0.539
Thbs1	thrombospondin 1	0.521
Plg	plasminogen	0.486	Mouse
Nos2	nitric oxide synthase 2, inducible	0.419
Psen2	presenilin 2	0.359
Rb1	retinoblastoma 1	0.322
Ncstn	nicastrin	0.294
Mdm2	transformed mouse 3T3 cell double minute 2	0.287
Tnfrsf22	tumor necrosis factor receptor superfamily, member 22	0.265
Ctnnb1	catenin (cadherin associated protein), beta 1	0.260
Esr1	estrogen receptor 1 (alpha)	0.242
Stat3	signal transducer and activator of transcription 3	0.239
Pten	phosphatase and tensin homolog	0.212
Fas	Fas (TNF receptor superfamily member 6)	0.175
Lyz2	lysozyme 2	0.159
Smad3	MAD homolog 3 (Drosophila)	0.151
Plau	plasminogen activator, urokinase	0.147	Mouse
Nos1	nitric oxide synthase 1, neuronal	0.138
Fgg	fibrinogen gamma chain	0.138
Cav1	caveolin 1, caveolae protein	0.127
Braf	Braf transforming gene	0.123	Mouse
Runx1	runt related transcription factor 1	0.116
Tnfrsf23	tumor necrosis factor receptor superfamily, member 23	0.109
Csf1	colony stimulating factor 1 (macrophage)	0.096
Itch	itchy, E3 ubiquitin protein ligase	0.092
Fgfr1	fibroblast growth factor receptor 1	0.091
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.090
Plaur	plasminogen activator, urokinase receptor	0.080
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.079
App	amyloid beta (A4) precursor protein	0.074
Hif1a	hypoxia inducible factor 1, alpha subunit	0.074
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.074
Ptma	prothymosin alpha	0.069
Il6	interleukin 6	0.069
Trp73	transformation related protein 73	0.068
Tlr4	toll-like receptor 4	0.063
Il4ra	interleukin 4 receptor, alpha	0.060
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.060
Vhl	von Hippel-Lindau tumor suppressor	0.059
Ambp	alpha 1 microglobulin/bikunin	0.057
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.056
Pvr	poliovirus receptor	0.055
Kit	kit oncogene	0.053
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.052
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.051
Lox	lysyl oxidase	0.045
Vangl2	vang-like 2 (van gogh, Drosophila)	0.042
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.041
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.041
F2	coagulation factor II	0.040
Il6st	interleukin 6 signal transducer	0.035
Slc12a4	solute carrier family 12, member 4	0.035
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.035
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.034
Cfi	complement component factor i	0.034
Brca2	breast cancer 2	0.034
Ikbkb	inhibitor of kappaB kinase beta	0.034
Tgfb1	transforming growth factor, beta 1	0.033
Lif	leukemia inhibitory factor	0.030
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.029
Cxcl1	chemokine (C-X-C motif) ligand 1	0.029
Traf6	TNF receptor-associated factor 6	0.029
Erlin2	ER lipid raft associated 2	0.029
Nf1	neurofibromatosis 1	0.028
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.028
Cxcl2	chemokine (C-X-C motif) ligand 2	0.028
Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	0.028
Snai1	snail homolog 1 (Drosophila)	0.028
Myd88	myeloid differentiation primary response gene 88	0.026
Litaf	LPS-induced TN factor	0.026
Itgb3	integrin beta 3	0.026
Timp1	tissue inhibitor of metalloproteinase 1	0.026
Osmr	oncostatin M receptor	0.026
Msh2	mutS homolog 2 (E. coli)	0.025
Apoa1	apolipoprotein A-I	0.025
Tgm2	transglutaminase 2, C polypeptide	0.025
Cyr61	cysteine rich protein 61	0.024
Il10	interleukin 10	0.024
Zfp36	zinc finger protein 36	0.024
Adm	adrenomedullin	0.023
Qsox1	quiescin Q6 sulfhydryl oxidase 1	0.022
Nbn	nibrin	0.021
Tlr2	toll-like receptor 2	0.021
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.020
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.020
Lepr	leptin receptor	0.020
Adam17	a disintegrin and metallopeptidase domain 17	0.020
Vegfa	vascular endothelial growth factor A	0.019
Rras	Harvey rat sarcoma oncogene, subgroup R	0.019
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.019
Stk11	serine/threonine kinase 11	0.019
Tnip1	TNFAIP3 interacting protein 1	0.019
Cldn2	claudin 2	0.019
Atr	ataxia telangiectasia and Rad3 related	0.019
Nos3	nitric oxide synthase 3, endothelial cell	0.019
Fbln2	fibulin 2	0.019
Ccl7	chemokine (C-C motif) ligand 7	0.019
Cyld	cylindromatosis (turban tumor syndrome)	0.018
Ch25h	cholesterol 25-hydroxylase	0.018
Rhoc	ras homolog gene family, member C	0.018
Hnrnpa1	heterogeneous nuclear ribonucleoprotein A1	0.018
Fst	follistatin	0.017
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.017
Anxa5	annexin A5	0.017
Ptch1	patched homolog 1	0.017
Mapk3	mitogen-activated protein kinase 3	0.017
Asgr2	asialoglycoprotein receptor 2	0.016
Ahsg	alpha-2-HS-glycoprotein	0.016
Atf3	activating transcription factor 3	0.016
Ldlr	low density lipoprotein receptor	0.016
Ccnd1	cyclin D1	0.016
Socs3	suppressor of cytokine signaling 3	0.016
Lyst	lysosomal trafficking regulator	0.016
Spp1	secreted phosphoprotein 1	0.015
Meox2	mesenchyme homeobox 2	0.015
Pdpn	podoplanin	0.015
Hbegf	heparin-binding EGF-like growth factor	0.015
Kng1	kininogen 1	0.015
Mvp	major vault protein	0.015
Adam8	a disintegrin and metallopeptidase domain 8	0.014
Kitl	kit ligand	0.014
Mecp2	methyl CpG binding protein 2	0.014
Fosl1	fos-like antigen 1	0.014
Arid5a	AT rich interactive domain 5A (MRF1-like)	0.014
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.014
Vasp	vasodilator-stimulated phosphoprotein	0.014
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.014
Apof	apolipoprotein F	0.013
Traf2	TNF receptor-associated factor 2	0.013
Errfi1	ERBB receptor feedback inhibitor 1	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.013
Inhba	inhibin beta-A	0.013
Vav2	vav 2 oncogene	0.013
Gc	group specific component	0.013
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.012
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.012
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.012
Ces1c	carboxylesterase 1C	0.012
Cnbp	cellular nucleic acid binding protein	0.012
Ier3	immediate early response 3	0.012
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.012
Ctnnd1	catenin (cadherin associated protein), delta 1	0.012
Gem	GTP binding protein (gene overexpressed in skeletal muscle)	0.012
Traf3ip2	TRAF3 interacting protein 2	0.011
Casp3	caspase 3	0.011
Emp1	epithelial membrane protein 1	0.011
Mid1	midline 1	0.011
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.011
Rbl1	retinoblastoma-like 1 (p107)	0.011
Vdr	vitamin D receptor	0.011
Procr	protein C receptor, endothelial	0.011
Il1r1	interleukin 1 receptor, type I	0.011
Irf1	interferon regulatory factor 1	0.011
Bcl3	B-cell leukemia/lymphoma 3	0.010
C77027	expressed sequence C77027	0.010
H2afz	H2A histone family, member Z	0.010
Ccr2	chemokine (C-C motif) receptor 2	0.010