Mus musculus

0 known processes

Commd4

COMM domain containing 4

(Aliases: 1110039H05Rik)

Commd4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amino acid metabolic process GO:0006521 5 0.182
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.126
regulation of cellular component biogenesis GO:0044087 181 0.118
cytoplasmic transport GO:0016482 234 0.070
trna wobble base modification GO:0002097 2 0.068
cellular metal ion homeostasis GO:0006875 151 0.067
regulation of cell motility GO:2000145 236 0.066
protein modification by small protein conjugation or removal GO:0070647 207 0.066
positive regulation of cellular component biogenesis GO:0044089 94 0.065
golgi to endosome transport GO:0006895 3 0.065
cellular response to growth factor stimulus GO:0071363 197 0.063
sequestering of calcium ion GO:0051208 18 0.061
regulation of ion homeostasis GO:2000021 64 0.056
synapse organization GO:0050808 125 0.052
negative regulation of neuron death GO:1901215 98 0.049
cellular chemical homeostasis GO:0055082 215 0.046
cellular ketone metabolic process GO:0042180 84 0.046
protein modification by small protein conjugation GO:0032446 187 0.045
sequestering of metal ion GO:0051238 19 0.045
regulation of cellular ketone metabolic process GO:0010565 66 0.044
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.044
positive regulation of skeletal muscle fiber development GO:0048743 3 0.043
t cell activation GO:0042110 289 0.043
release of sequestered calcium ion into cytosol GO:0051209 42 0.041
organelle assembly GO:0070925 177 0.041
peptidyl amino acid modification GO:0018193 336 0.038
regulation of ion transport GO:0043269 215 0.038
positive regulation of protein phosphorylation GO:0001934 242 0.037
trna wobble uridine modification GO:0002098 2 0.037
positive regulation of protein modification process GO:0031401 299 0.036
regulation of homeostatic process GO:0032844 182 0.034
cellular ion homeostasis GO:0006873 165 0.034
cellular amine metabolic process GO:0044106 44 0.033
vesicle localization GO:0051648 86 0.033
homeostasis of number of cells GO:0048872 210 0.033
histone modification GO:0016570 159 0.033
regulation of vesicle mediated transport GO:0060627 139 0.032
regulation of membrane potential GO:0042391 192 0.032
microtubule based process GO:0007017 236 0.032
response to growth factor GO:0070848 198 0.032
regulation of neuron death GO:1901214 134 0.032
organelle fission GO:0048285 170 0.032
synaptic transmission GO:0007268 329 0.031
central nervous system morphogenesis GO:0021551 2 0.031
heterocycle catabolic process GO:0046700 280 0.031
regulation of cell projection organization GO:0031344 206 0.031
arp2 3 complex mediated actin nucleation GO:0034314 3 0.031
t cell proliferation GO:0042098 120 0.031
cellular homeostasis GO:0019725 240 0.030
divalent inorganic cation transport GO:0072511 178 0.030
synapse assembly GO:0007416 56 0.030
modification dependent macromolecule catabolic process GO:0043632 133 0.030
negative regulation of protein metabolic process GO:0051248 282 0.029
cation transport GO:0006812 399 0.029
cellular amino acid metabolic process GO:0006520 103 0.029
macromolecule catabolic process GO:0009057 281 0.028
nucleoside triphosphate catabolic process GO:0009143 205 0.028
organelle localization GO:0051640 179 0.028
regulation of metal ion transport GO:0010959 106 0.028
organic cyclic compound catabolic process GO:1901361 295 0.028
divalent metal ion transport GO:0070838 172 0.027
cytosolic calcium ion transport GO:0060401 48 0.026
gtp catabolic process GO:0006184 143 0.026
positive regulation of cell motility GO:2000147 116 0.026
protein catabolic process GO:0030163 221 0.026
negative regulation of cellular protein metabolic process GO:0032269 247 0.025
cellular protein catabolic process GO:0044257 155 0.025
cation homeostasis GO:0055080 212 0.025
regulation of protein heterodimerization activity GO:0043497 2 0.025
cellular macromolecule catabolic process GO:0044265 206 0.024
cytosolic calcium ion homeostasis GO:0051480 70 0.024
calcium ion transport into cytosol GO:0060402 48 0.024
ion transmembrane transport GO:0034220 361 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
regulation of cysteine type endopeptidase activity GO:2000116 65 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
regulation of cytoplasmic transport GO:1903649 112 0.024
germ cell development GO:0007281 185 0.024
carbohydrate derivative catabolic process GO:1901136 231 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 4 0.024
organophosphate catabolic process GO:0046434 232 0.024
neuron death GO:0070997 154 0.023
regulation of intracellular transport GO:0032386 159 0.023
tissue homeostasis GO:0001894 115 0.023
negative regulation of cellular component organization GO:0051129 194 0.023
dendrite development GO:0016358 115 0.023
regulation of synapse assembly GO:0051963 29 0.023
dna catabolic process endonucleolytic GO:0000737 15 0.023
positive regulation of cell activation GO:0050867 158 0.023
regulation of neuron differentiation GO:0045664 281 0.022
cellular process regulating host cell cycle in response to virus GO:0060154 3 0.022
cellular response to glucose stimulus GO:0071333 45 0.022
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.022
negative regulation of protein processing GO:0010955 79 0.021
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
regulation of proteolysis GO:0030162 164 0.021
leukocyte differentiation GO:0002521 342 0.021
ubiquitin dependent protein catabolic process GO:0006511 129 0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.021
positive regulation of apoptotic process GO:0043065 217 0.021
anatomical structure homeostasis GO:0060249 145 0.021
lymphocyte homeostasis GO:0002260 64 0.021
regulation of cell cycle GO:0051726 281 0.020
regulation of apoptotic dna fragmentation GO:1902510 5 0.020
positive regulation of protein oligomerization GO:0032461 4 0.020
amine metabolic process GO:0009308 45 0.020
divalent inorganic cation homeostasis GO:0072507 138 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.020
cellular calcium ion homeostasis GO:0006874 119 0.019
nucleotide catabolic process GO:0009166 217 0.019
regulation of endocytosis GO:0030100 69 0.019
cellular nitrogen compound catabolic process GO:0044270 280 0.019
regulation of cellular amine metabolic process GO:0033238 20 0.019
meiotic nuclear division GO:0007126 115 0.019
membrane lipid metabolic process GO:0006643 53 0.019
maintenance of location GO:0051235 89 0.019
aromatic compound catabolic process GO:0019439 286 0.019
leukocyte homeostasis GO:0001776 79 0.019
regulation of hydrolase activity GO:0051336 246 0.018
regulation of gtp catabolic process GO:0033124 113 0.018
positive regulation of nucleoside metabolic process GO:0045979 91 0.018
metal ion homeostasis GO:0055065 189 0.018
guanosine containing compound catabolic process GO:1901069 144 0.018
establishment of vesicle localization GO:0051650 81 0.018
membrane organization GO:0061024 245 0.018
cellular component assembly involved in morphogenesis GO:0010927 139 0.018
calcium ion transport GO:0006816 159 0.018
calcium ion homeostasis GO:0055074 127 0.018
regulation of calcium ion transport into cytosol GO:0010522 31 0.018
cellular response to dna damage stimulus GO:0006974 207 0.018
endomembrane system organization GO:0010256 147 0.018
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.018
cellular divalent inorganic cation homeostasis GO:0072503 127 0.018
nucleoside catabolic process GO:0009164 206 0.018
ribonucleoside metabolic process GO:0009119 245 0.017
leukocyte proliferation GO:0070661 172 0.017
positive regulation of apoptotic signaling pathway GO:2001235 95 0.017
protein maturation GO:0051604 176 0.017
male gamete generation GO:0048232 285 0.017
neuron apoptotic process GO:0051402 142 0.017
negative regulation of protein modification process GO:0031400 163 0.017
extrinsic apoptotic signaling pathway GO:0097191 126 0.017
transmembrane transport GO:0055085 412 0.017
regulation of lymphocyte activation GO:0051249 240 0.017
negative regulation of homeostatic process GO:0032845 71 0.017
membrane fusion GO:0061025 38 0.017
negative regulation of binding GO:0051100 39 0.017
regulation of arp2 3 complex mediated actin nucleation GO:0034315 1 0.017
protein localization to membrane GO:0072657 108 0.017
lymphocyte proliferation GO:0046651 164 0.017
nuclear division GO:0000280 158 0.017
regulation of transferase activity GO:0051338 263 0.016
cellular response to cytokine stimulus GO:0071345 189 0.016
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.016
glucose homeostasis GO:0042593 128 0.016
wnt signaling pathway GO:0016055 188 0.016
negative regulation of neuron apoptotic process GO:0043524 92 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
negative regulation of molecular function GO:0044092 258 0.016
striated muscle cell development GO:0055002 125 0.016
regulation of cell migration GO:0030334 219 0.016
regulation of cell activation GO:0050865 289 0.016
cell fate commitment GO:0045165 210 0.016
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.016
dna metabolic process GO:0006259 303 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
dephosphorylation GO:0016311 129 0.016
myeloid cell differentiation GO:0030099 233 0.016
nucleobase containing small molecule metabolic process GO:0055086 352 0.016
regulation of anatomical structure size GO:0090066 178 0.015
purine containing compound catabolic process GO:0072523 213 0.015
negative regulation of growth GO:0045926 99 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
ameboidal type cell migration GO:0001667 128 0.015
endocytosis GO:0006897 168 0.015
ribonucleotide metabolic process GO:0009259 291 0.015
cilium morphogenesis GO:0060271 102 0.015
mrna metabolic process GO:0016071 84 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
regulation of binding GO:0051098 111 0.015
camera type eye development GO:0043010 266 0.015
positive regulation of lamellipodium organization GO:1902745 3 0.015
hematopoietic progenitor cell differentiation GO:0002244 143 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.015
positive regulation of cellular catabolic process GO:0031331 148 0.014
spermatogenesis GO:0007283 284 0.014
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
stem cell development GO:0048864 219 0.014
adult behavior GO:0030534 135 0.014
cell type specific apoptotic process GO:0097285 268 0.014
regulation of neuron projection development GO:0010975 169 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
positive regulation of melanocyte differentiation GO:0045636 5 0.014
positive regulation of mitochondrial membrane permeability GO:0035794 12 0.014
mitotic cell cycle GO:0000278 195 0.014
golgi vesicle transport GO:0048193 30 0.014
guanosine containing compound metabolic process GO:1901068 144 0.013
protein localization to organelle GO:0033365 185 0.013
cellular glucose homeostasis GO:0001678 52 0.013
positive regulation of gtpase activity GO:0043547 85 0.013
synaptic vesicle localization GO:0097479 59 0.013
stem cell differentiation GO:0048863 268 0.013
regulation of lamellipodium assembly GO:0010591 3 0.013
regulation of calcium ion transport GO:0051924 69 0.013
regulation of glucose metabolic process GO:0010906 60 0.013
digestive tract development GO:0048565 190 0.013
response to organic cyclic compound GO:0014070 198 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.013
positive regulation of nervous system development GO:0051962 221 0.013
meiotic cell cycle process GO:1903046 77 0.013
negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 3 0.013
negative regulation of ossification GO:0030279 49 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
cell growth GO:0016049 130 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.013
actin polymerization or depolymerization GO:0008154 54 0.013
t cell homeostasis GO:0043029 35 0.013
lymphocyte differentiation GO:0030098 242 0.013
nucleoside triphosphate metabolic process GO:0009141 230 0.013
regulation of protein kinase activity GO:0045859 232 0.013
positive regulation of cell death GO:0010942 224 0.013
regulation of neuron apoptotic process GO:0043523 122 0.013
cell adhesion GO:0007155 329 0.013
regulation of actin cytoskeleton organization GO:0032956 84 0.013
regulation of protein binding GO:0043393 60 0.013
digestive system development GO:0055123 200 0.013
establishment of organelle localization GO:0051656 122 0.013
negative regulation of wnt signaling pathway GO:0030178 73 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.012
regulation of epithelial cell proliferation GO:0050678 141 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
mitochondrion organization GO:0007005 134 0.012
regulation of cell adhesion GO:0030155 154 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.012
response to radiation GO:0009314 165 0.012
regulation of protein processing GO:0070613 96 0.012
mrna splicing via spliceosome GO:0000398 43 0.012
myeloid cell homeostasis GO:0002262 114 0.012
cytokine production GO:0001816 319 0.012
negative regulation of cell development GO:0010721 169 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
cellular response to topologically incorrect protein GO:0035967 25 0.012
response to oxidative stress GO:0006979 123 0.012
regulation of apoptotic signaling pathway GO:2001233 197 0.012
positive regulation of leukocyte proliferation GO:0070665 73 0.012
glucose metabolic process GO:0006006 92 0.012
renal system development GO:0072001 225 0.012
cellular response to oxidative stress GO:0034599 76 0.012
apoptotic signaling pathway GO:0097190 306 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.011
cellular response to hexose stimulus GO:0071331 47 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.011
regulation of protein homodimerization activity GO:0043496 4 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
apoptotic process involved in mammary gland involution GO:0060057 4 0.011
regulation of t cell proliferation GO:0042129 92 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
nitrogen compound transport GO:0071705 271 0.011
negative regulation of vesicle fusion GO:0031339 1 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
ribonucleoside catabolic process GO:0042454 206 0.011
locomotory behavior GO:0007626 195 0.011
b cell selection GO:0002339 3 0.011
cell communication by chemical coupling GO:0010643 2 0.011
regulation of cell substrate adhesion GO:0010810 73 0.011
regulation of mammary gland involution GO:1903519 4 0.011
protein processing GO:0016485 163 0.011
meiotic cell cycle GO:0051321 122 0.011
cell division GO:0051301 120 0.011
muscle tissue development GO:0060537 308 0.011
pigmentation GO:0043473 71 0.011
signal transduction in absence of ligand GO:0038034 55 0.011
carbohydrate homeostasis GO:0033500 128 0.011
blood vessel morphogenesis GO:0048514 285 0.011
proteasomal protein catabolic process GO:0010498 98 0.011
regulation of organelle organization GO:0033043 289 0.011
positive regulation of transferase activity GO:0051347 167 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
positive regulation of leukocyte differentiation GO:1902107 86 0.010
spermatid differentiation GO:0048515 115 0.010
embryonic organ morphogenesis GO:0048562 276 0.010
leukocyte migration GO:0050900 124 0.010
antigen receptor mediated signaling pathway GO:0050851 64 0.010
receptor biosynthetic process GO:0032800 3 0.010
purine nucleotide catabolic process GO:0006195 211 0.010
smoothened signaling pathway GO:0007224 105 0.010
vesicle organization GO:0016050 60 0.010
reactive oxygen species metabolic process GO:0072593 84 0.010
regulation of purine nucleotide catabolic process GO:0033121 122 0.010
regulation of cell cycle process GO:0010564 160 0.010
microtubule cytoskeleton organization GO:0000226 157 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
cell substrate adhesion GO:0031589 130 0.010

Commd4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system cancer DOID:0060083 0 0.033
hematologic cancer DOID:2531 0 0.033
cancer DOID:162 0 0.033
leukemia DOID:1240 0 0.033
disease of cellular proliferation DOID:14566 0 0.033
organ system cancer DOID:0050686 0 0.033
gastrointestinal system cancer DOID:3119 0 0.014
large intestine cancer DOID:5672 0 0.014
colon cancer DOID:219 0 0.014
intestinal cancer DOID:10155 0 0.014
colorectal cancer DOID:9256 0 0.014