Mus musculus

20 known processes

Col6a1

collagen, type VI, alpha 1

(Aliases: Col6a-1,AI747156)

Col6a1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to amino acid stimulus GO:0071230 29 0.991
extracellular structure organization GO:0043062 148 0.988
extracellular matrix organization GO:0030198 147 0.987
response to amino acid GO:0043200 37 0.978
cellular response to growth factor stimulus GO:0071363 197 0.813
cell substrate adhesion GO:0031589 130 0.788
response to organonitrogen compound GO:0010243 246 0.715
protein trimerization GO:0070206 13 0.713
Human
regulation of cell adhesion GO:0030155 154 0.707
regulation of cell substrate adhesion GO:0010810 73 0.707
fibril organization GO:0097435 2 0.701
ossification GO:0001503 216 0.683
Human
connective tissue development GO:0061448 179 0.674
retinal blood vessel morphogenesis GO:0061304 3 0.667
response to growth factor GO:0070848 198 0.646
skeletal system development GO:0001501 356 0.643
cell matrix adhesion GO:0007160 68 0.594
cellular response to acid chemical GO:0071229 68 0.582
palate development GO:0060021 76 0.562
protein heterotrimerization GO:0070208 8 0.555
Human
aorta smooth muscle tissue morphogenesis GO:0060414 2 0.516
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.500
limb bud formation GO:0060174 10 0.495
regulation of removal of superoxide radicals GO:2000121 4 0.490
skeletal system morphogenesis GO:0048705 203 0.480
negative regulation of gastrulation GO:2000542 3 0.475
cellular response to organonitrogen compound GO:0071417 145 0.462
positive regulation of ras protein signal transduction GO:0046579 13 0.455
extrinsic apoptotic signaling pathway GO:0097191 126 0.445
cell adhesion GO:0007155 329 0.421
anatomical structure homeostasis GO:0060249 145 0.400
bone development GO:0060348 120 0.378
cartilage condensation GO:0001502 18 0.376
chondrocyte differentiation GO:0002062 72 0.353
extracellular fibril organization GO:0043206 2 0.330
lung development GO:0030324 164 0.319
respiratory tube development GO:0030323 167 0.303
protein oligomerization GO:0051259 67 0.290
Human
regulation of apoptotic signaling pathway GO:2001233 197 0.273
aorta morphogenesis GO:0035909 22 0.270
response to acid chemical GO:0001101 111 0.259
protein heterooligomerization GO:0051291 14 0.251
Human
signal transduction in absence of ligand GO:0038034 55 0.239
sensory perception of sound GO:0007605 97 0.232
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.228
regulation of cell motility GO:2000145 236 0.226
elastic fiber assembly GO:0048251 4 0.225
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.224
negative regulation of cell adhesion GO:0007162 45 0.223
head morphogenesis GO:0060323 34 0.220
positive regulation of cell substrate adhesion GO:0010811 47 0.216
embryonic organ morphogenesis GO:0048562 276 0.215
negative regulation of cell substrate adhesion GO:0010812 16 0.212
limb morphogenesis GO:0035108 149 0.211
muscle tissue development GO:0060537 308 0.206
wound healing GO:0042060 157 0.204
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.202
bone trabecula formation GO:0060346 9 0.202
cardiac muscle tissue development GO:0048738 130 0.200
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.196
forebrain development GO:0030900 302 0.194
replacement ossification GO:0036075 26 0.191
response to superoxide GO:0000303 16 0.185
embryonic skeletal system morphogenesis GO:0048704 91 0.170
proteoglycan metabolic process GO:0006029 38 0.169
cartilage development GO:0051216 140 0.166
negative regulation of apoptotic signaling pathway GO:2001234 104 0.165
negative regulation of tooth mineralization GO:0070171 1 0.157
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.155
bone morphogenesis GO:0060349 78 0.153
notochord development GO:0030903 20 0.153
basement membrane organization GO:0071711 8 0.150
aorta development GO:0035904 23 0.149
sensory perception GO:0007600 245 0.148
negative regulation of blood vessel morphogenesis GO:2000181 25 0.147
embryonic skeletal system development GO:0048706 120 0.145
trabecula formation GO:0060343 24 0.144
protein hydroxylation GO:0018126 4 0.143
collagen fibril organization GO:0030199 32 0.136
cellular response to superoxide GO:0071451 14 0.134
negative regulation of cell migration GO:0030336 59 0.132
face development GO:0060324 38 0.131
negative regulation of neuron migration GO:2001223 6 0.130
trabecula morphogenesis GO:0061383 40 0.129
cardiac chamber morphogenesis GO:0003206 93 0.129
response to transforming growth factor beta GO:0071559 88 0.127
tissue homeostasis GO:0001894 115 0.126
blood vessel morphogenesis GO:0048514 285 0.124
skeletal muscle organ development GO:0060538 163 0.120
heart morphogenesis GO:0003007 178 0.119
cell aggregation GO:0098743 18 0.118
regulation of ras protein signal transduction GO:0046578 114 0.117
growth plate cartilage development GO:0003417 14 0.116
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.114
direct ossification GO:0036072 5 0.111
endochondral bone morphogenesis GO:0060350 50 0.110
regulation of rho protein signal transduction GO:0035023 71 0.110
cerebral cortex development GO:0021987 86 0.108
regulation of cell migration GO:0030334 219 0.105
regulation of peptidase activity GO:0052547 96 0.102
multicellular organismal homeostasis GO:0048871 164 0.102
neuron migration GO:0001764 122 0.101
angiogenesis GO:0001525 201 0.099
small gtpase mediated signal transduction GO:0007264 97 0.096
muscle tissue morphogenesis GO:0060415 53 0.093
regulation of tooth mineralization GO:0070170 2 0.092
negative regulation of angiogenesis GO:0016525 25 0.090
limb development GO:0060173 166 0.090
response to organic cyclic compound GO:0014070 198 0.089
appendage morphogenesis GO:0035107 149 0.088
sensory perception of mechanical stimulus GO:0050954 107 0.088
response to catecholamine GO:0071869 4 0.084
respiratory system development GO:0060541 190 0.084
positive regulation of cell adhesion GO:0045785 80 0.083
nephron development GO:0072006 109 0.081
digestive system development GO:0055123 200 0.081
Human
negative regulation of ossification GO:0030279 49 0.081
artery development GO:0060840 53 0.081
sensory organ morphogenesis GO:0090596 242 0.079
cellular response to bmp stimulus GO:0071773 14 0.078
regulation of proteolysis GO:0030162 164 0.076
response to inorganic substance GO:0010035 96 0.075
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.075
response to decreased oxygen levels GO:0036293 59 0.073
glycoprotein metabolic process GO:0009100 116 0.072
cardiac ventricle morphogenesis GO:0003208 50 0.072
removal of superoxide radicals GO:0019430 12 0.070
appendage development GO:0048736 166 0.067
body morphogenesis GO:0010171 45 0.067
positive regulation of peptidase activity GO:0010952 49 0.066
regulation of angiogenesis GO:0045765 81 0.066
collagen biosynthetic process GO:0032964 7 0.064
regulation of sphingolipid biosynthetic process GO:0090153 1 0.062
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.061
digestive tract development GO:0048565 190 0.060
Human
face morphogenesis GO:0060325 29 0.060
positive regulation of bone remodeling GO:0046852 13 0.058
renal system development GO:0072001 225 0.058
collagen metabolic process GO:0032963 17 0.057
positive regulation of rho protein signal transduction GO:0035025 7 0.057
negative regulation of immune system process GO:0002683 209 0.056
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.056
regulation of chondrocyte differentiation GO:0032330 33 0.056
regulation of neuron projection development GO:0010975 169 0.056
response to bmp GO:0071772 14 0.055
reactive oxygen species metabolic process GO:0072593 84 0.054
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.053
single organism cell adhesion GO:0098602 156 0.052
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.051
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.049
negative regulation of cell development GO:0010721 169 0.048
positive regulation of hydrolase activity GO:0051345 148 0.048
negative regulation of cell proliferation GO:0008285 296 0.047
skin development GO:0043588 220 0.046
ear development GO:0043583 200 0.045
urogenital system development GO:0001655 261 0.044
negative regulation of nervous system development GO:0051961 156 0.044
cardiac muscle tissue morphogenesis GO:0055008 44 0.044
tendon development GO:0035989 6 0.043
otic vesicle development GO:0071599 14 0.043
tissue migration GO:0090130 68 0.043
gland development GO:0048732 330 0.043
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.042
rho protein signal transduction GO:0007266 32 0.042
multicellular organismal catabolic process GO:0044243 7 0.042
defense response to bacterium GO:0042742 119 0.042
retinal ganglion cell axon guidance GO:0031290 18 0.041
chondrocyte development GO:0002063 24 0.041
spermatogenesis GO:0007283 284 0.040
extracellular matrix assembly GO:0085029 12 0.040
negative regulation of cell motility GO:2000146 61 0.039
insulin metabolic process GO:1901142 3 0.039
ras protein signal transduction GO:0007265 77 0.039
regulation of neuron migration GO:2001222 22 0.039
plasma membrane organization GO:0007009 90 0.038
positive regulation of cell development GO:0010720 237 0.038
response to oxidative stress GO:0006979 123 0.038
pallium development GO:0021543 120 0.037
regulation of hydrolase activity GO:0051336 246 0.036
regulation of endodermal cell differentiation GO:1903224 2 0.036
bone resorption GO:0045453 38 0.036
cellular response to oxygen radical GO:0071450 14 0.035
response to peptide hormone GO:0043434 127 0.035
response to peptide GO:1901652 136 0.035
positive regulation of axon extension GO:0045773 20 0.035
antibacterial peptide secretion GO:0002779 1 0.034
cardiac ventricle development GO:0003231 83 0.033
response to thyroid hormone GO:0097066 2 0.033
negative regulation of epithelial cell proliferation GO:0050680 64 0.032
peptide cross linking via chondroitin 4 sulfate glycosaminoglycan GO:0019800 8 0.032
regulation of ceramide biosynthetic process GO:2000303 1 0.031
positive regulation of cell migration GO:0030335 109 0.031
peptide cross linking GO:0018149 10 0.031
intussusceptive angiogenesis GO:0002041 2 0.030
response to monosaccharide GO:0034284 67 0.030
cell type specific apoptotic process GO:0097285 268 0.029
positive regulation of bone resorption GO:0045780 13 0.029
cellular lipid metabolic process GO:0044255 323 0.029
sequestering of bmp in extracellular matrix GO:0035582 3 0.028
regulation of hormone levels GO:0010817 211 0.028
negative regulation of macrophage chemotaxis GO:0010760 1 0.028
striated muscle tissue development GO:0014706 293 0.027
muscle cell development GO:0055001 133 0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.027
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.027
positive regulation of cell projection organization GO:0031346 95 0.027
anatomical structure maturation GO:0071695 49 0.027
regulation of cell projection organization GO:0031344 206 0.027
synaptic transmission cholinergic GO:0007271 7 0.027
positive regulation of nervous system development GO:0051962 221 0.026
antibacterial peptide production GO:0002778 2 0.026
regulation of reactive oxygen species metabolic process GO:2000377 40 0.026
cellular response to abiotic stimulus GO:0071214 56 0.026
antimicrobial peptide secretion GO:0002776 1 0.025
cellular response to mechanical stimulus GO:0071260 7 0.025
regionalization GO:0003002 337 0.025
cellular response to thyroid hormone stimulus GO:0097067 1 0.025
positive regulation of phospholipase activity GO:0010518 3 0.025
erythropoietin mediated signaling pathway GO:0038162 1 0.024
negative regulation of vasculature development GO:1901343 26 0.024
multicellular organismal macromolecule metabolic process GO:0044259 19 0.023
inner ear morphogenesis GO:0042472 101 0.023
positive regulation of apoptotic process GO:0043065 217 0.023
neuromuscular process controlling balance GO:0050885 59 0.023
regulation of vasculogenesis GO:2001212 9 0.022
superoxide metabolic process GO:0006801 27 0.022
cardiac chamber development GO:0003205 108 0.022
regulation of cartilage development GO:0061035 44 0.022
synaptic transmission GO:0007268 329 0.022
regulation of extent of cell growth GO:0061387 52 0.022
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.022
notochord cell differentiation GO:0060034 1 0.021
protein maturation GO:0051604 176 0.021
negative regulation of growth GO:0045926 99 0.021
sulfur compound metabolic process GO:0006790 100 0.021
positive regulation of proteolysis GO:0045862 85 0.021
cellular response to hormone stimulus GO:0032870 150 0.021
cellular modified amino acid metabolic process GO:0006575 63 0.021
oxidation reduction process GO:0055114 342 0.021
membrane lipid metabolic process GO:0006643 53 0.021
antimicrobial peptide biosynthetic process GO:0002777 2 0.020
endothelium development GO:0003158 45 0.020
regulation of response to reactive oxygen species GO:1901031 9 0.020
regulation of system process GO:0044057 200 0.020
telencephalon development GO:0021537 186 0.020
negative regulation of biomineral tissue development GO:0070168 11 0.019
axonogenesis GO:0007409 274 0.019
protein processing GO:0016485 163 0.019
endothelial cell apoptotic process GO:0072577 9 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
integrin mediated signaling pathway GO:0007229 27 0.019
cellular response to fluid shear stress GO:0071498 4 0.019
regulation of neuron differentiation GO:0045664 281 0.018
regulation of cellular response to stress GO:0080135 159 0.018
biomineral tissue development GO:0031214 64 0.018
developmental programmed cell death GO:0010623 41 0.018
hormone secretion GO:0046879 128 0.018
regulation of bone resorption GO:0045124 24 0.017
vegf activated neuropilin signaling pathway involved in axon guidance GO:1902378 1 0.017
eye photoreceptor cell development GO:0042462 31 0.017
positive regulation of cell death GO:0010942 224 0.017
negative regulation of bmp signaling pathway GO:0030514 35 0.017
chondroitin sulfate metabolic process GO:0030204 17 0.017
response to monoamine GO:0071867 4 0.017
peptidyl amino acid modification GO:0018193 336 0.017
regulation of organelle organization GO:0033043 289 0.017
innate immune response GO:0045087 157 0.017
regulation of macrophage migration inhibitory factor signaling pathway GO:2000446 1 0.016
epithelial tube morphogenesis GO:0060562 303 0.016
ventricular cardiac muscle tissue development GO:0003229 38 0.016
retina development in camera type eye GO:0060041 119 0.016
positive regulation of programmed cell death GO:0043068 218 0.016
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.016
regulation of cellular response to oxidative stress GO:1900407 19 0.016
response to reactive oxygen species GO:0000302 56 0.016
chondroitin sulfate proteoglycan metabolic process GO:0050654 20 0.016
regulation of cellular amine metabolic process GO:0033238 20 0.015
regulation of macrophage chemotaxis GO:0010758 8 0.015
ear morphogenesis GO:0042471 118 0.015
myeloid leukocyte migration GO:0097529 57 0.015
metal ion homeostasis GO:0055065 189 0.015
defense response to other organism GO:0098542 197 0.015
regulation of synaptic vesicle priming GO:0010807 4 0.015
chemotaxis GO:0006935 247 0.015
ameboidal type cell migration GO:0001667 128 0.015
synapse organization GO:0050808 125 0.015
cell adhesion mediated by integrin GO:0033627 18 0.014
cellular response to external stimulus GO:0071496 88 0.014
cellular response to nitric oxide GO:0071732 4 0.014
insulin processing GO:0030070 2 0.014
male gamete generation GO:0048232 285 0.014
regulation of transmission of nerve impulse GO:0051969 1 0.014
cardiac muscle cell development GO:0055013 39 0.014
regulation of secretion by cell GO:1903530 249 0.014
oviduct development GO:0060066 3 0.014
bmp signaling pathway GO:0030509 93 0.014
cell recognition GO:0008037 83 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
regulation of cellular response to growth factor stimulus GO:0090287 82 0.013
negative regulation of endodermal cell differentiation GO:1903225 1 0.013
peripheral nervous system axon regeneration GO:0014012 2 0.013
divalent metal ion transport GO:0070838 172 0.013
apoptotic signaling pathway GO:0097190 306 0.013
positive regulation of growth GO:0045927 104 0.012
organonitrogen compound biosynthetic process GO:1901566 192 0.012
endothelial cell migration GO:0043542 44 0.012
odontogenesis GO:0042476 78 0.012
lung alveolus development GO:0048286 45 0.012
regulation of axon extension GO:0030516 43 0.012
regulation of gastrulation GO:0010470 16 0.012
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:1900238 1 0.012
positive regulation of insulin secretion GO:0032024 26 0.012
response to radiation GO:0009314 165 0.012
sperm egg recognition GO:0035036 37 0.012
endochondral bone growth GO:0003416 19 0.012
tissue remodeling GO:0048771 102 0.012
gastrulation GO:0007369 116 0.012
Human
cellular ketone metabolic process GO:0042180 84 0.012
response to increased oxygen levels GO:0036296 2 0.012
metanephric glomerular basement membrane development GO:0072274 1 0.012
regulation of secretion GO:0051046 274 0.012
salivary gland development GO:0007431 37 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
bone trabecula morphogenesis GO:0061430 12 0.011
peptide hormone secretion GO:0030072 109 0.011
developmental maturation GO:0021700 193 0.011
cardiac cell development GO:0055006 41 0.011
cellular response to oxidative stress GO:0034599 76 0.011
notch signaling pathway GO:0007219 71 0.011
protein catabolic process GO:0030163 221 0.011
response to steroid hormone GO:0048545 56 0.011
macrophage colony stimulating factor signaling pathway GO:0038145 2 0.011
telencephalon cell migration GO:0022029 55 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
positive regulation of neuron projection development GO:0010976 79 0.011
cell cell adhesion GO:0098609 41 0.011
cellular response to dna damage stimulus GO:0006974 207 0.011
protein autoprocessing GO:0016540 2 0.011
regulation of multi organism process GO:0043900 111 0.011
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.011
medulla oblongata development GO:0021550 3 0.011
placenta blood vessel development GO:0060674 31 0.011
wound healing spreading of cells GO:0044319 8 0.011
renal system vasculature development GO:0061437 15 0.011
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.011
homeostasis of number of cells GO:0048872 210 0.011
antibacterial peptide biosynthetic process GO:0002780 2 0.011
meiotic cell cycle process GO:1903046 77 0.011
neuron death GO:0070997 154 0.010
regulation of neuron death GO:1901214 134 0.010
hair follicle morphogenesis GO:0031069 29 0.010
regulation of cell size GO:0008361 72 0.010
negative regulation of neuron death GO:1901215 98 0.010
regulation of biomineral tissue development GO:0070167 33 0.010
regulation of lipase activity GO:0060191 15 0.010
sprouting angiogenesis GO:0002040 26 0.010
macrophage migration inhibitory factor signaling pathway GO:0035691 2 0.010
response to erythropoietin GO:0036017 1 0.010
endocytosis GO:0006897 168 0.010
positive regulation of cell motility GO:2000147 116 0.010
digestive tract morphogenesis GO:0048546 147 0.010
Human

Col6a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.976
Human
muscular disease DOID:0080000 0 0.976
Human
disease of anatomical entity DOID:7 0 0.976
Human
musculoskeletal system disease DOID:17 0 0.976
Human
muscle tissue disease DOID:66 0 0.976
Human
osteochondrodysplasia DOID:2256 0 0.792
bone development disease DOID:0080006 0 0.792
bone disease DOID:0080001 0 0.792
connective tissue disease DOID:65 0 0.792
muscular dystrophy DOID:9884 0 0.602
Human
collagen disease DOID:854 0 0.552
ehlers danlos syndrome DOID:13359 0 0.552
congenital muscular dystrophy DOID:0050557 0 0.426
Human
heart disease DOID:114 0 0.067
cardiovascular system disease DOID:1287 0 0.067
osteogenesis imperfecta DOID:12347 0 0.060
osteoporosis DOID:11476 0 0.060
bone remodeling disease DOID:0080005 0 0.060
bone resorption disease DOID:0080011 0 0.060
retinal disease DOID:5679 0 0.015
retinal degeneration DOID:8466 0 0.015
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
nervous system disease DOID:863 0 0.015
eye disease DOID:5614 0 0.015