IMP

Process View

Mus musculus

3 genes annotated in mouse

Multi-species View

insulin metabolic process

GO:1901142

The chemical reactions and pathways involving insulin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "insulin metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "insulin metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Tcf7	transcription factor 7, T-cell specific	0.963	Mouse
Lef1	lymphoid enhancer binding factor 1	0.910	Mouse
Otx2	orthodenticle homolog 2 (Drosophila)	0.592
Emx1	empty spiracles homolog 1 (Drosophila)	0.467
Ctnnb1	catenin (cadherin associated protein), beta 1	0.464
Pax2	paired box gene 2	0.302
Sel1l	sel-1 suppressor of lin-12-like (C. elegans)	0.252
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.228
Lhx2	LIM homeobox protein 2	0.173
Ppap2b	phosphatidic acid phosphatase type 2B	0.153
Numb	numb gene homolog (Drosophila)	0.149
Sox2	SRY-box containing gene 2	0.121
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.106
Ambp	alpha 1 microglobulin/bikunin	0.102
Htt	huntingtin	0.099
Slc35a3	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3	0.095
App	amyloid beta (A4) precursor protein	0.085
Fgfr1	fibroblast growth factor receptor 1	0.085
Ext1	exostoses (multiple) 1	0.076
Tmem146	transmembrane protein 146	0.074
Tnks1bp1	tankyrase 1 binding protein 1	0.071
Tgif2	TGFB-induced factor homeobox 2	0.067
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.064
Itgav	integrin alpha V	0.063
Emx2	empty spiracles homolog 2 (Drosophila)	0.059
Sgpl1	sphingosine phosphate lyase 1	0.049
Ero1l	ERO1-like (S. cerevisiae)	0.046	Mouse
Cadps2	Ca2+-dependent activator protein for secretion 2	0.046
Neurod1	neurogenic differentiation 1	0.045
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.045
Sox11	SRY-box containing gene 11	0.043
Vat1	vesicle amine transport protein 1 homolog (T californica)	0.042
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.040
Lat	linker for activation of T cells	0.040
Col6a1	collagen, type VI, alpha 1	0.039
Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	0.038
Sfrp1	secreted frizzled-related protein 1	0.037
Hes1	hairy and enhancer of split 1 (Drosophila)	0.037
Ptk2	PTK2 protein tyrosine kinase 2	0.036
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.036
Mab21l1	mab-21-like 1 (C. elegans)	0.035
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.034
Pcolce	procollagen C-endopeptidase enhancer protein	0.034
Foxf2	forkhead box F2	0.033
Braf	Braf transforming gene	0.033
Mtmr1	myotubularin related protein 1	0.033
Atp1a4	ATPase, Na+/K+ transporting, alpha 4 polypeptide	0.032
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.032
Otx1	orthodenticle homolog 1 (Drosophila)	0.032
Hes5	hairy and enhancer of split 5 (Drosophila)	0.031
Cdh1	cadherin 1	0.031
Hmgcs2	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	0.030
Psen1	presenilin 1	0.029
Adam10	a disintegrin and metallopeptidase domain 10	0.028
Mgp	matrix Gla protein	0.027
Gas1	growth arrest specific 1	0.027
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.027
Ptk7	PTK7 protein tyrosine kinase 7	0.027
Rims2	regulating synaptic membrane exocytosis 2	0.026
Pitx2	paired-like homeodomain transcription factor 2	0.025
Mapk9	mitogen-activated protein kinase 9	0.025
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.025
Twist1	twist homolog 1 (Drosophila)	0.025
Elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	0.024
Lrp6	low density lipoprotein receptor-related protein 6	0.024
Cpxm1	carboxypeptidase X 1 (M14 family)	0.024	Mouse
Tead2	TEA domain family member 2	0.024
Trip6	thyroid hormone receptor interactor 6	0.024
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.023
C1galt1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	0.023
Myo10	myosin X	0.023
Ctnna1	catenin (cadherin associated protein), alpha 1	0.023
Slk	STE20-like kinase (yeast)	0.023
Pdx1	pancreatic and duodenal homeobox 1	0.023
Ctnnd1	catenin (cadherin associated protein), delta 1	0.023
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.023
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.023
Rspo1	R-spondin homolog (Xenopus laevis)	0.022
Hipk3	homeodomain interacting protein kinase 3	0.022
Pou4f1	POU domain, class 4, transcription factor 1	0.022
Shf	Src homology 2 domain containing F	0.022
Hic1	hypermethylated in cancer 1	0.021
Irs2	insulin receptor substrate 2	0.021
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.021
Syt9	synaptotagmin IX	0.021
Rpgrip1l	Rpgrip1-like	0.021
Cdx2	caudal type homeobox 2	0.020
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.020
Ahr	aryl-hydrocarbon receptor	0.020
Myb	myeloblastosis oncogene	0.019
Cadm4	cell adhesion molecule 4	0.019
Fbln1	fibulin 1	0.019
Acbd3	acyl-Coenzyme A binding domain containing 3	0.019
Hdlbp	high density lipoprotein (HDL) binding protein	0.019
Dcn	decorin	0.019
Onecut1	one cut domain, family member 1	0.019
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.019
Zbtb7a	zinc finger and BTB domain containing 7a	0.019
Ptprf	protein tyrosine phosphatase, receptor type, F	0.019
Pdcd6ip	programmed cell death 6 interacting protein	0.019
Flnc	filamin C, gamma	0.018
Bmp4	bone morphogenetic protein 4	0.018
Snap25	synaptosomal-associated protein 25	0.018
Axin2	axin2	0.018
Il6st	interleukin 6 signal transducer	0.018
Igfbp6	insulin-like growth factor binding protein 6	0.018
Tmem150a	transmembrane protein 150A	0.018
Cd44	CD44 antigen	0.018
Dlg1	discs, large homolog 1 (Drosophila)	0.018
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.018
Hpca	hippocalcin	0.017
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.017
Hpn	hepsin	0.017
Sec14l2	SEC14-like 2 (S. cerevisiae)	0.017
Igfbp3	insulin-like growth factor binding protein 3	0.017
Map4k5	mitogen-activated protein kinase kinase kinase kinase 5	0.017
Ccnd1	cyclin D1	0.017
Ybx2	Y box protein 2	0.017
Mmp11	matrix metallopeptidase 11	0.017
Tfrc	transferrin receptor	0.017
Dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.017
Pdzk1	PDZ domain containing 1	0.017
Lrp5	low density lipoprotein receptor-related protein 5	0.017
Gsbs	G substrate	0.016
Hspa4l	heat shock protein 4 like	0.016
Crabp1	cellular retinoic acid binding protein I	0.016
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.016
Bgn	biglycan	0.016
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.016
Cldn3	claudin 3	0.016
Bcl11a	B-cell CLL/lymphoma 11A (zinc finger protein)	0.016
Pld1	phospholipase D1	0.016
Pdlim5	PDZ and LIM domain 5	0.016
Pou4f2	POU domain, class 4, transcription factor 2	0.016
Wwc1	WW, C2 and coiled-coil domain containing 1	0.016
Plxdc2	plexin domain containing 2	0.016
Rhbdd3	rhomboid domain containing 3	0.016
Krt8	keratin 8	0.016
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.016
Zmynd10	zinc finger, MYND domain containing 10	0.016
Magt1	magnesium transporter 1	0.016
Ate1	arginyltransferase 1	0.016
Mitf	microphthalmia-associated transcription factor	0.015
Igf1r	insulin-like growth factor I receptor	0.015
Clmn	calmin	0.015
Traf6	TNF receptor-associated factor 6	0.015
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.015
Scg5	secretogranin V	0.015
Slain1	SLAIN motif family, member 1	0.015
Tram1	translocating chain-associating membrane protein 1	0.015
Faah	fatty acid amide hydrolase	0.015
Nfib	nuclear factor I/B	0.015
Resp18	regulated endocrine-specific protein 18	0.015
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.015
Fkbp10	FK506 binding protein 10	0.015
Zfp362	zinc finger protein 362	0.015
Fmod	fibromodulin	0.015
Xiap	X-linked inhibitor of apoptosis	0.015
Igsf9	immunoglobulin superfamily, member 9	0.015
Rbp1	retinol binding protein 1, cellular	0.014
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.014
Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.014
Smad6	MAD homolog 6 (Drosophila)	0.014
Trhde	TRH-degrading enzyme	0.014
Pkdcc	protein kinase domain containing, cytoplasmic	0.014
Rin2	Ras and Rab interactor 2	0.014
Fut9	fucosyltransferase 9	0.014
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.014
Nphp1	nephronophthisis 1 (juvenile) homolog (human)	0.014
Gsk3b	glycogen synthase kinase 3 beta	0.014
Ndrg1	N-myc downstream regulated gene 1	0.014
Anxa11	annexin A11	0.014
Hsd17b7	hydroxysteroid (17-beta) dehydrogenase 7	0.013
Tox	thymocyte selection-associated high mobility group box	0.013
Thbs2	thrombospondin 2	0.013
Hsf2	heat shock factor 2	0.013
Xpr1	xenotropic and polytropic retrovirus receptor 1	0.013
Insm1	insulinoma-associated 1	0.013
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.013
3110047P20Rik	RIKEN cDNA 3110047P20 gene	0.013
Irf6	interferon regulatory factor 6	0.013
Akap12	A kinase (PRKA) anchor protein (gravin) 12	0.013
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.013
Ccdc81	coiled-coil domain containing 81	0.013
Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Mtap1b	microtubule-associated protein 1B	0.013
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.013
Rrbp1	ribosome binding protein 1	0.013
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.013
Rab33a	RAB33A, member of RAS oncogene family	0.013
Kif3b	kinesin family member 3B	0.013
Fndc3b	fibronectin type III domain containing 3B	0.013
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.013
Thbs1	thrombospondin 1	0.013
Elmod1	ELMO domain containing 1	0.012
Pdpn	podoplanin	0.012
Lamb2	laminin, beta 2	0.012
Reep6	receptor accessory protein 6	0.012
Mrc2	mannose receptor, C type 2	0.012
Fam183b	family with sequence similarity 183, member B	0.012
Prnp	prion protein	0.012
Clcn3	chloride channel 3	0.012
Rbks	ribokinase	0.012
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.012
Bhlhe22	basic helix-loop-helix family, member e22	0.012
Anpep	alanyl (membrane) aminopeptidase	0.012
Clstn1	calsyntenin 1	0.012
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.012
Nf2	neurofibromatosis 2	0.012
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.012
Mmp23	matrix metallopeptidase 23	0.012
Npc1	Niemann Pick type C1	0.012
St5	suppression of tumorigenicity 5	0.012
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.012
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.012
Lrp4	low density lipoprotein receptor-related protein 4	0.012
Tenc1	tensin like C1 domain-containing phosphatase	0.012
Prkci	protein kinase C, iota	0.012
Sgms1	sphingomyelin synthase 1	0.012
Bcl2	B-cell leukemia/lymphoma 2	0.012
Polr3g	polymerase (RNA) III (DNA directed) polypeptide G	0.012
Ptgis	prostaglandin I2 (prostacyclin) synthase	0.012
Wwc2	WW, C2 and coiled-coil domain containing 2	0.012
Arhgdig	Rho GDP dissociation inhibitor (GDI) gamma	0.012
Fgf12	fibroblast growth factor 12	0.012
Ralgps2	Ral GEF with PH domain and SH3 binding motif 2	0.012
Gdf10	growth differentiation factor 10	0.012
Isl1	ISL1 transcription factor, LIM/homeodomain	0.012
Gpc4	glypican 4	0.011
Angptl2	angiopoietin-like 2	0.011
Nsd1	nuclear receptor-binding SET-domain protein 1	0.011
Nsg2	neuron specific gene family member 2	0.011
Fbn2	fibrillin 2	0.011
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.011
Pipox	pipecolic acid oxidase	0.011
Canx	calnexin	0.011
Cbs	cystathionine beta-synthase	0.011
Ctsl	cathepsin L	0.011
Dock5	dedicator of cytokinesis 5	0.011
Glis3	GLIS family zinc finger 3	0.011
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.011
2410089E03Rik	RIKEN cDNA 2410089E03 gene	0.011
Fst	follistatin	0.011
Sft2d2	SFT2 domain containing 2	0.011
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.011
Fbxo36	F-box protein 36	0.011
Pim2	proviral integration site 2	0.011
Pofut1	protein O-fucosyltransferase 1	0.011
Fzd7	frizzled homolog 7 (Drosophila)	0.011
Dtnb	dystrobrevin, beta	0.011
Cxcl14	chemokine (C-X-C motif) ligand 14	0.011
Sh3d19	SH3 domain protein D19	0.011
Pou3f1	POU domain, class 3, transcription factor 1	0.011
H2-Q10	histocompatibility 2, Q region locus 10	0.011
Sorbs3	sorbin and SH3 domain containing 3	0.011
Aldh7a1	aldehyde dehydrogenase family 7, member A1	0.011
Hspa13	heat shock protein 70 family, member 13	0.011
Vav3	vav 3 oncogene	0.011
Rimklb	ribosomal modification protein rimK-like family member B	0.011
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.011
Gphn	gephyrin	0.010
Cpd	carboxypeptidase D	0.010	Mouse
Tmem198	transmembrane protein 198	0.010
Ttr	transthyretin	0.010
Barhl2	BarH-like 2 (Drosophila)	0.010
Azi1	5-azacytidine induced gene 1	0.010
Rab11fip5	RAB11 family interacting protein 5 (class I)	0.010
Alkbh5	alkB, alkylation repair homolog 5 (E. coli)	0.010
Stk39	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)	0.010
Ncoa2	nuclear receptor coactivator 2	0.010
Galc	galactosylceramidase	0.010
Lama1	laminin, alpha 1	0.010
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.010
Slit3	slit homolog 3 (Drosophila)	0.010
Reln	reelin	0.010
Mobkl2b	MOB1, Mps One Binder kinase activator-like 2B (yeast)	0.010
Fam20c	family with sequence similarity 20, member C	0.010
Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1	0.010
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.010
AI428936	expressed sequence AI428936	0.010