Mus musculus

553 known processes

Psen1

presenilin 1

(Aliases: PS-1,PS1,S182,Ad3h)

Psen1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
somite specification GO:0001757 4 1.000
lateral inhibition GO:0046331 1 1.000
Fly
negative regulation of blood vessel endothelial cell migration GO:0043537 3 1.000
regulation of somitogenesis GO:0014807 6 1.000
notch signaling pathway GO:0007219 71 1.000
notch receptor processing GO:0007220 4 1.000
regulation of epidermal growth factor activated receptor activity GO:0007176 7 1.000
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 1.000
cardiac right atrium morphogenesis GO:0003213 3 0.999
cell migration involved in endocardial cushion formation GO:0003273 3 0.999
somitogenesis GO:0001756 69 0.999
negative regulation of neuron differentiation GO:0045665 101 0.999
embryonic organ morphogenesis GO:0048562 276 0.999
neuroblast fate determination GO:0007400 1 0.999
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.999
growth involved in heart morphogenesis GO:0003241 4 0.999
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.999
protein processing GO:0016485 163 0.998
compartment pattern specification GO:0007386 4 0.998
arterial endothelial cell differentiation GO:0060842 5 0.998
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.998
formation of radial glial scaffolds GO:0021943 4 0.997
neural tube development GO:0021915 160 0.997
segment specification GO:0007379 15 0.996
forebrain development GO:0030900 302 0.996
cell cell signaling involved in cell fate commitment GO:0045168 35 0.996
Fly
axonogenesis GO:0007409 274 0.996
glycoprotein biosynthetic process GO:0009101 89 0.995
neural tube patterning GO:0021532 43 0.995
cell adhesion GO:0007155 329 0.995
Human Fly
ubiquitin dependent protein catabolic process GO:0006511 129 0.994
anagen GO:0042640 13 0.994
epithelial tube morphogenesis GO:0060562 303 0.994
activation of mapkk activity GO:0000186 15 0.994
positive regulation of map kinase activity GO:0043406 84 0.994
negative regulation of cell development GO:0010721 169 0.994
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.993
regulation of cardioblast differentiation GO:0051890 3 0.993
regionalization GO:0003002 337 0.992
photoreceptor cell morphogenesis GO:0008594 3 0.992
skeletal system development GO:0001501 356 0.992
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.991
Mouse
ventricular trabecula myocardium morphogenesis GO:0003222 11 0.991
modification dependent macromolecule catabolic process GO:0043632 133 0.991
positive regulation of transcription of notch receptor target GO:0007221 4 0.991
atrioventricular node development GO:0003162 3 0.990
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.989
glycoprotein metabolic process GO:0009100 116 0.989
blood vessel endothelial cell differentiation GO:0060837 6 0.988
positive regulation of apoptotic signaling pathway GO:2001235 95 0.987
Mouse
membrane protein proteolysis GO:0033619 10 0.987
Human
endothelial tube morphogenesis GO:0061154 2 0.986
regulation of pro b cell differentiation GO:2000973 5 0.985
copper ion homeostasis GO:0055070 9 0.984
cell fate determination involved in pattern specification GO:0060582 1 0.983
glomerular mesangial cell differentiation GO:0072008 3 0.983
modification dependent protein catabolic process GO:0019941 133 0.982
telencephalon cell migration GO:0022029 55 0.982
myeloid dendritic cell differentiation GO:0043011 16 0.982
neuroblast division in subventricular zone GO:0021849 2 0.980
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.979
Zebrafish
regulation of resting membrane potential GO:0060075 3 0.979
regulation of protein serine threonine kinase activity GO:0071900 157 0.979
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.979
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.978
glycosylation GO:0070085 62 0.977
positive regulation of notch signaling pathway GO:0045747 18 0.977
regulation of cellular amino acid metabolic process GO:0006521 5 0.977
glial cell fate determination GO:0007403 3 0.977
blood vessel lumenization GO:0072554 2 0.976
neuroblast differentiation GO:0014016 2 0.974
pharynx development GO:0060465 1 0.974
glomerular capillary formation GO:0072104 6 0.974
ciliary body morphogenesis GO:0061073 3 0.971
embryonic heart tube development GO:0035050 65 0.969
regulation of cardiac cell fate specification GO:2000043 1 0.966
digestive tract development GO:0048565 190 0.966
epithelial cell proliferation GO:0050673 174 0.965
negative regulation of protein maturation GO:1903318 79 0.964
establishment of synaptic vesicle localization GO:0097480 57 0.964
morphogenesis of an endothelium GO:0003159 2 0.963
regulation of neuron differentiation GO:0045664 281 0.962
somite development GO:0061053 81 0.962
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.962
notch signaling involved in heart development GO:0061314 5 0.962
dorsal ventral neural tube patterning GO:0021904 28 0.962
negative regulation of protein phosphorylation GO:0001933 126 0.961
regulation of map kinase activity GO:0043405 120 0.960
peptidyl tyrosine modification GO:0018212 145 0.960
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 1 0.958
regulation of blood vessel endothelial cell migration GO:0043535 12 0.957
glomerular mesangial cell development GO:0072144 3 0.955
negative regulation of epidermis development GO:0045683 9 0.954
telencephalon development GO:0021537 186 0.952
negative regulation of glial cell proliferation GO:0060253 4 0.952
response to symbiont GO:0009608 2 0.952
carbohydrate derivative biosynthetic process GO:1901137 183 0.951
appendage development GO:0048736 166 0.951
autophagy GO:0006914 45 0.951
inner ear receptor cell differentiation GO:0060113 61 0.949
cardiac endothelial cell differentiation GO:0003348 4 0.949
sprouting angiogenesis GO:0002040 26 0.947
kidney development GO:0001822 213 0.947
embryonic heart tube morphogenesis GO:0003143 51 0.942
synaptic vesicle transport GO:0048489 57 0.941
negative regulation of endothelial cell migration GO:0010596 4 0.940
cellular ketone metabolic process GO:0042180 84 0.937
brain morphogenesis GO:0048854 32 0.937
negative regulation of neuron projection development GO:0010977 50 0.934
cellular amide metabolic process GO:0043603 58 0.932
determination of heart left right asymmetry GO:0061371 48 0.931
regulation of apoptotic signaling pathway GO:2001233 197 0.931
pericardium morphogenesis GO:0003344 5 0.929
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.928
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.927
regulation of cellular amine metabolic process GO:0033238 20 0.925
glial cell migration GO:0008347 7 0.925
cell fate commitment GO:0045165 210 0.924
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.923
negative regulation of epidermal cell differentiation GO:0045605 7 0.923
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.923
organic hydroxy compound transport GO:0015850 93 0.923
regulation of astrocyte differentiation GO:0048710 20 0.923
germ cell development GO:0007281 185 0.921
regulation of binding GO:0051098 111 0.920
response to starvation GO:0042594 65 0.919
sensory organ boundary specification GO:0008052 1 0.918
regulation of notch signaling pathway GO:0008593 35 0.916
Fly
cell fate commitment involved in pattern specification GO:0060581 14 0.916
negative regulation of cell projection organization GO:0031345 56 0.915
appendage morphogenesis GO:0035107 149 0.915
myeloid dendritic cell activation GO:0001773 25 0.914
negative regulation of anoikis GO:2000811 2 0.913
mesenchyme development GO:0060485 152 0.912
embryonic appendage morphogenesis GO:0035113 126 0.910
dendrite development GO:0016358 115 0.909
mesangial cell differentiation GO:0072007 4 0.909
embryonic skeletal system development GO:0048706 120 0.907
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.905
protein glycosylation GO:0006486 55 0.904
protein maturation GO:0051604 176 0.904
dendritic cell differentiation GO:0097028 26 0.904
regulation of cell migration GO:0030334 219 0.903
extrinsic apoptotic signaling pathway GO:0097191 126 0.902
Mouse
heart field specification GO:0003128 6 0.902
positive regulation of protein kinase activity GO:0045860 144 0.901
neuroblast fate commitment GO:0014017 1 0.899
positive regulation of keratinocyte differentiation GO:0045618 3 0.898
blood vessel endothelial cell migration GO:0043534 23 0.896
venous blood vessel morphogenesis GO:0048845 7 0.896
choline transport GO:0015871 3 0.895
negative regulation of auditory receptor cell differentiation GO:0045608 2 0.895
protein catabolic process GO:0030163 221 0.895
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.894
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.893
Mouse
negative regulation of kinase activity GO:0033673 81 0.887
negative regulation of glial cell differentiation GO:0045686 21 0.882
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.882
hair follicle morphogenesis GO:0031069 29 0.880
negative regulation of protein processing GO:0010955 79 0.878
regulation of chemotaxis GO:0050920 53 0.876
regulation of transferase activity GO:0051338 263 0.875
determination of left right symmetry GO:0007368 80 0.875
hair follicle development GO:0001942 85 0.874
positive regulation of mapk cascade GO:0043410 170 0.871
regulation of proteolysis GO:0030162 164 0.870
i kappab phosphorylation GO:0007252 6 0.869
regulation of cardiac muscle tissue development GO:0055024 31 0.864
macromolecule glycosylation GO:0043413 55 0.863
positive regulation of osteoclast differentiation GO:0045672 15 0.863
dorsal aorta morphogenesis GO:0035912 5 0.857
cardiac right ventricle formation GO:0003219 3 0.857
pigment cell differentiation GO:0050931 27 0.856
Zebrafish
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.852
negative regulation of apoptotic signaling pathway GO:2001234 104 0.851
molting cycle GO:0042303 90 0.847
axis elongation involved in somitogenesis GO:0090245 4 0.844
morphogenesis of a branching epithelium GO:0061138 193 0.844
glomerulus vasculature morphogenesis GO:0072103 6 0.843
establishment of vesicle localization GO:0051650 81 0.840
placenta blood vessel development GO:0060674 31 0.839
cellular amino acid metabolic process GO:0006520 103 0.836
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.836
beta amyloid metabolic process GO:0050435 14 0.835
membrane protein ectodomain proteolysis GO:0006509 7 0.835
Human
mechanoreceptor differentiation GO:0042490 67 0.834
organelle localization GO:0051640 179 0.831
cytoskeleton dependent intracellular transport GO:0030705 50 0.830
lung induction GO:0060492 3 0.827
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.826
respiratory system development GO:0060541 190 0.824
Mouse
stem cell maintenance GO:0019827 130 0.818
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.817
learning or memory GO:0007611 148 0.817
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.814
negative regulation of mechanoreceptor differentiation GO:0045632 3 0.812
melanocyte differentiation GO:0030318 25 0.812
Zebrafish
hair cycle GO:0042633 90 0.811
cardiac cell fate specification GO:0060912 2 0.809
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.808
glomerular epithelial cell development GO:0072310 6 0.808
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.807
renal system development GO:0072001 225 0.807
regulation of extracellular matrix assembly GO:1901201 2 0.807
muscle tissue development GO:0060537 308 0.805
urogenital system development GO:0001655 261 0.804
regulation of synaptic plasticity GO:0048167 87 0.802
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.802
Mouse
smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 2 0.802
gastrulation GO:0007369 116 0.799
skin morphogenesis GO:0043589 38 0.792
macromolecule catabolic process GO:0009057 281 0.792
cardiac muscle tissue development GO:0048738 130 0.791
regulation of endothelial cell chemotaxis GO:2001026 1 0.790
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.788
Mouse
regulation of dna templated transcription in response to stress GO:0043620 9 0.788
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.787
negative regulation of endothelial cell differentiation GO:0045602 2 0.786
renal tubule development GO:0061326 87 0.785
positive regulation of kinase activity GO:0033674 155 0.784
glomerular visceral epithelial cell development GO:0072015 6 0.782
pyramidal neuron migration GO:0021852 1 0.780
interleukin 4 secretion GO:0072602 5 0.772
regulation of gliogenesis GO:0014013 50 0.770
carbohydrate metabolic process GO:0005975 230 0.768
epidermis morphogenesis GO:0048730 33 0.767
cardiac septum morphogenesis GO:0060411 46 0.764
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.763
cardiac muscle tissue morphogenesis GO:0055008 44 0.763
cerebral cortex development GO:0021987 86 0.762
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.759
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000058 14 0.757
cell type specific apoptotic process GO:0097285 268 0.756
regulation of kinase activity GO:0043549 249 0.756
regulation of endodermal cell fate specification GO:0042663 2 0.753
cardiac left ventricle morphogenesis GO:0003214 9 0.747
vascular smooth muscle cell differentiation GO:0035886 11 0.744
cardiac vascular smooth muscle cell development GO:0060948 3 0.742
negative regulation of cell proliferation GO:0008285 296 0.738
positive regulation of cell cycle GO:0045787 92 0.734
pulmonary valve morphogenesis GO:0003184 5 0.733
hindbrain radial glia guided cell migration GO:0021932 12 0.733
l amino acid transport GO:0015807 32 0.732
negative regulation of proteolysis GO:0045861 74 0.730
hair cell differentiation GO:0035315 40 0.729
leukocyte differentiation GO:0002521 342 0.729
morphogenesis of embryonic epithelium GO:0016331 159 0.728
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.727
peptidyl amino acid modification GO:0018193 336 0.726
amine metabolic process GO:0009308 45 0.726
pallium development GO:0021543 120 0.721
stem cell differentiation GO:0048863 268 0.721
cerebral cortex neuron differentiation GO:0021895 19 0.721
l glutamate transport GO:0015813 16 0.718
endodermal cell fate commitment GO:0001711 12 0.717
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.715
striated muscle contraction GO:0006941 45 0.713
Mouse
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.712
regulation of protein tyrosine kinase activity GO:0061097 17 0.712
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.707
negative regulation of molecular function GO:0044092 258 0.704
positive regulation of protein phosphorylation GO:0001934 242 0.702
humoral immune response GO:0006959 57 0.701
epidermis development GO:0008544 187 0.701
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.695
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.693
mesoderm development GO:0007498 100 0.692
apoptotic process involved in development GO:1902742 28 0.691
heart morphogenesis GO:0003007 178 0.689
limb morphogenesis GO:0035108 149 0.688
branching morphogenesis of an epithelial tube GO:0048754 159 0.677
skeletal system morphogenesis GO:0048705 203 0.675
embryonic limb morphogenesis GO:0030326 126 0.675
negative regulation of cellular protein catabolic process GO:1903363 22 0.672
formation of organ boundary GO:0010160 1 0.671
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.670
regulation of protein kinase activity GO:0045859 232 0.669
peptidyl tyrosine phosphorylation GO:0018108 143 0.669
negative regulation of phosphorylation GO:0042326 166 0.667
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.665
cell chemotaxis GO:0060326 81 0.663
endodermal cell fate specification GO:0001714 4 0.663
negative regulation of bmp signaling pathway GO:0030514 35 0.659
neuron apoptotic process GO:0051402 142 0.652
regulation of mitotic cell cycle phase transition GO:1901990 73 0.650
negative regulation of astrocyte differentiation GO:0048712 10 0.647
positive regulation of transcription by glucose GO:0046016 3 0.645
coronary vein morphogenesis GO:0003169 2 0.641
cell adhesion mediated by integrin GO:0033627 18 0.641
cardiac chamber development GO:0003205 108 0.639
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.637
digestive tract morphogenesis GO:0048546 147 0.636
myeloid leukocyte differentiation GO:0002573 119 0.635
cell fate specification GO:0001708 72 0.634
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.633
wnt signaling pathway GO:0016055 188 0.631
Zebrafish
ameboidal type cell migration GO:0001667 128 0.630
gland development GO:0048732 330 0.628
cognition GO:0050890 149 0.628
glomerulus morphogenesis GO:0072102 10 0.627
positive regulation of protein modification process GO:0031401 299 0.626
regulation of protein complex assembly GO:0043254 83 0.626
Mouse
dorsal aorta development GO:0035907 6 0.622
regulation of receptor recycling GO:0001919 8 0.620
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 4 0.620
photoreceptor cell differentiation GO:0046530 52 0.619
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.618
establishment of organelle localization GO:0051656 122 0.616
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.616
heart trabecula morphogenesis GO:0061384 26 0.616
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.615
positive regulation of proteolysis GO:0045862 85 0.613
cellular homeostasis GO:0019725 240 0.613
positive regulation of bmp signaling pathway GO:0030513 23 0.609
mitotic cell cycle process GO:1903047 159 0.607
cellular chemical homeostasis GO:0055082 215 0.607
mesangial cell development GO:0072143 4 0.606
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.605
negative regulation of nervous system development GO:0051961 156 0.604
positive regulation of astrocyte differentiation GO:0048711 8 0.602
germ line stem cell division GO:0042078 2 0.597
germ line stem cell maintenance GO:0030718 6 0.592
pole plasm assembly GO:0007315 2 0.590
regulation of epidermis development GO:0045682 33 0.587
meiotic cell cycle GO:0051321 122 0.587
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.580
regulation of mitotic cell cycle GO:0007346 126 0.579
regulation of anoikis GO:2000209 2 0.575
regulation of epidermal cell differentiation GO:0045604 21 0.572
negative regulation of protein modification process GO:0031400 163 0.570
digestive system development GO:0055123 200 0.569
blood vessel morphogenesis GO:0048514 285 0.568
protein modification by small protein conjugation or removal GO:0070647 207 0.568
ossification GO:0001503 216 0.568
regulation of cardiac muscle cell differentiation GO:2000725 9 0.568
smoothened signaling pathway GO:0007224 105 0.567
positive regulation of cell cycle phase transition GO:1901989 17 0.566
memory GO:0007613 58 0.562
photoreceptor cell development GO:0042461 40 0.562
negative regulation of cellular protein metabolic process GO:0032269 247 0.562
hair cycle phase GO:0044851 16 0.562
regulation of striated muscle cell differentiation GO:0051153 81 0.562
adult behavior GO:0030534 135 0.561
regulation of auditory receptor cell differentiation GO:0045607 4 0.560
limb development GO:0060173 166 0.558
neuron projection guidance GO:0097485 141 0.555
left right pattern formation GO:0060972 23 0.554
synaptic transmission GO:0007268 329 0.551
negative regulation of striated muscle cell differentiation GO:0051154 14 0.547
segmentation GO:0035282 93 0.544
forebrain cell migration GO:0021885 58 0.543
insulin secretion involved in cellular response to glucose stimulus GO:0035773 36 0.540
endoderm development GO:0007492 45 0.540
cardiac conduction system development GO:0003161 12 0.538
regulation of ligase activity GO:0051340 10 0.536
regulation of endodermal cell differentiation GO:1903224 2 0.536
auditory receptor cell differentiation GO:0042491 37 0.535
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.533
endocytosis GO:0006897 168 0.533
embryonic skeletal system morphogenesis GO:0048704 91 0.532
heparan sulfate proteoglycan metabolic process GO:0030201 10 0.532
neuron migration GO:0001764 122 0.531
mesenchymal cell differentiation GO:0048762 107 0.530
positive regulation of cardiac muscle cell differentiation GO:2000727 6 0.529
regulation of cilium assembly GO:1902017 7 0.529
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.526
negative regulation of inner ear receptor cell differentiation GO:2000981 3 0.525
spermatogenesis GO:0007283 284 0.524
positive regulation of g1 s transition of mitotic cell cycle GO:1900087 9 0.523
cellular protein catabolic process GO:0044257 155 0.523
regulation of protein binding GO:0043393 60 0.522
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.521
metanephros development GO:0001656 79 0.520
proximal tubule development GO:0072014 5 0.520
heart formation GO:0060914 16 0.519
negative regulation of epithelial cell migration GO:0010633 9 0.517
myeloid cell differentiation GO:0030099 233 0.517
regulation of glial cell differentiation GO:0045685 41 0.513
compound eye development GO:0048749 1 0.512
negative regulation of fat cell differentiation GO:0045599 36 0.510
lung development GO:0030324 164 0.508
Mouse
inner ear receptor cell fate commitment GO:0060120 6 0.508
negative regulation of pro b cell differentiation GO:2000974 1 0.508
forebrain radial glial cell differentiation GO:0021861 4 0.507
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.506
regulation of cellular catabolic process GO:0031329 242 0.506
positive regulation of mitotic cell cycle GO:0045931 41 0.503
epithelial cell differentiation involved in kidney development GO:0035850 23 0.502
regulation of hematopoietic progenitor cell differentiation GO:1901532 18 0.500
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.499
morphogenesis of a polarized epithelium GO:0001738 37 0.499
nephron tubule morphogenesis GO:0072078 68 0.496
receptor recycling GO:0001881 11 0.495
long term memory GO:0007616 15 0.492
glomerular visceral epithelial cell differentiation GO:0072112 10 0.491
regulation of receptor activity GO:0010469 41 0.489
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.487
regulation of cell cycle phase transition GO:1901987 77 0.485
glomerular epithelial cell differentiation GO:0072311 10 0.484
morphogenesis of an epithelial sheet GO:0002011 27 0.484
negative regulation of cellular catabolic process GO:0031330 47 0.483
mitotic cell cycle GO:0000278 195 0.483
regulation of cellular component biogenesis GO:0044087 181 0.481
Mouse
jak stat cascade GO:0007259 42 0.480
developmental programmed cell death GO:0010623 41 0.474
regulation of osteoclast differentiation GO:0045670 36 0.473
regulation of lipid metabolic process GO:0019216 118 0.472
sensory organ morphogenesis GO:0090596 242 0.471
organelle assembly GO:0070925 177 0.470
cardiac muscle cell differentiation GO:0055007 69 0.469
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.469
glial cell apoptotic process GO:0034349 3 0.469
neuron death GO:0070997 154 0.468
microtubule based process GO:0007017 236 0.467
small gtpase mediated signal transduction GO:0007264 97 0.464
regulation of establishment of planar polarity GO:0090175 28 0.462
cellular amine metabolic process GO:0044106 44 0.462
regulation of cellular ketone metabolic process GO:0010565 66 0.460
adult locomotory behavior GO:0008344 91 0.458
nephric duct formation GO:0072179 4 0.455
establishment of tissue polarity GO:0007164 28 0.455
neural tube formation GO:0001841 108 0.453
peripheral nervous system neuron axonogenesis GO:0048936 3 0.449
cardiac atrium development GO:0003230 24 0.449
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.448
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.445
regulation of hydrolase activity GO:0051336 246 0.444
carbon catabolite regulation of transcription GO:0045990 4 0.442
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.440
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.439
regulation of epithelial to mesenchymal transition GO:0010717 22 0.439
negative regulation of dendrite development GO:2000171 9 0.438
response to lithium ion GO:0010226 10 0.437
positive regulation of cell fate commitment GO:0010455 8 0.436
signal transduction in absence of ligand GO:0038034 55 0.435
regulation of protein maturation GO:1903317 96 0.434
bone remodeling GO:0046849 53 0.432
multi organism reproductive behavior GO:0044705 29 0.431
biological phase GO:0044848 20 0.430
hypermethylation of cpg island GO:0044027 3 0.426
carbon catabolite activation of transcription GO:0045991 4 0.425
regulation of microtubule based process GO:0032886 52 0.425
cellular response to starvation GO:0009267 57 0.422
erbb signaling pathway GO:0038127 32 0.421
secondary heart field specification GO:0003139 6 0.418
regulation of stem cell differentiation GO:2000736 50 0.417
negative regulation of cardiac muscle tissue development GO:0055026 8 0.417
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.416
endocardial cushion cell differentiation GO:0061443 1 0.416
cerebral cortex cell migration GO:0021795 44 0.415
kidney morphogenesis GO:0060993 83 0.414
embryonic viscerocranium morphogenesis GO:0048703 8 0.412
positive regulation of cell development GO:0010720 237 0.412
microtubule based movement GO:0007018 84 0.411
hippocampus development GO:0021766 52 0.409
positive regulation of creb transcription factor activity GO:0032793 4 0.409
cerebral cortex radially oriented cell migration GO:0021799 31 0.407
clara cell differentiation GO:0060486 4 0.405
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.405
female sex differentiation GO:0046660 84 0.404
glomerulus vasculature development GO:0072012 14 0.401
positive regulation of glial cell differentiation GO:0045687 21 0.395
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.394
regulation of cell motility GO:2000145 236 0.394
meiotic nuclear division GO:0007126 115 0.393
osteoclast differentiation GO:0030316 62 0.390
exocytosis GO:0006887 121 0.390
prostate gland morphogenesis GO:0060512 32 0.388
developmental maturation GO:0021700 193 0.388
regulation of mesodermal cell fate specification GO:0042661 5 0.387
positive regulation of cellular protein catabolic process GO:1903364 34 0.386
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.386
actin cytoskeleton organization GO:0030036 220 0.385
developmental growth involved in morphogenesis GO:0060560 138 0.385
negative regulation of protein modification by small protein conjugation or removal GO:1903321 20 0.385
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.385
mapk cascade GO:0000165 281 0.383
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.382
kidney interstitial fibroblast differentiation GO:0072071 5 0.380
odontogenesis GO:0042476 78 0.380
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.378

Psen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.981
Human
disease of anatomical entity DOID:7 0 0.981
Human
nervous system disease DOID:863 0 0.981
Human
heart disease DOID:114 0 0.967
Human
cardiovascular system disease DOID:1287 0 0.967
Human
dementia DOID:1307 0 0.958
Human
alzheimer s disease DOID:10652 0 0.958
Human
disease of mental health DOID:150 0 0.958
Human
tauopathy DOID:680 0 0.958
Human
neurodegenerative disease DOID:1289 0 0.958
Human
cognitive disorder DOID:1561 0 0.958
Human
integumentary system disease DOID:16 0 0.954
Human
muscular disease DOID:0080000 0 0.918
Human
musculoskeletal system disease DOID:17 0 0.918
Human
muscle tissue disease DOID:66 0 0.918
Human
disease of cellular proliferation DOID:14566 0 0.589
skin disease DOID:37 0 0.548
Human
gastrointestinal system disease DOID:77 0 0.419