Mus musculus

0 known processes

Ndc80

NDC80 homolog, kinetochore complex component (S. cerevisiae)

(Aliases: AV139730,HEC1,Kntc2,2610020P18Rik,HEC)

Ndc80 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nuclear division GO:0000280 158 0.655
meiotic nuclear division GO:0007126 115 0.549
microtubule based process GO:0007017 236 0.444
Human
organelle fission GO:0048285 170 0.440
dna metabolic process GO:0006259 303 0.435
meiotic cell cycle process GO:1903046 77 0.413
regulation of cell cycle process GO:0010564 160 0.342
meiotic cell cycle GO:0051321 122 0.302
spindle assembly involved in mitosis GO:0090307 4 0.225
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.222
organelle localization GO:0051640 179 0.216
Human
mitotic cytokinesis GO:0000281 4 0.209
female meiosis chromosome segregation GO:0016321 1 0.187
mitotic sister chromatid cohesion GO:0007064 1 0.170
establishment of organelle localization GO:0051656 122 0.169
Human
male meiosis GO:0007140 37 0.157
regulation of chromosome organization GO:0033044 83 0.151
centrosome duplication GO:0051298 16 0.147
cytokinetic process GO:0032506 2 0.142
fertilization GO:0009566 127 0.141
mitotic cell cycle process GO:1903047 159 0.140
Human
chromosome segregation GO:0007059 48 0.139
Human
regulation of protein localization GO:0032880 231 0.129
regulation of chromosome segregation GO:0051983 21 0.129
positive regulation of cell cycle GO:0045787 92 0.119
regulation of organelle organization GO:0033043 289 0.110
male gamete generation GO:0048232 285 0.109
regulation of cell cycle phase transition GO:1901987 77 0.107
microtubule organizing center organization GO:0031023 28 0.106
cellular response to dna damage stimulus GO:0006974 207 0.102
regulation of cell cycle GO:0051726 281 0.102
microtubule cytoskeleton organization GO:0000226 157 0.101
Human
maintenance of location GO:0051235 89 0.096
Human
mitotic cell cycle GO:0000278 195 0.096
Human
regulation of microtubule cytoskeleton organization GO:0070507 37 0.090
dna repair GO:0006281 107 0.083
regulation of microtubule based process GO:0032886 52 0.081
positive regulation of chromosome segregation GO:0051984 4 0.074
cellular protein catabolic process GO:0044257 155 0.072
mitotic nuclear division GO:0007067 48 0.072
centrosome cycle GO:0007098 23 0.070
nucleoside phosphate catabolic process GO:1901292 222 0.069
dna replication GO:0006260 52 0.068
regulation of mitotic cell cycle phase transition GO:1901990 73 0.068
metaphase plate congression GO:0051310 2 0.067
cell division GO:0051301 120 0.067
positive regulation of protein modification process GO:0031401 299 0.067
negative regulation of cellular component organization GO:0051129 194 0.067
cytokinesis GO:0000910 17 0.066
development of primary sexual characteristics GO:0045137 143 0.062
protein catabolic process GO:0030163 221 0.060
negative regulation of cell cycle phase transition GO:1901988 48 0.058
nucleotide metabolic process GO:0009117 332 0.057
cellular amino acid metabolic process GO:0006520 103 0.056
centrosome organization GO:0051297 26 0.056
positive regulation of mitotic cell cycle GO:0045931 41 0.054
cellular ketone metabolic process GO:0042180 84 0.054
female meiotic division GO:0007143 21 0.050
meiosis ii GO:0007135 7 0.050
spindle localization GO:0051653 22 0.049
Human
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.048
negative regulation of protein metabolic process GO:0051248 282 0.048
spermatogenesis GO:0007283 284 0.048
maintenance of location in cell GO:0051651 24 0.046
Human
macromolecule catabolic process GO:0009057 281 0.046
mitotic sister chromatid segregation GO:0000070 14 0.046
cellular amine metabolic process GO:0044106 44 0.045
regulation of cellular ketone metabolic process GO:0010565 66 0.044
microtubule polymerization or depolymerization GO:0031109 26 0.043
regulation of cellular amine metabolic process GO:0033238 20 0.043
regulation of cellular protein catabolic process GO:1903362 61 0.042
regulation of cytoskeleton organization GO:0051493 122 0.041
regulation of cell migration GO:0030334 219 0.040
muscle tissue development GO:0060537 308 0.040
purine nucleotide catabolic process GO:0006195 211 0.039
sister chromatid segregation GO:0000819 20 0.039
positive regulation of cellular catabolic process GO:0031331 148 0.038
regulation of mitotic cell cycle GO:0007346 126 0.038
modification dependent protein catabolic process GO:0019941 133 0.038
regulation of cell division GO:0051302 76 0.037
negative regulation of cell cycle GO:0045786 123 0.037
negative regulation of organelle organization GO:0010639 90 0.037
regulation of protein catabolic process GO:0042176 108 0.037
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
dna recombination GO:0006310 92 0.035
epithelial tube morphogenesis GO:0060562 303 0.034
proteasomal protein catabolic process GO:0010498 98 0.034
regulation of kinase activity GO:0043549 249 0.034
positive regulation of protein phosphorylation GO:0001934 242 0.033
regulation of proteasomal protein catabolic process GO:0061136 46 0.033
purine nucleoside catabolic process GO:0006152 205 0.033
nucleoside monophosphate catabolic process GO:0009125 59 0.033
single fertilization GO:0007338 82 0.033
dephosphorylation GO:0016311 129 0.033
spindle midzone assembly GO:0051255 1 0.033
regulation of transferase activity GO:0051338 263 0.032
regulation of establishment of protein localization GO:0070201 181 0.032
glycosyl compound catabolic process GO:1901658 206 0.032
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.032
meiotic cytokinesis GO:0033206 5 0.032
positive regulation of protein kinase activity GO:0045860 144 0.032
dna conformation change GO:0071103 37 0.031
cellularization GO:0007349 1 0.031
meiosis i GO:0007127 60 0.031
germ cell development GO:0007281 185 0.030
lipid biosynthetic process GO:0008610 179 0.030
nucleoside triphosphate metabolic process GO:0009141 230 0.029
glycosyl compound metabolic process GO:1901657 246 0.029
amine metabolic process GO:0009308 45 0.029
regulation of cytokine production GO:0001817 266 0.029
establishment of spindle localization GO:0051293 19 0.029
Human
double strand break repair GO:0006302 48 0.029
negative regulation of proteolysis GO:0045861 74 0.029
response to cell cycle checkpoint signaling GO:0072396 1 0.029
spindle assembly involved in meiosis GO:0090306 4 0.028
microtubule based movement GO:0007018 84 0.028
striated muscle tissue development GO:0014706 293 0.028
cleavage furrow formation GO:0036089 2 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
nuclear transport GO:0051169 139 0.028
protein localization to organelle GO:0033365 185 0.028
negative regulation of microtubule polymerization or depolymerization GO:0031111 15 0.028
ubiquitin dependent protein catabolic process GO:0006511 129 0.028
blood vessel morphogenesis GO:0048514 285 0.028
establishment of meiotic spindle orientation GO:0051296 1 0.028
centriole assembly GO:0098534 6 0.027
regulation of double strand break repair via homologous recombination GO:0010569 2 0.027
embryonic epithelial tube formation GO:0001838 130 0.027
organophosphate catabolic process GO:0046434 232 0.027
protein depolymerization GO:0051261 34 0.027
purine nucleoside metabolic process GO:0042278 241 0.027
modification dependent macromolecule catabolic process GO:0043632 133 0.027
neuron migration GO:0001764 122 0.026
lateral inhibition GO:0046331 1 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
response to organic cyclic compound GO:0014070 198 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
purine nucleotide metabolic process GO:0006163 302 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.026
nucleoside triphosphate catabolic process GO:0009143 205 0.026
neural tube formation GO:0001841 108 0.026
atp catabolic process GO:0006200 55 0.025
leukocyte mediated immunity GO:0002443 174 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
regulation of mitotic sister chromatid segregation GO:0033047 12 0.025
regulation of cellular component size GO:0032535 121 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.025
astral microtubule organization GO:0030953 3 0.025
negative regulation of cellular protein metabolic process GO:0032269 247 0.025
organelle assembly GO:0070925 177 0.025
organonitrogen compound catabolic process GO:1901565 264 0.024
spindle checkpoint GO:0031577 12 0.024
nucleoside catabolic process GO:0009164 206 0.024
endomembrane system organization GO:0010256 147 0.024
ribonucleoside monophosphate catabolic process GO:0009158 57 0.024
chromatin organization GO:0006325 206 0.024
regulation of protein kinase activity GO:0045859 232 0.024
regulation of protein complex disassembly GO:0043244 28 0.024
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.023
cellular protein complex assembly GO:0043623 116 0.023
regulation of homeostatic process GO:0032844 182 0.023
positive regulation of cytokine production GO:0001819 174 0.023
spindle assembly involved in female meiosis GO:0007056 3 0.023
purine containing compound catabolic process GO:0072523 213 0.023
purine ribonucleoside catabolic process GO:0046130 205 0.023
cell maturation GO:0048469 127 0.023
regulation of nuclear division GO:0051783 56 0.023
cellular nitrogen compound catabolic process GO:0044270 280 0.023
regulation of mitosis GO:0007088 29 0.023
adaptive immune response GO:0002250 155 0.023
regulation of microtubule depolymerization GO:0031114 13 0.023
response to organonitrogen compound GO:0010243 246 0.023
chromatin modification GO:0016568 187 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.023
attachment of spindle microtubules to kinetochore GO:0008608 4 0.022
Human
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.022
purine nucleoside monophosphate catabolic process GO:0009128 58 0.022
regulation of intracellular transport GO:0032386 159 0.022
purine ribonucleoside metabolic process GO:0046128 241 0.022
cytokine production GO:0001816 319 0.022
mitotic spindle assembly checkpoint GO:0007094 7 0.022
peptidyl amino acid modification GO:0018193 336 0.022
regulation of protein transport GO:0051223 163 0.022
cellular macromolecule catabolic process GO:0044265 206 0.021
regulation of lymphocyte activation GO:0051249 240 0.021
lymphocyte differentiation GO:0030098 242 0.021
negative regulation of phosphorus metabolic process GO:0010563 184 0.021
g1 s transition of mitotic cell cycle GO:0000082 57 0.021
positive regulation of organelle organization GO:0010638 128 0.020
immune effector process GO:0002252 321 0.020
establishment or maintenance of cell polarity GO:0007163 86 0.020
Human
microtubule nucleation GO:0007020 2 0.020
regulation of proteolysis GO:0030162 164 0.020
cell fate commitment GO:0045165 210 0.020
sister chromatid cohesion GO:0007062 12 0.020
dna endoreduplication GO:0042023 4 0.020
ribonucleotide metabolic process GO:0009259 291 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.020
ribonucleoside catabolic process GO:0042454 206 0.020
mitotic spindle organization GO:0007052 10 0.020
Human
response to radiation GO:0009314 165 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
regulation of cellular response to stress GO:0080135 159 0.019
positive regulation of cell cycle process GO:0090068 61 0.019
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.019
chromosome separation GO:0051304 14 0.019
purine containing compound metabolic process GO:0072521 311 0.019
purine nucleoside triphosphate catabolic process GO:0009146 203 0.019
regulation of cell motility GO:2000145 236 0.019
cytoplasmic transport GO:0016482 234 0.019
ribonucleoside triphosphate metabolic process GO:0009199 220 0.019
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.019
mitotic spindle checkpoint GO:0071174 9 0.019
nucleoside phosphate metabolic process GO:0006753 338 0.018
atp metabolic process GO:0046034 75 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
homeostasis of number of cells GO:0048872 210 0.018
protein modification by small protein conjugation GO:0032446 187 0.018
organic cyclic compound catabolic process GO:1901361 295 0.018
cell cycle g2 m phase transition GO:0044839 20 0.018
asymmetric stem cell division GO:0098722 3 0.018
spindle assembly GO:0051225 13 0.018
nucleotide catabolic process GO:0009166 217 0.018
developmental maturation GO:0021700 193 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
protein maturation GO:0051604 176 0.018
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.018
lymphocyte mediated immunity GO:0002449 139 0.017
protein citrullination GO:0018101 2 0.017
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.017
negative regulation of protein processing GO:0010955 79 0.017
mitotic chromosome condensation GO:0007076 1 0.017
histone threonine phosphorylation GO:0035405 1 0.017
erythrocyte differentiation GO:0030218 88 0.017
negative regulation of microtubule depolymerization GO:0007026 13 0.017
apoptotic signaling pathway GO:0097190 306 0.017
oxidation reduction process GO:0055114 342 0.017
regulation of cytoplasmic transport GO:1903649 112 0.017
positive regulation of chromosome organization GO:2001252 33 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
posttranscriptional regulation of gene expression GO:0010608 155 0.017
negative regulation of transferase activity GO:0051348 85 0.017
dna biosynthetic process GO:0071897 22 0.017
cell activation involved in immune response GO:0002263 126 0.016
mitotic centrosome separation GO:0007100 4 0.016
angiogenesis GO:0001525 201 0.016
forebrain development GO:0030900 302 0.016
negative regulation of protein modification process GO:0031400 163 0.016
mitotic sister chromatid separation GO:0051306 9 0.016
peptidyl serine modification GO:0018209 83 0.016
wnt signaling pathway GO:0016055 188 0.016
intracellular mrna localization GO:0008298 4 0.016
positive regulation of mitosis GO:0045840 14 0.016
regulation of protein maturation GO:1903317 96 0.016
leukocyte differentiation GO:0002521 342 0.016
protein polymerization GO:0051258 57 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
female gamete generation GO:0007292 74 0.015
cell type specific apoptotic process GO:0097285 268 0.015
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.015
protein polyubiquitination GO:0000209 33 0.015
neural tube development GO:0021915 160 0.015
muscle cell differentiation GO:0042692 261 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
regulation of exit from mitosis GO:0007096 1 0.015
tube closure GO:0060606 91 0.015
regulation of secretion GO:0051046 274 0.015
regulation of mapk cascade GO:0043408 248 0.015
regulation of muscle tissue development GO:1901861 97 0.015
epithelial tube formation GO:0072175 130 0.015
negative regulation of molecular function GO:0044092 258 0.015
regulation of protein processing GO:0070613 96 0.015
positive regulation of cellular protein catabolic process GO:1903364 34 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
telencephalon development GO:0021537 186 0.014
cell cycle g1 s phase transition GO:0044843 57 0.014
innate immune response GO:0045087 157 0.014
positive regulation of histone h3 k9 methylation GO:0051574 4 0.014
regulation of t cell activation GO:0050863 170 0.014
cellular lipid metabolic process GO:0044255 323 0.014
small molecule biosynthetic process GO:0044283 132 0.014
regulation of neuron differentiation GO:0045664 281 0.014
nucleoside metabolic process GO:0009116 246 0.014
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.014
positive regulation of transferase activity GO:0051347 167 0.014
placenta development GO:0001890 140 0.014
negative regulation of protein catabolic process GO:0042177 36 0.013
oogenesis GO:0048477 56 0.013
mapk cascade GO:0000165 281 0.013
regulation of cellular catabolic process GO:0031329 242 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.013
regulation of response to wounding GO:1903034 189 0.013
microtubule depolymerization GO:0007019 15 0.013
dna packaging GO:0006323 30 0.013
cellular homeostasis GO:0019725 240 0.013
regulation of secretion by cell GO:1903530 249 0.013
nucleobase containing small molecule metabolic process GO:0055086 352 0.013
positive regulation of kinase activity GO:0033674 155 0.013
intracellular protein transport GO:0006886 204 0.013
negative regulation of mitosis GO:0045839 10 0.013
negative regulation of sister chromatid segregation GO:0033046 7 0.013
rho protein signal transduction GO:0007266 32 0.013
ribonucleotide catabolic process GO:0009261 208 0.013
positive regulation of cell division GO:0051781 31 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
positive regulation of nuclear division GO:0051785 27 0.013
heterocycle catabolic process GO:0046700 280 0.013
histone serine phosphorylation GO:0035404 5 0.013
carbohydrate derivative catabolic process GO:1901136 231 0.013
peptidyl serine phosphorylation GO:0018105 74 0.012
negative regulation of phosphorylation GO:0042326 166 0.012
protein localization to chromosome centromeric region GO:0071459 1 0.012
establishment of spindle orientation GO:0051294 15 0.012
Human
cellular response to growth factor stimulus GO:0071363 197 0.012
fatty acid metabolic process GO:0006631 121 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
cation transport GO:0006812 399 0.012
regulation of hydrolase activity GO:0051336 246 0.012
positive regulation of nfat protein import into nucleus GO:0051533 1 0.012
meiotic chromosome segregation GO:0045132 19 0.012
spindle organization GO:0007051 28 0.012
Human
positive regulation of protein catabolic process GO:0045732 60 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
positive regulation of hydrolase activity GO:0051345 148 0.012
b cell activation involved in immune response GO:0002312 50 0.012
purine nucleoside monophosphate metabolic process GO:0009126 81 0.012
meiotic dna repair synthesis GO:0000711 4 0.012
myeloid cell differentiation GO:0030099 233 0.012
milk ejection GO:0060156 1 0.012
regulation of anatomical structure size GO:0090066 178 0.012
aromatic compound catabolic process GO:0019439 286 0.012
neuron death GO:0070997 154 0.012
regulation of cell cycle g2 m phase transition GO:1902749 10 0.012
negative regulation of cellular protein catabolic process GO:1903363 22 0.012
positive regulation of nervous system development GO:0051962 221 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
b cell activation GO:0042113 161 0.012
negative regulation of cellular catabolic process GO:0031330 47 0.012
regulation of cell cycle g1 s phase transition GO:1902806 35 0.012
horizontal cell localization GO:0035852 1 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
response to light stimulus GO:0009416 135 0.011
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.011
regulation of nucleocytoplasmic transport GO:0046822 73 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
regulation of cell projection organization GO:0031344 206 0.011
ribonucleoside monophosphate metabolic process GO:0009161 80 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
positive regulation of intracellular transport GO:0032388 70 0.011
reciprocal meiotic recombination GO:0007131 16 0.011
regulation of adaptive immune response GO:0002819 90 0.011
establishment of protein localization to organelle GO:0072594 118 0.011
stem cell development GO:0048864 219 0.011
positive regulation of cell development GO:0010720 237 0.011
divalent metal ion transport GO:0070838 172 0.011
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.011
blood circulation GO:0008015 195 0.011
myeloid cell homeostasis GO:0002262 114 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of asymmetric cell division GO:0009786 4 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
regulation of cytokinesis GO:0032465 5 0.011
cellular protein complex disassembly GO:0043624 36 0.011
regulation of inflammatory response GO:0050727 147 0.011
transmembrane transport GO:0055085 412 0.010
pallium development GO:0021543 120 0.010
sensory perception GO:0007600 245 0.010
regulation of skeletal muscle fiber development GO:0048742 36 0.010
negative regulation of cell division GO:0051782 24 0.010
gland development GO:0048732 330 0.010
protein import GO:0017038 101 0.010
regulation of actin filament length GO:0030832 45 0.010

Ndc80 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.419
cancer DOID:162 0 0.183
organ system cancer DOID:0050686 0 0.064
breast cancer DOID:1612 0 0.048
thoracic cancer DOID:5093 0 0.048
immune system disease DOID:2914 0 0.022
disease of anatomical entity DOID:7 0 0.022
large intestine cancer DOID:5672 0 0.017
gastrointestinal system cancer DOID:3119 0 0.017
intestinal cancer DOID:10155 0 0.017
colorectal cancer DOID:9256 0 0.013
hematopoietic system disease DOID:74 0 0.011