IMP

Process View

Mus musculus

15 genes annotated in mouse

negative regulation of proteasomal ubiquitin dependent protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of proteasomal ubiquitin dependent protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of proteasomal ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.907
Ccnb1	cyclin B1	0.894
Cdk1	cyclin-dependent kinase 1	0.839
Fgfr2	fibroblast growth factor receptor 2	0.668
Ccnb2	cyclin B2	0.541
Ccna2	cyclin A2	0.523
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.506	Fly
Prc1	protein regulator of cytokinesis 1	0.494
Cdca8	cell division cycle associated 8	0.489
Mdm2	transformed mouse 3T3 cell double minute 2	0.414
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.383
Kif22	kinesin family member 22	0.317
Kif20a	kinesin family member 20A	0.281
Gli3	GLI-Kruppel family member GLI3	0.236
Cdk2	cyclin-dependent kinase 2	0.186
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.184
Spag5	sperm associated antigen 5	0.180
Ccnf	cyclin F	0.175
Birc5	baculoviral IAP repeat-containing 5	0.155
Sgol2	shugoshin-like 2 (S. pombe)	0.136
Cenpe	centromere protein E	0.136
Sgol1	shugoshin-like 1 (S. pombe)	0.114
Pthlh	parathyroid hormone-like peptide	0.107
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.107	Yeast
Ckap2	cytoskeleton associated protein 2	0.104
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.101
Mdm4	transformed mouse 3T3 cell double minute 4	0.094
Glrx3	glutaredoxin 3	0.094
Kif11	kinesin family member 11	0.093
Stil	Scl/Tal1 interrupting locus	0.091
Aurka	aurora kinase A	0.087
Ooep	oocyte expressed protein homolog (dog)	0.087
Lin9	lin-9 homolog (C. elegans)	0.086
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.086
Cenpn	centromere protein N	0.084
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.081
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.079
Aurkb	aurora kinase B	0.077
Ube2c	ubiquitin-conjugating enzyme E2C	0.074
Pou5f1	POU domain, class 5, transcription factor 1	0.071
Csnk1g2	casein kinase 1, gamma 2	0.067
Anln	anillin, actin binding protein	0.067
Cops4	COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)	0.067
Depdc1a	DEP domain containing 1a	0.067
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.065
Arid1a	AT rich interactive domain 1A (SWI-like)	0.061
Ctnnb1	catenin (cadherin associated protein), beta 1	0.053
Cops6	COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)	0.052
Ccne2	cyclin E2	0.051	Fly
Rrm2	ribonucleotide reductase M2	0.050
Ect2	ect2 oncogene	0.048
Cbx1	chromobox homolog 1 (Drosophila HP1 beta)	0.048
Plk4	polo-like kinase 4 (Drosophila)	0.047
Sox9	SRY-box containing gene 9	0.047
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.046	Fly
Cep55	centrosomal protein 55	0.045
Smad3	MAD homolog 3 (Drosophila)	0.043
Cdca5	cell division cycle associated 5	0.042
Ar	androgen receptor	0.041
Fgfr3	fibroblast growth factor receptor 3	0.041
Kif4	kinesin family member 4	0.041
Kif2c	kinesin family member 2C	0.039
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.039
Ncapg	non-SMC condensin I complex, subunit G	0.037
Pten	phosphatase and tensin homolog	0.037
Mrpl24	mitochondrial ribosomal protein L24	0.036
Melk	maternal embryonic leucine zipper kinase	0.036
Kif23	kinesin family member 23	0.036
Plk1	polo-like kinase 1 (Drosophila)	0.036	Human
Fgf9	fibroblast growth factor 9	0.035
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.035
Arid1b	AT rich interactive domain 1B (SWI-like)	0.034
Kntc1	kinetochore associated 1	0.033
Smc4	structural maintenance of chromosomes 4	0.033
Gli2	GLI-Kruppel family member GLI2	0.032
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.032
Col2a1	collagen, type II, alpha 1	0.031
Rb1	retinoblastoma 1	0.031
Ptgs2	prostaglandin-endoperoxide synthase 2	0.031
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.030
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.030
Suv39h2	suppressor of variegation 3-9 homolog 2 (Drosophila)	0.030
Drap1	Dr1 associated protein 1 (negative cofactor 2 alpha)	0.030
Dctn1	dynactin 1	0.029
Ubxn1	UBX domain protein 1	0.029	Human
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.028
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.028
Mbd3	methyl-CpG binding domain protein 3	0.028
Aimp1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	0.027
4632434I11Rik	RIKEN cDNA 4632434I11 gene	0.027
Ccne1	cyclin E1	0.027	Fly
Cenpf	centromere protein F	0.027
Ptch1	patched homolog 1	0.026
Dsn1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.026
Trp63	transformation related protein 63	0.025
Brca1	breast cancer 1	0.025
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.025
Pcna	proliferating cell nuclear antigen	0.025
Mki67	antigen identified by monoclonal antibody Ki 67	0.025
Brca2	breast cancer 2	0.024
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.024
Ech1	enoyl coenzyme A hydratase 1, peroxisomal	0.024
Mastl	microtubule associated serine/threonine kinase-like	0.024
Racgap1	Rac GTPase-activating protein 1	0.024
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.023
Sfn	stratifin	0.023
Ehmt2	euchromatic histone lysine N-methyltransferase 2	0.023
Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	0.023
Trim59	tripartite motif-containing 59	0.022
Rad51c	RAD51 homolog c (S. cerevisiae)	0.022
Smarcb1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.022
Top2a	topoisomerase (DNA) II alpha	0.022
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.022
Gsg2	germ cell-specific gene 2	0.022
Bmi1	Bmi1 polycomb ring finger oncogene	0.022
Creb1	cAMP responsive element binding protein 1	0.022
Bmp7	bone morphogenetic protein 7	0.022
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.021
Arl6ip6	ADP-ribosylation factor-like 6 interacting protein 6	0.021
Shcbp1	Shc SH2-domain binding protein 1	0.021
Gtse1	G two S phase expressed protein 1	0.021
Smad4	MAD homolog 4 (Drosophila)	0.021
6720463M24Rik	RIKEN cDNA 6720463M24 gene	0.020
Fignl1	fidgetin-like 1	0.020
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.020
Acd	adrenocortical dysplasia	0.020
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.020
Asf1a	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.020
Gm13290	predicted gene 13290	0.020
Ttk	Ttk protein kinase	0.020	Yeast Fly
Pot1a	protection of telomeres 1A	0.020
Lig4	ligase IV, DNA, ATP-dependent	0.020
Cks2	CDC28 protein kinase regulatory subunit 2	0.020
Rnf2	ring finger protein 2	0.019
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.019
Mis18bp1	MIS18 binding protein 1	0.019
Cdkn3	cyclin-dependent kinase inhibitor 3	0.018
Hdac3	histone deacetylase 3	0.018
Fbxo5	F-box protein 5	0.018	Human Fly
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.017
Bmp4	bone morphogenetic protein 4	0.017
Cul4a	cullin 4A	0.017
Vdac3	voltage-dependent anion channel 3	0.017
Kiss1	KiSS-1 metastasis-suppressor	0.017
Ccdc99	coiled-coil domain containing 99	0.017
Ckap2l	cytoskeleton associated protein 2-like	0.017
H2afx	H2A histone family, member X	0.017
Sox2	SRY-box containing gene 2	0.017
Trp73	transformation related protein 73	0.017
Trim23	tripartite motif-containing 23	0.017
Ercc6l	excision repair cross-complementing rodent repair deficiency complementation group 6 - like	0.016
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.016
Skp1a	S-phase kinase-associated protein 1A	0.016
Cenpk	centromere protein K	0.016
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.016
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.016
Stub1	STIP1 homology and U-Box containing protein 1	0.016
Hist1h2bm	histone cluster 1, H2bm	0.015
Use1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	0.015
Zmym2	zinc finger, MYM-type 2	0.015
Klhdc2	kelch domain containing 2	0.015
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.015
Rrp1	ribosomal RNA processing 1 homolog (S. cerevisiae)	0.015
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.015
Ergic3	ERGIC and golgi 3	0.015
Ncaph	non-SMC condensin I complex, subunit H	0.015
Hoxa10	homeobox A10	0.015
Gdf1	growth differentiation factor 1	0.014
4930547N16Rik	RIKEN cDNA 4930547N16 gene	0.014
Cenpq	centromere protein Q	0.014
Scaf4	SR-related CTD-associated factor 4	0.014
Tcf21	transcription factor 21	0.014
Vps72	vacuolar protein sorting 72 (yeast)	0.014
Cops7b	COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana)	0.014
Ncapd3	non-SMC condensin II complex, subunit D3	0.014
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.014
Wnt5a	wingless-related MMTV integration site 5A	0.014
Hoxd13	homeobox D13	0.013
Rpgrip1l	Rpgrip1-like	0.013
Cyth2	cytohesin 2	0.013
Sgta	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	0.013
Hoxa13	homeobox A13	0.013
Ncapg2	non-SMC condensin II complex, subunit G2	0.013
Spry2	sprouty homolog 2 (Drosophila)	0.013
March7	membrane-associated ring finger (C3HC4) 7	0.013
Axin1	axin 1	0.013
Lrr1	leucine rich repeat protein 1	0.013
Zeb1	zinc finger E-box binding homeobox 1	0.013
Aamp	angio-associated migratory protein	0.013
Mtch1	mitochondrial carrier homolog 1 (C. elegans)	0.012
Sos2	son of sevenless homolog 2 (Drosophila)	0.012
Sall4	sal-like 4 (Drosophila)	0.012
Apoa1bp	apolipoprotein A-I binding protein	0.012
Rim4	recombination induced mutation 4	0.012
Cenpi	centromere protein I	0.012
Nlrp5	NLR family, pyrin domain containing 5	0.012
Pbx1	pre B-cell leukemia transcription factor 1	0.012
Tm2d2	TM2 domain containing 2	0.011
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.011
Ptbp2	polypyrimidine tract binding protein 2	0.011
Lrp6	low density lipoprotein receptor-related protein 6	0.011
E2f7	E2F transcription factor 7	0.011
Pax2	paired box gene 2	0.011
Skil	SKI-like	0.011
Thoc7	THO complex 7 homolog (Drosophila)	0.011
Nf1	neurofibromatosis 1	0.011
Lrp2	low density lipoprotein receptor-related protein 2	0.011
Foxc1	forkhead box C1	0.011
Mterfd1	MTERF domain containing 1	0.011
Mllt1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.011
Rad51ap1	RAD51 associated protein 1	0.011
Pknox1	Pbx/knotted 1 homeobox	0.011
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.011
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.011
Anapc2	anaphase promoting complex subunit 2	0.011
H1	histocompatibility 1	0.011
Ube3a	ubiquitin protein ligase E3A	0.011
Tsc2	tuberous sclerosis 2	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.010
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.010
Hist2h4	histone cluster 2, H4	0.010
Ufc1	ubiquitin-fold modifier conjugating enzyme 1	0.010
Git1	G protein-coupled receptor kinase-interactor 1	0.010
Rbmxl2	RNA binding motif protein, X-linked-like 2	0.010
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.010
Rab24	RAB24, member RAS oncogene family	0.010