Mus musculus

48 known processes

Cul5

cullin 5

(Aliases: C330021I08Rik,VACM-1,VACM1,8430423K24Rik,C030032G03Rik,4921514I20Rik,AI852817)

Cul5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 4 0.364
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.276
regulation of activation of jak2 kinase activity GO:0010534 1 0.257
radial glia guided migration of purkinje cell GO:0021942 6 0.252
activation of janus kinase activity GO:0042976 2 0.242
layer formation in cerebral cortex GO:0021819 13 0.218
regulation of activation of janus kinase activity GO:0010533 1 0.190
cellular amino acid metabolic process GO:0006520 103 0.175
cerebral cortex radially oriented cell migration GO:0021799 31 0.151
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 1 0.120
regulation of cellular amino acid metabolic process GO:0006521 5 0.107
negative regulation of molecular function GO:0044092 258 0.103
cellular amine metabolic process GO:0044106 44 0.102
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.101
negative regulation of cellular amine metabolic process GO:0033239 1 0.099
g protein coupled receptor signaling pathway GO:0007186 243 0.099
amine metabolic process GO:0009308 45 0.099
regulation of cellular amine metabolic process GO:0033238 20 0.096
cerebral cortex cell migration GO:0021795 44 0.091
negative regulation of phosphorus metabolic process GO:0010563 184 0.089
pallium development GO:0021543 120 0.087
protein ubiquitination GO:0016567 171 0.082
cellular ketone metabolic process GO:0042180 84 0.081
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.080
regulation of cellular ketone metabolic process GO:0010565 66 0.079
hindbrain radial glia guided cell migration GO:0021932 12 0.078
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.076
response to amino acid GO:0043200 37 0.075
cd4 positive alpha beta t cell activation GO:0035710 45 0.075
negative regulation of phosphate metabolic process GO:0045936 184 0.074
protein modification by small protein conjugation or removal GO:0070647 207 0.072
response to peptide GO:1901652 136 0.072
cellular response to amino acid stimulus GO:0071230 29 0.070
protein modification by small protein conjugation GO:0032446 187 0.069
regulation of protein localization GO:0032880 231 0.066
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.063
cerebral cortex radial glia guided migration GO:0021801 17 0.062
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.061
cytokine mediated signaling pathway GO:0019221 115 0.061
immune effector process GO:0002252 321 0.060
negative regulation of protein modification process GO:0031400 163 0.059
response to peptide hormone GO:0043434 127 0.057
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.057
regulation of kinase activity GO:0043549 249 0.055
negative regulation of protein phosphorylation GO:0001933 126 0.055
positive regulation of protein modification process GO:0031401 299 0.054
negative regulation of protein metabolic process GO:0051248 282 0.053
negative regulation of intracellular signal transduction GO:1902532 167 0.052
forebrain cell migration GO:0021885 58 0.052
negative regulation of lymphocyte activation GO:0051250 91 0.051
regulation of cytokine production GO:0001817 266 0.051
regulation of t helper cell differentiation GO:0045622 14 0.051
leukocyte differentiation GO:0002521 342 0.050
insulin receptor signaling pathway GO:0008286 49 0.050
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 3 0.050
negative regulation of defense response GO:0031348 77 0.049
positive regulation of transferase activity GO:0051347 167 0.049
cellular response to acid chemical GO:0071229 68 0.049
regulation of establishment of protein localization GO:0070201 181 0.048
negative regulation of phosphorylation GO:0042326 166 0.048
body fluid secretion GO:0007589 53 0.048
regulation of transferase activity GO:0051338 263 0.048
fat cell differentiation GO:0045444 160 0.047
cellular response to insulin stimulus GO:0032869 78 0.047
leukocyte activation involved in immune response GO:0002366 126 0.047
peptidyl amino acid modification GO:0018193 336 0.047
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.047
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 10 0.046
cellular response to hormone stimulus GO:0032870 150 0.046
hindbrain development GO:0030902 128 0.045
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.045
regulation of defense response GO:0031347 233 0.045
response to acid chemical GO:0001101 111 0.045
regulation of body fluid levels GO:0050878 162 0.045
lymphocyte differentiation GO:0030098 242 0.044
positive regulation of kinase activity GO:0033674 155 0.043
negative regulation of inflammatory response GO:0050728 61 0.043
regulation of secretion GO:0051046 274 0.043
negative regulation of leukocyte differentiation GO:1902106 51 0.043
regulation of secretion by cell GO:1903530 249 0.043
spongiotrophoblast layer development GO:0060712 15 0.042
inflammatory response GO:0006954 244 0.042
t helper cell differentiation GO:0042093 28 0.041
negative regulation of alpha beta t cell activation GO:0046636 18 0.041
regulation of protein kinase activity GO:0045859 232 0.041
regulation of inflammatory response GO:0050727 147 0.041
regulation of neuron differentiation GO:0045664 281 0.040
morphogenesis of a branching structure GO:0001763 203 0.040
positive regulation of protein phosphorylation GO:0001934 242 0.040
negative regulation of immune effector process GO:0002698 55 0.040
negative regulation of immune system process GO:0002683 209 0.039
negative regulation of cell activation GO:0050866 111 0.039
response to organonitrogen compound GO:0010243 246 0.039
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.039
cellular response to cytokine stimulus GO:0071345 189 0.039
regulation of response to wounding GO:1903034 189 0.039
cerebral cortex development GO:0021987 86 0.038
positive regulation of protein kinase activity GO:0045860 144 0.037
cytokine production GO:0001816 319 0.037
cell activation involved in immune response GO:0002263 126 0.037
protein secretion GO:0009306 111 0.036
cell differentiation involved in embryonic placenta development GO:0060706 26 0.036
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.036
trophoblast giant cell differentiation GO:0060707 15 0.036
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.036
negative regulation of cellular protein metabolic process GO:0032269 247 0.035
male gamete generation GO:0048232 285 0.035
peptidyl tyrosine phosphorylation GO:0018108 143 0.035
regulation of t helper 1 cell differentiation GO:0045625 7 0.034
regulation of protein secretion GO:0050708 82 0.034
positive regulation of nervous system development GO:0051962 221 0.034
lymphocyte activation involved in immune response GO:0002285 93 0.034
jak stat cascade GO:0007259 42 0.034
regulation of alpha beta t cell activation GO:0046634 53 0.034
negative regulation of response to wounding GO:1903035 77 0.033
macromolecule catabolic process GO:0009057 281 0.033
regulation of alpha beta t cell differentiation GO:0046637 35 0.033
regulation of adaptive immune response GO:0002819 90 0.033
negative regulation of t cell activation GO:0050868 65 0.033
placenta development GO:0001890 140 0.033
lactation GO:0007595 25 0.033
negative regulation of alpha beta t cell differentiation GO:0046639 12 0.033
regulation of cell activation GO:0050865 289 0.033
cellular response to peptide GO:1901653 92 0.032
negative regulation of jak stat cascade GO:0046426 7 0.032
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.032
spermatogenesis GO:0007283 284 0.032
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.032
adaptive immune response GO:0002250 155 0.031
negative regulation of growth GO:0045926 99 0.031
positive regulation of cell development GO:0010720 237 0.030
peptidyl tyrosine modification GO:0018212 145 0.030
organonitrogen compound catabolic process GO:1901565 264 0.030
glycosyl compound metabolic process GO:1901657 246 0.029
mammary gland lobule development GO:0061377 22 0.029
response to insulin GO:0032868 100 0.029
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.029
positive regulation of adaptive immune response GO:0002821 61 0.028
cellular response to organonitrogen compound GO:0071417 145 0.028
purine nucleotide metabolic process GO:0006163 302 0.028
forebrain development GO:0030900 302 0.028
establishment of mitochondrion localization GO:0051654 4 0.028
t cell activation GO:0042110 289 0.028
positive regulation of immune effector process GO:0002699 107 0.028
regulation of cytokine secretion GO:0050707 61 0.028
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.028
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.027
alpha beta t cell activation GO:0046631 91 0.027
cellular response to peptide hormone stimulus GO:0071375 92 0.027
negative regulation of lymphocyte differentiation GO:0045620 32 0.027
purine ribonucleotide metabolic process GO:0009150 290 0.027
t cell differentiation involved in immune response GO:0002292 30 0.026
cation transport GO:0006812 399 0.026
membrane organization GO:0061024 245 0.025
regulation of protein transport GO:0051223 163 0.025
organelle assembly GO:0070925 177 0.025
regulation of mapk cascade GO:0043408 248 0.025
embryonic placenta development GO:0001892 98 0.025
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.025
negative regulation of t cell differentiation GO:0045581 23 0.024
nitrogen compound transport GO:0071705 271 0.024
oxidation reduction process GO:0055114 342 0.024
multicellular organism growth GO:0035264 161 0.024
nucleobase containing small molecule metabolic process GO:0055086 352 0.023
t cell activation involved in immune response GO:0002286 43 0.023
nucleotide metabolic process GO:0009117 332 0.023
heterocycle catabolic process GO:0046700 280 0.023
positive regulation of lymphocyte activation GO:0051251 140 0.022
striated muscle tissue development GO:0014706 293 0.022
regulation of leukocyte differentiation GO:1902105 159 0.022
alpha beta t cell differentiation GO:0046632 69 0.022
gland development GO:0048732 330 0.022
organophosphate catabolic process GO:0046434 232 0.022
cellular response to dna damage stimulus GO:0006974 207 0.021
aromatic compound catabolic process GO:0019439 286 0.021
positive regulation of jak stat cascade GO:0046427 22 0.021
ribose phosphate metabolic process GO:0019693 291 0.021
cytokine secretion GO:0050663 72 0.020
regulation of t cell differentiation GO:0045580 83 0.020
purine containing compound metabolic process GO:0072521 311 0.020
organelle disassembly GO:1903008 2 0.020
epidermal growth factor receptor signaling pathway GO:0007173 28 0.020
ribonucleoside metabolic process GO:0009119 245 0.020
telencephalon development GO:0021537 186 0.020
mammary gland alveolus development GO:0060749 22 0.020
cellular nitrogen compound catabolic process GO:0044270 280 0.020
regulation of type 2 immune response GO:0002828 18 0.020
positive regulation of leukocyte differentiation GO:1902107 86 0.020
positive regulation of cell activation GO:0050867 158 0.020
nucleoside phosphate metabolic process GO:0006753 338 0.020
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.019
morphogenesis of a branching epithelium GO:0061138 193 0.019
positive regulation of alpha beta t cell activation GO:0046635 39 0.019
lateral inhibition GO:0046331 1 0.019
alpha beta t cell activation involved in immune response GO:0002287 31 0.019
regulation of jak stat cascade GO:0046425 34 0.019
erbb signaling pathway GO:0038127 32 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.019
regulation of t helper 2 cell differentiation GO:0045628 8 0.019
organic hydroxy compound metabolic process GO:1901615 203 0.018
microtubule based process GO:0007017 236 0.018
t cell differentiation GO:0030217 174 0.018
nucleoside phosphate catabolic process GO:1901292 222 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.018
regulation of lymphocyte differentiation GO:0045619 107 0.018
purine ribonucleotide catabolic process GO:0009154 208 0.018
response to radiation GO:0009314 165 0.018
ribonucleoside catabolic process GO:0042454 206 0.018
intracellular mrna localization GO:0008298 4 0.018
type 2 immune response GO:0042092 23 0.018
cognition GO:0050890 149 0.018
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 16 0.017
cellular protein catabolic process GO:0044257 155 0.017
chromatin organization GO:0006325 206 0.017
response to organic cyclic compound GO:0014070 198 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
mitochondrion distribution GO:0048311 4 0.017
cytoplasmic transport GO:0016482 234 0.017
purine nucleoside metabolic process GO:0042278 241 0.017
muscle tissue development GO:0060537 308 0.017
skeletal muscle organ development GO:0060538 163 0.017
methylation GO:0032259 134 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
purine containing compound catabolic process GO:0072523 213 0.017
positive regulation of cellular amine metabolic process GO:0033240 5 0.017
mitochondrion organization GO:0007005 134 0.017
ribonucleotide metabolic process GO:0009259 291 0.017
purine ribonucleoside metabolic process GO:0046128 241 0.017
positive regulation of t cell activation GO:0050870 101 0.016
regulation of t helper 1 type immune response GO:0002825 17 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
lateral line system development GO:0048925 1 0.016
intracellular distribution of mitochondria GO:0048312 1 0.016
nucleoside catabolic process GO:0009164 206 0.016
retina development in camera type eye GO:0060041 119 0.016
mapk cascade GO:0000165 281 0.016
positive regulation of homeostatic process GO:0032846 64 0.016
negative regulation of t helper cell differentiation GO:0045623 9 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
purine nucleoside triphosphate catabolic process GO:0009146 203 0.016
positive regulation of necrotic cell death GO:0010940 1 0.016
stem cell differentiation GO:0048863 268 0.016
protein localization to organelle GO:0033365 185 0.016
camera type eye development GO:0043010 266 0.016
regulation of cellular catabolic process GO:0031329 242 0.016
labyrinthine layer development GO:0060711 49 0.015
tyrosine phosphorylation of stat protein GO:0007260 23 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
t helper 1 cell differentiation GO:0045063 13 0.015
nucleocytoplasmic transport GO:0006913 139 0.015
regulation of organelle organization GO:0033043 289 0.015
oocyte axis specification GO:0007309 2 0.015
t helper 1 type immune response GO:0042088 25 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
muscle cell differentiation GO:0042692 261 0.015
learning or memory GO:0007611 148 0.015
organic cyclic compound catabolic process GO:1901361 295 0.015
embryonic placenta morphogenesis GO:0060669 25 0.015
telencephalon cell migration GO:0022029 55 0.014
compound eye development GO:0048749 1 0.014
microtubule sliding GO:0051012 1 0.014
mitochondrion transport along microtubule GO:0047497 3 0.014
regulation of system process GO:0044057 200 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
epithelial cell development GO:0002064 159 0.014
mrna transport GO:0051028 13 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
locomotory behavior GO:0007626 195 0.014
endomembrane system organization GO:0010256 147 0.014
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
cellular homeostasis GO:0019725 240 0.014
Rat
purine nucleoside catabolic process GO:0006152 205 0.014
plasma membrane organization GO:0007009 90 0.014
regulation of homeostatic process GO:0032844 182 0.014
regulation of membrane potential GO:0042391 192 0.013
protein catabolic process GO:0030163 221 0.013
skeletal system development GO:0001501 356 0.013
glycosyl compound catabolic process GO:1901658 206 0.013
positive regulation of organelle organization GO:0010638 128 0.013
regulation of cell projection organization GO:0031344 206 0.013
nucleobase containing compound transport GO:0015931 27 0.013
nucleoside metabolic process GO:0009116 246 0.013
organonitrogen compound biosynthetic process GO:1901566 192 0.013
cation transmembrane transport GO:0098655 266 0.013
regulation of cell cycle process GO:0010564 160 0.013
protein polymerization GO:0051258 57 0.013
regulation of cell motility GO:2000145 236 0.013
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.013
male meiosis GO:0007140 37 0.013
striated muscle cell development GO:0055002 125 0.013
dephosphorylation GO:0016311 129 0.013
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
Fly
cellularization GO:0007349 1 0.013
maintenance of location GO:0051235 89 0.013
stem cell development GO:0048864 219 0.013
regulation of t cell activation GO:0050863 170 0.012
nuclear transport GO:0051169 139 0.012
regulation of mrna metabolic process GO:1903311 43 0.012
positive regulation of t cell differentiation GO:0045582 52 0.012
negative regulation of cell cycle GO:0045786 123 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
regulation of hydrolase activity GO:0051336 246 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.012
sensory perception GO:0007600 245 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.012
Fly
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.012
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.012
rna processing GO:0006396 105 0.012
protein localization to membrane GO:0072657 108 0.012
regulation of ion transport GO:0043269 215 0.012
sensory organ morphogenesis GO:0090596 242 0.012
negative regulation of type 2 immune response GO:0002829 8 0.012
atp metabolic process GO:0046034 75 0.012
nuclear division GO:0000280 158 0.012
regulation of cell migration GO:0030334 219 0.012
negative regulation of neuron differentiation GO:0045665 101 0.012
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.012
oocyte construction GO:0007308 2 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
regulation of anatomical structure size GO:0090066 178 0.012
chromosome organization involved in meiosis GO:0070192 39 0.012
branching involved in labyrinthine layer morphogenesis GO:0060670 9 0.011
nucleotide catabolic process GO:0009166 217 0.011
ossification GO:0001503 216 0.011
regulation of cellular response to insulin stimulus GO:1900076 30 0.011
transmission of nerve impulse GO:0019226 76 0.011
multi multicellular organism process GO:0044706 109 0.011
dna repair GO:0006281 107 0.011
sensory system development GO:0048880 3 0.011
centrosome separation GO:0051299 4 0.011
rna localization GO:0006403 23 0.011
myosin filament assembly GO:0031034 2 0.011
cellular protein complex assembly GO:0043623 116 0.011
reactive oxygen species metabolic process GO:0072593 84 0.011
cellular chemical homeostasis GO:0055082 215 0.011
Rat
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.011
apoptotic signaling pathway GO:0097190 306 0.011
regulation of neuron projection development GO:0010975 169 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.011
negative regulation of cell development GO:0010721 169 0.011
response to alcohol GO:0097305 48 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.011
macromolecule methylation GO:0043414 120 0.011
regulation of cell cycle GO:0051726 281 0.011
Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
cellular component assembly involved in morphogenesis GO:0010927 139 0.011
muscle cell development GO:0055001 133 0.011
cellular response to lipid GO:0071396 145 0.011
anion transport GO:0006820 177 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
anatomical structure homeostasis GO:0060249 145 0.010
axis elongation involved in somitogenesis GO:0090245 4 0.010
inorganic ion transmembrane transport GO:0098660 234 0.010
ribonucleotide catabolic process GO:0009261 208 0.010
establishment of meiotic spindle orientation GO:0051296 1 0.010
placenta blood vessel development GO:0060674 31 0.010
divalent metal ion transport GO:0070838 172 0.010
ion transmembrane transport GO:0034220 361 0.010
transmembrane transport GO:0055085 412 0.010
limb development GO:0060173 166 0.010
neural tube development GO:0021915 160 0.010
labyrinthine layer morphogenesis GO:0060713 21 0.010
inorganic cation transmembrane transport GO:0098662 207 0.010
response to extracellular stimulus GO:0009991 127 0.010
regulation of rna export from nucleus GO:0046831 4 0.010
protein targeting GO:0006605 143 0.010
positive regulation of cell death GO:0010942 224 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
cofactor metabolic process GO:0051186 80 0.010
regulation of proteolysis GO:0030162 164 0.010
positive regulation of lymphocyte differentiation GO:0045621 61 0.010

Cul5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.033
sensory system disease DOID:0050155 0 0.018
eye and adnexa disease DOID:1492 0 0.018
eye disease DOID:5614 0 0.018
immune system disease DOID:2914 0 0.018
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
hematopoietic system disease DOID:74 0 0.011
retinal disease DOID:5679 0 0.011
musculoskeletal system disease DOID:17 0 0.010