IMP

Process View

Mus musculus

2 genes annotated in mouse

activation of janus kinase activity

The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of janus kinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activation of janus kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Lepr	leptin receptor	1.000
Ren1	renin 1 structural	1.000
Tgfb1	transforming growth factor, beta 1	0.996
Stat3	signal transducer and activator of transcription 3	0.995
Jak2	Janus kinase 2	0.995
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.980
Agtr1a	angiotensin II receptor, type 1a	0.966	Rat
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.966	Human
Il6st	interleukin 6 signal transducer	0.910
Stat5a	signal transducer and activator of transcription 5A	0.878
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.837
Slc12a1	solute carrier family 12, member 1	0.822
Socs3	suppressor of cytokine signaling 3	0.813	Mouse
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.781
Nos3	nitric oxide synthase 3, endothelial cell	0.751
Cish	cytokine inducible SH2-containing protein	0.694	Mouse
Tnf	tumor necrosis factor	0.689
Umod	uromodulin	0.669
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.651
Stat5b	signal transducer and activator of transcription 5B	0.610
Cav1	caveolin 1, caveolae protein	0.580
Socs1	suppressor of cytokine signaling 1	0.559
Foxp3	forkhead box P3	0.538
Vdr	vitamin D receptor	0.487
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.435
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.407
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.390
Vav2	vav 2 oncogene	0.370
Esr1	estrogen receptor 1 (alpha)	0.360
Fas	Fas (TNF receptor superfamily member 6)	0.344
Ptprc	protein tyrosine phosphatase, receptor type, C	0.341
Ptgs2	prostaglandin-endoperoxide synthase 2	0.339
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.299
Egfr	epidermal growth factor receptor	0.295
Cul5	cullin 5	0.242
Pim1	proviral integration site 1	0.233
Socs2	suppressor of cytokine signaling 2	0.229	Mouse
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.206
Agtrap	angiotensin II, type I receptor-associated protein	0.198
Vegfa	vascular endothelial growth factor A	0.189
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.189
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.185
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.168
Fyn	Fyn proto-oncogene	0.152
Ar	androgen receptor	0.147
Bcl3	B-cell leukemia/lymphoma 3	0.140
Insr	insulin receptor	0.140
Vav3	vav 3 oncogene	0.134
Rag1	recombination activating gene 1	0.129
Ikzf1	IKAROS family zinc finger 1	0.120
Il2rg	interleukin 2 receptor, gamma chain	0.118
Thra	thyroid hormone receptor alpha	0.117
Sh2b1	SH2B adaptor protein 1	0.116
Kit	kit oncogene	0.105
Irs1	insulin receptor substrate 1	0.102
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.099
Col1a1	collagen, type I, alpha 1	0.099
Nos2	nitric oxide synthase 2, inducible	0.095
Jak1	Janus kinase 1	0.095	Mouse
Lck	lymphocyte protein tyrosine kinase	0.088
Apoe	apolipoprotein E	0.077
Csf1	colony stimulating factor 1 (macrophage)	0.075
Wwox	WW domain-containing oxidoreductase	0.069
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.061
Bdkrb2	bradykinin receptor, beta 2	0.060
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.058
Pnpla2	patatin-like phospholipase domain containing 2	0.057
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.056
Vav1	vav 1 oncogene	0.055
Nos1	nitric oxide synthase 1, neuronal	0.052
Wt1	Wilms tumor 1 homolog	0.051
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.048
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.048
Il6	interleukin 6	0.047
Itga1	integrin alpha 1	0.046
S1pr1	sphingosine-1-phosphate receptor 1	0.045
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.044
Rap2c	RAP2C, member of RAS oncogene family	0.044
Plcg1	phospholipase C, gamma 1	0.043
Foxn1	forkhead box N1	0.040
Gcgr	glucagon receptor	0.038
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.036
Tcra	T-cell receptor alpha chain	0.036
Cyp11b2	cytochrome P450, family 11, subfamily b, polypeptide 2	0.033
Vgf	VGF nerve growth factor inducible	0.032
Il1r1	interleukin 1 receptor, type I	0.031
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.031
Igf1	insulin-like growth factor 1	0.031
Irf1	interferon regulatory factor 1	0.030
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.030
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.030
Ugcg	UDP-glucose ceramide glucosyltransferase	0.030
Junb	Jun-B oncogene	0.028
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.027
Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3	0.027
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.026
Il10	interleukin 10	0.023
Pim2	proviral integration site 2	0.023
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.023
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.022
Zbtb7b	zinc finger and BTB domain containing 7B	0.022
Lipe	lipase, hormone sensitive	0.022
Irs2	insulin receptor substrate 2	0.022
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.022
Wnk4	WNK lysine deficient protein kinase 4	0.021
Pparg	peroxisome proliferator activated receptor gamma	0.021
Aqp2	aquaporin 2	0.021
Gdf15	growth differentiation factor 15	0.021
Ssfa2	sperm specific antigen 2	0.020
Rora	RAR-related orphan receptor alpha	0.020
C78228	expressed sequence C78228	0.020
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.019
Mefv	Mediterranean fever	0.019
Elf3	E74-like factor 3	0.019
Hbegf	heparin-binding EGF-like growth factor	0.019
Agtr2	angiotensin II receptor, type 2	0.018
Arrdc3	arrestin domain containing 3	0.017
G0s2	G0/G1 switch gene 2	0.017
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.017
Vhl	von Hippel-Lindau tumor suppressor	0.017
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.017
Il17ra	interleukin 17 receptor A	0.017
Tead4	TEA domain family member 4	0.017
Tgfbr2	transforming growth factor, beta receptor II	0.016
4933426M11Rik	RIKEN cDNA 4933426M11 gene	0.016
Myb	myeloblastosis oncogene	0.016
Prlr	prolactin receptor	0.016
Aprt	adenine phosphoribosyl transferase	0.016
Prkce	protein kinase C, epsilon	0.016
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.016
Gna13	guanine nucleotide binding protein, alpha 13	0.015
Elk4	ELK4, member of ETS oncogene family	0.015
Prl3d2	prolactin family 3, subfamily d, member 1	0.015	Rat
Kiss1	KiSS-1 metastasis-suppressor	0.015
Src	Rous sarcoma oncogene	0.015
Cyld	cylindromatosis (turban tumor syndrome)	0.015
Lrrc8c	leucine rich repeat containing 8 family, member C	0.015
Hipk3	homeodomain interacting protein kinase 3	0.014
Batf	basic leucine zipper transcription factor, ATF-like	0.014
Egr1	early growth response 1	0.014
Man1a	mannosidase 1, alpha	0.014
Fgf21	fibroblast growth factor 21	0.014
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.014
Inpp5d	inositol polyphosphate-5-phosphatase D	0.014
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.013
Pxk	PX domain containing serine/threonine kinase	0.013
Tgfbr1	transforming growth factor, beta receptor I	0.013
Col4a3	collagen, type IV, alpha 3	0.013
Aldob	aldolase B, fructose-bisphosphate	0.012
Kl	klotho	0.012
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.012
Zap70	zeta-chain (TCR) associated protein kinase	0.012
Rhox6	reproductive homeobox 6	0.012
Mapk8	mitogen-activated protein kinase 8	0.012
Cd247	CD247 antigen	0.012
Smad3	MAD homolog 3 (Drosophila)	0.012
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.012
Nfil3	nuclear factor, interleukin 3, regulated	0.011
Fam83g	family with sequence similarity 83, member G	0.011
Akr1b7	aldo-keto reductase family 1, member B7	0.011
Cideb	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	0.011
Lpin1	lipin 1	0.011
Glis2	GLIS family zinc finger 2	0.011
Lcat	lecithin cholesterol acyltransferase	0.011
Mov10	Moloney leukemia virus 10	0.011
Itgb3	integrin beta 3	0.011
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.011
Ahr	aryl-hydrocarbon receptor	0.011
Jak3	Janus kinase 3	0.011	Mouse
Fto	fat mass and obesity associated	0.011
Phospho1	phosphatase, orphan 1	0.010
2310014H01Rik	RIKEN cDNA 2310014H01 gene	0.010
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.010
Kiss1r	KISS1 receptor	0.010
Gnrh1	gonadotropin releasing hormone 1	0.010
Bhlhe40	basic helix-loop-helix family, member e40	0.010
Cpe	carboxypeptidase E	0.010