Mus musculus

618 known processes

Bcl2

B-cell leukemia/lymphoma 2

(Aliases: C430015F12Rik,AW986256,Bcl-2,D630044D05Rik,D830018M01Rik)

Bcl2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 1.000
Mouse
urogenital system development GO:0001655 261 1.000
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 1.000
Mouse
release of cytochrome c from mitochondria GO:0001836 23 1.000
cellular response to gamma radiation GO:0071480 4 1.000
Mouse
mesonephric tubule development GO:0072164 94 1.000
cellular process regulating host cell cycle in response to virus GO:0060154 3 1.000
Mouse
renal tubule development GO:0061326 87 1.000
glomerulus development GO:0032835 40 1.000
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 1.000
kidney development GO:0001822 213 1.000
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 1.000
Mouse
nephron morphogenesis GO:0072028 69 1.000
regulation of mitochondrion organization GO:0010821 27 1.000
Worm
nephron development GO:0072006 109 1.000
nephron tubule morphogenesis GO:0072078 68 1.000
spermatid differentiation GO:0048515 115 0.999
Mouse
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.999
Mouse
kidney morphogenesis GO:0060993 83 0.999
kidney epithelium development GO:0072073 121 0.999
nephron tubule development GO:0072080 84 0.999
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.998
Mouse
ureteric bud development GO:0001657 94 0.998
morphogenesis of a branching structure GO:0001763 203 0.998
regulation of release of cytochrome c from mitochondria GO:0090199 11 0.998
apoptotic process involved in mammary gland involution GO:0060057 4 0.998
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.998
cellular response to radiation GO:0071478 28 0.998
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.997
Mouse
ureteric bud morphogenesis GO:0060675 62 0.997
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 4 0.997
Mouse
alpha beta t cell differentiation GO:0046632 69 0.997
mesonephros development GO:0001823 97 0.997
apoptotic mitochondrial changes GO:0008637 48 0.997
spermatogenesis GO:0007283 284 0.997
Mouse
mesonephric epithelium development GO:0072163 94 0.997
amine metabolic process GO:0009308 45 0.996
mitochondrial fusion GO:0008053 9 0.996
Mouse Worm
muscle cell differentiation GO:0042692 261 0.996
positive regulation of mitochondrion organization GO:0010822 17 0.996
Worm
negative regulation of protein metabolic process GO:0051248 282 0.996
Zebrafish Mouse
mesenchymal cell differentiation GO:0048762 107 0.996
mesenchyme development GO:0060485 152 0.995
regulation of smooth muscle cell migration GO:0014910 6 0.995
regulation of neuron differentiation GO:0045664 281 0.995
branching involved in ureteric bud morphogenesis GO:0001658 56 0.995
mesenchymal cell development GO:0014031 93 0.994
cd8 positive alpha beta t cell lineage commitment GO:0043375 1 0.994
myotube differentiation GO:0014902 105 0.993
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 4 0.993
Mouse
lymphocyte differentiation GO:0030098 242 0.992
regulation of apoptotic signaling pathway GO:2001233 197 0.992
skin development GO:0043588 220 0.992
regulation of membrane potential GO:0042391 192 0.990
ossification GO:0001503 216 0.990
stem cell development GO:0048864 219 0.989
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.988
Mouse
positive regulation of nervous system development GO:0051962 221 0.988
development of primary sexual characteristics GO:0045137 143 0.988
germ cell development GO:0007281 185 0.987
formation of radial glial scaffolds GO:0021943 4 0.987
positive regulation of glial cell proliferation GO:0060252 4 0.987
purine nucleotide metabolic process GO:0006163 302 0.987
Worm
epithelial tube morphogenesis GO:0060562 303 0.987
branching morphogenesis of an epithelial tube GO:0048754 159 0.987
muscle tissue development GO:0060537 308 0.986
nephron epithelium morphogenesis GO:0072088 68 0.986
extrinsic apoptotic signaling pathway GO:0097191 126 0.986
positive regulation of cell death GO:0010942 224 0.985
Mouse
multicellular organism growth GO:0035264 161 0.984
negative regulation of osteoblast proliferation GO:0033689 4 0.983
negative regulation of fibroblast proliferation GO:0048147 14 0.983
Mouse
odontogenesis GO:0042476 78 0.983
Mouse
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.983
nephron epithelium development GO:0072009 92 0.982
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.982
Worm
renal system development GO:0072001 225 0.981
single organism cell adhesion GO:0098602 156 0.979
ribonucleotide metabolic process GO:0009259 291 0.979
Worm
positive regulation of apoptotic process GO:0043065 217 0.979
Mouse
apoptotic process involved in patterning of blood vessels GO:1902262 6 0.977
Mouse
regulation of fibroblast proliferation GO:0048145 34 0.977
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.977
Mouse
mitochondrial outer membrane permeabilization GO:0097345 10 0.976
Mouse
male gamete generation GO:0048232 285 0.976
Mouse
gtp catabolic process GO:0006184 143 0.975
Worm
positive regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903378 3 0.975
Mouse
cellular amino acid metabolic process GO:0006520 103 0.975
regulation of developmental pigmentation GO:0048070 14 0.974
membrane organization GO:0061024 245 0.974
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.973
positive regulation of cell development GO:0010720 237 0.973
glycosyl compound metabolic process GO:1901657 246 0.972
Worm
regulation of endocytic recycling GO:2001135 3 0.972
sphingolipid metabolic process GO:0006665 45 0.972
Mouse
axonogenesis GO:0007409 274 0.972
hair follicle development GO:0001942 85 0.971
female sex differentiation GO:0046660 84 0.971
apoptotic process involved in morphogenesis GO:0060561 25 0.970
Mouse
digestive tract development GO:0048565 190 0.970
metanephric tubule development GO:0072170 18 0.968
apoptotic signaling pathway GO:0097190 306 0.968
positive regulation of b cell apoptotic process GO:0002904 4 0.968
Mouse
mammary gland morphogenesis GO:0060443 54 0.967
Mouse
positive regulation of neuroepithelial cell differentiation GO:1902913 5 0.967
organ growth GO:0035265 117 0.965
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.965
Human Mouse
lymphocyte proliferation GO:0046651 164 0.964
Human Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.964
regulation of osteoblast proliferation GO:0033688 15 0.964
positive regulation of hydrolase activity GO:0051345 148 0.964
Mouse Worm
negative regulation of cell proliferation GO:0008285 296 0.963
positive regulation of peptidase activity GO:0010952 49 0.963
Mouse
ovarian follicle development GO:0001541 40 0.962
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.961
Mouse
b cell proliferation GO:0042100 53 0.961
Human Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.960
metanephros development GO:0001656 79 0.960
nucleoside triphosphate metabolic process GO:0009141 230 0.958
Worm
skeletal muscle organ development GO:0060538 163 0.958
negative regulation of apoptotic signaling pathway GO:2001234 104 0.958
positive regulation of mammary gland involution GO:1903521 4 0.958
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.957
Mouse
t cell activation GO:0042110 289 0.957
negative regulation of phosphorus metabolic process GO:0010563 184 0.957
Mouse
positive regulation of proteolysis GO:0045862 85 0.955
Mouse
positive regulation of endocytic recycling GO:2001137 2 0.954
sensory organ morphogenesis GO:0090596 242 0.954
mesonephric tubule morphogenesis GO:0072171 63 0.952
muscle cell migration GO:0014812 19 0.949
glycosyl compound catabolic process GO:1901658 206 0.948
Worm
actin cytoskeleton organization GO:0030036 220 0.948
appendage morphogenesis GO:0035107 149 0.948
Mouse
smooth muscle cell migration GO:0014909 10 0.946
gtp metabolic process GO:0046039 144 0.945
Worm
epidermis development GO:0008544 187 0.943
syncytium formation by plasma membrane fusion GO:0000768 42 0.941
regulation of purine nucleotide metabolic process GO:1900542 169 0.941
Worm
cochlear nucleus development GO:0021747 4 0.939
negative regulation of b cell apoptotic process GO:0002903 7 0.939
Mouse
positive regulation of programmed cell death GO:0043068 218 0.938
Mouse
muscle cell development GO:0055001 133 0.937
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.937
Mouse
hypothalamus development GO:0021854 16 0.937
Mouse
gland development GO:0048732 330 0.936
leukocyte differentiation GO:0002521 342 0.934
pallium development GO:0021543 120 0.934
Mouse
regulation of peptidase activity GO:0052547 96 0.933
Zebrafish Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.933
b cell differentiation GO:0030183 78 0.933
ear development GO:0043583 200 0.933
regulation of nucleotide metabolic process GO:0006140 169 0.930
Worm
regulation of melanocyte differentiation GO:0045634 7 0.928
cell type specific apoptotic process GO:0097285 268 0.927
positive regulation of pigment cell differentiation GO:0050942 5 0.926
apoptotic process involved in development GO:1902742 28 0.925
Mouse
nucleoside catabolic process GO:0009164 206 0.925
Worm
activation of cysteine type endopeptidase activity GO:0097202 27 0.924
Mouse
post embryonic organ development GO:0048569 17 0.923
Mouse
positive regulation of melanocyte differentiation GO:0045636 5 0.923
purine nucleotide catabolic process GO:0006195 211 0.921
Worm
development of primary female sexual characteristics GO:0046545 73 0.920
neuron migration GO:0001764 122 0.918
Mouse
digestive system development GO:0055123 200 0.918
negative regulation of protein modification process GO:0031400 163 0.918
Mouse
regulation of organ morphogenesis GO:2000027 144 0.918
regulation of cellular catabolic process GO:0031329 242 0.918
Worm
negative regulation of cellular protein metabolic process GO:0032269 247 0.918
Zebrafish Mouse
cellular response to acid chemical GO:0071229 68 0.916
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 203 0.915
Worm
response to organic cyclic compound GO:0014070 198 0.915
renal tubule morphogenesis GO:0061333 72 0.915
diencephalon development GO:0021536 63 0.913
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.913
Mouse
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.912
Mouse
lymphocyte homeostasis GO:0002260 64 0.911
response to endoplasmic reticulum stress GO:0034976 53 0.911
Human Mouse
b cell activation GO:0042113 161 0.911
cation transport GO:0006812 399 0.909
regulation of bmp signaling pathway GO:0030510 60 0.908
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.907
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.906
Mouse
alpha beta t cell activation GO:0046631 91 0.906
positive regulation of protein oligomerization GO:0032461 4 0.906
neuron apoptotic process GO:0051402 142 0.905
hematopoietic progenitor cell differentiation GO:0002244 143 0.904
regulation of ion transport GO:0043269 215 0.903
purine nucleoside catabolic process GO:0006152 205 0.903
Worm
positive regulation of leukocyte apoptotic process GO:2000108 21 0.902
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 65 0.902
Zebrafish Mouse
stem cell differentiation GO:0048863 268 0.900
maintenance of location GO:0051235 89 0.899
ribonucleoside triphosphate catabolic process GO:0009203 199 0.899
Worm
regulation of striated muscle cell differentiation GO:0051153 81 0.897
cell growth GO:0016049 130 0.897
axon guidance GO:0007411 141 0.897
t cell apoptotic process GO:0070231 39 0.896
Mouse
neuronal action potential GO:0019228 54 0.895
digestive tract morphogenesis GO:0048546 147 0.895
positive regulation of neuron maturation GO:0014042 2 0.895
protein oligomerization GO:0051259 67 0.895
Mouse
positive regulation of bmp signaling pathway GO:0030513 23 0.892
regulation of mitotic cell cycle phase transition GO:1901990 73 0.892
cytosolic calcium ion transport GO:0060401 48 0.890
metanephric glomerular mesangium development GO:0072223 3 0.889
regulation of protein oligomerization GO:0032459 4 0.889
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 3 0.888
Mouse
positive regulation of nucleotide catabolic process GO:0030813 88 0.887
Worm
cellular response to nutrient levels GO:0031669 64 0.887
genitalia development GO:0048806 37 0.887
Mouse
male gonad development GO:0008584 88 0.886
striated muscle tissue development GO:0014706 293 0.883
regulation of myotube differentiation GO:0010830 62 0.883
establishment of protein localization to organelle GO:0072594 118 0.883
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.882
Human Mouse
ribose phosphate metabolic process GO:0019693 291 0.881
Worm
oogenesis GO:0048477 56 0.880
positive regulation of myotube differentiation GO:0010831 24 0.879
skeletal muscle fiber development GO:0048741 58 0.879
retina development in camera type eye GO:0060041 119 0.878
Mouse
thymocyte apoptotic process GO:0070242 19 0.874
Mouse
skeletal system development GO:0001501 356 0.874
t cell differentiation in thymus GO:0033077 77 0.874
positive regulation of growth GO:0045927 104 0.873
lipid homeostasis GO:0055088 63 0.872
hair cycle GO:0042633 90 0.871
rhythmic process GO:0048511 174 0.870
guanosine containing compound catabolic process GO:1901069 144 0.870
Worm
eye photoreceptor cell differentiation GO:0001754 41 0.869
gonad development GO:0008406 141 0.869
response to oxygen levels GO:0070482 62 0.867
negative regulation of growth GO:0045926 99 0.866
organelle fusion GO:0048284 28 0.865
Mouse Worm
response to ionizing radiation GO:0010212 42 0.863
nucleobase containing small molecule metabolic process GO:0055086 352 0.863
Worm
activation of immune response GO:0002253 138 0.863
Human
regulation of cell migration GO:0030334 219 0.862
regulation of nitrogen utilization GO:0006808 2 0.862
cell substrate adhesion GO:0031589 130 0.861
regulation of mitochondrial membrane permeability GO:0046902 17 0.857
embryonic digit morphogenesis GO:0042733 56 0.854
Mouse
regulation of protein stability GO:0031647 52 0.851
t helper cell differentiation GO:0042093 28 0.851
nucleoside phosphate metabolic process GO:0006753 338 0.849
Worm
response to nutrient levels GO:0031667 109 0.848
regulation of dna templated transcription in response to stress GO:0043620 9 0.847
divalent inorganic cation homeostasis GO:0072507 138 0.847
mitochondrial membrane organization GO:0007006 26 0.847
immune effector process GO:0002252 321 0.847
Human
purine ribonucleoside metabolic process GO:0046128 241 0.845
Worm
protein maturation GO:0051604 176 0.845
Zebrafish Mouse
post embryonic eye morphogenesis GO:0048050 4 0.844
Mouse
mammary gland epithelial cell proliferation GO:0033598 24 0.841
Mouse
regulation of membrane permeability GO:0090559 18 0.841
nucleotide catabolic process GO:0009166 217 0.840
Worm
connective tissue development GO:0061448 179 0.840
positive regulation of gtp catabolic process GO:0033126 85 0.840
Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.839
regulation of lymphocyte apoptotic process GO:0070228 41 0.839
Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.832
positive regulation of nucleoside metabolic process GO:0045979 91 0.831
Worm
hindbrain development GO:0030902 128 0.830
positive regulation of cell maturation GO:1903431 4 0.830
cell adhesion GO:0007155 329 0.827
regulation of hydrolase activity GO:0051336 246 0.827
Zebrafish Mouse Worm
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 3 0.827
Mouse
nucleotide metabolic process GO:0009117 332 0.827
Worm
neural nucleus development GO:0048857 22 0.826
developmental programmed cell death GO:0010623 41 0.826
signal transduction by p53 class mediator GO:0072331 51 0.823
Mouse
response to uv b GO:0010224 5 0.823
regulation of killing of cells of other organism GO:0051709 4 0.822
peptidyl amino acid modification GO:0018193 336 0.821
carbohydrate metabolic process GO:0005975 230 0.821
spleen development GO:0048536 39 0.820
response to peptide hormone GO:0043434 127 0.819
Rat
modulation by virus of host morphology or physiology GO:0019048 3 0.817
muscle fiber development GO:0048747 76 0.816
protein localization to mitochondrion GO:0070585 15 0.815
Mouse
positive regulation of developmental pigmentation GO:0048087 6 0.815
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 14 0.814
Mouse
nucleoside metabolic process GO:0009116 246 0.814
Worm
bmp signaling pathway GO:0030509 93 0.812
multicellular organismal signaling GO:0035637 91 0.810
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.809
Mouse
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 10 0.807
Mouse
telencephalon development GO:0021537 186 0.806
Mouse
negative regulation of bmp signaling pathway GO:0030514 35 0.802
negative regulation of cell growth GO:0030308 44 0.802
peptidyl tyrosine phosphorylation GO:0018108 143 0.801
regulation of gtp catabolic process GO:0033124 113 0.800
Worm
dephosphorylation GO:0016311 129 0.799
regulation of pigment cell differentiation GO:0050932 7 0.798
ribonucleoside triphosphate metabolic process GO:0009199 220 0.797
Worm
regulation of skeletal muscle fiber development GO:0048742 36 0.796
response to organonitrogen compound GO:0010243 246 0.790
Human Mouse Rat
glial cell apoptotic process GO:0034349 3 0.789
Rat
purine ribonucleotide metabolic process GO:0009150 290 0.781
Worm
organic hydroxy compound metabolic process GO:1901615 203 0.777
cellular macromolecule catabolic process GO:0044265 206 0.777
negative regulation of intracellular transport GO:0032387 38 0.777
cellular response to extracellular stimulus GO:0031668 81 0.777
pigmentation GO:0043473 71 0.777
protein localization to membrane GO:0072657 108 0.776
Mouse
cranial nerve structural organization GO:0021604 13 0.776
regulation of muscle tissue development GO:1901861 97 0.775
metanephric nephron epithelium development GO:0072243 19 0.775
regulation of protein targeting GO:1903533 61 0.773
gliogenesis GO:0042063 141 0.769
Rat
myeloid cell homeostasis GO:0002262 114 0.766
Mouse
carbon catabolite activation of transcription GO:0045991 4 0.766
neuron maturation GO:0042551 29 0.764
positive regulation of nucleotide metabolic process GO:0045981 114 0.764
Worm
negative regulation of immune system process GO:0002683 209 0.763
establishment of protein localization to membrane GO:0090150 54 0.759
Mouse
positive regulation of mitochondrial membrane permeability GO:0035794 12 0.758
Mouse
biomineral tissue development GO:0031214 64 0.758
regulation of proteolysis GO:0030162 164 0.758
Zebrafish Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.757
camera type eye development GO:0043010 266 0.755
Mouse
t cell differentiation GO:0030217 174 0.754
lymphocyte apoptotic process GO:0070227 54 0.753
Mouse
immune response activating signal transduction GO:0002757 116 0.749
Human
renal filtration cell differentiation GO:0061318 10 0.749
regulation of cellular component biogenesis GO:0044087 181 0.748
signal transduction in absence of ligand GO:0038034 55 0.747
regulation of cell cycle GO:0051726 281 0.746
antigen receptor mediated signaling pathway GO:0050851 64 0.745
Human
embryonic limb morphogenesis GO:0030326 126 0.744
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.741
Worm
kidney vasculature development GO:0061440 15 0.740
cellular calcium ion homeostasis GO:0006874 119 0.738
meiotic cell cycle GO:0051321 122 0.738
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.737
Zebrafish Mouse
post embryonic organ morphogenesis GO:0048563 8 0.736
Mouse
regulation of cell cycle process GO:0010564 160 0.735
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.735
regulation of actin cytoskeleton organization GO:0032956 84 0.731
mesoderm development GO:0007498 100 0.729
viral process GO:0016032 41 0.724
single organismal cell cell adhesion GO:0016337 131 0.723
ribonucleoside catabolic process GO:0042454 206 0.723
Worm
protein targeting GO:0006605 143 0.722
myeloid cell apoptotic process GO:0033028 22 0.722
zymogen activation GO:0031638 41 0.721
Mouse
regulation of tissue remodeling GO:0034103 38 0.721
Mouse
vesicle organization GO:0016050 60 0.720
regulation of nucleotide catabolic process GO:0030811 122 0.719
Worm
peptidyl serine modification GO:0018209 83 0.717
development of primary male sexual characteristics GO:0046546 88 0.715
cell substrate junction assembly GO:0007044 24 0.715
purine containing compound metabolic process GO:0072521 311 0.714
Worm
response to alkaloid GO:0043279 34 0.713
Human Mouse Rat
negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 4 0.711
female gamete generation GO:0007292 74 0.709
regulation of endothelial cell migration GO:0010594 22 0.707
carbohydrate derivative biosynthetic process GO:1901137 183 0.704
leukocyte proliferation GO:0070661 172 0.703
Human Mouse
cellular protein catabolic process GO:0044257 155 0.703
odontogenesis of dentin containing tooth GO:0042475 66 0.703
Mouse
pronephric nephron development GO:0039019 1 0.702
response to radiation GO:0009314 165 0.700
ribonucleotide catabolic process GO:0009261 208 0.698
Worm
ovulation cycle GO:0042698 59 0.697
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.696
Worm
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.696
Mouse
membrane fusion GO:0061025 38 0.693
Mouse Worm
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.692
Mouse
leukocyte apoptotic process GO:0071887 71 0.689
Mouse
cerebral cortex development GO:0021987 86 0.688
Mouse
b cell receptor signaling pathway GO:0050853 20 0.686
Human
regulation of t cell differentiation GO:0045580 83 0.686
regulation of binding GO:0051098 111 0.686
Human
epithelial cell proliferation GO:0050673 174 0.684
Mouse
b cell homeostatic proliferation GO:0002358 2 0.684
Mouse
organelle fission GO:0048285 170 0.681
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.680
regulation of protein localization GO:0032880 231 0.678
positive regulation of killing of cells of other organism GO:0051712 3 0.674
male sex differentiation GO:0046661 109 0.673
limb morphogenesis GO:0035108 149 0.671
Mouse
negative regulation of calcium ion transport GO:0051926 9 0.671
forebrain development GO:0030900 302 0.664
Mouse
regulation of protein complex assembly GO:0043254 83 0.663
positive regulation of calcium ion transport into cytosol GO:0010524 9 0.661
Mouse
b cell homeostasis GO:0001782 34 0.660
t cell proliferation GO:0042098 120 0.660
Mouse
regulation of neuron projection development GO:0010975 169 0.656
cellular response to decreased oxygen levels GO:0036294 18 0.653
muscle cell proliferation GO:0033002 52 0.652
metencephalon development GO:0022037 89 0.649
angiogenesis GO:0001525 201 0.649
Mouse
blood vessel morphogenesis GO:0048514 285 0.648
Mouse
release of sequestered calcium ion into cytosol GO:0051209 42 0.648
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.647
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.647
cardiac right atrium morphogenesis GO:0003213 3 0.647
regulation of myeloid cell apoptotic process GO:0033032 19 0.646
cellular response to glucose starvation GO:0042149 5 0.646
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.646
positive regulation of neuron death GO:1901216 28 0.643
Mouse
mitochondrial transport GO:0006839 36 0.642
carbohydrate homeostasis GO:0033500 128 0.641
positive regulation of protein modification process GO:0031401 299 0.638
formation of primary germ layer GO:0001704 77 0.637
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death GO:1902445 2 0.636
Mouse
actin filament organization GO:0007015 113 0.636
t cell activation involved in immune response GO:0002286 43 0.632
positive regulation of cellular response to oxidative stress GO:1900409 6 0.632
Mouse
respiratory system development GO:0060541 190 0.632
positive regulation of organelle organization GO:0010638 128 0.631
Worm
regulation of peptidyl serine phosphorylation GO:0033135 39 0.631
positive regulation of peptidyl serine phosphorylation GO:0033138 25 0.628
negative regulation of cell migration GO:0030336 59 0.625
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.623
synaptic transmission GO:0007268 329 0.621
melanin metabolic process GO:0006582 12 0.619
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.618
purine containing compound catabolic process GO:0072523 213 0.618
Worm
cellular response to external stimulus GO:0071496 88 0.613
multicellular organismal response to stress GO:0033555 62 0.613
negative regulation of cellular component organization GO:0051129 194 0.608
divalent metal ion transport GO:0070838 172 0.606
negative regulation of cytoplasmic transport GO:1903650 29 0.605
regulation of cell adhesion GO:0030155 154 0.603
positive regulation of interleukin 5 secretion GO:2000664 1 0.602
thymus development GO:0048538 41 0.602
positive regulation of oxidative stress induced neuron death GO:1903223 3 0.601
Mouse
response to mycotoxin GO:0010046 1 0.601
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 226 0.601
Worm
negative regulation of ossification GO:0030279 49 0.600
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.598
Human Mouse
epithelium migration GO:0090132 63 0.597
pigment metabolic process GO:0042440 32 0.597
g1 s transition of mitotic cell cycle GO:0000082 57 0.596
cellular response to abiotic stimulus GO:0071214 56 0.595
Mouse
peptidyl serine phosphorylation GO:0018105 74 0.593
b cell selection GO:0002339 3 0.592
Mouse
positive regulation of gliogenesis GO:0014015 27 0.590
regulation of cellular amino acid metabolic process GO:0006521 5 0.589
mammary gland epithelium development GO:0061180 65 0.588
Mouse
epithelial cell development GO:0002064 159 0.584
regulation of cell cycle phase transition GO:1901987 77 0.583
negative regulation of molecular function GO:0044092 258 0.580
Zebrafish
protein localization to nucleus GO:0034504 121 0.579
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.576
ribonucleoside metabolic process GO:0009119 245 0.576
Worm
female gonad development GO:0008585 71 0.575
regulation of neuron death GO:1901214 134 0.575
positive regulation of striated muscle cell differentiation GO:0051155 35 0.575
positive regulation of neuron apoptotic process GO:0043525 25 0.574
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.573
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.573
negative regulation of fat cell differentiation GO:0045599 36 0.572
regulation of metanephros development GO:0072215 15 0.572
aromatic compound catabolic process GO:0019439 286 0.572
Worm
interspecies interaction between organisms GO:0044419 83 0.569
vagina development GO:0060068 11 0.567
Mouse
regulation of axon extension GO:0030516 43 0.566
mesangial cell differentiation GO:0072007 4 0.561
adherens junction organization GO:0034332 28 0.556
negative regulation of neuron death GO:1901215 98 0.554
positive regulation of cell cycle GO:0045787 92 0.554
positive regulation of smooth muscle cell migration GO:0014911 4 0.552
positive regulation of neuron differentiation GO:0045666 141 0.552
b cell apoptotic process GO:0001783 19 0.552
Mouse
purine ribonucleoside catabolic process GO:0046130 205 0.551
Worm
response to starvation GO:0042594 65 0.546
oligodendrocyte differentiation GO:0048709 53 0.545
Rat
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.544
regulation of nucleoside metabolic process GO:0009118 130 0.543
Worm
proteasomal protein catabolic process GO:0010498 98 0.542
liposaccharide metabolic process GO:1903509 27 0.540
Mouse
negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 3 0.540
Mouse
sertoli cell proliferation GO:0060011 5 0.537
Mouse
sequestering of calcium ion GO:0051208 18 0.537
response to hypoxia GO:0001666 58 0.535
small gtpase mediated signal transduction GO:0007264 97 0.535
leukocyte activation involved in immune response GO:0002366 126 0.533
renal system vasculature development GO:0061437 15 0.532
positive regulation of t cell differentiation GO:0045582 52 0.531
metanephric nephron development GO:0072210 34 0.530
negative regulation of cell motility GO:2000146 61 0.528
negative regulation of calcium ion transport into cytosol GO:0010523 2 0.528
somitogenesis GO:0001756 69 0.527

Bcl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.996
cancer DOID:162 0 0.974
phaeochromocytoma DOID:0050771 0 0.752
cell type benign neoplasm DOID:0060084 0 0.752
benign neoplasm DOID:0060072 0 0.752
disease of anatomical entity DOID:7 0 0.655
gastrointestinal system disease DOID:77 0 0.655
urinary system disease DOID:18 0 0.626
kidney cancer DOID:263 0 0.545
urinary system cancer DOID:3996 0 0.545
organ system cancer DOID:0050686 0 0.545